Article ; Online: Urinary and exhaled biomarkers of exercise-induced bronchoconstriction in atopic asthmatic children.
2019 Volume 54, Issue 9, Page(s) 1447–1456
Abstract: Background: Exercise-induced bronchoconstriction (EIB) reflects poor asthma control. Assessing noninvasive biomarkers associated with EIB could help to monitor patients in the pediatric age.: Aims: To test exhaled and urinary biomarkers for assessing ...
Abstract | Background: Exercise-induced bronchoconstriction (EIB) reflects poor asthma control. Assessing noninvasive biomarkers associated with EIB could help to monitor patients in the pediatric age. Aims: To test exhaled and urinary biomarkers for assessing EIB in atopic asthmatic children. Methods: In 45 atopic patients (11.1 ± 1.8 years, 25 males) we measured the fractional exhaled nitric oxide (FE Results: Patients yielded higher FE Conclusion: Concentrations of peripheral airway NO are complementary with urinary adenosine for assessing EIB and promising tools of asthma control in pediatric patients with the atopic phenotype. |
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MeSH term(s) | Adenosine/urine ; Asthma/immunology ; Asthma/physiopathology ; Asthma/urine ; Asthma, Exercise-Induced/urine ; Biomarkers/analysis ; Biomarkers/urine ; Bronchial Provocation Tests ; Bronchoconstriction ; Child ; Deoxyadenosines/urine ; Eosinophils ; Exercise Test ; Exhalation ; Female ; Humans ; Hypersensitivity, Immediate ; Immunoglobulin E/analysis ; Leukocyte Count ; Male ; Nitric Oxide/analysis ; Skin Tests ; Spirometry |
Chemical Substances | 8-hydroxy-2'-deoxyadenosine ; Biomarkers ; Deoxyadenosines ; Nitric Oxide (31C4KY9ESH) ; Immunoglobulin E (37341-29-0) ; Adenosine (K72T3FS567) |
Language | English |
Publishing date | 2019-06-19 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 632784-9 |
ISSN | 1099-0496 ; 8755-6863 |
ISSN (online) | 1099-0496 |
ISSN | 8755-6863 |
DOI | 10.1002/ppul.24419 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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