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  1. Article ; Online: Letter by Cainzos-Achirica Regarding Article, "Incidental Coronary Artery Calcium: Opportunistic Screening of Previous Nongated Chest Computed Tomography Scans to Improve Statin Rates (NOTIFY-1 Project)".

    Cainzos-Achirica, Miguel

    Circulation

    2023  Volume 148, Issue 5, Page(s) 440

    MeSH term(s) Humans ; Calcium ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Coronary Vessels/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Coronary Artery Disease/diagnostic imaging ; Vascular Calcification/diagnostic imaging ; Incidental Findings ; Coronary Angiography
    Chemical Substances Calcium (SY7Q814VUP) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.063210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Polypill in Persons without Cardiovascular Disease.

    Cainzos-Achirica, Miguel

    The New England journal of medicine

    2021  Volume 384, Issue 17, Page(s) 1675–1676

    MeSH term(s) Antihypertensive Agents ; Aspirin ; Cardiovascular Diseases ; Humans ; Hydrochlorothiazide
    Chemical Substances Antihypertensive Agents ; Hydrochlorothiazide (0J48LPH2TH) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-04-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2102972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Debates in cardiac CT: The force of data is with CAC - and it's rock solid.

    Cainzos-Achirica, Miguel / Nasir, Khurram

    Journal of cardiovascular computed tomography

    2022  Volume 16, Issue 4, Page(s) 286–289

    Abstract: In 2022, the data supporting the use of the coronary artery calcium (CAC) score for further risk assessment in asymptomatic individuals uncertain about their management is rich and rock solid. The strong correlations between CAC burden, total coronary ... ...

    Abstract In 2022, the data supporting the use of the coronary artery calcium (CAC) score for further risk assessment in asymptomatic individuals uncertain about their management is rich and rock solid. The strong correlations between CAC burden, total coronary plaque, and incident coronary heart disease and atherosclerotic cardiovascular disease events have been confirmed across multiple cohorts. This information can be used to make personalized decisions involving preventive therapy allocation, informed by absolute risk and expected absolute risk reduction. A more flexible risk management if CAC ​= ​0 is now endorsed across international guidelines, from the US to Europe and Oceania, and recent studies confirming a very low prevalence of severe coronary stenosis and of high-risk plaque features among asymptomatic people with CAC ​= ​0 provide further reassurance about the "power of zero". In contrast, evidence supporting a potential role of coronary computed tomography angiography (CCTA) for risk assessment on top of CAC is very limited in primary prevention. The same is true for the attractive but so far unproven paradigm of using CCTA to screen for subclinical plaque in the general population in lieu of traditional risk scores. The ongoing SCOT-HEART 2 will shed light on the benefits/risks of this strategy, and we encourage our esteemed contenders to include CAC testing as part of the CCTA arm of the trial to maximize clinical relevance. Moving forward, CCTA may have a role in further enhancing the allocation of add-on therapies on top of statins, an interesting area of innovation. However, for now, we pose that rather than replacing CAC with CCTA, the priority should be to improve reimbursement and access to CAC testing, so that more individuals unsure about their risk management can benefit from this information.
    MeSH term(s) Calcium ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/therapy ; Coronary Stenosis ; Humans ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Risk Assessment ; Risk Factors ; Tomography, X-Ray Computed/methods
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2022.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6761: Show issues Location:
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  4. Article ; Online: Role of coronary artery calcium score in the primary prevention of cardiovascular disease.

    Nasir, Khurram / Cainzos-Achirica, Miguel

    BMJ (Clinical research ed.)

    2021  Volume 373, Page(s) n776

    Abstract: First developed in 1990, the Agatston coronary artery calcium (CAC) score is an international guideline-endorsed decision aid for further risk assessment and personalized management in the primary prevention of atherosclerotic cardiovascular disease. ... ...

    Abstract First developed in 1990, the Agatston coronary artery calcium (CAC) score is an international guideline-endorsed decision aid for further risk assessment and personalized management in the primary prevention of atherosclerotic cardiovascular disease. This review discusses key international studies that have informed this 30 year journey, from an initial coronary plaque screening paradigm to its current role informing personalized shared decision making. Special attention is paid to the prognostic value of a CAC score of zero (the so called "power of zero"), which, in a context of low estimated risk thresholds for the consideration of preventive therapy with statins in current guidelines, may be used to
    MeSH term(s) Atherosclerosis/diagnosis ; Atherosclerosis/epidemiology ; Atherosclerosis/prevention & control ; Calcium/analysis ; Computed Tomography Angiography ; Coronary Angiography ; Coronary Vessels/chemistry ; Coronary Vessels/diagnostic imaging ; Diabetes Mellitus/epidemiology ; Humans ; Hypercholesterolemia/epidemiology ; Mass Screening/methods ; Mass Screening/standards ; Practice Guidelines as Topic ; Primary Prevention/standards ; Review Literature as Topic ; Risk Assessment/methods ; Risk Factors
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Further improvements in coronary heart disease mortality in Spain: context, paradoxes, and pathways forward.

    Cainzos-Achirica, Miguel / Bilal, Usama

    Revista espanola de cardiologia (English ed.)

    2021  Volume 74, Issue 10, Page(s) 823–826

    MeSH term(s) Coronary Disease/epidemiology ; Heart Failure ; Humans ; Spain/epidemiology
    Language Spanish
    Publishing date 2021-06-20
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2021.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Coronary Artery Calcium for Personalized Risk Management-A Second Chance for Aspirin in Primary Prevention?

    Cainzos-Achirica, Miguel / Greenland, Philip

    JAMA cardiology

    2020  Volume 6, Issue 2, Page(s) 187–188

    MeSH term(s) Aspirin/therapeutic use ; Calcium ; Coronary Vessels ; Humans ; Primary Prevention ; Risk Management
    Chemical Substances Aspirin (R16CO5Y76E) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2020.4961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Suboptimal Management of Cardiovascular Risk Factors Among Non-US-Citizen Immigrants: Time to Build a Healthier Immigrant Workforce in the United States.

    Cainzos-Achirica, Miguel / Nasir, Khurram

    Circulation. Cardiovascular quality and outcomes

    2020  Volume 13, Issue 3, Page(s) e006498

    MeSH term(s) Adult ; Cardiovascular Diseases ; Emigrants and Immigrants ; Humans ; Prevalence ; Risk Factors ; United States ; Workforce
    Language English
    Publishing date 2020-03-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.120.006498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6744: Show issues Location:
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  8. Article ; Online: Implications of the Plaque Density Paradox for Risk Assessment in 2020.

    Cainzos-Achirica, Miguel / Agrawal, Tanushree

    JACC. Cardiovascular imaging

    2020  Volume 14, Issue 1, Page(s) 243–245

    MeSH term(s) Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Humans ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Risk Assessment
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2020.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6846: Show issues Location:
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  9. Article ; Online: Polypill for Population-Level Primary Cardiovascular Prevention in Underserved Populations-A Social Epidemiology Counterargument.

    Cainzos-Achirica, Miguel / Bilal, Usama

    The American journal of medicine

    2020  Volume 133, Issue 10, Page(s) e541–e543

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Aspirin/therapeutic use ; Cardiovascular Diseases/prevention & control ; Delivery of Health Care ; Diet ; Drug Combinations ; Drug Monitoring ; Environmental Pollution ; Health Literacy ; Health Services Accessibility ; Healthcare Financing ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Implementation Science ; Medically Underserved Area ; Medication Adherence ; Platelet Aggregation Inhibitors/therapeutic use ; Poverty ; Primary Prevention ; Sedentary Behavior ; Social Determinants of Health ; Social Support ; Tobacco Use
    Chemical Substances Antihypertensive Agents ; Drug Combinations ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2020.04.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Supplements for the Treatment of Mild COVID-19-Challenging Health Beliefs With Science From A to Z.

    Michos, Erin D / Cainzos-Achirica, Miguel

    JAMA network open

    2021  Volume 4, Issue 2, Page(s) e210431

    MeSH term(s) Ascorbic Acid ; COVID-19 ; Dietary Supplements ; Humans ; SARS-CoV-2 ; Zinc
    Chemical Substances Zinc (J41CSQ7QDS) ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.0431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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