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  1. Article ; Online: Surgical training and capacity development in the South African internship programme.

    Boden, R / Majiet, I / Balde, I / Naledi, T / Panieri, E / Cairncross, L / Maswime, S

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2023  Volume 113, Issue 8, Page(s) 17–21

    Abstract: Medical practitioners in South Africa manage a quadruple burden of disease. Junior doctors, who contribute significantly to the health workforce, must complete 2 years of internship training and 1 year of community service work in state health facilities ...

    Abstract Medical practitioners in South Africa manage a quadruple burden of disease. Junior doctors, who contribute significantly to the health workforce, must complete 2 years of internship training and 1 year of community service work in state health facilities after graduation to register as an independent medical practitioner. The aim of this article is to give a critical appraisal of the current national internship programme and why it was implemented, and outline suggestions for future changes. There is a compelling need to train competent, confident doctors while ensuring that the requirements and demands of our health system remain a central concern.
    MeSH term(s) Humans ; Internship and Residency ; South Africa ; Physicians ; Health Workforce ; Social Welfare
    Language English
    Publishing date 2023-08-03
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0038-2469 ; 0256-9574
    ISSN (online) 2078-5135
    ISSN 0038-2469 ; 0256-9574
    DOI 10.7196/SAMJ.2023.v113i8.137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of COVID-19 on breast cancer diagnostic and surgical services at a South African academic hospital.

    Van Wyngaard, T / Cairncross, L / Maswime, S / Roodt, L / Malherbe, F

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2022  Volume 60, Issue 2, Page(s) 119–123

    Abstract: Background: The purpose of the study was to describe the impact of the COVID-19 pandemic on diagnostic and surgical breast cancer services at Groote Schuur Hospital (GSH) and affiliated hospitals.: Methods: All patients, newly diagnosed, awaiting ... ...

    Abstract Background: The purpose of the study was to describe the impact of the COVID-19 pandemic on diagnostic and surgical breast cancer services at Groote Schuur Hospital (GSH) and affiliated hospitals.
    Methods: All patients, newly diagnosed, awaiting surgery, and listed for neoadjuvant chemotherapy (NACT) by the breast surgical service from 23 March - 23 June 2020 were included. A historic control was used where appropriate consisting of patients presenting in the same period in 2019. Clinic attendance records and surgical waiting lists were used to identify patients in the three months and data were extracted from hospital records including hospital admission records and surgical operative notes.
    Results: The number of patients who presented with a new breast symptom to the diagnostic breast clinic decreased from 1 094 in 2019 to 299 in 2020, representing a 72.6% decrease. Telemedicine use as a function of the total follow-ups increased from 53% (n = 1 350) in 2019 to 75% (
    Conclusion: The impact of COVID-19 on breast cancer services has been both at the diagnostic level and in delays to surgery. A new online referral system improved referral efficacy translating to more cancers being diagnosed as a function of total referrals. The drop in absolute numbers of cancer diagnoses, however, represents an unmet health need. An expansion of our telemedicine service mitigated COVID risk in the outpatient setting. The greatest impact on our treatment decisions was seen in the cohort of patients placed on neo-adjuvant endocrine therapy (NET). We saw a global decrease in breast surgeries performed, with the greatest decrease being in reconstructions.
    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/surgery ; COVID-19/epidemiology ; Female ; Hospitals ; Humans ; Pandemics ; South Africa/epidemiology
    Language English
    Publishing date 2022-07-18
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Competency Assessment of General Surgery Trainees: A Perspective From the Global South, in a CBME-Naive Context.

    Nel, D / McNamee, L / Wright, M / Alseidi, A A / Cairncross, L / Jonas, E / Burch, V

    Journal of surgical education

    2023  Volume 80, Issue 10, Page(s) 1462–1471

    Abstract: Objective: Before proceeding with local implementation of competency-based medical education-related assessment practices designed and evaluated in the Global North, we sought to challenge the assumption that this would be perceived as both necessary ... ...

    Abstract Objective: Before proceeding with local implementation of competency-based medical education-related assessment practices designed and evaluated in the Global North, we sought to challenge the assumption that this would be perceived as both necessary and acceptable in our context where training and assessment is based on a traditional, knowledge-focused approach. The aim of this study was to determine the perspectives of general surgery trainees and consultants towards the assessment of competence, how this has been achieved previously, and how it should be performed in the future at the University of Cape Town (UCT), South Africa.
    Design: Semi-structured interviews were conducted with consultants and trainees. Interviews were transcribed and then analyzed using a Reflexive Thematic Analysis approach.
    Setting and participants: Ten consultants (5 senior and 5 junior) and 10 trainees (5 South African and 5 international) from the Division of General Surgery at UCT in August 2022.
    Results: Five unique themes were developed: (1) Assessment of competence is essential, (2) competence includes multiple domains of practice, (3) a surgeon must be able to operate, (4) previously used methods were inadequate to assess competence, and (5) frequent assessment with feedback is desired. The themes were considered in the context of Situated Learning Theory, particularly Communities of Practice and their role in the training for, and authentic assessment of, competence in general surgery trainees.
    Conclusions: Participants described a need to develop and implement a new competency assessment program for general surgery training in this context, which is aligned with described competency-based medical education principles. Thoughtful integration of the formative and summative use of direct observation in the workplace, with a clear emphasis on procedural ability and the provision of high-quality feedback, may enhance the successful implementation of a strategy for competency-based assessment in general surgery training programs.
    MeSH term(s) Humans ; Competency-Based Education/methods ; Internship and Residency ; Program Evaluation ; Surgeons ; Clinical Competence
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2023.06.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Surgery for Pheochromocytoma: A Single-Center Review of 60 Cases from South Africa.

    Nel, D / Panieri, E / Malherbe, F / Steyn, R / Cairncross, L

    World journal of surgery

    2020  Volume 44, Issue 6, Page(s) 1918–1924

    Abstract: Background: There is a paucity of data on the presentation and surgical management of pheochromocytoma in developing nations, particularly in Africa.: Methods: This study was a retrospective review, which included all patients managed by the Groote ... ...

    Abstract Background: There is a paucity of data on the presentation and surgical management of pheochromocytoma in developing nations, particularly in Africa.
    Methods: This study was a retrospective review, which included all patients managed by the Groote Schuur Hospital/University of Cape Town Endocrine Surgery unit for pheochromocytoma and abdominal paragangliomas, from January 2002 to June 2019.
    Results: Sixty patients were included in the study, of which 33% were male and 67% female. The mean age was 47 years (range 14-81). The median tumor size was 6 cm, with 45% larger than 6 cm. 92% were located in the adrenal gland (87% unilateral, 5% bilateral), and 8% were extra-adrenal. The conversion rate for laparoscopic cases was 20%, with 55% of cases overall completed laparoscopically. Eleven patients with tumors > 6 cm were initially attempted laparoscopically, of which 3 were converted to open, without any associated increased morbidity. A major adverse event was recorded for 5 cases (8%), including 1 mortality. Overall morbidity, blood loss, operating time and hospital stay were all significantly reduced in the laparoscopic group. There were 5 patients with malignant disease (8%).
    Conclusion: This large series, from an established academic endocrine surgery unit in Africa, can serve as a benchmark for units with similar settings and resource limitations, to compare their surgical management and perioperative outcomes.
    MeSH term(s) Adolescent ; Adrenal Gland Neoplasms/pathology ; Adrenal Gland Neoplasms/surgery ; Adrenal Glands/pathology ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Laparoscopy ; Length of Stay ; Male ; Middle Aged ; Pheochromocytoma/pathology ; Pheochromocytoma/surgery ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05420-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biochemical assessment of the neurotoxicity of gold nanoparticles functionalized with colorectal cancer-targeting peptides in a rat model.

    Pereira, M C / Adewale, O B / Roux, S / Cairncross, L / Davids, H

    Human & experimental toxicology

    2021  Volume 40, Issue 11, Page(s) 1962–1973

    Abstract: The application of gold nanoparticle-peptide conjugates as theranostic agents for colorectal cancer shows much promise. This study aimed at determining the neurotoxic impact of 14 nm gold nanoparticles (AuNPs) functionalized with colorectal cancer- ... ...

    Abstract The application of gold nanoparticle-peptide conjugates as theranostic agents for colorectal cancer shows much promise. This study aimed at determining the neurotoxic impact of 14 nm gold nanoparticles (AuNPs) functionalized with colorectal cancer-targeting peptides (namely p.C, p.L or p.14) in a rat model. Brain tissue samples, obtained from Wistar rats that received a single injection of citrate-capped AuNPs, polyethylene glycol-coated (PEG) AuNPs, p.C-PEG-AuNPs, p.L-PEG-AuNPs or p.14-PEG-AuNPs, and sacrificed after 2- and 12-weeks, respectively, were analysed. Inflammation marker (tumour necrosis factor-α, interleukin-6, interleukin-1β), oxidative stress (superoxide dismutase, catalase, glutathione peroxidase) and apoptotic biomarker (cytochrome
    MeSH term(s) Animals ; Colorectal Neoplasms/drug therapy ; Gold/therapeutic use ; Gold/toxicity ; Male ; Metal Nanoparticles/therapeutic use ; Metal Nanoparticles/toxicity ; Molecular Targeted Therapy/adverse effects ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/physiopathology ; Rats ; Rats, Wistar
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1027454-6
    ISSN 1477-0903 ; 0144-5952 ; 0960-3271
    ISSN (online) 1477-0903
    ISSN 0144-5952 ; 0960-3271
    DOI 10.1177/09603271211017611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Magseed placement before neoadjuvant chemotherapy to facilitate subsequent breastconserving surgery - a single-centre audit.

    Malherbe, F / Roodt, L / Noor, F / Gamieldien, R / Chetty, D / Anderson, D / Thebe, T / Cairncross, L

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie

    2022  Volume 60, Issue 2, Page(s) 109–114

    Abstract: Background: A radio-opaque clip is placed in all patients planned for breast-conserving surgery (BCS) receiving neoadjuvant chemotherapy (NACT) to localise the tumour bed in case response to chemotherapy makes later localisation impossible. A tumour ... ...

    Abstract Background: A radio-opaque clip is placed in all patients planned for breast-conserving surgery (BCS) receiving neoadjuvant chemotherapy (NACT) to localise the tumour bed in case response to chemotherapy makes later localisation impossible. A tumour that was localised with a radio-opaque clip before NACT will then need a second localisation procedure, after the completion of NACT to aid BCS. The two most commonly used methods are hookwire and radioguided occult lesion localisation. Magseed
    Methods: A retrospective cohort study was performed, collecting data on patients who had a Magseed placed before or during NACT from December 2018 to February 2020.
    Results: Twenty-one Magseed devices were placed into the breasts of 20 patients, 18 under ultrasound guidance, and three under stereotactic guidance. The average breast volume of individuals who had seeds placed was 1 532 g ± 869 g. The duration that the seeds were in situ was 138 days ± 45 days. All preoperatively placed seeds were retrieved at the surgery with no observed migration outside the tumour bed.
    Conclusion: Magseed placement before NACT is a safe and technically simple technique that can be done under ultrasound guidance in the majority of cases. It has the advantage of being a single procedure with an associated reduction in time off work and travel cost to the patient, as well as flexibility in terms of the time of placement.
    MeSH term(s) Breast ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy, Segmental/methods ; Neoadjuvant Therapy ; Retrospective Studies ; Ultrasonography
    Language English
    Publishing date 2022-07-18
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 416504-4
    ISSN 2078-5151 ; 0038-2361
    ISSN (online) 2078-5151
    ISSN 0038-2361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Palpable breast lumps: An age-based approach to evaluation and diagnosis.

    Malherbe, Francois / Nel, Daniel / Molabe, Hunadi / Cairncross, Lydia / Roodt, Liana

    South African family practice : official journal of the South African Academy of Family Practice/Primary Care

    2022  Volume 64, Issue 1, Page(s) e1–e5

    Abstract: A palpable breast lump is a common presentation of breast disease to a general practitioner. Fortunately, investigation of most of these lumps will lead to a benign diagnosis. It is essential to have a clear and systematic approach when investigating a ... ...

    Abstract A palpable breast lump is a common presentation of breast disease to a general practitioner. Fortunately, investigation of most of these lumps will lead to a benign diagnosis. It is essential to have a clear and systematic approach when investigating a palpable breast lump to avoid over investigation with the resultant increase in healthcare cost and anxiety. This article will discuss an approach to evaluating and diagnosing a palpable breast lump in the primary care setting.
    MeSH term(s) Breast/diagnostic imaging ; Breast Diseases/diagnosis ; Female ; Humans ; Mammography ; Palpation ; Ultrasonography, Mammary
    Language English
    Publishing date 2022-09-23
    Publishing country South Africa
    Document type Journal Article
    ISSN 2078-6204
    ISSN (online) 2078-6204
    DOI 10.4102/safp.v64i1.5571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19 exposes health worker shortages in the USA and UK, but nationalism and self-interest must not exploit medical workforces from low- and middle-income countries.

    Fagan, J J / Cairncross, L / Biccard, B / Fieggen, G / Maswime, S

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2020  Volume 110, Issue 5, Page(s) 12905

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Developing Countries ; Foreign Medical Graduates/ethics ; Foreign Medical Graduates/supply & distribution ; Foreign Medical Graduates/trends ; Health Personnel/classification ; Health Personnel/ethics ; Health Services Accessibility/trends ; Health Services Needs and Demand/trends ; Health Workforce/ethics ; Health Workforce/trends ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; United Kingdom ; United States
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country South Africa
    Document type Letter
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0038-2469 ; 0256-9574
    ISSN (online) 2078-5135
    ISSN 0038-2469 ; 0256-9574
    DOI 10.7196/SAMJ.2020.v110i5.14774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Contraceptive needs and fertility intentions of women with breast cancer in Cape Town, South Africa: a qualitative study.

    Harries, Jane / Constant, Deborah / Cairncross, Lydia / Moodley, Jennifer

    BMC women's health

    2020  Volume 20, Issue 1, Page(s) 224

    Abstract: Background: No known studies have been undertaken in South Africa exploring the contraceptive and fertility needs and preferences of women of reproductive age (18-49) diagnosed with breast cancer. This study set out to understand the contraceptive needs ...

    Abstract Background: No known studies have been undertaken in South Africa exploring the contraceptive and fertility needs and preferences of women of reproductive age (18-49) diagnosed with breast cancer. This study set out to understand the contraceptive needs and fertility intentions of women with breast cancer in Cape Town, South Africa.
    Methods: Qualitative in-depth interviews were conducted with 24 women diagnosed with breast cancer and 4 health care providers at a tertiary hospital in Cape Town, South Africa. We explored contraceptive use prior to diagnosis; the impact of breast cancer on future fertility intentions and contraceptive use; understanding of suitable contraceptive methods during and after treatment and women's fertility related counseling needs during their continuum of care. Data were analysed using a thematic analysis approach.
    Results: Since being diagnosed with breast cancer, of those women using a contraceptive method, the non-hormonal intrauterine device (IUD) was the most commonly used method. However, women reported receiving limited information from health care providers about contraceptive use and future fertility planning post treatment when fertility desires might change. Many women reported limited information received from healthcare providers about the impact of cancer treatment on their future fertility. Most women did not receive information around fertility preservation options, and few were familiar with the concept. Providers focus was more on preventing pregnancy during treatment and ensuring a patient was on a non-hormonal contraceptive method. Providers supported a more holistic, multidisciplinary approach to breast cancer patient's contraceptive and future fertility needs.
    Conclusions: Limited contraceptive and future fertility counseling were reported by women despite many women being provided with the IUD. There is a need for improved information and counseling regarding the impact of treatment on contraceptive and fertility options. It is important that cancer care providers provide timely information regarding fertility options and communicate with patients about their fertility concerns prior to treatment and throughout the course of survivorship. The development of evidence-based information tools to enhance patient-provider communication and counseling could address knowledge gaps.
    MeSH term(s) Adult ; Breast Neoplasms/drug therapy ; Breast Neoplasms/psychology ; Contraception/methods ; Contraception Behavior ; Contraceptive Agents/administration & dosage ; Family Planning Services/organization & administration ; Female ; Fertility ; Health Services Needs and Demand ; Humans ; Intention ; Interviews as Topic ; Pregnancy ; Qualitative Research ; Reproductive Health Services ; South Africa
    Chemical Substances Contraceptive Agents
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1472-6874
    ISSN (online) 1472-6874
    DOI 10.1186/s12905-020-01094-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Entrustable professional activities in postgraduate general surgery training: a scoping review protocol.

    Nel, Daniel / Jonas, Eduard / Burch, Vanessa / Nel, Amy / Cairncross, Lydia / Alseidi, Adnan / George, Brian / Ten Cate, Olle

    BMJ open

    2023  Volume 13, Issue 3, Page(s) e067322

    Abstract: Introduction: The competency-based medical education (CBME) movement continues to gain momentum in postgraduate physician training, resulting in increasing interest among surgical training programmes on how to implement it effectively. Entrustable ... ...

    Abstract Introduction: The competency-based medical education (CBME) movement continues to gain momentum in postgraduate physician training, resulting in increasing interest among surgical training programmes on how to implement it effectively. Entrustable professional activities (EPAs) were introduced to connect competencies (characteristics/abilities of learners) and the professional activities to be entrusted to them on qualification/graduation. Although reviews related to the field of general surgery have been published on specific aspects of CBME, for example, workplace-based assessment, there is a paucity of published guidance available for surgeon-educators to plan and implement CBME using an EPA framework. This scoping review aims to provide an overview of the current use of EPAs in general surgery.
    Methods and analysis: This scoping review will be based on the original five-stage approach described by Arksey and O'Malley with the addition of protocol-specific items from the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols extension for scoping reviews. The primary research question focuses on describing how EPAs have been used in general surgery and where potential gaps remain that warrant further study. The review will include peer-reviewed journal publications and an extensive review of grey literature sources. The following databases will be searched for published literature from 1 January 2005 to 31 December 2022: PubMed; CINAHL, Africa-Wide Information, PsycInfo and ERIC (via EBSCOhost); Scopus; and SciELO (via Web of Science). Studies that describe the use of EPAs for curriculum design, teaching and/or assessment of competence in postgraduate general surgery training will be eligible for inclusion.
    Ethics and dissemination: The institutional ethics board of the University of Cape Town has granted a waiver of formal approval requirement. The dissemination strategy includes publication of results in peer-reviewed journals, presentation at international conferences and presentation to relevant stakeholders as deemed appropriate.
    MeSH term(s) Humans ; Curriculum ; Competency-Based Education/methods ; Workplace ; Clinical Competence ; Bibliometrics ; Research Design ; Systematic Reviews as Topic ; Review Literature as Topic
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-067322
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