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Book ; Online: Mantelzell-Lymphom

Dreyling, Martin / Buske, Christian / Cairoli, Anne / Heß, Georg / Mey, Ulrich Jeremi Manuel / Pott, Christiane / Raderer, Markus

Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

(Onkopedia Leitlinien)

2021

Abstract: Das Mantelzell - Lymphom wird histologisch als indolentes (zytisches) Lymphom klassifiziert, zeigt einen heterogenen, bei einem Teil der Patienten aggressiven Verlauf. Pathognomonisch ist die chromosomale Translokation t(11;14) mit konsekutiver ... ...

Institution	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie Schweizerische Gesellschaft für Medizinische Onkologie Schweizerische Gesellschaft für Hämatologie
Author's details	DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V., OeGHO - Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SSMO/SSOM/SGMO - Schweizerische Gesellschaft für Medizinische Onkologie, SGH-SSH - Schweizerische Gesellschaft für Hämatologie/Société Suisse d'Hématologie ; Autoren: Martin Dreyling, Christian Buske, Anne Cairoli, Georg Heß, Ulrich J. M. Mey, Christiane Pott, Markus Raderer
Series title	Onkopedia Leitlinien
Abstract	Das Mantelzell - Lymphom wird histologisch als indolentes (zytisches) Lymphom klassifiziert, zeigt einen heterogenen, bei einem Teil der Patienten aggressiven Verlauf. Pathognomonisch ist die chromosomale Translokation t(11;14) mit konsekutiver Überexpression von Cyclin-D1. Die große Mehrzahl der Patienten wird in fortgeschrittenen Stadien diagnostiziert. Die Prognose kann mittels des klinischen MCL International Prognostic Index (MIPI) bzw. etablierter biologischer Faktoren (blastische Variante, Ki-67, p53-Alteration (Mutationen in PCR oder NGS, Überexpression in der Immunhistochemie) abgeschätzt werden. Der MIPI-c führt die klinische Prognoseabschätzung mit dem biologischen Marker Ki67 zusammen, und erlaubt eine differenziertere Risikoabschätzung, ohne zurzeit eine Therapiestratifizierung nach sich zu ziehen. Die mediane Überlebenszeit liegt für alle Patienten bei etwa 5 Jahren, mit erheblichen Unterschieden in den verschiedenen Risikogruppen.
Subject code	610
Language	German
Size	1 Online-Ressource (16 Seiten), Diagramme
Edition	Stand: Mai 2021
Publisher	DGHO Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
Publishing place	Berlin
Publishing country	Germany
Document type	Book ; Online
Note	Autoren früherer Versionen: Johannes Drach, Michael Herold, Mathias J. Rummel ; Open Access
HBZ-ID	HT021152769
DOI	10.4126/FRL01-006430439
Database	Repository for Life Sciences

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Article ; Online: Pseudo-macrocytosis in chronic lymphocytic leukaemia.

Costanza, Mariangela / Coutaz, Christine / Cairoli, Anne / Gavillet, Mathilde

International journal of laboratory hematology

2023 Volume 45, Issue 5, Page(s) 623–624

MeSH term(s)	Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Anemia ; Erythrocyte Indices ; Folic Acid Deficiency
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.14091
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Article ; Online: Fungal spore contamination mimicking parasitic infection.

Blum, Sabine / Cairoli, Anne

Blood

2019 Volume 134, Issue 10, Page(s) 841

MeSH term(s)	Animals ; Diagnosis, Differential ; Equipment Contamination ; Hematologic Tests/instrumentation ; Hematologic Tests/methods ; Histological Techniques/instrumentation ; Humans ; Lymphoma, B-Cell/blood ; Lymphoma, B-Cell/complications ; Male ; Microfilariae/isolation & purification ; Middle Aged ; Parasitic Diseases/blood ; Parasitic Diseases/complications ; Parasitic Diseases/diagnosis ; Spores, Fungal/isolation & purification ; Spores, Fungal/physiology
Language	English
Publishing date	2019-09-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2019002010
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Article ; Online: Successful autologous hematopoietic stem cell transplantation in a refractory anti-Caspr1 antibody nodopathy.

Afanasiev, Vadim / Tsouni, Pinelopi / Kuntzer, Thierry / Cairoli, Anne / Delmont, Emilien / Vallat, Jean-Michel / Devaux, Jérôme / Théaudin, Marie

Journal of the peripheral nervous system : JPNS

2024 Volume 29, Issue 1, Page(s) 116–119

Abstract: Aim: Autoimmune nodopathies have specific clinicopathologic features, antibodies directed against nodal proteins (neurofascin 186) or paranodal proteins (neurofascin 155, contactin 1, contactin-associated protein 1 (Caspr1)), and usually have a poor ... ...

Abstract	Aim: Autoimmune nodopathies have specific clinicopathologic features, antibodies directed against nodal proteins (neurofascin 186) or paranodal proteins (neurofascin 155, contactin 1, contactin-associated protein 1 (Caspr1)), and usually have a poor response to first-line therapies for chronic inflammatory demyelinating polyradiculoneuropathy. Anti-Caspr1 nodopathy treated with autologous hematopoietic stem cell transplantation (AHSCT) has not been previously reported. Methods: We report the first case of an anti-Caspr1 antibody-positive nodopathy refractory to high-intensity immunosuppressive treatment, including rituximab, that responded dramatically to AHSCT. Results: A 53-year-old woman presented with a rapidly progressive generalized ataxic, painful motor, and inflammatory neuropathy supported by neurophysiologic and MRI studies. Initial tests for antibodies to nodal/paranodal proteins were negative. She was treated with multiple courses of intravenous immunoglobulin and methylprednisolone, plasma exchange, rituximab, and cyclophosphamide without significant clinical benefit. Repeated testing for antibodies to nodal/paranodal proteins yielded a positive result for anti-Caspr1/IgG4 isotype antibodies. Given the poor response to multiple high intensity treatments and the relatively young age of the patient, we decided to perform AHSCT at 30 months post-onset. Immediately after AHSCT, she stopped all immunomodulatory or immunosuppressive therapy. The Overall Neuropathy Limitation Score improved from 8/12 to 4/12 at 6 months post-AHSCT. At 3 months post-AHSCT, IgG4 against Caspr1 was negative and no reactivity against paranodes could be detected. Conclusion: We report a particularly severe anti-Caspr1 antibody autoimmune nodopathy that responded dramatically to AHSCT. Although the rarity of the disease limits the possibility of larger studies, AHSCT may be a valuable therapy in treatment-refractory cases.
MeSH term(s)	Female ; Humans ; Child, Preschool ; Middle Aged ; Rituximab/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Axons/pathology ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/therapy ; Immunoglobulin G ; Autoantibodies
Chemical Substances	Rituximab (4F4X42SYQ6) ; Immunoglobulin G ; Autoantibodies
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	1364009-4
ISSN	1529-8027 ; 1085-9489
ISSN (online)	1529-8027
ISSN	1085-9489
DOI	10.1111/jns.12610
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Article: Successful salvage therapy for refractory primary cutaneous gamma-delta T-cell lymphoma with a combination of brentuximab vedotin and gemcitabine.

Voruz, Sophie / de Leval, Laurence / Cairoli, Anne

Experimental hematology & oncology

2021 Volume 10, Issue 1, Page(s) 32

Abstract: Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very rare lymphoma with an aggressive clinical course and a dismal outcome. The prognosis is linked to a pronounced resistance to chemotherapy and radiotherapy. No standard treatment approach ... ...

Abstract	Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very rare lymphoma with an aggressive clinical course and a dismal outcome. The prognosis is linked to a pronounced resistance to chemotherapy and radiotherapy. No standard treatment approach is defined due to the low frequency of the disease and lack of prospective studies. CD30 is expressed in almost half of the cases of PCGD-TCL, which offers a potential therapeutic option. We report the successful treatment of a 68-year-old man who suffered PCGD-TCL with a combination of Brentuximab Vedotin and Gemcitabine after the failure of two lines of previous chemotherapy. CD30 expression was only partial. The treatment was very well tolerated and allowed the patient to benefit from allogeneic hematopoietic stem cell transplantation.
Language	English
Publishing date	2021-05-13
Publishing country	England
Document type	Letter
ZDB-ID	2669066-4
ISSN	2162-3619
ISSN	2162-3619
DOI	10.1186/s40164-021-00225-2
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Article: Simultaneous kinetics of oral vorinostat in plasma and cerebrospinal fluid in a patient with cutaneous T-cell lymphoma with CNS involvement.

Papadopoulou, Vasiliki / Degrauwe, Nils / Decosterd, Laurent Arthur / Buclin, Thierry / Cairoli, Anne

International journal of clinical pharmacology and therapeutics

2023 Volume 61, Issue 6, Page(s) 270–272

MeSH term(s)	Humans ; Vorinostat/therapeutic use ; Kinetics ; Lymphoma, T-Cell, Cutaneous/drug therapy ; Lymphoma, T-Cell, Cutaneous/pathology ; Antineoplastic Agents/therapeutic use ; Skin Neoplasms/drug therapy
Chemical Substances	Vorinostat (58IFB293JI) ; Antineoplastic Agents
Language	English
Publishing date	2023-04-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP204364
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Article ; Online: Successful Rapid Oral Desensitization to Ibrutinib in a Patient With Severe Immediate Hypersensitivity Reaction.

Tsilimidos, Gerasimos / Horisberger, Alice / Ribi, Camillo / Cairoli, Anne / Stalder, Gregoire

Clinical lymphoma, myeloma & leukemia

2021 Volume 21, Issue 10, Page(s) e745–e747

MeSH term(s)	Adenine/analogs & derivatives ; Adenine/pharmacology ; Adenine/therapeutic use ; Administration, Oral ; Central Nervous System Neoplasms/drug therapy ; Female ; Humans ; Hypersensitivity, Immediate/drug therapy ; Middle Aged ; Piperidines/pharmacology ; Piperidines/therapeutic use
Chemical Substances	Piperidines ; ibrutinib (1X70OSD4VX) ; Adenine (JAC85A2161)
Language	English
Publishing date	2021-05-24
Publishing country	United States
Document type	Case Reports ; Editorial
ZDB-ID	2540992-X
ISSN	2152-2669 ; 2152-2650
ISSN (online)	2152-2669
ISSN	2152-2650
DOI	10.1016/j.clml.2021.05.014
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Article ; Online: Sinonasal relapses of a primary isolated extranodal NK/T-cell lymphoma of the testis.

Hallak, Bassel / Cairoli, Anne / Bouayed, Salim / Berthod, Grégoire

BMJ case reports

2019 Volume 12, Issue 8

Abstract: WHO first recognised extranodal NK/T-cell lymphoma (ENKTCL) in 2001, thanks to technical advances in anatomopathology and immunohistochemistry. It is divided into nasal and extranasal subgroups depending on the primary site. Primary isolated NK/T-cell ... ...

Abstract	WHO first recognised extranodal NK/T-cell lymphoma (ENKTCL) in 2001, thanks to technical advances in anatomopathology and immunohistochemistry. It is divided into nasal and extranasal subgroups depending on the primary site. Primary isolated NK/T-cell lymphoma of the testis is rare. Typical recurrence sites of primary testicular NK/T-cell lymphoma are the gastrointestinal tract, lymph nodes, skin, spleen and central nervous system. Nasal relapses of a primary NK/T-cell lymphoma of the testis are very rare and according to our knowledge, no other case has been reported yet in the literature. The authors report the case of a 35-year-old Caucasian man relapsing twice in the nasal cavity 1 year after initial diagnosis and treatment of a primary isolated, stage IE, ENKTCL of the testis. We report the clinical and radiological presentation of the nasal relapses and the different modalities of treatment that were applied. Sinonasal relapses of an isolated primary NK/T-cell lymphoma of the testis are very rare. ENKTCL is a very aggressive entity, even at an early stage, therefore, requiring a multimodal treatment approach including chemotherapy and radiotherapy. New strategies to treat this disease are needed.
MeSH term(s)	Adult ; Combined Modality Therapy ; Diagnosis, Differential ; Humans ; Lymphoma, Extranodal NK-T-Cell/diagnosis ; Lymphoma, Extranodal NK-T-Cell/pathology ; Lymphoma, Extranodal NK-T-Cell/therapy ; Male ; Neoplasm Metastasis ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/therapy ; Nose Neoplasms/diagnosis ; Nose Neoplasms/diagnostic imaging ; Nose Neoplasms/secondary ; Nose Neoplasms/therapy ; Positron-Emission Tomography ; Testicular Neoplasms/diagnosis ; Testicular Neoplasms/pathology ; Testicular Neoplasms/therapy ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-08-13
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2019-230221
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Article ; Online: Follicular Lymphoma Presenting With Symptomatic Bone Involvement: A Clinicopathologic and Molecular Analysis of 16 Cases.

Sarro, Rossella / Bisig, Bettina / Guey, Baptiste / Missiaglia, Edoardo / Cairoli, Anne / Omoumi, Patrick / Letovanec, Igor / Ferry, Judith A / Hasserjian, Robert P / de Leval, Laurence

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2024 Volume 37, Issue 4, Page(s) 100440

Abstract: Primary bone lymphoma (PBL) is rare and mostly represented by diffuse large B-cell lymphomas (DLBCL). Follicular lymphoma (FL), albeit commonly disseminating to the bone marrow, rarely presents primarily as bone lesions. Here, we studied 16 patients (12 ... ...

Abstract	Primary bone lymphoma (PBL) is rare and mostly represented by diffuse large B-cell lymphomas (DLBCL). Follicular lymphoma (FL), albeit commonly disseminating to the bone marrow, rarely presents primarily as bone lesions. Here, we studied 16 patients (12 men:4 women, median age 60 years) who presented with bone pain and/or skeletal radiologic abnormalities revealing bone FL. Lesions were multifocal in 11 patients (spine ± appendicular skeleton), and unifocal in 5 patients (femoral, tibial, or vertebral). An infiltrate of centrocytes and centroblasts (CD20+ CD5- CD10+ BCL2+ BCL6+) with abundant reactive T cells and an increased reticulin fibrosis massively replaced the marrow spaces between preserved bone trabeculae. The pattern was diffuse ± nodular, often with paratrabecular reinforcement and/or peripheral paratrabecular extension. Ki-67 was usually <15%. Two cases had necrosis. BCL2 rearrangement was demonstrated in 14 of 14 evaluable cases (with concomitant BCL6 rearrangement in one). High-throughput sequencing revealed BCL2, KMT2D, and TNFRSF14 to be the most frequently mutated genes. After staging, 5 qualified for PBL (3 limited stage) and 11 had stage IV systemic FL. All patients received rituximab ± polychemotherapy as firstline treatment, and 7 received local therapy (6 radiotherapy and 2 surgery). Three patients experienced transformation to DLBCL. At the last follow-up (15/16, median 48 months), 11 patients achieved complete remission, including all cases with PBL and most patients with limited extraosseous disease (3-year progression-free survival 71%). One patient died of unrelated cause (3-year overall survival 91%). FL may manifest as a localized or polyostotic bone disease. A minority represent PBL, whereas most reveal systemic disease.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Lymphoma, Follicular/genetics ; Lymphoma, Follicular/therapy ; Lymphoma, Follicular/pathology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Rituximab ; Progression-Free Survival ; Proto-Oncogene Proteins c-bcl-2/genetics
Chemical Substances	Rituximab (4F4X42SYQ6) ; Proto-Oncogene Proteins c-bcl-2
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1016/j.modpat.2024.100440
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Article ; Online: Acute lymphoblastic leukaemia presenting as euglycaemic ketoacidosis in a patient with type 1 diabetes.

Gavillet, Mathilde / Schaefer, Niklaus / Lapointe, Anne-Karine / Spertini, Olivier / Cairoli, Anne

The Lancet. Haematology

2021 Volume 8, Issue 7, Page(s) e534

MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 1/complications ; Humans ; Ketosis/complications ; Ketosis/diagnosis ; Male ; Positron-Emission Tomography ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Young Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2021-06-25
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	2352-3026
ISSN (online)	2352-3026
DOI	10.1016/S2352-3026(21)00062-4
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