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  1. Article ; Online: An ensemble recruited by α

    Brown, Jordan A / Petersen, Nicholas / Centanni, Samuel W / Jin, Allie Y / Yoon, Hye Jean / Cajigas, Stephanie A / Bedenbaugh, Michelle N / Luchsinger, Joseph R / Patel, Sachin / Calipari, Erin S / Simerly, Richard B / Winder, Danny G

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2022  Volume 48, Issue 8, Page(s) 1133–1143

    Abstract: ... ...

    Abstract α
    MeSH term(s) Mice ; Animals ; Guanfacine/pharmacology ; Norepinephrine/pharmacology ; Neurons ; Substance-Related Disorders ; Signal Transduction ; Septal Nuclei
    Chemical Substances Guanfacine (30OMY4G3MK) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2022-09-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-022-01442-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2379: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Dopamine release in the nucleus accumbens core signals perceived saliency.

    Kutlu, Munir Gunes / Zachry, Jennifer E / Melugin, Patrick R / Cajigas, Stephanie A / Chevee, Maxime F / Kelly, Shannon J / Kutlu, Banu / Tian, Lin / Siciliano, Cody A / Calipari, Erin S

    Current biology : CB

    2021  Volume 31, Issue 21, Page(s) 4748–4761.e8

    Abstract: A large body of work has aimed to define the precise information encoded by dopaminergic projections innervating the nucleus accumbens (NAc). Prevailing models are based on reward prediction error (RPE) theory, in which dopamine updates associations ... ...

    Abstract A large body of work has aimed to define the precise information encoded by dopaminergic projections innervating the nucleus accumbens (NAc). Prevailing models are based on reward prediction error (RPE) theory, in which dopamine updates associations between rewards and predictive cues by encoding perceived errors between predictions and outcomes. However, RPE cannot describe multiple phenomena to which dopamine is inextricably linked, such as behavior driven by aversive and neutral stimuli. We combined a series of behavioral tasks with direct, subsecond dopamine monitoring in the NAc of mice, machine learning, computational modeling, and optogenetic manipulations to describe behavior and related dopamine release patterns across multiple contingencies reinforced by differentially valenced outcomes. We show that dopamine release only conforms to RPE predictions in a subset of learning scenarios but fits valence-independent perceived saliency encoding across conditions. Here, we provide an extended, comprehensive framework for accumbal dopamine release in behavioral control.
    MeSH term(s) Animals ; Cues ; Dopamine ; Mice ; Nucleus Accumbens ; Optogenetics ; Reward
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.08.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice.

    Perusini, Jennifer N / Cajigas, Stephanie A / Cohensedgh, Omid / Lim, Sean C / Pavlova, Ina P / Donaldson, Zoe R / Denny, Christine A

    Hippocampus

    2017  Volume 27, Issue 10, Page(s) 1110–1122

    Abstract: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques and tau neurofibrillary tangles. APPswe/PS1dE9 (APP/PS1) mice have been developed as an AD model and are characterized by plaque formation at 4- ... ...

    Abstract Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques and tau neurofibrillary tangles. APPswe/PS1dE9 (APP/PS1) mice have been developed as an AD model and are characterized by plaque formation at 4-6 months of age. Here, we sought to better understand AD-related cognitive decline by characterizing various types of memory. In order to better understand how memory declines with AD, APP/PS1 mice were bred with ArcCreER
    MeSH term(s) Aging/pathology ; Aging/physiology ; Aging/psychology ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Alzheimer Disease/psychology ; Alzheimer Disease/therapy ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Cognition/physiology ; Dentate Gyrus/pathology ; Dentate Gyrus/physiopathology ; Disease Models, Animal ; Disease Progression ; Humans ; Male ; Memory/physiology ; Memory Disorders/pathology ; Memory Disorders/physiopathology ; Memory Disorders/therapy ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Neuropsychological Tests ; Optogenetics ; Presenilin-1/genetics ; Presenilin-1/metabolism ; Social Behavior ; Spatial Behavior/physiology
    Chemical Substances APP protein, human ; Amyloid beta-Protein Precursor ; PSEN1 protein, human ; Presenilin-1
    Language English
    Publishing date 2017-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.22756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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