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Article: SPECIAL ISSUE: "FOCUS ON PEDIATRIC CARDIOLOGY".

Calabrò, M P

Journal of biological regulators and homeostatic agents

2020 Volume 34, Issue 4 Suppl. 2, Page(s) 1–1

Abstract: This special issue provides a rich blend of news, reviews and clinical studies on many aspects of the understanding, management and prevention of cardiovascular disease in childhood. Primary care in pediatric cardiology, principally, must concern with ... ...

Abstract	This special issue provides a rich blend of news, reviews and clinical studies on many aspects of the understanding, management and prevention of cardiovascular disease in childhood. Primary care in pediatric cardiology, principally, must concern with prevention of heart disease and early detection of existing illness. In addition, pediatricians must be able to maintain the vigilance of "healthy" children in order to prevent cardiovascular risk in adulthood. With these goals, the themes presented in this "mosaic" of topics include - Cardiovascular involvement in genetic syndromes, SIDS and infectious, endocrine, kidney, storage or autoimmune diseases. - Pulmonary hypertension and patent ductus arteriosus in premature infants. - Cardiovascular risk in obese or hypertensive children. - Bicupid aortic valve and aortic dysfunction - Covid 19 and heart disease in childhood I thank the Researchers and Professors of Catanzaro, Palermo, Pavia, Brescia, Taormina and Messina University for their interesting and up-to-date scientific contributions, and I hope the information gathered in this issue will be useful to the reader.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Cardiology ; Child ; Coronavirus Infections ; Humans ; Infant ; Pandemics ; Pediatrics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-09-30
Publishing country	Italy
Document type	Introductory Journal Article
ZDB-ID	639196-5
ISSN	1724-6083 ; 0393-974X
ISSN (online)	1724-6083
ISSN	0393-974X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Network Analysis Performed on Transcriptomes of Parkinson's Disease Patients Reveals Dysfunction in Protein Translation.

D'Angiolini, Simone / Lui, Maria / Mazzon, Emanuela / Calabrò, Marco

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra region of the brain. The hallmark pathological feature of PD is the accumulation of misfolded ...

Abstract	Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra region of the brain. The hallmark pathological feature of PD is the accumulation of misfolded proteins, leading to the formation of intracellular aggregates known as Lewy bodies. Recent data evidenced how disruptions in protein synthesis, folding, and degradation are events commonly observed in PD and may provide information on the molecular background behind its etiopathogenesis. In the present study, we used a publicly available transcriptomic microarray dataset of peripheral blood of PD patients and healthy controls (GSE6613) to investigate the potential dysregulation of elements involved in proteostasis-related processes at the transcriptomic level. Our bioinformatics analysis revealed 375 differentially expressed genes (DEGs), of which 281 were down-regulated and 94 were up-regulated. Network analysis performed on the observed DEGs highlighted a cluster of 36 elements mainly involved in the protein synthesis processes. Different enriched ontologies were related to translation initiation and regulation, ribosome structure, and ribosome components nuclear export. Overall, this data consistently points to a generalized impairment of the translational machinery and proteostasis. Dysregulation of these mechanics has been associated with PD pathogenesis. Understanding the precise regulation of such processes may shed light on the molecular mechanisms of PD and provide potential data for early diagnosis.
MeSH term(s)	Humans ; Parkinson Disease/metabolism ; Transcriptome ; Lewy Bodies/metabolism ; Gene Expression Profiling ; Protein Biosynthesis ; Substantia Nigra/metabolism
Language	English
Publishing date	2024-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021299
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Article ; Online: In Silico Analysis Highlights Potential Predictive Indicators Associated with Secondary Progressive Multiple Sclerosis.

Calabrò, Marco / Lui, Maria / Mazzon, Emanuela / D'Angiolini, Simone

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: Multiple sclerosis (MS) is a complex inflammatory disease affecting the central nervous system. Most commonly, it begins with recurrent symptoms followed by partial or complete recovery, known as relapsing-remitting MS (RRMS). Over time, many RRMS ... ...

Abstract	Multiple sclerosis (MS) is a complex inflammatory disease affecting the central nervous system. Most commonly, it begins with recurrent symptoms followed by partial or complete recovery, known as relapsing-remitting MS (RRMS). Over time, many RRMS patients progress to secondary progressive MS (SPMS), marked by gradual symptom deterioration. The factors triggering this transition remain unknown, lacking predictive biomarkers. This study aims to identify blood biomarkers specific to SPMS. We analyzed six datasets of SPMS and RRMS patients' blood and brain tissues, and compared the differential expressed genes (DEGs) obtained to highlight DEGs reflecting alterations occurring in both brain and blood tissues and the potential biological processes involved. We observed a total of 38 DEGs up-regulated in both blood and brain tissues, and their interaction network was evaluated through network analysis. Among the aforementioned DEGs, 21 may be directly involved with SPMS transition. Further, we highlighted three biological processes, including the calcineurin-NFAT pathway, related to this transition. The investigated DEGs may serve as a promising means to monitor the transition from RRMS to SPMS, which is still elusive. Given that they can also be sourced from blood samples, this approach could offer a relatively rapid and convenient method for monitoring MS and facilitating expedited assessments.
MeSH term(s)	Humans ; Multiple Sclerosis, Chronic Progressive/genetics ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis, Relapsing-Remitting/metabolism ; Brain/metabolism ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063374
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Article: SPECIAL ISSUE: "FOCUS ON PEDIATRIC CARDIOLOGY"

Calabrò, M. P.

J Biol Regul Homeost Agents

Abstract: This special issue provides a rich blend of news, reviews and clinical studies on many aspects of the understanding, management and prevention of cardiovascular disease in childhood Primary care in pediatric cardiology, principally, must concern with ... ...

Abstract	This special issue provides a rich blend of news, reviews and clinical studies on many aspects of the understanding, management and prevention of cardiovascular disease in childhood Primary care in pediatric cardiology, principally, must concern with prevention of heart disease and early detection of existing illness In addition, pediatricians must be able to maintain the vigilance of "healthy" children in order to prevent cardiovascular risk in adulthood With these goals, the themes presented in this "mosaic" of topics include - Cardiovascular involvement in genetic syndromes, SIDS and infectious, endocrine, kidney, storage or autoimmune diseases - Pulmonary hypertension and patent ductus arteriosus in premature infants - Cardiovascular risk in obese or hypertensive children - Bicupid aortic valve and aortic dysfunction - Covid 19 and heart disease in childhood I thank the Researchers and Professors of Catanzaro, Palermo, Pavia, Brescia, Taormina and Messina University for their interesting and up-to-date scientific contributions, and I hope the information gathered in this issue will be useful to the reader
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #809071
Database	COVID19

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Article ; Online: Body weight changes and bipolar disorder: a molecular pathway analysis.

Calabró, Marco / Briuglia, Silvana / Crisafulli, Concetta / Drago, Antonio

Pharmacogenetics and genomics

2022 Volume 32, Issue 9, Page(s) 308–320

Abstract: Background: There is evidence suggesting a link between weight-related disorders and bipolar disorder (BD). The pathophysiology of the association includes psychological, social and psychotropic treatment-related variables, together with psychiatric ... ...

Abstract	Background: There is evidence suggesting a link between weight-related disorders and bipolar disorder (BD). The pathophysiology of the association includes psychological, social and psychotropic treatment-related variables, together with psychiatric comorbidity. Weight changes during BD may influence compliance to the treatment, quality of life and prognosis, and can modulate risk of death associated with, for example, diabetes or cardiovascular disorders. Methods: The STEP-BD sample is analyzed through a hypothesis-free molecular pathway analysis in order to detect the molecular pathways that distinguish individuals who experience weight change during BD treatment from those who do not. A total of 618 individuals were available for the analysis, mean age = 41.19 ± 12.58, females = 351 (56.8%). Socioeconomic variables and treatment-related variables were included as clinical covariates. A cluster analysis in the genetic dataset provided the genetic covariate input to the study to avoid stratification factors. Result: After applying the quality analysis that is typical for this kind of investigation, no Genome Wide Association Study significant finding was retrieved. Six molecular pathways were found to be significantly associated with weight change during the first 3 months of treatment after correction for multiple testing. Of those, CDC42 (R-HSA-9013148) participates in insulin synthesis and secretion and contributes to the pathogenesis of insulin resistance and Rac Family Small GTPase 1 (R-HSA-9013149) is involved in metabolic regulation of pancreatic islet β-cells and in diabetes pathophysiology. Discussion: Pathways that are central in energy homeostasis may play a role to separate individuals with BD that will experience weight changes during treatment from those who will not. If confirmed, such finding can be instrumental in the identification of the correct preventive strategies and most correct treatment to increase compliance and efficacy in the treatment of BD.
MeSH term(s)	Female ; Humans ; Adult ; Middle Aged ; Bipolar Disorder/drug therapy ; Bipolar Disorder/genetics ; Quality of Life ; Genome-Wide Association Study ; Psychotropic Drugs/therapeutic use ; Body Weight
Chemical Substances	Psychotropic Drugs
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2175826-8
ISSN	1744-6880 ; 0960-314X ; 1744-6872
ISSN (online)	1744-6880
ISSN	0960-314X ; 1744-6872
DOI	10.1097/FPC.0000000000000484
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3660: Show issues

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Article ; Online: Maternal mind-mindedness and communicative functions in free-play and mealtime contexts: Stability, continuity and relations with child language at 16 months.

Longobardi, Emiddia / Spataro, Pietro / Calabrò, Martina

Journal of child language

2021 Volume 49, Issue 4, Page(s) 635–660

Abstract: The present study aimed at investigating the contextual stability, the contextual continuity and the concurrent associations between maternal measures (general language, communicative functions and mind-mindedness) and child measures (total number of ... ...

Abstract	The present study aimed at investigating the contextual stability, the contextual continuity and the concurrent associations between maternal measures (general language, communicative functions and mind-mindedness) and child measures (total number of word types and tokens) in two different contexts, free-play and mealtime. To this purpose, the interactions occurring between 25 mothers and their 16-month-old children in each context were video-recorded, transcribed and later coded for the selected measures. Significant contextual stability was observed in the mothers' production of general language measures (total number of utterances, total number of words and MLU), in the children's production of word types and tokens, and in some communicative functions (Tutorial, Control and Asynchronous). No contextual stability was found for the mothers' production of attuned mind-related comments. For continuity, both mothers and children produced more utterances and words in the free-play than in the mealtime context; the production of attuned mind-related comments and the use of the Control function were also more frequent in the free-play context. Lastly, the analysis of the concurrent correlations indicated that, especially in the mealtime context, the number of words produced by children was positively associated with the number of words produced by mothers and by their use of the Tutorial and Didactic functions, but negatively associated with their use of the Control function. The mothers' production of attuned mind-related comments bore no relation with children's expressive language. Similarities and differences with previous findings are discussed.
MeSH term(s)	Child ; Child Language ; Female ; Humans ; Infant ; Language Development ; Meals ; Mother-Child Relations ; Mothers
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1466489-6
ISSN	1469-7602 ; 0305-0009
ISSN (online)	1469-7602
ISSN	0305-0009
DOI	10.1017/S0305000920000835
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The biological pathways of Alzheimer disease: a review.

Calabrò, Marco / Rinaldi, Carmela / Santoro, Giuseppe / Crisafulli, Concetta

AIMS neuroscience

2020 Volume 8, Issue 1, Page(s) 86–132

Abstract: Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older people, which severely impairs patients' quality of life. In the recent years, the number of affected individuals has seen a rapid increase. It is estimated that up to ... ...

Abstract	Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older people, which severely impairs patients' quality of life. In the recent years, the number of affected individuals has seen a rapid increase. It is estimated that up to 107 million subjects will be affected by 2050 worldwide. Research in this area has revealed a lot about the biological and environmental underpinnings of Alzheimer, especially its correlation with β-Amyloid and Tau related mechanics; however, the precise molecular events and biological pathways behind the disease are yet to be discovered. In this review, we focus our attention on the biological mechanics that may lie behind Alzheimer development. In particular, we briefly describe the genetic elements and discuss about specific biological processes potentially associated with the disease.
Language	English
Publishing date	2020-12-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2777113-1
ISSN	2373-7972 ; 2373-7972
ISSN (online)	2373-7972
ISSN	2373-7972
DOI	10.3934/Neuroscience.2021005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sustainability in Healthcare: Perspectives and Reflections Regarding Laboratory Medicine.

Molero, Aroa / Calabrò, Michele / Vignes, Maguelone / Gouget, Bernard / Gruson, Damien

Annals of laboratory medicine

2020 Volume 41, Issue 2, Page(s) 139–144

Abstract: Healthcare structures serve to protect and improve public health; however, they can have negative effects on human well-being and the environment. Thus, sustainability is an important target in a rapidly changing healthcare environment. We analyzed the ... ...

Abstract	Healthcare structures serve to protect and improve public health; however, they can have negative effects on human well-being and the environment. Thus, sustainability is an important target in a rapidly changing healthcare environment. We analyzed the state of the art in research on healthcare and sustainability by exploring literature on different healthcare systems and their relations with the environment. Our review presents conceptual and practical developments regarding sustainability, as well as an overview of their evolution in the healthcare sector over time. We also discuss how sustainability could be applied to reduce the environmental impact of clinical laboratories by ensuring that resources are used efficiently and responsibly. Finally, we describe how laboratory medicine can contribute to a sustainable healthcare system through integration of innovation and emerging technologies while providing high-quality services to patients and caregivers.
MeSH term(s)	Delivery of Health Care ; Humans ; Laboratories
Language	English
Publishing date	2020-10-15
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2677441-0
ISSN	2234-3814 ; 2234-3814
ISSN (online)	2234-3814
ISSN	2234-3814
DOI	10.3343/alm.2021.41.2.139
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reducing rates of

Casari, E / De Luca, C / Calabrò, M / Scuderi, C / Daleno, C / Ferrario, A

Antimicrobial resistance and infection control

2018 Volume 7, Page(s) 40

Abstract: Background: Clostridium difficile: Methods: Our hospital made a decision to switch from the use of toxin immunoassay to a stand-alone nucleic acid test. This change was accompanied by the provision of clear sampling guidance and rejection criteria ... ...

Abstract	Background: Clostridium difficile Methods: Our hospital made a decision to switch from the use of toxin immunoassay to a stand-alone nucleic acid test. This change was accompanied by the provision of clear sampling guidance and rejection criteria and this study aimed to assess the impact of that change. We analysed sample numbers, numbers of positive results, and the proportion of cases assessed as healthcare acquired over a 6-year period during which the testing method was changed from a toxin A/B immunoassay to a stand-alone commercial nucleic acid test after the first two years. Results: Sample numbers and numbers of cases assessed as healthcare acquired fell following the introduction of the nucleic acid test and sampling guidance, while infection rates in other hospitals in the same region remained relatively stable. Conclusions: It is our opinion that the use of a highly sensitive assay together with clear sampling guidance offers the optimal approach to patient management and best use of isolation facilities.
MeSH term(s)	Bacterial Toxins/genetics ; Bacterial Toxins/isolation & purification ; Clostridium Infections/diagnosis ; Clostridium Infections/prevention & control ; Clostridium difficile/genetics ; Clostridium difficile/pathogenicity ; Hospitals ; Humans ; Immunoassay ; Nucleic Acid Amplification Techniques/methods ; Specimen Handling/methods ; Specimen Handling/standards
Chemical Substances	Bacterial Toxins
Language	English
Publishing date	2018-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2666706-X
ISSN	2047-2994 ; 2047-2994
ISSN (online)	2047-2994
ISSN	2047-2994
DOI	10.1186/s13756-018-0332-2
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Article ; Online: Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings.

Lybech, Line K M / Calabró, Marco / Briuglia, Silvana / Drago, Antonio / Crisafulli, Concetta

Genes

2021 Volume 12, Issue 10

Abstract: Suicide in Bipolar Disorder (BD) is a relevant clinical concern. Genetics may shape the individual risk for suicide behavior in BD, together with known clinical factors. The lack of consistent replication in BD may be associated with its multigenetic ... ...

Abstract	Suicide in Bipolar Disorder (BD) is a relevant clinical concern. Genetics may shape the individual risk for suicide behavior in BD, together with known clinical factors. The lack of consistent replication in BD may be associated with its multigenetic component. In the present contribution we analyzed a sample of BD individuals (from STEP-BD database) to identify the genetic variants potentially associated with three different suicide-related phenotypes: (1) a feeling that the life was not worth living; (2) fantasies about committing a violent suicide; (3) previous attempted suicide. The sample under analysis included 1115 BD individuals. None of the SNPs reached genome-wide significance. However, a trend of association was evidenced for rs2767403, an intron variant of AOPEP gene, in association with phenotype #1 (
MeSH term(s)	Adult ; Aged ; Aminopeptidases/genetics ; Bipolar Disorder/complications ; Bipolar Disorder/genetics ; Bipolar Disorder/physiopathology ; Genetic Predisposition to Disease ; Genome/genetics ; Genome-Wide Association Study ; Humans ; Middle Aged ; Phenotype ; Polymorphism, Single Nucleotide ; Receptors, Notch/genetics ; Risk Factors ; Signal Transduction/genetics ; Suicidal Ideation ; Suicide, Attempted/prevention & control ; gamma-Aminobutyric Acid/genetics
Chemical Substances	Receptors, Notch ; gamma-Aminobutyric Acid (56-12-2) ; AOPEP protein, human (EC 3.4.11.-) ; Aminopeptidases (EC 3.4.11.-)
Language	English
Publishing date	2021-09-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12101482
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