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Article ; Online: How to do bedside mediastinal decompression in tension pneumomediastinum.

Palmieri, Francesco / Gobatti, Davide / Magnoli, Matteo / Calabrese, Francesco / Sampietro, Roberto

2024 Volume 94, Issue 5, Page(s) 950–951

Abstract: Tension pneumomediastinum is uncommon but it is a rapidly progress condition that can lead to cardiogenic shock. Mediastinal decompression is an emergency procedure and the knowledge of this technique is a life-saving treatment. ...

Abstract	Tension pneumomediastinum is uncommon but it is a rapidly progress condition that can lead to cardiogenic shock. Mediastinal decompression is an emergency procedure and the knowledge of this technique is a life-saving treatment.
MeSH term(s)	Humans ; Mediastinal Emphysema/surgery ; Mediastinal Emphysema/etiology ; Decompression, Surgical/methods ; Mediastinum/surgery ; Male ; Shock, Cardiogenic/surgery ; Shock, Cardiogenic/etiology ; Point-of-Care Systems ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2024-02-02
Publishing country	Australia
Document type	Journal Article ; Case Reports
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.18881
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Article ; Online: Assessing the Short-Term Prognosis of Patients with Cirrhosis Using the DIC Scores.

Pasta, Andrea / Calabrese, Francesco / Giannini, Edoardo G

Thrombosis and haemostasis

2023 Volume 123, Issue 7, Page(s) 744–746

MeSH term(s)	Humans ; Prognosis ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Disseminated Intravascular Coagulation
Language	English
Publishing date	2023-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/a-2039-1575
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Article ; Online: Microbial ecology, biochemical and nutritional features in sprouted composite type I sourdough made of wheat and blend flours

Calasso, Maria / Ressa, Arianna / Calabrese, Francesco Maria / Minervini, Fabio / De Angelis, Maria

LWT. 2023 Sept. 20, p.115285-

2023 , Page(s) 115285–

Abstract: Germination is a biotechnological process helpful in obtaining new plants from grains. We tested the impact of processing condition (sprouting and dough yield) and flour composition on type I sourdoughs biochemical and nutritional parameters we here used ...

Abstract	Germination is a biotechnological process helpful in obtaining new plants from grains. We tested the impact of processing condition (sprouting and dough yield) and flour composition on type I sourdoughs biochemical and nutritional parameters we here used four flour matrices and precisely: i) refined commercial wheat flour, ii) sprouted and iii) non-sprouted whole wheat flour and iv) a blend composed of sprouted whole wheat and sprouted lentils. We here compared a set of 24 samples based on different group stratifications including three different sampling times (starting, after 24h and at the 10th refreshment). Moreover, we inspected the microbiota and its relative taxa abundance by 16S rRNA target sequencing and qPCR absolute quantification. Our result highlighted how the sprouted process together with the dough yield influenced key substrate like raffinose and lead to a change of taxa composition as evinced for the increased relative abundances of Pediococcus genus. Other key taxa in the microbiota were shaped by tested conditions and the alpha and beta diversity evidenced how matrix impact the intergroup clustering. The presented results shed new light on the increased properties and the related health promoting effects of type I sourdough obtained with the sprouting process.
Keywords	Pediococcus ; germination ; microbial ecology ; microorganisms ; raffinose ; sourdough ; species diversity ; wheat ; whole wheat flour ; Fermentation ; Sprouting process ; Dough yield
Language	English
Dates of publication	2023-0920
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2023.115285
Database	NAL-Catalogue (AGRICOLA)

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Article: Assessing the Short-Term Prognosis of Patients with Cirrhosis Using the DIC Scores

Pasta, Andrea / Calabrese, Francesco / Giannini, Edoardo G.

Thrombosis and Haemostasis

2023 Volume 123, Issue 07, Page(s) 744–746

Language	English
Publishing date	2023-02-20
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/a-2039-1575
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Article: Antibiotics Self Medication among Children: A Systematic Review.

Bert, Fabrizio / Previti, Christian / Calabrese, Francesco / Scaioli, Giacomo / Siliquini, Roberta

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: The phenomenon of bacterial antimicrobial resistance (AMR) is a rapidly growing global problem. Overuse and misuse of antibiotics as well as self-prescription are among the most important causes contributing to the growth of antibiotic resistance in ... ...

Abstract	The phenomenon of bacterial antimicrobial resistance (AMR) is a rapidly growing global problem. Overuse and misuse of antibiotics as well as self-prescription are among the most important causes contributing to the growth of antibiotic resistance in humans. This systematic review describes the phenomenon of antibiotics self-medication (ASM) in children. The study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist by searching PubMed, Scopus, and Web of Science until July 2022. Published English language studies containing information regarding parents knowledge, attitudes, and behaviors in self-administration of antibiotics in children were included. A total of 702 articles were identified, and 57 were selected. A higher prevalence of ASM among children was found in the Middle-East (34%), Africa (22%), Asia (20%) and South America (17%), while the lowest prevalence was found in Europe (8%). High distance from hospital, and low income, such as having more than one child, are related with an increased risk of ASM in children. Fever and cough can also promote the misuse of antibiotics by parents. A greater attention to the regulation of the sale of antimicrobial drugs can certainly limit the risk of self-medicating behavior.
Language	English
Publishing date	2022-11-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11111583
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Article ; Online: Food Intolerances, Food Allergies and IBS: Lights and Shadows.

Pasta, Andrea / Formisano, Elena / Calabrese, Francesco / Plaz Torres, Maria Corina / Bodini, Giorgia / Marabotto, Elisa / Pisciotta, Livia / Giannini, Edoardo Giovanni / Furnari, Manuele

Nutrients

2024 Volume 16, Issue 2

Abstract: This narrative review delves into the intricate relationship between irritable bowel syndrome (IBS) and food intolerances. IBS, a chronic functional gastrointestinal disorder, is characterized by symptoms like abdominal pain and altered bowel habits. The ...

Abstract	This narrative review delves into the intricate relationship between irritable bowel syndrome (IBS) and food intolerances. IBS, a chronic functional gastrointestinal disorder, is characterized by symptoms like abdominal pain and altered bowel habits. The prevalence of IBS has increased globally, especially among young adults. Food and dietary habits play a crucial role in IBS management. About 85-90% of IBS patients report symptom exacerbation linked to specific food consumption, highlighting the strong connection between food intolerances and IBS. Food intolerances often exhibit a dose-dependent pattern, posing a challenge in identifying trigger foods. This issue is further complicated by the complex nature of gastrointestinal physiology and varying food compositions. This review discusses various dietary patterns and their impact on IBS, including the low-FODMAP diet, gluten-free diet, and Mediterranean diet. It highlights the importance of a personalized approach in dietary management, considering individual symptom variability and dietary history. In conclusion, this review emphasizes the need for accurate diagnosis and holistic management of IBS, considering the complex interplay between dietary factors and gastrointestinal pathophysiology. It underlines the importance of patient education and adherence to treatment plans, acknowledging the challenges posed by the variability in dietary triggers and the psychological impact of dietary restrictions.
MeSH term(s)	Young Adult ; Humans ; Food Intolerance ; Irritable Bowel Syndrome/epidemiology ; Irritable Bowel Syndrome/etiology ; Food Hypersensitivity/epidemiology ; Food ; Abdominal Pain
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020265
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Article: Assessment of Italian Population Awareness on One-Health, Zoonoses and the Mpox Vaccine: A Nationwide Cross-Sectional Study.

Bert, Fabrizio / Lo Moro, Giuseppina / Calabrese, Francesco / Barattero, Valentino / Peano, Alberto / Scaioli, Giacomo / Siliquini, Roberta

Vaccines

2024 Volume 12, Issue 3

Abstract: In recent decades, the rise of zoonotic diseases has emerged as a significant human health concern, highlighting the interconnectedness of human and animal health within the framework of the "One Health" (OH) concept. This study, conducted in Italy in ... ...

Abstract	In recent decades, the rise of zoonotic diseases has emerged as a significant human health concern, highlighting the interconnectedness of human and animal health within the framework of the "One Health" (OH) concept. This study, conducted in Italy in 2023, sought to gauge the general population's awareness of OH and zoonotic diseases while identifying influencing factors. Additionally, it aimed to assess awareness of an Mpox virus vaccine, particularly pertinent due to the 2022 outbreak across Europe. The online cross-sectional study encompassed 1058 participants, revealing that 54.26% were unfamiliar with OH and zoonoses. Median knowledge scores were 12 points (IQR = 9-15) for zoonoses and 8 points (IQR = 6-11) for OH. Notably, factors such as age, economic situation, healthcare employment, educational level, and health literacy significantly influenced knowledge scores. Merely 26.8% of participants were aware of the existence of an Mpox vaccine, with healthcare workers, individuals engaged in animal-related work, and non-heterosexual men demonstrating higher awareness. The findings underscored a limited public understanding of zoonotic diseases and One Health, with variations observed across specific demographic groups. Given the potential impact on public health, urgent educational initiatives are warranted. Moreover, the study highlighted a low awareness of the Mpox vaccine, emphasizing the necessity for targeted awareness campaigns directed at both professionals and the general public.
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12030258
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Article ; Online: Dynamic microbial and metabolic changes during Apulian Caciocavallo cheese-making and ripening produced according to a standardized protocol.

Vacca, Mirco / Celano, Giuseppe / Serale, Nadia / Costantino, Giuseppe / Calabrese, Francesco Maria / Calasso, Maria / De Angelis, Maria

Journal of dairy science

2024

Abstract: The cheese microbiota plays a critical role in influencing its sensory and physicochemical properties. In this study, traditional Apulian Caciocavallo cheese coming from 4 different dairies in the same area and produced following standardized procedures ... ...

Abstract	The cheese microbiota plays a critical role in influencing its sensory and physicochemical properties. In this study, traditional Apulian Caciocavallo cheese coming from 4 different dairies in the same area and produced following standardized procedures have been examined, as well as the different bulk milks and natural whey starter cultures used. Moreover, considering the cheese wheels as the blocks of Caciocavallo cheeses as whole, these were characterized at different layers (i.e., core, under-rind, and rind) of the block using a multi-omics approach. In addition to physical-chemical characterization, culturomics, quantitative PCR, metagenomics, and metabolomics analysis, have been carried out post-salting and throughout ripening time (2 mo) to investigate the major shifts in the succession of the microbiota and flavor development. Culture-dependent and 16S rRNA metataxonomics results clearly clustered samples based on the microbiota biodiversity related to the production dairy plant as the result of the use of different NWS or intrinsic conditions of each production site. At the beginning of the ripening, cheeses were dominated by the Lactobacillus and, in 2 dairies (Art and SdC), Streptococcus genera associated with the NWS. The analysis allowed us to show that, although the diversity of identified genera did not change significantly between the rind, under-rind and core fractions of the same samples, there was an evolution in the relative abundance and absolute quantification, modifying and differentiating profiles during ripening. The qPCR mainly differentiated the temporal adaptation of those species originating from bulk milks and those provided by NWSs. The primary starter detected in NWS and cheese reassured the high relative concentration of 1-butanol, 2-butanol, 2-heptanol, 2-butanone, acetoin, delta-dodecalactone, hexanoic acid ethyl ester, octanoic acid ethyl ester, and VFFA during ripening, while cheeses displaying low abundances of Streptococcus and Lactococcus (dairy Del) have a lower total concentration of acetoin compared with Art and SdC. However, the sub-dominant strains and NSLAB present in cheeses are responsible for the production of secondary metabolites belonging to the chemical classes of ketones, alcohols, and organic acids, reaffirming the importance and relevance of autochthonous strains of each dairy plant although considering a delimited production area.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2023-24049
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Article: Effects of Grape Pomace Polyphenols and In Vitro Gastrointestinal Digestion on Antimicrobial Activity: Recovery of Bioactive Compounds.

Caponio, Giusy Rita / Noviello, Mirella / Calabrese, Francesco Maria / Gambacorta, Giuseppe / Giannelli, Gianluigi / De Angelis, Maria

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 3

Abstract: Grape pomace (GP), a major byproduct obtained from the winemaking process, is characterized by a high amount of phenolic compounds and secondary plant metabolites, with potential beneficial effects on human health. Therefore, GP is a source of bioactive ... ...

Abstract	Grape pomace (GP), a major byproduct obtained from the winemaking process, is characterized by a high amount of phenolic compounds and secondary plant metabolites, with potential beneficial effects on human health. Therefore, GP is a source of bioactive compounds with antioxidant, antimicrobial, and anti-inflammatory activity. As people are paying more attention to sustainability, in this work, we evaluate two different extractions (aqueous and hydroalcoholic) of GP bioactive compounds. In vitro simulated gastrointestinal digestion of the GP extracts was performed to improve the bioavailability and bioaccessibility of polyphenols. The antioxidant activity (ABTS and DPPH assays) and the phenolic characterization of the extracts by UHPLC-DAD were evaluated. The antimicrobial effects of GP antioxidants in combination with a probiotic (
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11030567
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Article ; Online: Lichen Planopilaris: The first biopsy layer microbiota inspection.

Pinto, Daniela / Calabrese, Francesco Maria / De Angelis, Maria / Celano, Giuseppe / Giuliani, Giammaria / Rinaldi, Fabio

PloS one

2022 Volume 17, Issue 7, Page(s) e0269933

Abstract: Lichen Planopilaris (LPP) is a lymphatic disease affecting the scalp that is characterized by a chronic and destructive inflammation process, named as 'cicatricial alopecia' in which the hair follicles are targeted and may involve predominantly ... ...

Abstract	Lichen Planopilaris (LPP) is a lymphatic disease affecting the scalp that is characterized by a chronic and destructive inflammation process, named as 'cicatricial alopecia' in which the hair follicles are targeted and may involve predominantly lymphocytes or neutrophils. Scalp and biopsy layers have never been used to investigate microbial community composition and its relative taxa abundances in LPP. We sought to examine the significant taxa of this chronic relapsing inflammatory skin disease, together with inspect the existing connections with metabolic pathways featuring this microbial community. We used a multilevel analysis based on 16S rRNA marker sequencing in order to detect OTU abundances in pathologic/healthy samples, real time PCR for measuring the levels of IL-23 interleukin expression and urinary metabolomics to find out volatile organic metabolites (VOMs). By using a linear regression model, we described peculiar taxa that significantly differentiated LPP and healthy samples. We inspected taxa abundances and interleukin mRNA levels and the Microbacteriaceae family resulted negatively correlated with the IL-23 expression. Moreover, starting from 16S taxa abundances, we predicted the metabolic pathways featuring this microbial community. By inspecting microbial composition, sample richness, metabolomics profiles and the relative metabolic pathways in a cohort of LPP and healthy samples we deepened the contribution of significant taxa that are connected to inflammation maintenance and microbiota plasticity in LPP pathology.
MeSH term(s)	Alopecia/metabolism ; Biopsy ; Humans ; Inflammation ; Interleukin-23/genetics ; Lichen Planus/pathology ; Microbiota/genetics ; RNA, Ribosomal, 16S/genetics
Chemical Substances	Interleukin-23 ; RNA, Ribosomal, 16S
Language	English
Publishing date	2022-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0269933
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