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Article ; Online: Biventricular Function is Impaired in Right Ventricular Septal Pacing-A Prospective Study Using Myocardial Strain Imaging.

Toner, Liam / Chen, Janet X C / Ramchand, Jay / Srivastava, Piyush / O'Donnell, David / Calafiore, Paul / Jones, Elizabeth

Heart, lung & circulation

2022 Volume 32, Issue 3, Page(s) 373–378

Abstract: Background: Left ventricular (LV) dysfunction is known to occur after right ventricular (RV) pacing; the effect on RV function is less well studied. The aim of this study was to assess the impact of RV mid-septal pacing upon RV function using the novel ... ...

Abstract	Background: Left ventricular (LV) dysfunction is known to occur after right ventricular (RV) pacing; the effect on RV function is less well studied. The aim of this study was to assess the impact of RV mid-septal pacing upon RV function using the novel parameters of speckle-tracking derived RV global longitudinal strain (RV GLS) and RV free wall strain (RV FWS), as well as the conventional parameters RV fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), and tricuspid annular systolic velocity (RV S'). Methods: Thirty-two (32) consecutive patients with normal baseline LV and RV function requiring permanent pacemaker insertion (for high-grade AV block or sinus node dysfunction) were prospectively recruited. Echocardiography was performed prior to implantation, at 1 day, 1 month and 1 year after implantation, with 29 patients completing follow-up. Results: After 1 year, three patients (10%) with otherwise normal RV parameters developed abnormal RV strain patterns. Compared to 1 day after implantation, at 1 year significant reductions were observed in mean RV GLS (-24.8 to -21.8%) RV S' (15.1 to 12.2 cm/s), TAPSE (24.2 to 21.9 mm), RV GLS (-24.8 to -21.8%), left ventricular ejection fraction (LVEF) (66.0 to 57.9%), LV GLS (-19.9 to 17.0), all p<0.01. There was a non-significant reduction for RV FWS (-29.0 to -26.7%, p=0.06) and there was no change in RV FAC (49.1 to 46.9%, p=0.24). Conclusion: We report abnormalities of RV strain developing 1 year after pacemaker insertion. Measurement of myocardial strain is emerging as an additional method to detect patients at risk of RV dysfunction in those who have undergone pacemaker implantation.
MeSH term(s)	Humans ; Prospective Studies ; Stroke Volume ; Ventricular Function, Left ; Echocardiography/methods ; Heart Ventricles/diagnostic imaging ; Ventricular Function, Right ; Ventricular Dysfunction, Right/diagnostic imaging ; Ventricular Dysfunction, Right/etiology
Language	English
Publishing date	2022-12-20
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2022.11.004
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Zs.A 4988: Show issues

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Article ; Online: Letter to the Editor: Diagnosis of Cirrhotic Cardiomyopathy: The Role of an Impaired Cardiac Reserve.

Koshy, Anoop N / Farouque, Omar / Calafiore, Paul / Gow, Paul J

Hepatology (Baltimore, Md.)

2019 Volume 71, Issue 5, Page(s) 1883

MeSH term(s)	Cardiomyopathies/diagnosis ; Cardiomyopathies/etiology ; Heart ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis
Language	English
Publishing date	2019-11-09
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.31034
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Zs.A 1660: Show issues

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Article ; Online: Primary Angiosarcoma-A Rare Cause of Right Ventricular Outflow Tract Obstruction: Case Report and Literature Review.

Omair, Mohammad / Calafiore, Paul / Lim, Ruth / McGiffin, David / Farouque, Omar / Jones, Elizabeth

CASE (Philadelphia, Pa.)

2019 Volume 3, Issue 6, Page(s) 284–287

Language	English
Publishing date	2019-09-24
Publishing country	United States
Document type	Case Reports
ISSN	2468-6441
ISSN (online)	2468-6441
DOI	10.1016/j.case.2019.08.003
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Article ; Online: Arrhythmic Mitral Annulus Disjunction and Mitral Valve Prolapse: Components of the Same Clinical Spectrum?

Han, Hui-Chen / Calafiore, Paul / Teh, Andrew W / Farouque, Omar / Lim, Han S

Journal of the American College of Cardiology

2018 Volume 73, Issue 6, Page(s) 739

MeSH term(s)	Heart Ventricles ; Humans ; Mitral Valve ; Mitral Valve Prolapse ; Syndrome
Language	English
Publishing date	2018-04-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2018.10.090
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Infective ascending aortitis complicating suppurative appendicitis.

Ramchand, Jay / Roubos, Nicholas / Yudi, Matias / Calafiore, Paul / Jones, Elizabeth

International journal of cardiology

2016 Volume 204, Page(s) 15–16

MeSH term(s)	Adult ; Aorta/microbiology ; Aorta/pathology ; Aorta/surgery ; Aortitis/complications ; Aortitis/diagnosis ; Aortitis/surgery ; Appendicitis/complications ; Appendicitis/diagnosis ; Appendicitis/surgery ; Embolism/diagnosis ; Embolism/etiology ; Embolism/surgery ; Humans ; Male
Language	English
Publishing date	2016-02-01
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2015.11.155
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Zs.A 1673: Show issues

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Article ; Online: Validation of Epworth Richmond's Echocardiography Education Focused Year.

Brooks, Kyle S / Tan, Li H / Rozen, Thomas H / Kelly, Di / McKenzie, Dean P / Calafiore, Paul / Barrett, Jonathan

Critical care medicine

2019 Volume 48, Issue 1, Page(s) e34–e39

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Critical Care ; Echocardiography ; Education, Medical, Graduate ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Young Adult
Language	English
Publishing date	2019-11-15
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't ; Validation Study
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000004076
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Zs.A 1261: Show issues

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Article ; Online: Bacterial mural endocarditis. A case series.

Adel, Alexander / Jones, Elizabeth / Johns, Jennifer / Farouque, Omar / Calafiore, Paul

Heart, lung & circulation

2014 Volume 23, Issue 8, Page(s) e172–9

Abstract: Mural endocarditis represents a rare subset of intracardiac infections, with potentially life threatening sequelae. Clinically alike, with many shared aetiologies, substrates and risk factors such as valvular endocarditis, it can be difficult to ... ...

Abstract	Mural endocarditis represents a rare subset of intracardiac infections, with potentially life threatening sequelae. Clinically alike, with many shared aetiologies, substrates and risk factors such as valvular endocarditis, it can be difficult to differentiate without the use of sophisticated cardiovascular imaging techniques. Despite high rates of complications, there are no definite strategies for management. Herein we present three interesting cases of left ventricular mural endocarditis, without valvular involvement, due to staphylococcus aureus.
MeSH term(s)	Aged ; Endocarditis, Bacterial/diagnostic imaging ; Endocarditis, Bacterial/microbiology ; Female ; Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/microbiology ; Humans ; Male ; Middle Aged ; Staphylococcal Infections/diagnostic imaging ; Staphylococcus aureus ; Ultrasonography
Language	English
Publishing date	2014-08
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2014.03.026
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Zs.A 4988: Show issues

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Article ; Online: Inducible Left Ventricular Outflow Tract Obstruction in Patients Undergoing Liver Transplantation: Prevalence, Predictors, and Association With Cardiovascular Events.

Cailes, Benjamin / Koshy, Anoop N / Gow, Paul / Weinberg, Laurence / Srivastava, Piyush / Testro, Adam / Peverelle, Matthew / Ko, Jefferson / Salehi, Hamid / Jones, Elizabeth F / Calafiore, Paul / Farouque, Omar

Transplantation

2020 Volume 105, Issue 2, Page(s) 354–362

Abstract: Background: Inducible left ventricular outflow tract obstruction (LVOTO) is often encountered in liver transplantation (LT) candidates during cardiac workup. While the impact of LVOTO on adverse cardiovascular hemodynamics is well reported, it is ... ...

Abstract	Background: Inducible left ventricular outflow tract obstruction (LVOTO) is often encountered in liver transplantation (LT) candidates during cardiac workup. While the impact of LVOTO on adverse cardiovascular hemodynamics is well reported, it is unclear whether it predisposes to perioperative cardiovascular complications. Methods: Consecutive patients with end-stage liver disease undergoing dobutamine stress echocardiography (DSE) were evaluated at an LT center between 2010 and 2017. Perioperative major adverse cardiovascular events (MACEs) at 30 days and all-cause death were recorded from a prospectively maintained LT database. Results: We evaluated 560 patients who underwent DSE during LT workup, with LVOTO identified in 24.3% (n = 136). Of these, 309 patients progressed to transplant. Patients with LVOTO demonstrated a lower peak systolic blood pressure (SBP) and an overall reduction in SBP on DSE. A total of 85 MACEs were recorded in 72 patients (23.3%) including 3 deaths, 19 cases of heart failure, 11 cardiac arrests, 8 acute coronary syndromes, and 44 arrhythmias. MACE occurred in 15/64 patients (23.4%) with LVOTO and 57/245 (23.3%) without (P = 0.92). There was an increased risk of perioperative cardiac arrest in patients with LVOTO (7.4% versus 2.4%, P = 0.04). Intraoperatively, patients with LVOTO required higher doses of vasopressors (P = 0.01) and received greater volumes of fluid (10.5 ± 8.1 versus 8.4 ± 6.4 L, P = 0.03). Conclusions: Patients with end-stage liver disease and LVOTO demonstrate a reduction in SBP during physiological stress that may translate to hemodynamic instability during LT. LVOTO was not associated with an increased rate of perioperative MACE or death.
MeSH term(s)	Databases, Factual ; Echocardiography, Stress ; End Stage Liver Disease/diagnosis ; End Stage Liver Disease/mortality ; End Stage Liver Disease/surgery ; Female ; Hemodynamics ; Humans ; Liver Transplantation/adverse effects ; Liver Transplantation/mortality ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/epidemiology ; Postoperative Complications/mortality ; Postoperative Complications/physiopathology ; Prevalence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Ventricular Function, Left ; Ventricular Outflow Obstruction/diagnostic imaging ; Ventricular Outflow Obstruction/epidemiology ; Ventricular Outflow Obstruction/mortality ; Ventricular Outflow Obstruction/physiopathology
Language	English
Publishing date	2020-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003245
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Impaired Cardiac Reserve on Dobutamine Stress Echocardiography Predicts the Development of Hepatorenal Syndrome.

Koshy, Anoop N / Farouque, Omar / Cailes, Benjamin / Testro, Adam / Ramchand, Jay / Sajeev, Jithin K / Han, Hui-Chen / Srivastava, Piyush M / Jones, Elizabeth F / Salehi, Hamid / Teh, Andrew W / Lim, Han S / Calafiore, Paul / Gow, Paul J

The American journal of gastroenterology

2019 Volume 115, Issue 3, Page(s) 388–397

Abstract: Objectives: Cardiac dysfunction has been implicated in the genesis of hepatorenal syndrome (HRS). It is unclear whether a low cardiac output (CO) or attenuated contractile response to hemodynamic stress can predict its occurrence. We studied ... ...

Abstract	Objectives: Cardiac dysfunction has been implicated in the genesis of hepatorenal syndrome (HRS). It is unclear whether a low cardiac output (CO) or attenuated contractile response to hemodynamic stress can predict its occurrence. We studied cardiovascular hemodynamics in cirrhosis and assessed whether a diminished cardiac reserve with stress testing predicted the development of HRS on follow-up. Methods: Consecutive patients undergoing liver transplant workup with dobutamine stress echocardiography (DSE) were included. CO was measured at baseline and during low-dose dobutamine infusion at 10 μg/kg/min. HRS was diagnosed using guideline-based criteria. Results: A total of 560 patients underwent DSE, of whom 488 were included after preliminary assessment. There were 64 (13.1%) patients with established HRS. The HRS cohort had a higher baseline CO (8.0 ± 2 vs 6.9 ± 2 L/min; P < 0.001) and demonstrated a blunted response to low-dose dobutamine (ΔCO 29 ± 22% vs 44 ± 32%, P < 0.001) driven primarily by inotropic incompetence. Optimal cutpoint for ΔCO in patients with HRS was determined to be <25% and was used to define a low cardiac reserve. Among the 424 patients without HRS initially, 94 (22.1%) developed HRS over a mean follow-up of 1.5 years. Higher proportion with a low cardiac reserve developed HRS (52 [55.0%] vs 56 [16.9%]; hazard ratio 4.5; 95% confidence interval 3.0-6.7; P < 0.001). In a Cox multivariable model, low cardiac reserve remained the strongest predictor for the development of HRS (hazard ratio 3.9; 95% confidence interval 2.2-7.0; P < 0.001). Discussion: Patients with HRS demonstrated a higher resting CO and an attenuated cardiac reserve on stress testing. On longitudinal follow-up, low cardiac reserve was an independent predictor for the development of HRS. Assessment of cardiac reserve with DSE may provide a novel noninvasive risk marker for developing HRS in patients with advanced liver disease.HRS is a life-threatening complication of liver disease. We studied whether an inability to increase cardiac contraction in response to stress can assist in the prediction of HRS. We demonstrate that patients with liver disease who exhibit cardiac dysfunction during stress testing had a 4-fold increased risk of developing HRS. This may improve our ability for early diagnosis and treatment of patients at a higher risk of developing HRS.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cardiac Output ; Cardiotonic Agents ; Clinical Decision Rules ; Dobutamine ; Echocardiography, Stress/methods ; Female ; Follow-Up Studies ; Hepatorenal Syndrome/diagnosis ; Hepatorenal Syndrome/etiology ; Humans ; Kaplan-Meier Estimate ; Liver Cirrhosis/physiopathology ; Male ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Young Adult
Chemical Substances	Cardiotonic Agents ; Dobutamine (3S12J47372)
Language	English
Publishing date	2019-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000000462
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Article ; Online: Mitral Valve Prolapse and Sudden Cardiac Death: A Systematic Review.

Han, Hui-Chen / Ha, Francis J / Teh, Andrew W / Calafiore, Paul / Jones, Elizabeth F / Johns, Jennifer / Koshy, Anoop N / O'Donnell, David / Hare, David L / Farouque, Omar / Lim, Han S

Journal of the American Heart Association

2018 Volume 7, Issue 23, Page(s) e010584

Abstract: Background The relationship between mitral valve prolapse ( MVP ) and sudden cardiac death ( SCD ) remains controversial. In this systematic review, we evaluate the relationship between isolated MVP and SCD to better define a potential high-risk subtype. ...

Abstract	Background The relationship between mitral valve prolapse ( MVP ) and sudden cardiac death ( SCD ) remains controversial. In this systematic review, we evaluate the relationship between isolated MVP and SCD to better define a potential high-risk subtype. In addition, we determine whether premortem parameters could predict SCD in patients with MVP and the incidence of SCD in MVP . Methods and Results Electronic searches were conducted in PubMed and Embase for all English literature articles published between 1960 and 2018 regarding MVP and SCD or cardiac arrest. We also identified articles investigating predictors of ventricular arrhythmias or SCD and cohort studies reporting SCD outcomes in MVP . From 2180 citations, there were 79 articles describing 161 cases of MVP with SCD or cardiac arrest. The median age was 30 years and 69% of cases were female. Cardiac arrest occurred during situations of stress in 47% and was caused by ventricular fibrillation in 81%. Premature ventricular complexes on Holter monitoring (92%) were common. Most cases had bileaflet involvement (70%) with redundancy (99%) and nonsevere mitral regurgitation (83%). From 22 articles describing predictors for ventricular arrhythmias or SCD in MVP , leaflet redundancy was the only independent predictor of SCD . The incidence of SCD with MVP was estimated at 217 events per 100 000 person-years. Conclusions Isolated MVP and SCD predominantly affects young females with redundant bileaflet prolapse, with cardiac arrest usually occurring as a result of ventricular arrhythmias. To better understand the complex relationship between MVP and SCD , standardized reporting of clinical, electrophysiological, and cardiac imaging parameters with longitudinal follow-up is required.
MeSH term(s)	Death, Sudden, Cardiac/etiology ; Humans ; Mitral Valve Prolapse/complications ; Mitral Valve Prolapse/mortality ; Risk Factors
Language	English
Publishing date	2018-11-28
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.118.010584
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