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  1. Article ; Online: Alopecia areata in a patient with SARS-Cov-2 infection.

    Sgubbi, Paola / Savoia, Francesco / Calderoni, Ombretta / Longo, Rosita / Stinchi, Caterina / Tabanelli, Michela

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e14295

    MeSH term(s) Alopecia Areata/diagnosis ; Alopecia Areata/immunology ; Alopecia Areata/virology ; Antiviral Agents/therapeutic use ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/virology ; Female ; Host-Pathogen Interactions ; Humans ; Hydroxychloroquine/therapeutic use ; Middle Aged ; Risk Factors ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Le lesioni acro-ischemiche nei bambini-adolescenti in tempi di CoViD-19: dal micro-ambiente da clausura all’interferone.

    Marchetti, Federico / Guiducci, Claudia / Bigucci, Barbara / Iacono, Alessandra / Calderoni, Ombretta / Sorci, Maria Rita / Sparacino, Monica / Semprini, Simona / Vergine, Gianluca

    Recenti progressi in medicina

    2020  Volume 111, Issue 9, Page(s) 480–486

    Abstract: At the end of March 2020, just over a month after the first ascertained case of CoViD-19 infection in Italy, the first reports of acute lesions of acro-ischemia appeared, especially in pre-adolescents and adolescents. These manifestations have been ... ...

    Title translation Acro-ischemic injuries in children-adolescents during CoViD-19 pandemic: from lifestyle changes due to lockdown to interferone.
    Abstract At the end of March 2020, just over a month after the first ascertained case of CoViD-19 infection in Italy, the first reports of acute lesions of acro-ischemia appeared, especially in pre-adolescents and adolescents. These manifestations have been called in the course of these months in various ways, from "acro-ischemia acuta", "erythema pernio", "chilblains", up to characterize them more recently as "CoViD Toes". Clinical manifestations do not usually associate with other typical symptoms of Covid-19 and do not find a classical and defined serological antibody response (IgG and IgM). From a clinical point of view it is a localized and self-resolving problem of an interesting and relatively new pathogenetic model of disease in relation to a viral agent. Future studies must make us understand if there is in this specific condition a low viral load is not detectable by current methods and if this explains the inability to produce an adequate immune response for CoViD-19. It is important to determine whether the interferon immune response in some subjects can be the cause of both the low viremia and the endothelial damage so localized in the acral-site, as happens in other models of diseases (chilblain-lupus like). On the contrary, some authors believe that the acral lesions are attributable to chilblains caused by a series of favourable environmental conditions due to forced enclosure. We report the descriptive experience of 14 cases of acro-ischemia in children and adolescents observed in the territorial area of Ravenna and Rimini. The cases were subjected to the nasopharyngeal swab and to the search for antibodies with ELISA method for CoViD-19 both with negative results.
    MeSH term(s) Adolescent ; COVID-19 ; Chilblains/epidemiology ; Chilblains/etiology ; Chilblains/immunology ; Child ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Female ; Humans ; Interferons/immunology ; Ischemia/epidemiology ; Ischemia/etiology ; Ischemia/immunology ; Italy/epidemiology ; Life Style ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Quarantine ; Toes
    Chemical Substances Interferons (9008-11-1)
    Keywords covid19
    Language Italian
    Publishing date 2020-09-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3421.34060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Acro-ischemic injuries in children-adolescents during CoViD-19 pandemic: from lifestyle changes due to lockdown to interferone

    Marchetti, Federico / Guiducci, Claudia / Bigucci, Barbara / Iacono, Alessandra / Calderoni, Ombretta / Sorci, Maria Rita / Sparacino, Monica / Semprini, Simona / Vergine, Gianluca

    Recenti progressi in medicina

    Abstract: At the end of March 2020, just over a month after the first ascertained case of CoViD-19 infection in Italy, the first reports of acute lesions of acro-ischemia appeared, especially in pre-adolescents and adolescents These manifestations have been called ...

    Abstract At the end of March 2020, just over a month after the first ascertained case of CoViD-19 infection in Italy, the first reports of acute lesions of acro-ischemia appeared, especially in pre-adolescents and adolescents These manifestations have been called in the course of these months in various ways, from "acro-ischemia acuta", "erythema pernio", "chilblains", up to characterize them more recently as "CoViD Toes" Clinical manifestations do not usually associate with other typical symptoms of Covid-19 and do not find a classical and defined serological antibody response (IgG and IgM) From a clinical point of view it is a localized and self-resolving problem of an interesting and relatively new pathogenetic model of disease in relation to a viral agent Future studies must make us understand if there is in this specific condition a low viral load is not detectable by current methods and if this explains the inability to produce an adequate immune response for CoViD-19 It is important to determine whether the interferon immune response in some subjects can be the cause of both the low viremia and the endothelial damage so localized in the acral-site, as happens in other models of diseases (chilblain-lupus like) On the contrary, some authors believe that the acral lesions are attributable to chilblains caused by a series of favourable environmental conditions due to forced enclosure We report the descriptive experience of 14 cases of acro-ischemia in children and adolescents observed in the territorial area of Ravenna and Rimini The cases were subjected to the nasopharyngeal swab and to the search for antibodies with ELISA method for CoViD-19 both with negative results
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #760767
    Database COVID19

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  5. Article ; Online: Parental Use and Educational Campaigns on Sunbed Use Among Teenagers and Adolescents.

    Stanganelli, Ignazio / Naldi, Luigi / Falcini, Fabio / Magi, Serena / Mazzoni, Laura / Medri, Matelda / Bertoncini, Rita / Calderoni, Ombretta / Agnoletti, Veronica / Nadiani, Luca / Palmieri, Giuseppe / Di Nuzzo, Sergio / Pagliarello, Calogero / Gandini, Sara

    Medicine

    2016  Volume 95, Issue 11, Page(s) e3034

    Abstract: This study aimed to evaluate the prevalence of sunbed use among teenagers and the association between familial behavior and the adoption of UV-protective practices in this age group. We also assessed the impact of an educational program on students' ... ...

    Abstract This study aimed to evaluate the prevalence of sunbed use among teenagers and the association between familial behavior and the adoption of UV-protective practices in this age group. We also assessed the impact of an educational program on students' knowledge about the potential risks of sunbed use. The educational intervention focused on: (i) skin effects of UV radiation, (ii) photoaging and photocarcinogenesis, (iii) risk factors for skin cancer, (iv) indoor sun tanning and misleading concepts such as possible protective effect of sunbed use on skin cancer risk, (v) sun protection and relation with skin phototype, and (vi) early diagnosis of melanoma using the ABCDE check list and the ugly duckling sign. We carried out a survey of 3098 students and found a strong association between parental sunbed use and students' use of the same (P < 0.0001). Students who attended the educational intervention were more aware that sunbed use cannot prevent sunburns (P = 0.03) than those who did not attend, making adjustments for confounding variables. However, sunbed use by parents influenced the desire to use a sunbed more than participation in the educational intervention (P < 0.0001). In conclusion, although our results indicate that educational interventions can improve knowledge of the risk of sunbed use. They also reveal a strong correlation between sunbed use by teenagers and parental behavior that highlights the importance of educational interventions involving families.
    MeSH term(s) Adolescent ; Female ; Health Education ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Parents ; Sunbathing/psychology ; Young Adult
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000003034
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  6. Article ; Online: Long-term proactive management of psoriasis with calcipotriol and betamethasone dipropionate foam: an Italian consensus through a combined nominal group technique and Delphi approach.

    De Simone, Clara / Dapavo, Paolo / Malagoli, Piergiorgio / Martella, Alessandro / Campanati, Anna / Campione, Elena / Errichetti, Enzo / Franchi, Chiara / Gambardella, Alessio / Megna, Matteo / Osti, Federica / Ribero, Simone / Zagni, Giovanni / Calzavara-Pinton, Piergiacomo / Fabbrocini, Gabriella / Amoruso, Giuseppe Fabrizio / Baglieri, Francesco / Biamonte, Anna Silvia / Bianchelli, Tommaso /
    Bigi, Laura / Bortoli, Jarno / Brunetti, Bruno / Buligan, Cinzia / Cagni, Elisabetta / Calderoni, Ombretta / Caputo, Alighiero / Carrera, Carlo Giovanni / Carugno, Andrea / Chersi, Karin / Cicchelli, Stefano / De Natale, Flora / Di Maria, Domenico / Ferrari, Angelo Salvatore / Fogli, Emanuela / Forconi, Riccardo / Galeazzi, Augusto / Giovannini, Andrea / Giura, Maria Teresa / Iuculano, Massimo / Lazzaretti, Giuseppe / Leporati, Claudia / Magnanini, Massimiliano / Marconi, Barbara / Maruccia, Adriana / Miglietta, Roberta / Minuti, Anna / Mocci, Luigi / Modica, Sonia / Narcisi, Alessandra / Odorici, Giulia / Pazzaglia, Massimiliano / Peila, Rossana / Pertusi, Ginevra / Pezza, Michele / Pezzullo, Elio / Puccia, Nunzio / Raulo, Umberto / Rossi, Mariateresa / Rusignuolo, Sergio / Sapienza, Giada / Savarese, Catello / Scalisi, Mariaelena / Strippoli, Davide / Stroppiana, Elena / Tiberio, Rossana / Trischitta, Antonino / Tucci, Maria Giovanna / Vaira, Fabrizio / Verrone, Anna / Villa, Lucia / Zagni, Fabio / Zoccali, Andrea

    International journal of dermatology

    2022  Volume 61, Issue 12, Page(s) 1543–1551

    Abstract: Background: Although long-term management of psoriasis is paramount, this approach is challenging in clinical practice. In the recent PSO-LONG trial, a fixed-dose combination of betamethasone dipropionate (BD) and calcipotriol (Cal) foam applied twice a ...

    Abstract Background: Although long-term management of psoriasis is paramount, this approach is challenging in clinical practice. In the recent PSO-LONG trial, a fixed-dose combination of betamethasone dipropionate (BD) and calcipotriol (Cal) foam applied twice a week on non-consecutive days for 52 weeks (proactive treatment) reduced the risk of relapse. However, the role of Cal/BD foam in the long-term management of psoriasis needs further clarifications. The ProActive Management (PAM) program, a nationwide Italian project, aims at reaching a consensus on the role of proactive management of psoriasis.
    Methods: A steering committee generated some statements through the nominal group technique (NGT). The statements were voted by an expert panel in an adapted Delphi voting process.
    Results: Eighteen statements were proposed, and the majority of them (14/18) reached a consensus during the Delphi voting. The need to provide long-term proactive topical treatment to reduce the risk of relapse for the treatment of challenging diseases sites or in patients where phototherapy or systemic therapies are contraindicated/ineffective was widely recognized. A consensus was reached about the possibility to associate the proactive treatment with systemic and biological therapies, without the need for dose intensification, thus favoring a prolonged remission. Moreover, the proactive treatment was recognized as more effective than weekend therapy in increasing time free from relapses. Approaches to improve adherence, on the other hand, need further investigation.
    Conclusions: The inclusion in guidelines of a proactive strategy among the effective treatment options will be a fundamental step in the evolution of a mild-moderate psoriasis therapeutic approach.
    MeSH term(s) Humans ; Dermatologic Agents/therapeutic use ; Consensus ; Betamethasone ; Psoriasis/drug therapy ; Aerosols ; Treatment Outcome ; Recurrence ; Drug Combinations
    Chemical Substances betamethasone-17,21-dipropionate (826Y60901U) ; calcipotriene (143NQ3779B) ; Dermatologic Agents ; Betamethasone (9842X06Q6M) ; Aerosols ; Drug Combinations
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16192
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