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  1. Article ; Online: Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model.

    Caldwell, Guy A

    Disease models & mechanisms

    2023  Volume 16, Issue 6

    Abstract: On the 15th Anniversary of Disease Models & Mechanisms as a trailblazing venue for the dissemination of discoveries pertaining to human health involving model systems, we celebrate the journey of this journal, as mirrored through the evolution of ... ...

    Abstract On the 15th Anniversary of Disease Models & Mechanisms as a trailblazing venue for the dissemination of discoveries pertaining to human health involving model systems, we celebrate the journey of this journal, as mirrored through the evolution of research using the nematode roundworm, Caenorhabditis elegans. Driven by the exponential growth of genomic data, worms have advanced from a basic research tool to precise and elegant models for disease and have yielded substantive insights into numerous human disorders. A harbinger of functional genomic analysis since the inception of RNA interference screening, the directed application of C. elegans for identification of disease-modifying factors has revealed new pathways and therapeutic targets to accelerate translational outcomes. Together with advances in gene editing, worm models are now ushering in the era of precision medicine with characteristic expedience.
    MeSH term(s) Humans ; Animals ; Caenorhabditis elegans ; Gene Editing ; Genomics ; Models, Biological ; Precision Medicine
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Editorial
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models.

    Mew, Melanie / Caldwell, Kim A / Caldwell, Guy A

    Human molecular genetics

    2022  Volume 31, Issue R1, Page(s) R37–R46

    Abstract: The exponential accumulation of DNA sequencing data has opened new avenues for discovering the causative roles of single-nucleotide polymorphisms (SNPs) in neurological diseases. The opportunities emerging from this are staggering, yet only as good as ... ...

    Abstract The exponential accumulation of DNA sequencing data has opened new avenues for discovering the causative roles of single-nucleotide polymorphisms (SNPs) in neurological diseases. The opportunities emerging from this are staggering, yet only as good as our abilities to glean insights from this surplus of information. Whereas computational biology continues to improve with respect to predictions and molecular modeling, the differences between in silico and in vivo analysis remain substantial. Invertebrate in vivo model systems represent technically advanced, experimentally mature, high-throughput, efficient and cost-effective resources for investigating a disease. With a decades-long track record of enabling investigators to discern function from DNA, fly (Drosophila) and worm (Caenorhabditis elegans) models have never been better poised to serve as living engines of discovery. Both of these animals have already proven useful in the classification of genetic variants as either pathogenic or benign across a range of neurodevelopmental and neurodegenerative disorders-including autism spectrum disorders, ciliopathies, amyotrophic lateral sclerosis, Alzheimer's and Parkinson's disease. Pathogenic SNPs typically display distinctive phenotypes in functional assays when compared with null alleles and frequently lead to protein products with gain-of-function or partial loss-of-function properties that contribute to neurological disease pathogenesis. The utility of invertebrates is logically limited by overt differences in anatomical and physiological characteristics, and also the evolutionary distance in genome structure. Nevertheless, functional annotation of disease-SNPs using invertebrate models can expedite the process of assigning cellular and organismal consequences to mutations, ascertain insights into mechanisms of action, and accelerate therapeutic target discovery and drug development for neurological conditions.
    MeSH term(s) Animals ; Humans ; Caenorhabditis elegans/genetics ; Drosophila/genetics ; Mutation ; Neurodegenerative Diseases/genetics ; Parkinson Disease/genetics ; Disease Models, Animal ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddac203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3469: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Modeling neurodegeneration in

    Caldwell, Kim A / Willicott, Corey W / Caldwell, Guy A

    Disease models & mechanisms

    2020  Volume 13, Issue 10

    Abstract: The global burden of neurodegenerative diseases underscores the urgent need for innovative strategies to define new drug targets and disease-modifying factors. The ... ...

    Abstract The global burden of neurodegenerative diseases underscores the urgent need for innovative strategies to define new drug targets and disease-modifying factors. The nematode
    MeSH term(s) Aging/pathology ; Animals ; Animals, Genetically Modified ; Behavior, Animal ; Caenorhabditis elegans ; Disease Models, Animal ; Humans ; Nerve Degeneration/genetics ; Nerve Degeneration/pathology
    Language English
    Publishing date 2020-10-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.046110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Phenotypic modulation of pentylenetetrazole-induced convulsive behaviors in

    Vaji, Madeline A / Caldwell, Guy A / Caldwell, Kim A

    microPublication biology

    2020  Volume 2020

    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enhanced pentylenetetrazole sensitivity in a

    Vaji, Madeline A / Caldwell, Guy A / Caldwell, Kim A

    microPublication biology

    2020  Volume 2020

    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in

    Thies, Jennifer L / Willicott, Karolina / Craig, Maici L / Greene, Madeline R / DuGay, Cassandra N / Caldwell, Guy A / Caldwell, Kim A

    Cells

    2023  Volume 12, Issue 8

    Abstract: Oxidative stress is a contributing factor to Parkinson's disease (PD). Considering the prevalence of sporadic PD, environmental exposures are postulated to increase reactive oxygen species and either incite or exacerbate neurodegeneration. We previously ... ...

    Abstract Oxidative stress is a contributing factor to Parkinson's disease (PD). Considering the prevalence of sporadic PD, environmental exposures are postulated to increase reactive oxygen species and either incite or exacerbate neurodegeneration. We previously determined that exposure to the common soil bacterium,
    MeSH term(s) Animals ; Xanthine Dehydrogenase/metabolism ; Caenorhabditis elegans/metabolism ; Calcium/metabolism ; Xanthine Oxidase/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances Xanthine Dehydrogenase (EC 1.17.1.4) ; Calcium (SY7Q814VUP) ; Xanthine Oxidase (EC 1.17.3.2) ; Reactive Oxygen Species
    Language English
    Publishing date 2023-04-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12081170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A mechanosensory defect in a

    Schlein, Melissa L / Arituluk, Zekiye Ceren / Stephen, Cayman A / Caldwell, Guy A / Ciesla, Lukasz / Caldwell, Kim A

    microPublication biology

    2023  Volume 2023

    Abstract: Previous research has described promising neuroprotective and/or antioxidant properties for extracts derived from a ... ...

    Abstract Previous research has described promising neuroprotective and/or antioxidant properties for extracts derived from a few
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Attenuation of Dopaminergic Neurodegeneration in a

    Starr, Lindsey A / McKay, Luke E / Peter, Kylie N / Seyfarth, Lena M / Berkowitz, Laura A / Caldwell, Kim A / Caldwell, Guy A

    Journal of developmental biology

    2023  Volume 11, Issue 2

    Abstract: Differential RNA editing by adenosine deaminases that act on RNA (ADARs) has been implicated in several neurological disorders, including Parkinson's disease (PD). Here, we report results of a RNAi screen of genes differentially regulated ... ...

    Abstract Differential RNA editing by adenosine deaminases that act on RNA (ADARs) has been implicated in several neurological disorders, including Parkinson's disease (PD). Here, we report results of a RNAi screen of genes differentially regulated in
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720870-9
    ISSN 2221-3759 ; 2221-3759
    ISSN (online) 2221-3759
    ISSN 2221-3759
    DOI 10.3390/jdb11020020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Vacuolar protein sorting protein 41 (VPS41) at an intersection of endosomal traffic in neurodegenerative disease.

    Griffin, Edward F / Caldwell, Kim A / Caldwell, Guy A

    Neural regeneration research

    2019  Volume 14, Issue 7, Page(s) 1210–1212

    Language English
    Publishing date 2019-02-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.251329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Found in Translation: The Utility of

    Gaeta, Anthony L / Caldwell, Kim A / Caldwell, Guy A

    Brain sciences

    2019  Volume 9, Issue 4

    Abstract: Parkinson's Disease (PD) is the second-most common neurodegenerative disease in the world, yet the fundamental and underlying causes of the disease are largely unknown, and treatments remain sparse and impotent. Several biological systems have been ... ...

    Abstract Parkinson's Disease (PD) is the second-most common neurodegenerative disease in the world, yet the fundamental and underlying causes of the disease are largely unknown, and treatments remain sparse and impotent. Several biological systems have been employed to model the disease but the nematode roundworm
    Language English
    Publishing date 2019-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci9040073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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