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  1. Book: Neurobiology of addiction and co-morbid disorders

    Calipari, Erin S.

    (International review of neurobiology ; volume 157)

    2021  

    Author's details edited by Erin S. Calipari, Ph.D., Nicholas W. Gilpin,, Ph.D
    Series title International review of neurobiology ; volume 157
    Collection
    Language English
    Size xv, 472 Seiten, Illustrationen, Diagramme
    Edition First edition
    Publisher Academic Press, an imprint of Elsevier
    Publishing place Cambridge, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT020904456
    ISBN 978-0-12-820355-2 ; 0-12-820355-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 180 -157- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Monitoring Fast Synaptic Transmission of Neuromodulatory Transmitters To Define Drug Effects in the Brain.

    Christensen, Brooke A / Calipari, Erin S

    ACS chemical neuroscience

    2023  Volume 14, Issue 9, Page(s) 1573–1574

    Abstract: Catecholaminergic systems are involved in a range of psychiatric disorders and are central mediators of the effects of stimulants on the brain and behavior. Advances in analytical detection methods paired with creative application of these approaches ... ...

    Abstract Catecholaminergic systems are involved in a range of psychiatric disorders and are central mediators of the effects of stimulants on the brain and behavior. Advances in analytical detection methods paired with creative application of these approaches allow for recording noradrenergic and dopaminergic systems in the brain in isolation with subsecond resolution. Pauly et al. (
    MeSH term(s) Humans ; Brain ; Dopamine/pharmacology ; Methamphetamine/pharmacology ; Central Nervous System Stimulants/pharmacology ; Norepinephrine/pharmacology ; Synaptic Transmission
    Chemical Substances Dopamine (VTD58H1Z2X) ; Methamphetamine (44RAL3456C) ; Central Nervous System Stimulants ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dopamine Release in the Midbrain Promotes Anxiety.

    Calipari, Erin S

    Biological psychiatry

    2020  Volume 88, Issue 11, Page(s) 815–817

    MeSH term(s) Anxiety ; Dopamine ; Dopaminergic Neurons ; Interpeduncular Nucleus ; Mesencephalon
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2020-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2020.08.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system.

    Emerson, Soren D / Chevée, Maxime / Mews, Philipp / Calipari, Erin S

    Molecular and cellular neurosciences

    2023  Volume 125, Page(s) 103823

    Abstract: A large body of work has demonstrated that cocaine-induced changes in transcriptional regulation play a central role in the onset and maintenance of cocaine use disorder. An underappreciated aspect of this area of research, however, is that the ... ...

    Abstract A large body of work has demonstrated that cocaine-induced changes in transcriptional regulation play a central role in the onset and maintenance of cocaine use disorder. An underappreciated aspect of this area of research, however, is that the pharmacodynamic properties of cocaine can change depending on an organism's previous drug-exposure history. In this study, we utilized RNA sequencing to characterize how the transcriptome-wide effects of acute cocaine exposure were altered by a history of cocaine self-administration and long-term withdrawal (30 days) in the ventral tegmental area (VTA), nucleus accumbens (NAc), and prefrontal cortex (PFC) in male mice. First, we found that the gene expression patterns induced by a single cocaine injection (10 mg/kg) were discordant between cocaine-naïve mice and mice in withdrawal from cocaine self-administration. Specifically, the same genes that were upregulated by acute cocaine in cocaine-naïve mice were downregulated by the same dose of cocaine in mice undergoing long-term withdrawal; the same pattern of opposite regulation was observed for the genes downregulated by initial acute cocaine exposure. When we analyzed this dataset further, we found that the gene expression patterns that were induced by long-term withdrawal from cocaine self-administration showed a high degree of overlap with the gene expression patterns of acute cocaine exposure - even though animals had not consumed cocaine in 30 days. Interestingly, cocaine re-exposure at this withdrawal time point reversed this expression pattern. Finally, we found that this pattern was similar across the VTA, PFC, NAc, and within each brain region the same genes were induced by acute cocaine, re-induced during long-term withdrawal, and reversed by cocaine re-exposure. Together, we identified a longitudinal pattern of gene regulation that is conserved across the VTA, PFC, and NAc, and characterized the genes constituting this pattern in each brain region.
    MeSH term(s) Rats ; Mice ; Male ; Animals ; Cocaine/pharmacology ; Rats, Sprague-Dawley ; Nucleus Accumbens ; Brain/metabolism ; Ventral Tegmental Area/metabolism
    Chemical Substances Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1046640-x
    ISSN 1095-9327 ; 1044-7431
    ISSN (online) 1095-9327
    ISSN 1044-7431
    DOI 10.1016/j.mcn.2023.103823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3035: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The critical importance of understanding comorbidities to effectively treat drug addiction.

    Gilpin, Nicholas W / Calipari, Erin S

    International review of neurobiology

    2020  Volume 157, Page(s) xiii–xv

    MeSH term(s) Comorbidity ; Humans ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy
    Language English
    Publishing date 2020-11-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/S0074-7742(21)00021-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Food Restriction Level and Reinforcement Schedule Differentially Influence Behavior during Acquisition and Devaluation Procedures in Mice.

    Chevée, Maxime / Kim, Courtney J / Crow, Nevin / Follman, Emma G / Leonard, Michael Z / Calipari, Erin S

    eNeuro

    2023  Volume 10, Issue 9

    Abstract: Behavioral strategies are often classified based on whether reinforcer value controls reinforcement. Value-sensitive behaviors, in which animals update their actions when reinforcer value is changed, are classified as goal-directed; conversely, value- ... ...

    Abstract Behavioral strategies are often classified based on whether reinforcer value controls reinforcement. Value-sensitive behaviors, in which animals update their actions when reinforcer value is changed, are classified as goal-directed; conversely, value-insensitive actions, where behavior remains consistent when the reinforcer is removed or devalued, are considered habitual. Basic reinforcement schedules can help to bias behavior toward either process: random ratio (RR) schedules are thought to promote the formation of goal-directed behaviors while random intervals (RIs) promote habitual control. However, how the schedule-specific features of these tasks interact with other factors that influence learning to control behavior has not been well characterized. Using male and female mice, we asked how distinct food restriction levels, a strategy often used to increase task engagement, interact with RR and RI schedules to control performance during task acquisition and devaluation procedures. We determined that food restriction level has a stronger effect on the behavior of mice following RR schedules compared with RI schedules, and that it promotes a decrease in response rate during devaluation procedures that is best explained by the effects of extinction rather than devaluation. Surprisingly, food restriction accelerated the decrease in response rates observed following devaluation across sequential extinction sessions, but not within a single session. Our results support the idea that the relationships between schedules and behavioral control strategies are not clear-cut and suggest that an animal's engagement in a task must be accounted for, together with the structure of reinforcement schedules, to appropriately interpret the cognitive underpinnings of behavior.
    MeSH term(s) Male ; Female ; Mice ; Animals ; Reinforcement Schedule ; Conditioning, Operant/physiology ; Reinforcement, Psychology ; Motivation ; Behavior, Animal/physiology
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0063-23.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dopamine release at the time of a predicted aversive outcome causally controls the trajectory and expression of conditioned behavior.

    Kutlu, Munir Gunes / Tat, Jennifer / Christensen, Brooke A / Zachry, Jennifer E / Calipari, Erin S

    Cell reports

    2023  Volume 42, Issue 8, Page(s) 112948

    Abstract: Dopamine release in the nucleus accumbens (NAc) is causally linked to adaptive aversive learning, and its dysregulation is a core phenotype in anxiety and stress disorders. Here, we record NAc core dopamine during a task where mice learn to discriminate ... ...

    Abstract Dopamine release in the nucleus accumbens (NAc) is causally linked to adaptive aversive learning, and its dysregulation is a core phenotype in anxiety and stress disorders. Here, we record NAc core dopamine during a task where mice learn to discriminate between cues signaling two types of outcomes: (1) footshock presentation and (2) footshock omission. We show that dopamine release is evoked by footshock omission. This dopamine response is largest when the omission is unexpected and decreases over learning, and artificially increasing this signal disrupts discrimination learning. Conversely, optogenetic inhibition of dopamine responses to the footshock itself impairs learning. Finally, theory-driven computational modeling suggests that these effects can be explained by dopamine signaling the perceived saliency of predicted aversive events. Together, we elucidate the role of NAc dopamine in aversive learning and offer potential avenues for understanding the neural mechanisms involved in anxiety and stress disorders.
    MeSH term(s) Mice ; Animals ; Dopamine/metabolism ; Avoidance Learning/physiology ; Nucleus Accumbens/metabolism ; Cues ; Mental Disorders/metabolism
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The influence of reinforcement schedule on experience-dependent changes in motivation.

    Johnson, Amy R / Christensen, Brooke A / Kelly, Shannon J / Calipari, Erin S

    Journal of the experimental analysis of behavior

    2022  Volume 117, Issue 3, Page(s) 320–330

    Abstract: The progressive ratio procedure is used across fields to assess motivation for different reinforcers, define the effects of experimental interventions on motivation, and determine experience-dependent changes in motivation. However, less is known about ... ...

    Abstract The progressive ratio procedure is used across fields to assess motivation for different reinforcers, define the effects of experimental interventions on motivation, and determine experience-dependent changes in motivation. However, less is known about how operant training schedules affect performance on this widely utilized task. Here we designed an experiment to examine the effect of variable ratio versus fixed ratio training schedules of reinforcement on progressive ratio performance while holding other performance variables constant between groups. We found a robust increase in maximum ratio completed between the pretest and posttraining test highlighting a robust training effect on progressive ratio performance. However, it did not matter if the training was under a fixed or variable ratio schedule. Additionally, we show that neither individual rates during training nor extinction responding correlated with maximum ratio achieved during the sessions. Finally, we show that rates during the training sessions do correlate with extinction performance, suggesting that these variables measure a different aspect of performance that does not predict motivation.
    MeSH term(s) Conditioning, Operant ; Motivation ; Reinforcement Schedule ; Reinforcement, Psychology
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 219405-3
    ISSN 1938-3711 ; 0022-5002
    ISSN (online) 1938-3711
    ISSN 0022-5002
    DOI 10.1002/jeab.755
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article: Sensitivity to outcome devaluation in operant tasks is better predicted by food restriction level than reinforcement training schedule in mice.

    Chevée, Maxime / Kim, Courtney J / Crow, Nevin / Follman, Emma G / Calipari, Erin S

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Behavioral strategies are often classified based on whether reinforcement is controlled by the value of the reinforcer. Value-sensitive behaviors, in which animals update their actions when reinforcer value is changed, are classified as goal-directed; ... ...

    Abstract Behavioral strategies are often classified based on whether reinforcement is controlled by the value of the reinforcer. Value-sensitive behaviors, in which animals update their actions when reinforcer value is changed, are classified as goal-directed; conversely, value-insensitive actions, where behavior remains consistent when the reinforcer is removed or devalued, are considered habitual. Understanding the features of operant training that bias behavioral control toward either strategy is essential to understanding the cognitive and neuronal processes on which they rely. Using basic reinforcement principles, behavior can be biased toward relying on either process: random ratio (RR) schedules are thought to promote the formation of goal-directed behaviors while random intervals (RI) promote habitual control. However, how the schedule-specific features of these task structures relate to external factors to influence behavior is not well understood. Using male and female mice on distinct food restriction levels, we trained each group on RR schedules with responses-per-reinforcer rates matched to their RI counterparts to control for differences in reinforcement rate. We determined that food restriction level has a stronger effect on the behavior of mice following RR schedules than mice following RI schedules and that food restriction better predicted sensitivity to outcome devaluation than training schedule. Our results support the idea the relationships between RR or RI schedules with goal-directed or habitual behaviors, respectively, are more nuanced than previously appreciated and suggest that an animal's engagement in a task must be accounted for, together with the structure of reinforcement schedules, to appropriately interpret the cognitive underpinnings of behavior.
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.23.529699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Toward Standardized Guidelines for Investigating Neural Circuit Control of Behavior in Animal Research.

    Lewis, Alan S / Calipari, Erin S / Siciliano, Cody A

    eNeuro

    2021  Volume 8, Issue 2

    Abstract: With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals, behavioral neuroscience is now tasked with establishing field-wide standards for implementing and ... ...

    Abstract With the advent of tools for recording and manipulating activity with high spatiotemporal resolution in defined neural circuits in behaving animals, behavioral neuroscience is now tasked with establishing field-wide standards for implementing and interpreting these powerful approaches. Theoretical frameworks for what constitute proof of fundamental neurobiological principles is an ongoing and frequently debated topic. On the other hand, standardizing interpretation of individual experimental findings to avoid spurious conclusions in practice has received less attention. Even within subfields, similar assays are often used to support widely disparate conclusions which in part has contributed to a slew of studies claiming highly specified functions for cell types and circuits which are often in direct disagreement with one another. In this opinion piece, we discuss common pitfalls in design and interpretation of approaches for recording or manipulating neural activity in animal models of motivated behavior. We emphasize the importance of integrating findings across multiple behavioral assays concomitant with tempered inference regarding specialized neuronal functions as a standardized starting point for parsing circuit control of behavior. Our aim is to stimulate an open and accessible discourse in the literature to address issues of continuity across behavioral neurosciences.
    MeSH term(s) Animal Experimentation ; Animals ; Behavior, Animal ; Brain ; Models, Animal ; Nervous System ; Neurons ; Neurosciences ; Optogenetics
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0498-20.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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