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  1. Article ; Online: Considerations regarding FACE-Q® craniofacial as a newly developed QoL-PROMs questionnaire suitable for paediatric and adult cranioplasty patients.

    Ganau, Mario / Calisto, Amedeo / Thomas, Gregory P L

    Neurosurgical review

    2023  Volume 46, Issue 1, Page(s) 141

    MeSH term(s) Humans ; Child ; Adult ; Quality of Life ; Skull/surgery ; Surveys and Questionnaires
    Language English
    Publishing date 2023-06-19
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-023-02054-9
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  2. Article: Pre-operative imaging and post-operative appearance of standard paediatric neurosurgical approaches: a training guide for neuroradiologists.

    Ganau, Mario / Magdum, Shailendra A / Calisto, Amedeo

    Translational pediatrics

    2021  Volume 10, Issue 4, Page(s) 1231–1243

    Abstract: A short-cut narrative review was conducted according to the SANRA guidelines to identify studies describing normal and abnormal postoperative radiological features of the most common paediatric neurosurgical procedures. Rather than focusing on the ... ...

    Abstract A short-cut narrative review was conducted according to the SANRA guidelines to identify studies describing normal and abnormal postoperative radiological features of the most common paediatric neurosurgical procedures. Rather than focusing on the original pathology addressed by neurosurgical means, this review explored three main areas of operative neurosurgery: ventricular access, supratentorial & infratentorial craniotomies, and posterior fossa/craniocervical junction decompression. A total of twenty-three landmark papers were included for review based on their relevance to address the research question and serve as a practical guide for paediatric neuroradiology trainees and fellows. Accurate in text referencing of the ClinicalTrials.gov identifier, and weblink, has also been provided for all trials discussed in the results section. All the above is complemented by relevant iconography meant to describe a wide range of postoperative changes and early complications. Finally, the review is enriched by a discussion touching upon haemostatic agents, intentionally retained foreign bodies and the future of machine learning for neuroradiology reporting. Overall, the information presented in a systematic fashion will not only help trainees and fellows to deepen these topics and expand their knowledge in preparation for written and oral boards, but will also represent a useful resource for everyone including trained neuroradiologists and neurosurgeons themselves.
    Language English
    Publishing date 2021-04-24
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-20-484
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  3. Article ; Online: Commentary: A Simple Technique for Endoscopic Hypothalamic Hamartoma Disconnection in Refractory Epilepsy: 2-Dimensional Operative Video.

    Conti, Alfredo / La Torre, Domenico / Calisto, Amedeo

    Operative neurosurgery (Hagerstown, Md.)

    2020  Volume 19, Issue 2, Page(s) E161–E162

    MeSH term(s) Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/surgery ; Endoscopy ; Hamartoma/complications ; Hamartoma/diagnostic imaging ; Hamartoma/surgery ; Humans ; Hypothalamic Diseases/complications ; Hypothalamic Diseases/diagnostic imaging ; Hypothalamic Diseases/surgery
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1093/ons/opaa087
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  4. Article ; Online: Intracranial Empyema in Children: A Single-center Retrospective Case Series.

    Gilchrist, James J / Hoy, Tom / Bijker, Else M / Lees, Emily A / Wilkins, Laura / Oliver, Madeleine / Kelly, Dominic F / Paulus, Stéphane C / Calisto, Amedeo

    The Pediatric infectious disease journal

    2023  Volume 42, Issue 11, Page(s) e417–e420

    Abstract: We conducted a retrospective, observational study of 42 children with intracranial empyema admitted to a pediatric neurosurgical center over a 9-year period. Intracranial empyema is rare, but causes significant morbidity and mortality. Twenty-eight cases ...

    Abstract We conducted a retrospective, observational study of 42 children with intracranial empyema admitted to a pediatric neurosurgical center over a 9-year period. Intracranial empyema is rare, but causes significant morbidity and mortality. Twenty-eight cases had neurosurgical source control, more commonly for subdural collections. Streptococcus anginosus group bacteria are important pathogens in subdural empyema, whose isolation predicts more complicated postoperative courses.
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004064
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  5. Article ; Online: Complications following intracranial pressure monitoring in children: a 6-year single-center experience.

    Ma, Ruichong / Rowland, David / Judge, Andrew / Calisto, Amedeo / Jayamohan, Jayaratnam / Johnson, David / Richards, Peter / Magdum, Shailendra / Wall, Steven

    Journal of neurosurgery. Pediatrics

    2018  Volume 21, Issue 3, Page(s) 278–283

    Abstract: OBJECTIVE Intracranial pressure (ICP) monitoring is an important tool in the neurosurgeon's armamentarium and is used for a wide range of indications. There are many different ICP monitors available, of which fiber-optic intraparenchymal devices are very ...

    Abstract OBJECTIVE Intracranial pressure (ICP) monitoring is an important tool in the neurosurgeon's armamentarium and is used for a wide range of indications. There are many different ICP monitors available, of which fiber-optic intraparenchymal devices are very popular. Here, the authors document their experience performing ICP monitoring from 2005 to 2015 and specifically complication rates following insertion of the Microsensor ICP monitor. METHODS A retrospective case series review of all patients who underwent ICP monitoring over a 10-year period from 2005 to 2015 was performed. RESULTS There were 385 separate operations with an overall complication rate of 8.3% (32 of 385 cases). Hardware failure occurred in 4.2% of cases, the CSF leakage rate was 3.6%, the postoperative hemorrhage rate was 0.5%, and there was 1 case of infection (0.3% of cases). Only patients with hardware problems required further surgery as a result of their complications, and no patient had any permanent morbidity or mortality from the procedure. Younger patients (p = 0.001) and patients with pathologically high ICP (13% of patients with high ICP vs 6.5% of patients with normal ICP; p = 0.04) were significantly more likely to have complications. There was no significant difference in the complication rates between general neurosurgical patients and craniofacial patients (7.6% vs 8.8%, respectively; p = 0.67). CONCLUSIONS Intraparenchymal ICP monitoring is a safe procedure associated with low complications and morbidity in the pediatric craniofacial and neurosurgical population and should be offered to appropriate patients to assess ICP with the reassurance of the safety record reported in this study.
    MeSH term(s) Child ; Craniocerebral Trauma/complications ; Craniocerebral Trauma/diagnosis ; Craniofacial Abnormalities/complications ; Female ; Fiber Optic Technology/methods ; Humans ; Intracranial Hypertension/diagnostic imaging ; Intracranial Hypertension/etiology ; Intracranial Pressure/physiology ; Longitudinal Studies ; Male ; Monitoring, Physiologic/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2018-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2017.9.PEDS17360
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    Uk I Zs.135 -Pediatrics-: Show issues Location:
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  6. Article ; Online: A new approach for investigating intracranial pressure signal: filtering and morphological features extraction from continuous recording.

    Calisto, Andrea / Galeano, Massimiliano / Serrano, Salvatore / Calisto, Amedeo / Azzerboni, Bruno

    IEEE transactions on bio-medical engineering

    2013  Volume 60, Issue 3, Page(s) 830–837

    Abstract: Nowadays, the Intracranial Pressure (ICP) monitoring has become the most common method of investigation for both traumatic and chronic neural pathologies. ICP signals are typically triphasic, that is, in a single waveform, three subpeaks can be ... ...

    Abstract Nowadays, the Intracranial Pressure (ICP) monitoring has become the most common method of investigation for both traumatic and chronic neural pathologies. ICP signals are typically triphasic, that is, in a single waveform, three subpeaks can be identified. This work outlines a new algorithm to identify subpeaks from the ICP recordings and to extract a number of 20 meaningful parameter trends. The validity of the implemented method has been proved through a comparison between the automatic subpeaks identification by the algorithm and the manually marked subpeaks by a neurosurgeon. The automatic marking system has identified subpeaks for the 63.74% (mean value) of pulse waves, providing the position and amplitude of each identified subpeak within a tolerance of ±7 samples. This automatic system provides a feature set to be used by classification software to obtain more precise and easier diagnosis in all those cases that involve brain damages or diseases.
    MeSH term(s) Adult ; Aged ; Algorithms ; Diagnosis, Computer-Assisted ; Female ; Humans ; Hydrocephalus, Normal Pressure/diagnosis ; Hydrocephalus, Normal Pressure/physiopathology ; Intracranial Pressure/physiology ; Male ; Middle Aged ; Monitoring, Physiologic/instrumentation ; Monitoring, Physiologic/methods ; Reproducibility of Results ; Signal Processing, Computer-Assisted ; Spinal Puncture ; Transducers
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2012.2191550
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    Zs.A 425: Show issues Location:
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  7. Article ; Online: Endoscopic disconnection of hypothalamic hamartomas: safety and feasibility of robot-assisted, thulium laser-based procedures.

    Calisto, Amedeo / Dorfmüller, Georg / Fohlen, Martine / Bulteau, Christine / Conti, Alfredo / Delalande, Olivier

    Journal of neurosurgery. Pediatrics

    2014  Volume 14, Issue 6, Page(s) 563–572

    Abstract: Object: Hypothalamic hamartomas (HH) may induce drug-resistant epilepsy (DRE), thereby requiring surgical treatment. Conventionally, treatment is aimed at removing the lesion, but a disconnection procedure has been shown to be safer and at least as ... ...

    Abstract Object: Hypothalamic hamartomas (HH) may induce drug-resistant epilepsy (DRE), thereby requiring surgical treatment. Conventionally, treatment is aimed at removing the lesion, but a disconnection procedure has been shown to be safer and at least as effective. The thulium laser (Revolix) has been recently introduced in urological endoscopy because of its ability to deliver a smooth cut with good control of the extent of tissue damage. The authors sought to analyze the safety and efficacy of the thulium 2-μm laser applied through navigated, robot-assisted endoscopy in disconnection surgery for HHs.
    Methods: Twenty patients with HH who were drug resistant were treated during a 12-month period. Conventional disconnection by monopolar coagulation (endoscopic electrode) was performed in 13 patients, and thulium laser disconnection was performed in the remaining 7 patients. The endoscope was inserted into the ventricle contralateral to the attachment of the HH on the third ventricular wall. Results in terms of safety, efficacy, and ease of use of the instrument were analyzed.
    Results: All 20 patients achieved a satisfactory postoperative Engel score (Classes I-III). At 12 months, the Engel class was I or II in 8 of 13 patients (61.5%) who underwent monopolar coagulation and in 6 of 7 patients (85.7%) who underwent laser disconnection (p = 0.04). Seven of 13 patients (53.8%) who underwent monopolar coagulator disconnection and 2 of 7 patients (28.6%) who underwent laser disconnection had immediate postoperative complications. At the 3-month follow-up, only 2 patients (15.4%) treated by coagulation still experienced mild surgery-related recent memory deficits. No complications persisted at the 12-month follow-up.
    Conclusions: The disconnection procedure is a safe and effective treatment strategy to treat drug-resistant epilepsy in patients with HHs. With the limitations of initial experience and a short-term follow-up, it appears that the thulium 2-μm laser has the technical features to replace the standard coagulation in this procedure.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Feasibility Studies ; Female ; Follow-Up Studies ; Hamartoma/pathology ; Hamartoma/surgery ; Humans ; Hypothalamic Diseases/pathology ; Hypothalamic Diseases/surgery ; Infant ; Laser Coagulation/adverse effects ; Laser Coagulation/methods ; Laser Therapy/adverse effects ; Laser Therapy/methods ; Magnetic Resonance Imaging ; Male ; Neuroendoscopy ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods ; Safety ; Thulium/adverse effects ; Thulium/therapeutic use ; Treatment Outcome ; Videotape Recording
    Chemical Substances Thulium (8RKC5ATI4P)
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Journal Article ; Technical Report
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2014.8.PEDS13586
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  8. Article ; Online: Intrathecal baclofen pumps in the management of hypertonia in childhood: a UK and Ireland wide survey.

    Lodh, Rajib / Amin, Sam / Ammar, Amr / Bellis, Lucy / Brink, Phillip / Calisto, Amedeo / Crimmins, Darach / Eunson, Paul / Forsyth, Rob J / Goodden, John / Kaminska, Margaret / Kehoe, Joanne / Kirkpatrick, Martin / Kumar, Ram / Leonard, Jane / Lording, Alice / Martin, Katherine / Miller, Russell / Mordekar, Santosh R /
    Pettorini, Benedetta / Smith, Martin / Smith, Rachel / Sneade, Christine / Whitney, Andrea / Vloeberghs, Michael / Zaki, Hesham / Lumsden, Daniel E

    Archives of disease in childhood

    2021  Volume 106, Issue 12, Page(s) 1202–1206

    Abstract: Background: Intrathecal baclofen (ITB) is a useful treatment for hypertonia where non-invasive treatments have been ineffective or poorly tolerated. There is an absence of national guidance on selection criteria and a lack of literature regarding ... ...

    Abstract Background: Intrathecal baclofen (ITB) is a useful treatment for hypertonia where non-invasive treatments have been ineffective or poorly tolerated. There is an absence of national guidance on selection criteria and a lack of literature regarding patient characteristics and treatment details for children and young people (CYP) receiving ITB therapy in the UK and Ireland. We aimed to gather patient and treatment characteristics for CYP receiving ITB in the UK and Ireland.
    Methods: An electronic survey was sent to all paediatric ITB centres in the UK and Ireland. Anonymised data were returned between December 2019 and April 2020. CYP >16 years and those awaiting ITB pump removal were excluded from the dataset.
    Results: 176 CYP were identified as receiving ITB therapy across the UK and Ireland. The majority of CYP with ITB pumps were non-ambulant (93%) with a diagnosis of cerebral palsy (79%). Median age of ITB insertion was 9 years; median current age was 14 years. 79% of CYP had significant spasticity, 55% had significant dystonia. The most commonly used ITB dosing modes were continuous (73%) and flexible (23%).
    Conclusions: ITB pumps were most frequently used for non-ambulant CYP with cerebral palsy and existence of spasticity and/or dystonia in the UK and Ireland. Most CYP were receiving a continuous dose of ITB. There is significant variation in the number of paediatric ITB pumps across UK and Ireland. There is a need for development of nationally accepted paediatric referral criteria and clinical standards for ITB use.
    MeSH term(s) Adolescent ; Baclofen/administration & dosage ; Baclofen/therapeutic use ; Cerebral Palsy/diagnosis ; Cerebral Palsy/drug therapy ; Child ; Child, Preschool ; Cross-Sectional Studies ; Humans ; Injections, Spinal ; Ireland ; Male ; Muscle Hypertonia/drug therapy ; Muscle Relaxants, Central/administration & dosage ; Muscle Relaxants, Central/therapeutic use ; Muscle Spasticity/drug therapy ; Surveys and Questionnaires ; Treatment Outcome ; United Kingdom
    Chemical Substances Muscle Relaxants, Central ; Baclofen (H789N3FKE8)
    Language English
    Publishing date 2021-04-14
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-321487
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  9. Article: Clinical presentation of trigeminal neuralgia and the rationale of microvascular decompression.

    Tomasello, Francesco / Alafaci, Concetta / Angileri, Filippo Flavio / Calisto, Amedeo / Salpietro, Francesco Maria

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2008  Volume 29 Suppl 1, Page(s) S191–5

    Abstract: Among the facial pain syndromes, trigeminal neuralgia has a special position for many reasons. Already described in the Romans age, the specific features of its severe symptoms, the therapeutic debate and the recent curative possibilities, make this ... ...

    Abstract Among the facial pain syndromes, trigeminal neuralgia has a special position for many reasons. Already described in the Romans age, the specific features of its severe symptoms, the therapeutic debate and the recent curative possibilities, make this complex pain syndrome a unique entity. The clinical onset is predominantly unilateral and is described as an electric, lancinating, focal and sharp pain. It can last seconds to minutes initially, and sometimes can last as long as 1 hour. Usually the patient is symptom-free between attacks. Later in the course of the disease, patients report dull, aching, constant pain in the same distribution as the paroxysms. The pain can be triggered by non-noxious stimuli like chewing, talking, swallowing, wind on the face, cold and light touch. Thought to be attributable to fifth cranial nerve dysfunction, the first surgical attempts aimed to interrupt nerve continuity by means of a rizothomy, with disappearance of both pain and sensory disturbances. Further investigations claimed nerve compression by vascular structures as responsible of nervous dysfunction. Hence the attempt to perform a decompression in order to relieve the symptoms and maintain physiologic nerve function. From the successful attempts of first microvascular decompression descends the now standardised and widespread technique that is commonly used today to treat trigeminal neuralgia.
    MeSH term(s) Decompression, Surgical/methods ; Humans ; Microcirculation ; Trigeminal Neuralgia/etiology ; Trigeminal Neuralgia/surgery ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2008-06-10
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-008-0923-4
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  10. Article: The treatment of large supratentorial arachnoid cysts in infants with cyst-peritoneal shunting and Hakim programmable valve.

    Germanò, Antonino / Caruso, Gerardo / Caffo, Mariella / Baldari, Sergio / Calisto, Amedeo / Meli, Francesco / Tomasello, Francesco

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2003  Volume 19, Issue 3, Page(s) 166–173

    Abstract: Objective: This retrospective case series examines 7 infants with large supratentorial arachnoid cysts who underwent cyst-peritoneal shunting and insertion of a Hakim programmable valve. Comparing pre- and postoperative clinical data, neuroradiological ... ...

    Abstract Objective: This retrospective case series examines 7 infants with large supratentorial arachnoid cysts who underwent cyst-peritoneal shunting and insertion of a Hakim programmable valve. Comparing pre- and postoperative clinical data, neuroradiological and regional cerebral blood flow (rCBF) findings we evaluated the efficacy of the surgical procedure.
    Methods: Infants, ranging in age from 1 to 55 days (mean age 29.5 days), were assessed pre- and postoperatively by neurological examination, developmental profile and neuroimaging.
    Results: Post procedure, all patients showed a significant reduction in the cyst/brain ratio on neuroimaging (p<0.001), 6 had a normal developmental profile (p<0.001) and 5 cases showed a significant amelioration of clinical symptoms and neurological signs. Two patients underwent preoperative SPECT scans, which showed hypoperfusion in the area surrounding the cyst; this decreased rCBF also improved post shunting.
    Conclusions: Large supratentorial arachnoid cysts in infants can be successfully treated with cyst-peritoneal shunting and insertion of a Hakim programmable valve. This is the first study specifically aimed at evaluating the long-term results of these conditions.
    MeSH term(s) Arachnoid Cysts/pathology ; Arachnoid Cysts/surgery ; Brain Diseases/pathology ; Brain Diseases/surgery ; Brain Mapping ; Cerebrospinal Fluid Shunts/methods ; Craniotomy ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging ; Male ; Neurosurgical Procedures ; Retrospective Studies ; Surgical Instruments ; Tomography, X-Ray Computed
    Language English
    Publishing date 2003-03
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0256-7040 ; 0302-2803
    ISSN (online) 1433-0350
    ISSN 0256-7040 ; 0302-2803
    DOI 10.1007/s00381-002-0702-0
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