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  1. Book ; Online ; E-Book: Regenerative rehabilitation

    Greising, Sarah M. / Call, Jarrod A.

    from basic science to the clinic

    (Physiology in health and disease)

    2022  

    Author's details Sarah M. Greising, Jarrod A. Call editors
    Series title Physiology in health and disease
    Keywords Regenerative medicine ; Rehabilitation
    Subject code 610.28
    Language English
    Size 1 Online-Ressource (x, 459 Seiten), Illustrationen
    Publisher Springer ; American Physiological Society
    Publishing place Cham ; Bethesda
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021390824
    ISBN 978-3-030-95884-8 ; 9783030958831 ; 3-030-95884-1 ; 3030958833
    DOI 10.1007/978-3-030-95884-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: When is the right time to initiate rehabilitation? Time will tell….

    Greising, Sarah M / Call, Jarrod A

    Experimental physiology

    2024  

    Language English
    Publishing date 2024-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091702
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  3. Article ; Online: The role of exerkines on brain mitochondria: a mini-review.

    Heo, Junwon / Noble, Emily E / Call, Jarrod A

    Journal of applied physiology (Bethesda, Md. : 1985)

    2022  Volume 134, Issue 1, Page(s) 28–35

    Abstract: Exercise benefits many organ systems, including having a panacea-like effect on the brain. For example, aerobic exercise improves cognition and attention and reduces the risk of brain-related diseases, such as dementia, stress, and depression. Recent ... ...

    Abstract Exercise benefits many organ systems, including having a panacea-like effect on the brain. For example, aerobic exercise improves cognition and attention and reduces the risk of brain-related diseases, such as dementia, stress, and depression. Recent advances suggest that endocrine signaling from peripheral systems, such as skeletal muscle, mediates the effects of exercise on the brain. Consequently, it has been proposed that factors secreted by all organs in response to physical exercise should be more broadly termed the "exerkines." Accumulating findings suggest that exerkines derived from skeletal muscle, liver, and adipose tissues directly impact brain mitochondrial function. Mitochondria play a pivotal role in regulating neuronal energy metabolism, neurotransmission, cell repair, and maintenance in the brain, and therefore exerkines may act via impacting brain mitochondria to improve brain function and disease resistance. Therefore, herein we review studies investigating the impact of muscle-, liver-, and adipose tissue-derived exerkines on brain cognitive and metabolic function via modulating mitochondrial bioenergetics, content, and dynamics under healthy and/or disease conditions.
    MeSH term(s) Exercise/physiology ; Brain/metabolism ; Muscle, Skeletal/physiology ; Mitochondria ; Cognition/physiology
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00565.2022
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  4. Article ; Online: Autophagy: an essential but limited cellular process for timely skeletal muscle recovery from injury.

    Call, Jarrod A / Nichenko, Anna S

    Autophagy

    2020  Volume 16, Issue 7, Page(s) 1344–1347

    Abstract: Macroautophagy/autophagy induction, i.e., the formation of autophagosomes, is robust following many forms of muscle injury. Autophagy inhibition studies strongly indicate that autophagy is necessary for successful muscle fiber recovery. Now, there are ... ...

    Abstract Macroautophagy/autophagy induction, i.e., the formation of autophagosomes, is robust following many forms of muscle injury. Autophagy inhibition studies strongly indicate that autophagy is necessary for successful muscle fiber recovery. Now, there are accumulating pieces of evidence indicating that autophagosome clearance, i.e., autophagy flux, does not increase to match the burden of accumulating damaged proteins and organelles after muscle fiber damage, creating a bottleneck effect. Some potential consequences of the bottleneck effect are reduced regenerative capacity marked by the inadequate activation of muscle stem cells (i.e., satellite cells) and a lesser commitment toward differentiation due to a deficiency in energetic substrates and/or molecular signaling pathways. These findings highlight an emerging area of investigation for both autophagy and muscle regeneration fields. The identification of the molecular mechanisms governing autophagy and autophagy flux may serve as targets for future therapies to enhance the recovery of its function in healthy and diseased muscle.
    Abbreviations: BNIP3: BCL2/adenovirus E1B interacting protein 3; CQ: chloroquine; DMD: Duchenne muscular dystrophy; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; ULK1: unc-51 like kinase 1.
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2020.1753000
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  5. Article ; Online: Chronic hypoxia impairs skeletal muscle repair via HIF-2α stabilization.

    Yin, Amelia / Fu, Wenyan / Elengickal, Anthony / Kim, Joonhee / Liu, Yang / Bigot, Anne / Mamchaoui, Kamal / Call, Jarrod A / Yin, Hang

    Journal of cachexia, sarcopenia and muscle

    2024  Volume 15, Issue 2, Page(s) 631–645

    Abstract: Background: Chronic hypoxia and skeletal muscle atrophy commonly coexist in patients with COPD and CHF, yet the underlying physio-pathological mechanisms remain elusive. Muscle regeneration, driven by muscle stem cells (MuSCs), holds therapeutic ... ...

    Abstract Background: Chronic hypoxia and skeletal muscle atrophy commonly coexist in patients with COPD and CHF, yet the underlying physio-pathological mechanisms remain elusive. Muscle regeneration, driven by muscle stem cells (MuSCs), holds therapeutic potential for mitigating muscle atrophy. This study endeavours to investigate the influence of chronic hypoxia on muscle regeneration, unravel key molecular mechanisms, and explore potential therapeutic interventions.
    Methods: Experimental mice were exposed to prolonged normobaric hypoxic air (15% pO
    Results: Chronic hypoxia led to limb muscle atrophy (EDL: 17.7%, P < 0.001; Soleus: 11.5% reduction in weight, P < 0.001) and weakness (10.0% reduction in peak-isometric torque, P < 0.001), along with impaired muscle regeneration characterized by diminished myofibre cross-sectional areas, increased fibrosis (P < 0.001), and incomplete strength recovery (92.3% of pre-injury levels, P < 0.05). HIF-2α stabilization in MuSC under chronic hypoxia hindered MuSC proliferation (26.1% reduction of MuSC at 10 dpi, P < 0.01). HIF-2α ablation in MuSC mitigated the adverse effects of chronic hypoxia on muscle regeneration and MuSC proliferation (30.9% increase in MuSC numbers at 10 dpi, P < 0.01), while HIF-1α ablation did not have the same effect. HIF-2α stabilization under chronic hypoxia led to elevated local ACE, a novel direct target of HIF-2α. Notably, pharmacological interventions with PT2385 or lisinopril enhanced muscle regeneration under chronic hypoxia (PT2385: 81.3% increase, P < 0.001; lisinopril: 34.6% increase in MuSC numbers at 10 dpi, P < 0.05), suggesting their therapeutic potential for alleviating chronic hypoxia-associated muscle atrophy.
    Conclusions: Chronic hypoxia detrimentally affects skeletal muscle regeneration by stabilizing HIF-2α in MuSC and thereby diminishing MuSC proliferation. HIF-2α increases local ACE levels in skeletal muscle, contributing to hypoxia-induced regenerative deficits. Administration of HIF-2α or ACE inhibitors may prove beneficial to ameliorate chronic hypoxia-associated muscle atrophy and weakness by improving muscle regeneration under chronic hypoxia.
    MeSH term(s) Animals ; Mice ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Hypoxia ; Indans ; Lisinopril ; Muscle, Skeletal/metabolism ; Muscular Atrophy/etiology ; Sulfones
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Indans ; Lisinopril (E7199S1YWR) ; PT2385 ; Sulfones ; endothelial PAS domain-containing protein 1 (1B37H0967P)
    Language English
    Publishing date 2024-02-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13436
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  6. Article ; Online: The Influence of COVID-19 on Patient Mobilization and Injury Attributes in the ICU: A Retrospective Analysis of a Level II Trauma Center.

    Navarro, Yelissa / Huang, Elizabeth / Johnson, Chandler / Clark, Forrest / Coppola, Samuel / Modi, Suraj / Warren, Gordon L / Call, Jarrod A

    Trauma care (Basel, Switzerland)

    2024  Volume 4, Issue 1, Page(s) 44–59

    Abstract: The objectives of this study were to determine the effect of COVID-19 on physical therapy (PT) mobilization of trauma patients and to determine if mobilization affected patient course in the ICU. This retrospective study included patients who were ... ...

    Abstract The objectives of this study were to determine the effect of COVID-19 on physical therapy (PT) mobilization of trauma patients and to determine if mobilization affected patient course in the ICU. This retrospective study included patients who were admitted to the ICU of a level II trauma center. The patients were divided into two groups, i.e., those admitted before (
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-866X
    ISSN (online) 2673-866X
    DOI 10.3390/traumacare4010005
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  7. Article ; Online: Single-Leg Hop Stabilization Throughout Concussion Recovery: A Preliminary Biomechanical Assessment.

    Lempke, Landon B / Hoch, Matthew C / Call, Jarrod A / Schmidt, Julianne D / Lynall, Robert C

    Journal of sport rehabilitation

    2023  Volume 32, Issue 5, Page(s) 513–523

    Abstract: Context: Aberrant movement patterns among individuals with concussion history have been reported during sport-related movement. However, the acute postconcussion kinematic and kinetic biomechanical movement patterns during a rapid acceleration- ... ...

    Abstract Context: Aberrant movement patterns among individuals with concussion history have been reported during sport-related movement. However, the acute postconcussion kinematic and kinetic biomechanical movement patterns during a rapid acceleration-deceleration task have not been profiled and leaves their progressive trajectory unknown. Our study aimed to examine single-leg hop stabilization kinematics and kinetics between concussed and healthy-matched controls acutely (≤7 d) and when asymptomatic (≤72 h of symptom resolution).
    Design: Prospective, cohort laboratory study.
    Methods: Ten concussed (60% male; 19.2 [0.9] y; 178.7 [14.0] cm; 71.3 [18.0] kg) and 10 matched controls (60% male; 19.5 [1.2] y; 176.1 [12.6] cm; 71.0 [17.0] kg) completed the single-leg hop stabilization task under single and dual task (subtracting by 6's or 7's) at both time points. Participants stood on a 30-cm tall box set 50% of their height behind force plates while in an athletic stance. A synchronized light was illuminated randomly, queuing participants to initiate the movement as rapidly as possible. Participants then jumped forward, landed on their nondominant leg, and were instructed to reach and maintain stabilization as fast as possible upon ground contact. We used 2 (group) × 2 (time) mixed-model analyses of variance to compare single-leg hop stabilization outcomes separately during single and dual task.
    Results: We observed a significant main group effect for single-task ankle plantarflexion moment, with greater normalized torque (mean difference = 0.03 N·m/body weight; P = .048, g = 1.18) for concussed individuals across time points. A significant interaction effect for single-task reaction time indicated that concussed individuals had slower performance acutely relative to asymptomatic (mean difference = 0.09 s; P = .015, g = 0.64), while control group performance was stable. No other main or interaction effects for single-leg hop stabilization task metrics were present during single and dual task (P ≥ .051).
    Conclusions: Greater ankle plantarflexion torque coupled with slower reaction time may indicate stiff, conservative single-leg hop stabilization performance acutely following concussion. Our findings shed preliminary light on the recovery trajectories of biomechanical alterations following concussion and provide specific kinematic and kinetic focal points for future research.
    MeSH term(s) Humans ; Male ; Female ; Leg ; Prospective Studies ; Brain Concussion/diagnosis ; Lower Extremity ; Ankle ; Biomechanical Phenomena
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1106769-x
    ISSN 1543-3072 ; 1056-6716
    ISSN (online) 1543-3072
    ISSN 1056-6716
    DOI 10.1123/jsr.2022-0397
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  8. Article ; Online: Mitochondria-cytokine crosstalk following skeletal muscle injury and disuse: a mini-review.

    Qualls, Anita E / Southern, W Michael / Call, Jarrod A

    American journal of physiology. Cell physiology

    2021  Volume 320, Issue 5, Page(s) C681–C688

    Abstract: Skeletal muscle mitochondria are highly adaptable, highly dynamic organelles that maintain the functional integrity of the muscle fiber by providing ATP for contraction and cellular homeostasis (e.g., ... ...

    Abstract Skeletal muscle mitochondria are highly adaptable, highly dynamic organelles that maintain the functional integrity of the muscle fiber by providing ATP for contraction and cellular homeostasis (e.g., Na
    MeSH term(s) Alarmins/metabolism ; Animals ; Cytokines/genetics ; Cytokines/metabolism ; Humans ; Inflammation Mediators/metabolism ; Mitochondria, Muscle/metabolism ; Mitochondria, Muscle/pathology ; Muscle Contraction ; Muscle Fibers, Skeletal/metabolism ; Muscle Fibers, Skeletal/pathology ; Muscle Strength ; Muscle, Skeletal/injuries ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiopathology ; Muscular Atrophy/genetics ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Muscular Atrophy/physiopathology ; Recovery of Function ; Regeneration ; Signal Transduction ; Wounds and Injuries/genetics ; Wounds and Injuries/metabolism ; Wounds and Injuries/pathology ; Wounds and Injuries/physiopathology
    Chemical Substances Alarmins ; Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00462.2020
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  9. Article ; Online: Musculoskeletal Regeneration, Rehabilitation, and Plasticity Following Traumatic Injury.

    Greising, Sarah M / Corona, Benjamin T / Call, Jarrod A

    International journal of sports medicine

    2020  Volume 41, Issue 8, Page(s) 495–504

    Abstract: The musculoskeletal system has an integral role throughout life, including structural support to the body, protection, and allowing a range of fine to complex movements for daily living to elite sporting events. At various times, injuries to the ... ...

    Abstract The musculoskeletal system has an integral role throughout life, including structural support to the body, protection, and allowing a range of fine to complex movements for daily living to elite sporting events. At various times, injuries to the musculoskeletal system occur resulting in varying levels of impact to the person both acutely and chronically. Specifically, there is a spectrum of complexity in orthopedic injuries, with some such as common muscle strains, that while burdensome will have no impact on life-long functional ability, and others that can result in long lasting disability. Focusing on extremity injuries, this review highlights:
    MeSH term(s) Activities of Daily Living ; Athletic Injuries/physiopathology ; Athletic Injuries/rehabilitation ; Bone Regeneration ; Fractures, Bone/physiopathology ; Fractures, Bone/rehabilitation ; Humans ; Inflammation/physiopathology ; Lower Extremity/injuries ; Lower Extremity/physiopathology ; Muscle, Skeletal/injuries ; Muscle, Skeletal/physiopathology ; Physical Therapy Modalities ; Regeneration/physiology ; Upper Extremity/injuries ; Upper Extremity/physiopathology ; Wound Healing/physiology
    Language English
    Publishing date 2020-04-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-1128-7128
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  10. Article ; Online: In Vivo Measurement of Hindlimb Dorsiflexor Isometric Torque from Pig.

    Corona, Benjamin T / Call, Jarrod A / Borkowski, Matthew / Greising, Sarah M

    Journal of visualized experiments : JoVE

    2021  , Issue 175

    Abstract: Reliable assessment of skeletal muscle strength is arguably the most important outcome measure in neuromuscular and musculoskeletal disease and injury studies, particularly when evaluating regenerative therapies' efficacy. Additionally, a critical aspect ...

    Abstract Reliable assessment of skeletal muscle strength is arguably the most important outcome measure in neuromuscular and musculoskeletal disease and injury studies, particularly when evaluating regenerative therapies' efficacy. Additionally, a critical aspect of translating many regenerative therapies is the demonstration of scalability and effectiveness in a large animal model. Various physiological preparations have been established to evaluate intrinsic muscle function properties in basic science studies, primarily in small animal models. The practices may be categorized as: in vitro (isolated fibers, fiber bundles, or whole muscle), in situ (muscle with intact vascularization and innervation but distal tendon attached to a force transducer), and in vivo (structures of the muscle or muscle unit remain intact). There are strengths and weaknesses to each of these preparations; however, a clear advantage of in vivo strength testing is the ability to perform repeated measurements in the same animal. Herein, the materials and methods to reliably assess isometric torque produced by the hindlimb dorsiflexor muscles in vivo in response to standard peroneal electrical stimulation in anesthetized pigs are presented.
    MeSH term(s) Animals ; Hindlimb ; Isometric Contraction ; Lower Extremity ; Muscle Strength ; Muscle, Skeletal ; Swine ; Torque
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/62905
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