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Article ; Online: Assessing the Need for Routine Urinalysis in Foster Care Exams.

Jimenez, Melissa / Callahan, Kelly / Sakai-Bizmark, Rie / Estevez, Dennys / Neman, Sophia / Greiner, Mary V

2024 , Page(s) 99228241226496

Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228241226496
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Article ; Online: Battling Burnout: Strategies for Promoting Physician Wellness.

Callahan, Kelly / Christman, Grant / Maltby, Lauren

Advances in pediatrics

2018 Volume 65, Issue 1, Page(s) 1–17

MeSH term(s)	Burnout, Professional/diagnosis ; Burnout, Professional/therapy ; Cognitive Behavioral Therapy ; Depersonalization/psychology ; Efficiency ; Exercise ; Fatigue/psychology ; Humans ; Interpersonal Relations ; Job Satisfaction ; Meditation ; Mindfulness ; Motivation ; Organizational Policy ; Physician-Patient Relations ; Physicians/psychology ; Quality of Health Care ; Resilience, Psychological ; Self Care ; Social Support ; Surveys and Questionnaires
Language	English
Publishing date	2018-05-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	210524-x
ISSN	1878-1926 ; 0065-3101
ISSN (online)	1878-1926
ISSN	0065-3101
DOI	10.1016/j.yapd.2018.03.001
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Article: Infant Temperament and Behavioral Problems: Analysis of High-Risk Infants in Child Welfare.

Maltby, Lauren E / Callahan, Kelly L / Friedlander, Scott / Shetgiri, Rashmi

Journal of public child welfare

2018 Volume 13, Issue 5, Page(s) 512–528

Abstract: Researchers have demonstrated the association between difficult temperament in infancy and early childhood behavioral problems, but to date this has not been demonstrated in the child welfare population. This study utilized the National Survey of Child ... ...

Abstract	Researchers have demonstrated the association between difficult temperament in infancy and early childhood behavioral problems, but to date this has not been demonstrated in the child welfare population. This study utilized the National Survey of Child and Adolescent Well-Being (NSCAW), a nationally representative, longitudinal survey of children in the child-welfare system. The sample consisted of 1,084 infants 0-12 months old at baseline who were investigated for suspected child abuse. The researchers used longitudinal, multivariable logistic regression to examine the association between difficult temperament score in infants 0-12 months who had child welfare involvement and clinical-range Child Behavior Checklist (CBCL; Achenbach & Rescorla, 2000) score at 36-months-follow-up. Findings from this study suggest that among children with substantiated maltreatment, difficult temperament in infancy predicts early childhood behavioral problems. This relationship persists after adjusting for other risk factors, such as placement, caregiver depression, and family income. The study also discusses implications for child welfare practices.
Language	English
Publishing date	2018-10-25
Publishing country	United States
Document type	Journal Article
ISSN	1554-8732
ISSN	1554-8732
DOI	10.1080/15548732.2018.1536626
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Article ; Online: Hemorrhagic pyloroduodenal duplication cyst misdiagnosed as child abuse.

Callahan, Kelly / Lee, Steven / Stewart, Sara / Berkowitz, Carol

The Journal of pediatrics

2013 Volume 163, Issue 4, Page(s) 1224–1224.e1

MeSH term(s)	Child Abuse/diagnosis ; Cysts/diagnosis ; Cysts/surgery ; Developmental Disabilities/diagnosis ; Diagnosis, Differential ; Diagnostic Errors ; Duodenal Diseases/diagnosis ; Duodenal Diseases/surgery ; Endoscopy/methods ; Esophagitis/diagnosis ; Hemorrhage/diagnosis ; Humans ; Infant ; Male ; Pylorus/pathology ; Vomiting ; Weight Loss
Language	English
Publishing date	2013-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2013.04.005
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Article ; Online: Enteric virome of Ethiopian children participating in a clean water intervention trial.

Altan, Eda / Aiemjoy, Kristen / Phan, Tung G / Deng, Xutao / Aragie, Solomon / Tadesse, Zerihun / Callahan, Kelly E / Keenan, Jeremy / Delwart, Eric

PloS one

2018 Volume 13, Issue 8, Page(s) e0202054

Abstract: Background: The enteric viruses shed by different populations can be influenced by multiple factors including access to clean drinking water. We describe here the eukaryotic viral genomes in the feces of Ethiopian children participating in a clean water ...

Abstract	Background: The enteric viruses shed by different populations can be influenced by multiple factors including access to clean drinking water. We describe here the eukaryotic viral genomes in the feces of Ethiopian children participating in a clean water intervention trial. Methodology/principal findings: Fecal samples from 269 children with a mean age of 2.7 years were collected from 14 villages in the Amhara region of Ethiopia, half of which received a new hand-dug water well. Feces from these villages were then analyzed in 29 sample pools using viral metagenomics. A total of 127 different viruses belonging to 3 RNA and 3 DNA viral families were detected. Picornaviridae family sequence reads were the most commonly found, originating from 14 enterovirus and 6 parechovirus genotypes plus multiple members of four other picornavirus genera (cosaviruses, saliviruses, kobuviruses, and hepatoviruses). Picornaviruses with nearly identical capsid VP1 were detected in different pools reflecting recent spread of these viral strains. Next in read frequencies and positive pools were sequences from the Caliciviridae family including noroviruses GI and GII and sapoviruses. DNA viruses from multiple genera of the Parvoviridae family were detected (bocaviruses 1-4, bufavirus 3, and dependoparvoviruses), together with four species of adenoviruses and common anelloviruses shedding. RNA in the order Picornavirales and CRESS-DNA viral genomes, possibly originating from intestinal parasites or dietary sources, were also characterized. No significant difference was observed between the number of mammalian viruses shed from children from villages with and without a new water well. Conclusions: We describe an approach to estimate the efficacy of potentially virus transmission-reducing interventions and the first complete (DNA and RNA viruses) description of the enteric viromes of East African children. A wide diversity of human enteric viruses was found in both intervention and control groups. Mammalian enteric virome diversity was not reduced in children from villages with a new water well. This population-based sampling also provides a baseline of the enteric viruses present in Northern Ethiopia against which to compare future viromes.
MeSH term(s)	Child ; Child, Preschool ; Computational Biology/methods ; Enterovirus/classification ; Enterovirus/genetics ; Enterovirus Infections/epidemiology ; Enterovirus Infections/transmission ; Enterovirus Infections/virology ; Ethiopia ; Feces/virology ; Genome, Viral ; Genotype ; Host-Pathogen Interactions ; Humans ; Infant ; Metagenome ; Metagenomics ; Phylogeny ; Viral Tropism ; Water Microbiology
Language	English
Publishing date	2018-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0202054
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Article ; Online: Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti-Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti-Tumor Necrosis Factor on B Cells.

Meednu, Nida / Barnard, Jennifer / Callahan, Kelly / Coca, Andreea / Marston, Bethany / Thiele, Ralf / Tabechian, Darren / Bolster, Marcy / Curtis, Jeffrey / Mackay, Meggan / Graf, Jonathan / Keating, Richard / Smith, Edwin / Boyle, Karen / Keyes-Elstein, Lynette / Welch, Beverly / Goldmuntz, Ellen / Anolik, Jennifer H

Arthritis & rheumatology (Hoboken, N.J.)

2021 Volume 74, Issue 2, Page(s) 200–211

Abstract: Objective: B cells can become activated in germinal center (GC) reactions in secondary lymphoid tissue and in ectopic GCs in rheumatoid arthritis (RA) synovium that may be tumor necrosis factor (TNF) and lymphotoxin (LT) dependent. This study was ... ...

Abstract	Objective: B cells can become activated in germinal center (GC) reactions in secondary lymphoid tissue and in ectopic GCs in rheumatoid arthritis (RA) synovium that may be tumor necrosis factor (TNF) and lymphotoxin (LT) dependent. This study was undertaken to characterize the peripheral B cell compartment longitudinally during anti-TNF therapy in RA. Methods: Participants were randomized in a 2:1 ratio to receive standard dosing regimens of etanercept (n = 43) or adalimumab (n = 20) for 24 weeks. Eligible participants met the American College of Rheumatology 1987 criteria for RA, had clinically active disease (Disease Activity Score in 28 joints >4.4), and were receiving stable doses of methotrexate. The primary mechanistic end point was the change in switched memory B cell fraction from baseline to week 12 in each treatment group. Results: B cell subsets remained surprisingly stable over the course of the study regardless of treatment group, with no significant change in memory B cells. Blockade of TNF and LT with etanercept compared to blockade of TNF alone with adalimumab did not translate into significant differences in clinical response. The frequencies of multiple activated B cell populations, including CD21- double-negative memory and activated naive B cells, were higher in RA nonresponders at all time points, and CD95+ activated B cell frequencies were increased in patients receiving anti-TNF treatment in the nonresponder group. In contrast, frequencies of transitional B cells-a putative regulatory subset-were lower in the nonresponders. Conclusion: Overall, our results support the notion that peripheral blood B cell subsets are remarkably stable in RA and not differentially impacted by dual blockade of TNF and LT with etanercept or single blockade of TNF with adalimumab. Activated B cells do associate with a less robust response.
MeSH term(s)	Adalimumab/pharmacology ; Adalimumab/therapeutic use ; Adult ; Aged ; Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; B-Lymphocytes/drug effects ; B-Lymphocytes/physiology ; Etanercept/pharmacology ; Etanercept/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Single-Blind Method ; Tumor Necrosis Factor Inhibitors/pharmacology ; Tumor Necrosis Factor Inhibitors/therapeutic use
Chemical Substances	Antirheumatic Agents ; Tumor Necrosis Factor Inhibitors ; Adalimumab (FYS6T7F842) ; Etanercept (OP401G7OJC)
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Clinical Trial, Phase IV ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.41941
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Article ; Online: Epidemiology of Soil-Transmitted Helminth and Intestinal Protozoan Infections in Preschool-Aged Children in the Amhara Region of Ethiopia.

Aiemjoy, Kristen / Gebresillasie, Sintayehu / Stoller, Nicole E / Shiferaw, Ayalew / Tadesse, Zerihun / Chanyalew, Melsew / Aragie, Solomon / Callahan, Kelly / Keenan, Jeremy D

The American journal of tropical medicine and hygiene

2017 Volume 96, Issue 4, Page(s) 866–872

Abstract: AbstractIntestinal parasites are important contributors to global morbidity and mortality and are the second most common cause of outpatient morbidity in Ethiopia. This cross-sectional survey describes the prevalence of soil-transmitted helminths and ... ...

Abstract	AbstractIntestinal parasites are important contributors to global morbidity and mortality and are the second most common cause of outpatient morbidity in Ethiopia. This cross-sectional survey describes the prevalence of soil-transmitted helminths and intestinal protozoa in preschool children 0-5 years of age in seven communities in the Amhara region of Ethiopia, and investigates associations between infection, household water and sanitation characteristics, and child growth. Stool samples were collected from children 0-5 years of age, 1 g of sample was preserved in sodium acetate-acetic acid-formalin, and examined for intestinal helminth eggs and protozoa cysts ether-concentration method. A total of 212 samples were collected from 255 randomly selected children. The prevalence of
MeSH term(s)	Child, Preschool ; Ethiopia/epidemiology ; Female ; Helminthiasis/epidemiology ; Helminthiasis/transmission ; Humans ; Intestinal Diseases, Parasitic/epidemiology ; Intestinal Diseases, Parasitic/parasitology ; Male ; Protozoan Infections/epidemiology ; Protozoan Infections/parasitology ; Soil/parasitology ; Waist-Height Ratio
Chemical Substances	Soil
Language	English
Publishing date	2017-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.16-0800
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Article ; Online: Trachomatous Scar Ranking: A Novel Outcome for Trachoma Studies.

Baldwin, Angela / Ryner, Alexander M / Tadesse, Zerihun / Shiferaw, Ayalew / Callahan, Kelly / Fry, Dionna M / Zhou, Zhaoxia / Lietman, Thomas M / Keenan, Jeremy D

The American journal of tropical medicine and hygiene

2017 Volume 96, Issue 6, Page(s) 1378–1381

Abstract: AbstractWe evaluated a new trachoma scarring ranking system with potential use in clinical research. The upper right tarsal conjunctivas of 427 individuals from Ethiopian villages with hyperendemic trachoma were photographed. An expert grader first ... ...

Abstract	AbstractWe evaluated a new trachoma scarring ranking system with potential use in clinical research. The upper right tarsal conjunctivas of 427 individuals from Ethiopian villages with hyperendemic trachoma were photographed. An expert grader first assigned a scar grade to each photograph using the 1981 World Health Organization (WHO) grading system. Then, all photographs were ranked from least (rank = 1) to most scarring (rank = 427). Photographic grading found 79 (18.5%) conjunctivae without scarring (C0), 191 (44.7%) with minimal scarring (C1), 105 (24.6%) with moderate scarring (C2), and 52 (12.2%) with severe scarring (C3). The ranking method demonstrated good internal validity, exhibiting a monotonic increase in the median rank across the levels of the 1981 WHO grading system. Intrarater repeatability was better for the ranking method (intraclass correlation coefficient = 0.84, 95% CI = 0.74-0.94). Exhibiting better internal and external validity, this ranking method may be useful for evaluating the difference in scarring between groups of individuals.
MeSH term(s)	Child ; Cicatrix/classification ; Cicatrix/pathology ; Cluster Analysis ; Conjunctiva/pathology ; Ethiopia/epidemiology ; Female ; Humans ; Male ; Photography ; Randomized Controlled Trials as Topic ; Reproducibility of Results ; Trachoma/diagnosis ; Trachoma/epidemiology ; World Health Organization
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.16-0958
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Article ; Online: Contributions of the Guinea worm disease eradication campaign toward achievement of the Millennium Development Goals.

Callahan, Kelly / Bolton, Birgit / Hopkins, Donald R / Ruiz-Tiben, Ernesto / Withers, P Craig / Meagley, Kathryn

PLoS neglected tropical diseases

2013 Volume 7, Issue 5, Page(s) e2160

MeSH term(s)	Communicable Disease Control/trends ; Disease Eradication ; Dracunculiasis/epidemiology ; Dracunculiasis/prevention & control ; Global Health ; Humans ; Neglected Diseases/epidemiology ; Neglected Diseases/prevention & control
Language	English
Publishing date	2013-05-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0002160
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Article ; Online: Defining Diarrhea: A Population-Based Validation Study of Caregiver-Reported Stool Consistency in the Amhara Region of Ethiopia.

Aiemjoy, Kristen / Aragie, Solomon / Gebresillasie, Sintayehu / Fry, Dionna M / Dagnew, Adane / Hailu, Dagnachew / Chanyalew, Melsew / Tadesse, Zerihun / Stewart, Aisha / Callahan, Kelly / Freeman, Mathew / Neuhaus, John / Arnold, Benjamin F / Keenan, Jeremy D

The American journal of tropical medicine and hygiene

2018 Volume 98, Issue 4, Page(s) 1013–1020

Abstract: Diarrhea is a leading cause of death among children aged less than five years globally. Most studies of pediatric diarrhea rely on caregiver-reported stool consistency and frequency to define the disease. Research on the validity of caregiver-reported ... ...

Abstract	Diarrhea is a leading cause of death among children aged less than five years globally. Most studies of pediatric diarrhea rely on caregiver-reported stool consistency and frequency to define the disease. Research on the validity of caregiver-reported diarrhea is sparse. We collected stool samples from 2,398 children participating in two clinical trials in the Amhara region of Ethiopia. The consistency of each stool sample was graded by the child's caregiver and two trained laboratory technicians according to an illustrated stool consistency scale. We assessed the reliability of graded stool consistency among the technicians, and then compared the caregiver's grade with the technician's grade. We also tested if the illustrated stool consistency scale could improve the validity of caregiver's report. The weighted kappa measuring the agreement between the two laboratory technicians reached 0.90 after 500 stool samples were graded. The sensitivity of caregiver-reported loose or watery stool was 15.5% (95% confidence interval [CI]: 9.7, 24.2) and the specificity was 98.4% (95% CI 97.1, 99.1). With the illustrated scale, the sensitivity was 68.5% (95% CI: 58.5, 77.1) and the specificity was 86.1% (95% CI: 79.3, 90.9). The results indicate that caregiver-reported stool consistency using the terms "loose or watery" does not accurately describe stool consistency as graded by trained laboratory technicians. Given the predominance of using caregiver-reported stool consistency to define diarrheal disease, the low sensitivity identified in this study suggests that the burden of diarrheal disease may be underestimated and intervention effects could be biased. The illustrated scale is a potential low-lost tool to improve the validity of caregiver-reported stool consistency.
MeSH term(s)	Adult ; Caregivers ; Child ; Child, Preschool ; Diarrhea/classification ; Feces ; Female ; Humans ; Infant ; Male ; Reproducibility of Results ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2018-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.17-0806
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