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Article: The drooping lily sign.

Callahan, M J

2001 Volume 219, Issue 1, Page(s) 226–228

MeSH term(s)	Female ; Humans ; Hydronephrosis/diagnostic imaging ; Infant ; Kidney Calices/diagnostic imaging ; Kidney Tubules, Collecting/abnormalities ; Kidney Tubules, Collecting/diagnostic imaging ; Ureterocele/diagnostic imaging ; Urography
Language	English
Publishing date	2001-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiology.219.1.r01ap01226
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Article: Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys.

Callahan, M J

Psychopharmacology

1999 Volume 144, Issue 3, Page(s) 234–238

Abstract: Rationale: Cholinomimetic therapy in Alzheimer's disease (AD) has been hampered by narrow efficacious dose ranges and dose-limiting side effects. These limitations highlight the need for an alternative therapeutic approach for the symptomatic treatment ... ...

Abstract	Rationale: Cholinomimetic therapy in Alzheimer's disease (AD) has been hampered by narrow efficacious dose ranges and dose-limiting side effects. These limitations highlight the need for an alternative therapeutic approach for the symptomatic treatment of AD. Objectives: To determine in rhesus monkeys if combined treatment with the acetylcholinesterase inhibitor tacrine (Cognex) and the muscarinic agonist milameline improve behavioral efficacy in a scopolamine-reversal task without potentiating adverse side effects. Methods: Behavioral performance of rhesus monkeys was measured using a continuous performance task. The effects of tacrine and milameline, separately or in combination, were determined following administration of an impairing dose of the anticholinergic scopolamine. In addition, tacrine and milameline were given similarly in the absence of scopolamine to determine the presence of adverse side effects. Results: Tacrine and milameline, separately or in combination, reversed the scopolamine-induced decrease in responses on a continuous performance task. Administered in combination, tacrine and milameline significantly improved performance on this task at lower doses and across a broader dose range than when given separately. In the absence of scopolamine, combined treatment did not potentiate the appearance of side effects or produce adverse events significantly different from those observed with either compound alone. Conclusions: Tacrine and milameline given in combination broadened the range of doses significantly reversing a scopolamine-induced impairment without potentiating adverse side effects.
MeSH term(s)	Animals ; Cholinesterase Inhibitors/pharmacology ; Dihydropyridines/pharmacology ; Drug Interactions ; Female ; Macaca mulatta ; Male ; Muscarinic Agonists/pharmacology ; Oximes/pharmacology ; Psychomotor Performance/drug effects ; Scopolamine/pharmacology ; Tacrine/pharmacology
Chemical Substances	Cholinesterase Inhibitors ; Dihydropyridines ; Muscarinic Agonists ; Oximes ; Tacrine (4VX7YNB537) ; Scopolamine (DL48G20X8X) ; milameline (R9X77R42FN)
Language	English
Publishing date	1999-06
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s002130050998
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Article: Position-dependent ventricular tachycardia related to a peripherally inserted central catheter.

Bivins, M H / Callahan, M J

Mayo Clinic proceedings

2000 Volume 75, Issue 4, Page(s) 414–416

Abstract: Recently, peripherally inserted central venous catheters (PICCs) have been widely used for venous access. Advantages of a PICC over centrally inserted central catheters include the virtual elimination of the risk of pneumothorax, hemothorax, and arterial ...

Abstract	Recently, peripherally inserted central venous catheters (PICCs) have been widely used for venous access. Advantages of a PICC over centrally inserted central catheters include the virtual elimination of the risk of pneumothorax, hemothorax, and arterial puncture, along with a reduced risk of bleeding. However, the PICC has associated risks. We present 2 cases of body position-dependent ventricular tachycardia related to PICCs. These events occurred in patients with no prior history of cardiac arrhythmia and were corrected by repositioning of the PICC. They serve to identify a potentially serious cardiac complication of the PICC that, to our knowledge, has not been described previously.
MeSH term(s)	Adult ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/methods ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Posture ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/physiopathology
Language	English
Publishing date	2000-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.4065/75.4.414
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Article ; Online: 3D multidetector CT angiographic evaluation of extralobar pulmonary sequestration with anomalous venous drainage into the left internal mammary vein in a paediatric patient.

Lee, E Y / Dillon, J E / Callahan, M J / Voss, S D

The British journal of radiology

2006 Volume 79, Issue 945, Page(s) e99–102

Abstract: Pulmonary sequestration is a congenital lung malformation, defined by dysplastic and non-functioning lung tissue lacking normal tracheobronchial connections and accompanied by an anomalous systemic blood supply. Recognition of anomalous arteries and ... ...

Abstract	Pulmonary sequestration is a congenital lung malformation, defined by dysplastic and non-functioning lung tissue lacking normal tracheobronchial connections and accompanied by an anomalous systemic blood supply. Recognition of anomalous arteries and veins in pulmonary sequestration is paramount to making the correct diagnosis. In contrast to intralobar pulmonary sequestration, where anomalous venous drainage is usually into the pulmonary venous system, the pattern of anomalous venous drainage is more varied in extralobar pulmonary sequestration. To the best of our knowledge, anomalous venous drainage to the internal mammary vein in extralobar sequestrations has not been reported. We report an anomalous venous drainage into the internal mammary vein in an extralobar sequestration which was evaluated with 3D multidetector CT angiography.
MeSH term(s)	Breast/blood supply ; Bronchopulmonary Sequestration/diagnostic imaging ; Female ; Humans ; Infant ; Phlebography ; Tomography, X-Ray Computed/methods ; Veins
Language	English
Publishing date	2006-09
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr/45058144
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Article: Hypereosinophilic syndrome with characteristic left ventricular thrombus demonstrated by contrast echocardiography.

Adams, J C / Dal-Bianco, J P / Kumar, G / Callahan, M J

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2009 Volume 17, Issue 4, Page(s) 169–170

Abstract: Hypereosinophilic syndrome (HES) is a rare condition characterised by idiopathic eosinophilia with organ system involvement. The condition is far more common in males, with a typical onset in the third to sixth decade. Cardiac damage may result in the ... ...

Abstract	Hypereosinophilic syndrome (HES) is a rare condition characterised by idiopathic eosinophilia with organ system involvement. The condition is far more common in males, with a typical onset in the third to sixth decade. Cardiac damage may result in the formation of a characteristic apical thrombus readily visualised on two-dimensional echocardiography. Cardiac involvement portends a less favourable prognosis as it can be complicated by acute embolic events and progressive development of restrictive cardiomyopathy, valvular dysfunction, and heart failure. In this case report, we describe a middle-aged gentleman with HES and characteristic apical thrombus identified on contrast echocardiography. Although the use of contrast agents for assessment of left ventricular thrombus is documented in the literature,1 this case illustrates the application of contrast echocardiography in the evaluation of eosinophilia. (Neth Heart J 2009;17:169-70.).
Language	English
Publishing date	2009-05-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/BF03086240
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Article: Reliable assessment of perfusivity and diffusivity from diffusion imaging of the body.

Freiman, M / Voss, S D / Mulkern, R V / Perez-Rossello, J M / Callahan, M J / Warfield, Simon K

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

2012 Volume 15, Issue Pt 1, Page(s) 1–9

Abstract: Diffusion-weighted MRI of the body has the potential to provide important new insights into physiological and microstructural properties. The intra-voxel incoherent motion (IVIM) model relates the observed DW-MRI signal decay to parameters that reflect ... ...

Abstract	Diffusion-weighted MRI of the body has the potential to provide important new insights into physiological and microstructural properties. The intra-voxel incoherent motion (IVIM) model relates the observed DW-MRI signal decay to parameters that reflect perfusivity (D) and its volume fraction (f), and diffusivity (D). However, the commonly used voxel-wise fitting of the IVIM model leads to parameter estimates with poor precision, which has hampered their practical usage. In this work, we increase the estimates' precision by introducing a model of spatial homogeneity, through which we obtain estimates of model parameters for all of the voxels at once, instead of solving for each voxel independently. Furthermore, we introduce an efficient iterative solver which utilizes a model-based bootstrap estimate of the distribution of residuals and a binary graph cut to generate optimal model parameter updates. Simulation experiments show that our approach reduces the relative root mean square error of the estimated parameters by 80% for the D parameter and by 50% for the f and D parameters. We demonstrated the clinical impact of our model in distinguishing between enhancing and nonenhancing ileum segments in 24 Crohn's disease patients. Our model detected the enhanced segments with 91%/92% sensitivity/specificity which is better than the 81%/85% obtained by the voxel-independent approach.
MeSH term(s)	Algorithms ; Computer Simulation ; Crohn Disease/diagnosis ; Crohn Disease/pathology ; Diagnostic Imaging/methods ; Diffusion ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Image Processing, Computer-Assisted ; Monte Carlo Method ; ROC Curve ; Reproducibility of Results ; Sensitivity and Specificity
Language	English
Publishing date	2012-10-30
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
DOI	10.1007/978-3-642-33415-3_1
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Article: Permeation of Na+ through a delayed rectifier K+ channel in chick dorsal root ganglion neurons.

Callahan, M J / Korn, S J

The Journal of general physiology

1994 Volume 104, Issue 4, Page(s) 747–771

Abstract: In whole-cell patch clamp recordings from chick dorsal root ganglion neurons, removal of intracellular K+ resulted in the appearance of a large, voltage-dependent inward tail current (Icat). Icat was not Ca2+ dependent and was not blocked by Cd2+, but ... ...

Abstract	In whole-cell patch clamp recordings from chick dorsal root ganglion neurons, removal of intracellular K+ resulted in the appearance of a large, voltage-dependent inward tail current (Icat). Icat was not Ca2+ dependent and was not blocked by Cd2+, but was blocked by Ba2+. The reversal potential for Icat shifted with the Nernst potential for [Na+]. The channel responsible for Icat had a cation permeability sequence of Na+ >> Li+ >> TMA+ > NMG+ (PX/PNa = 1:0.33:0.1:0) and was impermeable to Cl-. Addition of high intracellular concentrations of K+, Cs+, or Rb+ prevented the occurrence of Icat. Inhibition of Icat by intracellular K+ was voltage dependent, with an IC50 that ranged from 3.0-8.9 mM at membrane potentials between -50 and -110 mV. This voltage-dependent shift in IC50 (e-fold per 52 mV) is consistent with a single cation binding site approximately 50% of the distance into the membrane field. Icat displayed anomolous mole fraction behavior with respect to Na+ and K+; Icat was inhibited by 5 mM extracellular K+ in the presence of 160 mM Na+ and potentiated by equimolar substitution of 80 mM K+ for Na+. The percent inhibition produced by both extracellular and intracellular K+ at 5 mM was identical. Reversal potential measurements revealed that K+ was 65-105 times more permeant than Na+ through the Icat channel. Icat exhibited the same voltage and time dependence of inactivation, the same voltage dependence of activation, and the same macroscopic conductance as the delayed rectifier K+ current in these neurons. We conclude that Icat is a Na+ current that passes through a delayed rectifier K+ channel when intracellular K+ is reduced to below 30 mM. At intracellular K+ concentrations between 1 and 30 mM, PK/PNa remained constant while the conductance at -50 mV varied from 80 to 0% of maximum. These data suggest that the high selectivity of these channels for K+ over Na+ is due to the inability of Na+ to compete with K+ for an intracellular binding site, rather than a barrier that excludes Na+ from entry into the channel or a barrier such as a selectivity filter that prevents Na+ ions from passing through the channel.
MeSH term(s)	Animals ; Anions/metabolism ; Anions/pharmacology ; Cations/metabolism ; Cations/pharmacology ; Cell Membrane Permeability/drug effects ; Chick Embryo ; Delayed Rectifier Potassium Channels ; Ganglia, Spinal/cytology ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/embryology ; Ganglia, Spinal/metabolism ; Ion Channel Gating/drug effects ; Membrane Potentials/drug effects ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Patch-Clamp Techniques ; Potassium/metabolism ; Potassium Channels/metabolism ; Potassium Channels, Voltage-Gated ; Sodium/metabolism ; Tetraethylammonium ; Tetraethylammonium Compounds/pharmacology ; Tetrodotoxin/pharmacology
Chemical Substances	Anions ; Cations ; Delayed Rectifier Potassium Channels ; Potassium Channels ; Potassium Channels, Voltage-Gated ; Tetraethylammonium Compounds ; Tetrodotoxin (4368-28-9) ; Tetraethylammonium (66-40-0) ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	English
Publishing date	1994-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.104.4.747
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Article: Harderian gland adenectomy: A method to eliminate confounding radio-opacity in the assessment of rat brain metabolism by 18F-fluoro-2-deoxy-D-glucose positron emission tomography

Brammer, D.W / Riley, J.M / Kreuser, S.C / Zasadny, K.R / Callahan, M.J / Davis, M.D

Journal of the American Association for Laboratory Animal Science : JAALAS. 2007 Sept., v. 46, no. 5

2007

Keywords	rats ; sebaceous glands ; surgery ; brain ; carbohydrate metabolism ; metabolic studies ; radiolabeling ; tomography ; radionuclides ; fluorine ; diagnostic techniques
Language	English
Dates of publication	2007-09
Size	p. 42-45.
Document type	Article
ISSN	1559-6109
Database	NAL-Catalogue (AGRICOLA)

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Article: Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice.

Callahan, M J / Lipinski, W J / Bian, F / Durham, R A / Pack, A / Walker, L C

The American journal of pathology

2001 Volume 158, Issue 3, Page(s) 1173–1177

Abstract: Transgenic mice (Tg2576) overexpressing human beta-amyloid precursor protein with the Swedish mutation (APP695SWE) develop Alzheimer's disease-like amyloid beta protein (Abeta) deposits by 8 to 10 months of age. These mice show elevated levels of Abeta40 ...

Abstract	Transgenic mice (Tg2576) overexpressing human beta-amyloid precursor protein with the Swedish mutation (APP695SWE) develop Alzheimer's disease-like amyloid beta protein (Abeta) deposits by 8 to 10 months of age. These mice show elevated levels of Abeta40 and Abeta42, as well as an age-related increase in diffuse and compact senile plaques in the brain. Senile plaque load was quantitated in the hippocampus and neocortex of 8- to 19-month-old male and female Tg2576 mice. In all mice, plaque burden increased markedly after the age of 12 months. At 15 and 19 months of age, senile plaque load was significantly greater in females than in males; in 91 mice studied at 15 months of age, the area occupied by plaques in female Tg2576 mice was nearly three times that of males. By enzyme-linked immunosorbent assay, female mice also had more Abeta40 and Abeta42 in the brain than did males, although this difference was less pronounced than the difference in histological plaque load. These data show that senescent female Tg2576 mice deposit more amyloid in the brain than do male mice, and may provide an animal model in which the influence of sex differences on cerebral amyloid pathology can be evaluated.
MeSH term(s)	Aging ; Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/biosynthesis ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Disease Models, Animal ; Female ; Hippocampus/metabolism ; Hippocampus/pathology ; Male ; Mice ; Mice, Transgenic ; Neocortex/metabolism ; Neocortex/pathology ; Peptide Fragments/biosynthesis ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Sex Factors
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Peptide Fragments ; amyloid beta-protein (1-40) ; amyloid beta-protein (1-42)
Language	English
Publishing date	2001-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.1016/s0002-9440(10)64064-3
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Article: The development of hypertrophic pyloric stenosis in a patient with prostaglandin-induced foveolar hyperplasia.

Callahan, M J / McCauley, R G / Patel, H / Hijazi, Z M

Pediatric radiology

1999 Volume 29, Issue 10, Page(s) 748–751

Abstract: Background: Hypertrophic pyloric stenosis (HPS) has been described in association with several obstructive antropyloric lesions including idiopathic foveolar hyperplasia (gastric mucosal hypertrophy), feeding tubes, eosinophilic gastroenteritis, and ... ...

Abstract	Background: Hypertrophic pyloric stenosis (HPS) has been described in association with several obstructive antropyloric lesions including idiopathic foveolar hyperplasia (gastric mucosal hypertrophy), feeding tubes, eosinophilic gastroenteritis, and hypertrophic antral polyps. Non obstructive antral webs have also been described with HPS. Patient and methods: We present a case of gastric-outlet obstruction in association with HPS, namely, prostaglandin-induced foveolar hyperplasia. This entity has been previously described, but rarely in association with HPS. We report a female infant requiring prostaglandin therapy for pulmonary atresia who developed dose-related prostaglandin-induced foveolar hyperplasia and symptoms of progressive non-bilious vomiting. Results: Initially, ultrasonography demonstrated evidence of antral mucosal hypertrophy as the cause for gastric-outlet obstruction. The patient subsequently developed progressive thickening of the antropyloric muscle, resulting in sonographic appearances of hypertrophic pyloric stenosis. Pyloromyotomy was eventually required for treatment of HPS. Conclusion: A common denominator of most of the above-described entities is thickening and/or hypertrophy of the antral mucosa. We suggest that the antropyloric musculature may hypertrophy in an effort to overcome the gastric-outlet obstruction caused by the adjacent thickened antral mucosa. In other words, these entities may represent examples of "secondary" hypertrophic pyloric stenosis.
MeSH term(s)	Female ; Gastric Mucosa/pathology ; Gastric Outlet Obstruction/diagnosis ; Gastric Outlet Obstruction/diagnostic imaging ; Gastric Outlet Obstruction/etiology ; Humans ; Hypertrophy/chemically induced ; Hypertrophy/diagnostic imaging ; Infant, Newborn ; Prostaglandins/adverse effects ; Prostaglandins/therapeutic use ; Pulmonary Atresia/drug therapy ; Pyloric Antrum/diagnostic imaging ; Pyloric Antrum/pathology ; Pyloric Stenosis/diagnosis ; Pyloric Stenosis/diagnostic imaging ; Pyloric Stenosis/etiology ; Ultrasonography
Chemical Substances	Prostaglandins
Language	English
Publishing date	1999-10
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s002470050688
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