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Article ; Online: Roth-like Spot in an Adult With Vitamin B

Driscoll, Diana / Callanan, David

Journal of vitreoretinal diseases

2021 Volume 6, Issue 5, Page(s) 412–413

Abstract: Purpose: This work reports retinal findings in an adult patient with vitamin B: Methods: A case review of a single patient is presented.: Results: A patient with a Roth-type retinal lesion and a history of nonepileptic seizures was found to have ... ...

Abstract	Purpose: This work reports retinal findings in an adult patient with vitamin B Methods: A case review of a single patient is presented. Results: A patient with a Roth-type retinal lesion and a history of nonepileptic seizures was found to have lymphocytic colitis. She was treated with pyridoxine, which resolved her seizures and the white-centered hemorrhage. Conclusions: Vitamin B
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Case Reports
ISSN	2474-1272
ISSN (online)	2474-1272
DOI	10.1177/24741264211028788
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Article ; Online: An Analysis of the Game Movement Demands of Women's Interprovincial Rugby Union.

Callanan, Danielle / Rankin, Paula / Fitzpatrick, Paula

Journal of strength and conditioning research

2021 Volume 35, Issue Suppl 2, Page(s) S20–S25

Abstract: Abstract: Callanan, D, Rankin, P, and Fitzpatrick, P. Analysis of the game movement demands of women's interprovincial rugby union. J Strength Cond Res 35(12S): S20-S25, 2021-The purpose of this study was to provide an objective analysis of the game ... ...

Abstract	Abstract: Callanan, D, Rankin, P, and Fitzpatrick, P. Analysis of the game movement demands of women's interprovincial rugby union. J Strength Cond Res 35(12S): S20-S25, 2021-The purpose of this study was to provide an objective analysis of the game movement demands of women's interprovincial rugby union (RU). Sixty-three (N = 128) interprovincial women RU players wore 10-Hz global positioning systems (PlayerTek by Catapult, Australia) during 12 interprovincial matches (116 individual player data sets). Players were classified according to forwards and backs, and positional subcategory groups: front row second row, back row, half-back, midfield, and back three. The mean total distance covered across the series was 5,696 ± 822 m, at a relative distance of 67.9 ± 6.9 m·min-1, while recording a mean maximal velocity of 6.5 ± 0.7 m·s-1. The backs covered a greater total distance (5,964 ± 807 m; d = 0.65), relative distance (70.1 ± 7.5 m·min-1; d = 0.63), mean maximal velocity (6.9 ± 0.5 m·s-1; d = 1.27), distance walking (1,152 ± 152 m; d = 0.54), jogging (3,120 ± 519 m; d = 0.56), and high-speed running (294 ± 150 m; d = 0.99) than the forwards. The midfield recorded the greatest total distance (6,144 ± 516 m; p = 0.013), with the front row registering the lowest. The half backs documented the greatest relative distance (73.2 ± 8.0 m·min-1; p = 0.005), with the back three reported to cover the greatest distances walking (1,169 ± 178 m; p = 0.001) and at high-speed distances (353 ± 175 m; p = 0.002). The back three also recorded the greatest mean maximal velocity (7.2 ± 0.4 m·s-1; p = 0.000). This is the first study in the Northern hemisphere to report the game movement demands of interprovincial women's RU and the information derived from this study may provide practitioners with normative data to assist coaches with preparation.
MeSH term(s)	Athletic Performance ; Female ; Football ; Geographic Information Systems ; Humans ; Movement ; Rugby ; Running
Language	English
Publishing date	2021-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0000000000004065
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Article ; Online: Significance of Worst Pattern of Invasion-5 in Early-Stage Oral Cavity Squamous Cell Carcinoma.

Mohamed, Shima / Jawad, Hadeel / Sullivan, Ryan O' / Callanan, Deirdre / Sheahan, Patrick / Feeley, Linda

Head and neck pathology

2023 Volume 17, Issue 3, Page(s) 679–687

Abstract: Background: There is an ongoing need to identify pathologic prognosticators in early-stage oral cavity squamous cell carcinoma (OCSCC) to aid selection of patients who may benefit from adjuvant treatment. The objective of this study was to evaluate the ... ...

Abstract	Background: There is an ongoing need to identify pathologic prognosticators in early-stage oral cavity squamous cell carcinoma (OCSCC) to aid selection of patients who may benefit from adjuvant treatment. The objective of this study was to evaluate the prognostic ability of worst pattern of invasion-5 (WPOI-5) defined by the presence of satellite nodules, extratumoural perineural invasion (PNI) and/or extratumoural lymphovascular space invasion (LVI) in low-stage, node negative OCSCC. Methods: This was a retrospective study of 160 patients with T1/T2N0 tumours staged using TNM7 treated surgically. Histology of the primary tumour was re-reviewed as appropriate to assess for the presence of WPOI-5 parameters. Univariate and multivariate analysis assessing impact of pathological features on survival outcomes was performed. Results: On univariate analysis, WPOI-5 and its 3 constituent components of satellite nodules, extratumoural PNI and extratumoural LVI were all significantly associated with disease-specific survival (DSS) and overall survival (OS). On multivariate analysis, satellite nodules (odds ratio 6.61, 95% CI 2.83-15.44, p < 0.0001) and extratumoural LVI (odds ratio 9.97, 95% CI 2.19-45.35, p = 0.003) were independently associated with OS. Postoperative radiotherapy (odds ratio 0.40, 95% CI 0.19-0.87, p = 0.02) and non-tongue subsite (odds ratio 3.03, 95% CI 1.70-5.39, p = 0.0002) were also significantly associated with OS on multivariate analysis. Conclusion: Satellite nodules and extratumoural LVI correlated significantly with survival outcomes in our early-stage OSCC cohort. Further study is required to investigate the benefit of adjuvant treatment in these cases and to ascertain if WPOI-5 parameters including satellite nodules should be mandatory reporting data elements.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/pathology ; Retrospective Studies ; Mouth Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Prognosis ; Neoplasm Invasiveness/pathology ; Head and Neck Neoplasms/pathology ; Neoplasm Staging
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-023-01571-9
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Article ; Online: Risk of disease transmission from flexible nasoendoscopy during the coronavirus disease 2019 pandemic.

Kavanagh, F G / Connolly, C / Farrell, E / Callanan, D / Brinkman, D / Affendi, A / Lang, E / Sheahan, P

The Journal of laryngology and otology

2021 Volume 135, Issue 3, Page(s) 246–249

Abstract: Background: Concerns have emerged regarding infection transmission during flexible nasoendoscopy.: Methods: Information was gathered prospectively on flexible nasoendoscopy procedures performed between March and June 2020. Patients and healthcare ... ...

Abstract	Background: Concerns have emerged regarding infection transmission during flexible nasoendoscopy. Methods: Information was gathered prospectively on flexible nasoendoscopy procedures performed between March and June 2020. Patients and healthcare workers were followed up to assess for coronavirus disease 2019 development. One-sided 97.5 per cent Poisson confidence intervals were calculated for upper limits of risk where zero events were observed. Results: A total of 286 patients were recruited. The most common indication for flexible nasoendoscopy was investigation of 'red flag' symptoms (67 per cent). Forty-seven patients (16 per cent, 95 per cent confidence interval = 13-21 per cent) had suspicious findings on flexible nasoendoscopy requiring further investigation. Twenty patients (7.1 per cent, 95 per cent confidence interval = 4.4-11 per cent) had new cancer diagnoses. Zero coronavirus disease 2019 infections were recorded in the 273 patients. No. 27 endoscopists (the doctors and nurses who carried out the procedures) were followed up.The risk of developing coronavirus disease 2019 after flexible nasoendoscopy was determined to be 0-1.3 per cent. Conclusion: The risk of coronavirus disease 2019 transmission associated with performing flexible nasoendoscopy in asymptomatic patients, while using appropriate personal protective equipment, is very low. Additional data are required to confirm these findings in the setting of further disease surges.
MeSH term(s)	Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Endoscopy/adverse effects ; Endoscopy/instrumentation ; Female ; Humans ; Infection Control/organization & administration ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Infectious Disease Transmission, Patient-to-Professional/statistics & numerical data ; Ireland ; Male ; Patient Selection ; Personal Protective Equipment ; Prospective Studies ; Retrospective Studies ; Risk Assessment
Language	English
Publishing date	2021-02-24
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S002221512100061X
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Article ; Online: Long term gastroesophageal reflux after atrial fibrillation ablation.

Callanan, Deborah

Heart rhythm

2010 Volume 7, Issue 3, Page(s) e1; author reply e1–2

MeSH term(s)	Anorexia/etiology ; Atrial Fibrillation/therapy ; Catheter Ablation/adverse effects ; Esophagitis, Peptic/drug therapy ; Esophagitis, Peptic/etiology ; Gastroesophageal Reflux/drug therapy ; Gastroesophageal Reflux/etiology ; Humans ; Time Factors ; Weight Loss
Language	English
Publishing date	2010-03
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2009.12.021
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Article: PolySialic Acid Nanoparticles Actuate Complement-Factor-H-Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related Macular Degeneration.

Peterson, Sheri L / Krishnan, Anitha / Patel, Diyan / Khanehzar, Ali / Lad, Amit / Shaughnessy, Jutamas / Ram, Sanjay / Callanan, David / Kunimoto, Derek / Genead, Mohamed A / Tolentino, Michael J

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 4

Abstract: The alternative pathway of the complement system is implicated in the etiology of age-related macular degeneration (AMD). Complement depletion with pegcetacoplan and avacincaptad pegol are FDA-approved treatments for geographic atrophy in AMD that, while ...

Abstract	The alternative pathway of the complement system is implicated in the etiology of age-related macular degeneration (AMD). Complement depletion with pegcetacoplan and avacincaptad pegol are FDA-approved treatments for geographic atrophy in AMD that, while effective, have clinically observed risks of choroidal neovascular (CNV) conversion, optic neuritis, and retinal vasculitis, leaving room for other equally efficacious but safer therapeutics, including Poly Sialic acid (PSA) nanoparticle (PolySia-NP)-actuated complement factor H (CFH) alternative pathway inhibition. Our previous paper demonstrated that PolySia-NP inhibits pro-inflammatory polarization and cytokine release. Here, we extend these findings by investigating the therapeutic potential of PolySia-NP to attenuate the alternative complement pathway. First, we show that PolySia-NP binds CFH and enhances affinity to C3b. Next, we demonstrate that PolySia-NP treatment of human serum suppresses alternative pathway hemolytic activity and C3b deposition. Further, we show that treating human macrophages with PolySia-NP is non-toxic and reduces markers of complement activity. Finally, we describe PolySia-NP-treatment-induced decreases in neovascularization and inflammatory response in a laser-induced CNV mouse model of neovascular AMD. In conclusion, PolySia-NP suppresses alternative pathway complement activity in human serum, human macrophage, and mouse CNV without increasing neovascularization.
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17040517
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Article ; Online: Comparison of royal college of pathologists and college of american pathologists definition for positive margins in oral cavity squamous cell carcinoma.

Brinkman, David / Callanan, Deirdre / Jawad, Hadeel / O'Sullivan, Ryan / O'Shea, Ross / Dias, Andrew / Feeley, Linda / Sheahan, Patrick

Oral oncology

2022 Volume 127, Page(s) 105797

Abstract: Background: Pathological margin assessment is an essential component of surgical management of oral cavity squamous cell carcinoma (OCSCC), however, in many studies, variable definitions of involved margins have been used. The purpose of the present ... ...

Abstract	Background: Pathological margin assessment is an essential component of surgical management of oral cavity squamous cell carcinoma (OCSCC), however, in many studies, variable definitions of involved margins have been used. The purpose of the present study was to compare the prognostic ability of involved margins according to Royal College of Pathologists (RCPath) and College of American Pathologists (CAP) guidance. Methods: Retrospective study of 300 patients with previously untreated OCSCC undergoing definitive surgical management. Main specimen margin status was defined according to RCPath guidance and CAP guidance. "Final margin status", incorporated the results of frozen sections and extra tumour bed resections. The prognostic impact of each margin definition was studied using univariate analysis, and in multivariate models including T-stage (AJCC 8th edition), nodal status (pN+), extranodal extension (ENE), and use of adjuvant radiotherapy. Results: Both RCPath and CAP positive margins were associated with local recurrence (LR), disease-specific survival (DSS), and overall survival (OS) on univariate analysis, while final margin status was associated with LR and DSS, but not OS. On multivariate analysis, only CAP positive main specimen margin status was independently associated with LR (odds ratio 2.44, 95% CI 1.37, 4.34), DSS (odds ratio 2.28, 95% CI 1.31, 3.82), and OS (odds ratio 1.59, 95% CI 1.04, 2.42). Conclusions: Involved main specimen margin as defined by CAP guidance has the advantage of being an independent prognosticator of LR and survival in our cohort.
MeSH term(s)	Head and Neck Neoplasms/pathology ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Pathologists ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/pathology
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2022.105797
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Impact of Modifying Abicipar Manufacturing Process in Patients with Neovascular Age-Related Macular Degeneration: MAPLE Study Results.

Callanan, David / Khurana, Rahul N / Maturi, Raj K / Patel, Sunil / Wykoff, Charles C / Eichenbaum, David / Khanani, Arshad M / Hassan, Tarek / Badger, Hanh / Mehta, Shraddha / Le, Grace / Attar, Mayssa / Seal, Jennifer / Li, Xiao-Yan

Clinical ophthalmology (Auckland, N.Z.)

2023 Volume 17, Page(s) 1367–1384

Abstract: Purpose: To evaluate the impact of modifying the abicipar pegol (abicipar) manufacturing process on the safety and treatment effect of abicipar in patients with neovascular age-related macular degeneration (nAMD).: Methods: A new process for ... ...

Abstract	Purpose: To evaluate the impact of modifying the abicipar pegol (abicipar) manufacturing process on the safety and treatment effect of abicipar in patients with neovascular age-related macular degeneration (nAMD). Methods: A new process for manufacturing abicipar was developed to reduce host cell impurities. In a prospective, Phase 2, multicenter, open-label, 28-week clinical trial, patients (n=123) with active nAMD received intravitreal injections of abicipar 2 mg at baseline (day 1) and weeks 4, 8, 16, and 24. Outcome measures included proportion of patients with stable vision (<15-letter loss from baseline; primary endpoint), change from baseline in best-corrected visual acuity (BCVA) and central retinal thickness (CRT), and adverse events. Results: Overall, 8.9% (11/123) of patients experienced intraocular inflammation (IOI) and discontinued treatment. IOI cases were assessed as mild (2.4% [3/123]), moderate (4.9% [6/123]), or severe (1.6% [2/123]) and resolved with steroid treatment. Visual acuity in most patients with IOI (8 of 11) recovered to baseline BCVA or better by study end. No cases of endophthalmitis or retinal vasculitis were reported. Stable vision was maintained for ≥95.9% (≥118/123) of patients at all study visits. At week 28, treatment-naïve patients showed a greater mean improvement from baseline in BCVA compared with previously treated patients (4.4 vs 1.8 letters) and a larger mean CRT reduction from baseline (98.5 vs 45.5 μm). Conclusion: Abicipar produced using a modified manufacturing process showed a moderately lower incidence and severity of IOI compared with Phase 3 abicipar studies. Beneficial effects of treatment were demonstrated.
Language	English
Publishing date	2023-05-11
Publishing country	New Zealand
Document type	Case Reports ; Clinical Trial
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S405994
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Article: Urinary perforation in spina bifida: Neurosurgical and infectious consequences.

Callanan, Deborah / Phillips, Timothy / Tullous, Micam

SAGE open medical case reports

2017 Volume 5, Page(s) 2050313X17744986

Abstract: As the number of medically complex children increases, pediatricians and emergency physicians face challenges in evaluating complications from devices placed to treat their underlying conditions. We present a child with spina bifida who developed a ... ...

Abstract	As the number of medically complex children increases, pediatricians and emergency physicians face challenges in evaluating complications from devices placed to treat their underlying conditions. We present a child with spina bifida who developed a perforation of his vesicostomy leading to peritonitis, septic shock, and urgent externalization of his ventriculoperitoneal shunt. Multiple consultants may need to be promptly involved in the management of children with underlying medical problems. Because procedural complications are often reported only in the surgical specialty literature, pediatricians and emergency physicians should seek information from their patients' specialists about potential problems.
Language	English
Publishing date	2017-12-11
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X17744986
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Article ; Online: Prognostic performance of TNM8 staging rules in oral cavity squamous cell carcinoma.

Jawad, Hadeel / Ashaari, Sarah Shahida / O'Shea, Ross / Callanan, Deirdre / Sheahan, Patrick / Feeley, Linda

Oral oncology

2020 Volume 111, Page(s) 105021

Abstract: Background: Two major changes to the staging of oral cavity squamous cell carcinoma (OCSCC) were adopted in TNM8: (1) depth of invasion is now used for T staging and (2) extranodal extension for N staging. The aim of this study was to evaluate if TNM8 ... ...

Abstract	Background: Two major changes to the staging of oral cavity squamous cell carcinoma (OCSCC) were adopted in TNM8: (1) depth of invasion is now used for T staging and (2) extranodal extension for N staging. The aim of this study was to evaluate if TNM8 stratifies OCSCC patients more accurately than TNM7 based on overall survival (OS) statistics and hazard discrimination. Methods: Retrospective study of 297 patients with OCSCC who underwent surgery at our institution. Clinical and pathological data were previously populated from review of medical charts and histological reports. Slides were re-reviewed for depth of invasion measurements. Patients were staged using both TNM7 and TNM8 with overall survival statistics analysed. Results: Overall 118 patients (39.7%) were upstaged using TNM8. Both TNM7 and TNM8 stage categories were highly significant for OS (all p values < 0.0001). Hazard discrimination analysis showed that TNM7 could only differentiate stage III from stage IV disease with significance (OS p = 0.01). In comparison TNM8 could distinguish between stage II and III disease (OS p = 0.047) and between stage III and IV disease (OS p = 0.004). Subsite analysis suggested that both editions of the staging system perform best for tongue primaries. Conclusions: Although TNM8 showed improved hazard discrimination in comparison to TNM7, problems with discriminative ability persisted with 8th edition staging criteria. Large scale validation studies will be required to direct future refinement of the staging rules and to establish if the continued use of a single staging system for all oral cavity subsites is appropriate.
MeSH term(s)	Female ; Humans ; Lymph Nodes/pathology ; Male ; Mouth Floor ; Mouth Neoplasms/mortality ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Neoplasm Invasiveness ; Neoplasm Staging/methods ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/mortality ; Squamous Cell Carcinoma of Head and Neck/pathology ; Squamous Cell Carcinoma of Head and Neck/surgery ; Tongue Neoplasms/mortality ; Tongue Neoplasms/pathology ; Tongue Neoplasms/surgery
Language	English
Publishing date	2020-10-01
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2020.105021
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