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  1. Article: Questions around a case of

    Gerard, Delphine / Callies, Arnaud / Simon, Laure / Ternisien, Catherine / Prot-Labarthe, Sonia

    European journal of hospital pharmacy : science and practice

    2023  

    Abstract: We report the case of a preterm infant presenting a thrombosis, discovered on ultrasound at 22 weeks of gestational age and confirmed at birth following additional examinations. We describe the anticoagulant treatment of this patient by intravenous ... ...

    Abstract We report the case of a preterm infant presenting a thrombosis, discovered on ultrasound at 22 weeks of gestational age and confirmed at birth following additional examinations. We describe the anticoagulant treatment of this patient by intravenous enoxaparin, tinzaparin and rivaroxaban, from questioning to practice.
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2023-003826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Safety and Efficacy of Ceftaroline in Neonates With Staphylococcal Late-onset Sepsis: A Case Series Analysis.

    Callies, Arnaud / Martin-Perceval, Lise / Crémet, Lise / Gély, Lilas / Ruellan, Anne-Lise / Verdier, Marie-Clemence / Gregoire, Matthieu / Flamant, Cyril / Guillouzouic, Aurélie / Prot-Labarthe, Sonia / Butin, Marine / Launay, Elise

    The Pediatric infectious disease journal

    2023  Volume 42, Issue 10, Page(s) 888–892

    Abstract: Treatment of late-onset neonatal staphylococcal sepsis is sometimes challenging with feared side effects of vancomycin, increasing minimal inhibitory concentrations and questions about catheter management. In case of failure, ceftaroline was administered ...

    Abstract Treatment of late-onset neonatal staphylococcal sepsis is sometimes challenging with feared side effects of vancomycin, increasing minimal inhibitory concentrations and questions about catheter management. In case of failure, ceftaroline was administered as a compassionate treatment in 16 infants (gestational age of less than 32 weeks and less than 28 postnatal days), whose first-line treatment failed. We report 11 successes and no severe adverse drug reactions. Larger data are required to confirm these encouraging results.
    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Anti-Bacterial Agents/adverse effects ; Staphylococcal Infections/drug therapy ; Vancomycin/adverse effects ; Bacteremia/drug therapy ; Neonatal Sepsis/drug therapy ; Sepsis/drug therapy ; Ceftaroline
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Performance of 11 Host Biomarkers Alone or in Combination in the Diagnosis of Late-Onset Sepsis in Hospitalized Neonates: The Prospective EMERAUDE Study.

    Pons, Sylvie / Trouillet-Assant, Sophie / Subtil, Fabien / Abbas-Chorfa, Fatima / Cornaton, Elise / Berthiot, Amélie / Galletti, Sonia / Plat, Aurélie / Rapin, Stephanie / Trapes, Laurene / Generenaz, Laurence / Brengel-Pesce, Karen / Callies, Arnaud / Plaisant, Franck / Claris, Olivier / Portefaix, Aurelie / Flamant, Cyril / Butin, Marine

    Biomedicines

    2023  Volume 11, Issue 6

    Abstract: Despite the high prevalence of late-onset sepsis (LOS) in neonatal intensive care units, a reliable diagnosis remains difficult. This prospective, multicenter cohort study aimed to identify biomarkers early to rule out the diagnosis of LOS in 230 ... ...

    Abstract Despite the high prevalence of late-onset sepsis (LOS) in neonatal intensive care units, a reliable diagnosis remains difficult. This prospective, multicenter cohort study aimed to identify biomarkers early to rule out the diagnosis of LOS in 230 neonates ≥7 days of life with signs of suspected LOS. Blood levels of eleven protein biomarkers (PCT, IL-10, IL-6, NGAL, IP-10, PTX3, CD14, LBP, IL-27, gelsolin, and calprotectin) were measured. Patients received standard of care blinded to biomarker results, and an independent adjudication committee blinded to biomarker results assigned each patient to either infected, not infected, or unclassified groups. Performances of biomarkers were assessed considering a sensitivity of at least 0.898. The adjudication committee classified 22% of patients as infected and all of these received antibiotics. A total of 27% of the not infected group also received antibiotics. The best biomarkers alone were IL-6, IL-10, and NGAL with an area under the curve (95% confidence interval) of 0.864 (0.798-0.929), 0.845 (0.777-0.914), and 0.829 (0.760-0.898), respectively. The best combinations of up to four biomarkers were PCT/IL-10, PTX3/NGAL, and PTX3/NGAL/gelsolin. The best models of biomarkers could have identified not infected patients early on and avoided up to 64% of unjustified antibiotics. At the onset of clinical suspicion of LOS, additional biomarkers could help the clinician in identifying non-infected patients.
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11061703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: La neuro-oncologie des adolescents et adultes jeunes (AJAS) : place d’une RCP nationale. Au nom de l’ANOCEF, GO-AJA et de la SFCE.

    Frappaz, Didier / Sunyach, Marie-Pierre / Le Rhun, Emilie / Blonski, Marie / Laurence, Valérie / Bonneville Levard, Alice / Loiseau, Hugues / Meyronnet, David / Callies, Arnaud / Laigle-Donadey, F / Faure Conter, Cecile

    Bulletin du cancer

    2016  Volume 103, Issue 12, Page(s) 1050–1056

    Abstract: The skills of adult versus pediatric neuro-oncologists are not completely similar though additive. Because the tumors and their protocols are different and the tolerance and expected sequelae are specific. Multidisciplinary meetings including adult and ... ...

    Title translation Adolescent and Young Adults (AYAS) brain tumor national Web conference. On behalf of ANOCEF, GO-AJA and SFCE societies.
    Abstract The skills of adult versus pediatric neuro-oncologists are not completely similar though additive. Because the tumors and their protocols are different and the tolerance and expected sequelae are specific. Multidisciplinary meetings including adult and pediatric neuro-oncologists are warranted to share expertise. Since 2008, a weekly national web based conference was held in France. Any patient with the following criteria could be discussed: Adolescent and Young Adults aged between 15 and 25 years, and any adult with a pediatric type pathology, including medulloblastoma, germ cell tumors, embryonic tumors, ependymoma, pilocytic astrocytoma.
    Results: Attendance during the year 2015 was as follows: 42 meetings were held; the median number of cases discussed at each meeting was 4 (1 to 8); the mean number of attendants was 7 (2 to 12). One hundred and sixty-eight cases concerning 121 patients were discussed. Mean age was 30 years old (7 to 67). Forty-eight percent were discussed at diagnosis. The patients had mostly medulloblastomas (40%), germ cell tumors (11%), ependymomas (11%), pineal tumors (7%) and embryonal tumors (8%). The rate of inclusion in protocols was increased since the opening of this web conference, especially for the germ cell tumor SIOP protocol that is opened without age restriction, and in RSMA standard risk or MEVITEM relapse adult medulloblastoma protocols.
    Conclusion: Multidisciplinary Web conference for AYAs is feasible and increases the inclusion rate in protocols. It should be developed further.
    MeSH term(s) Adolescent ; Adult ; Astrocytoma/therapy ; Brain Neoplasms/therapy ; Child ; Ependymoma/therapy ; Feasibility Studies ; France ; Humans ; Interdisciplinary Communication ; Medical Oncology ; Medulloblastoma/therapy ; Middle Aged ; Neoplasms, Germ Cell and Embryonal/therapy ; Neurology ; Pinealoma/therapy ; Telecommunications/organization & administration ; Telecommunications/statistics & numerical data ; Young Adult
    Language French
    Publishing date 2016-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2016.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.15: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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