LIVIVO - Search results -

Search results

Result 1 - 10 of total 118

Search options

Article ; Online: Enniatin B1: Emerging Mycotoxin and Emerging Issues.

De Felice, Beatrice / Spicer, Leon J / Caloni, Francesca

2023 Volume 15, Issue 6

Abstract: Although over the last 10 years several studies have focused on the emerging mycotoxins known as enniatins (ENNs), there is still a lack of knowledge regarding their toxicological effects and the development of a correct risk assessment. This is ... ...

Abstract	Although over the last 10 years several studies have focused on the emerging mycotoxins known as enniatins (ENNs), there is still a lack of knowledge regarding their toxicological effects and the development of a correct risk assessment. This is especially true for enniatin B1 (ENN B1), considered the younger sister of the widely studied enniatin B (ENN B). ENN B1 has been found in several food commodities and, as with other mycotoxins, presents antibacterial and antifungal properties. On the other hand, ENN B1 has shown cytotoxic activity, impairment of the cell cycle, the induction of oxidative stress, and changes in mitochondrial membrane permeabilization, as well as negative genotoxic and estrogenic effects. Overall, considering the paucity of information available regarding ENN B1, further studies are necessary to perform a risk assessment. This review summarizes information on the biological characteristics and toxicological effects of ENN B1 as well as the future challenges that this mycotoxin could present.
MeSH term(s)	Mycotoxins/metabolism ; Depsipeptides/metabolism ; Oxidative Stress ; Cell Cycle
Chemical Substances	Mycotoxins ; enniatins ; Depsipeptides
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins15060383
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi.

Caloni, Francesca / De Angelis, Isabella / Hartung, Thomas

Archives of toxicology

2022 Volume 96, Issue 7, Page(s) 1935–1950

Abstract: Alternative methods to animal use in toxicology are evolving with new advanced tools and multilevel approaches, to answer from one side to 3Rs requirements, and on the other side offering relevant and valid tests for drugs and chemicals, considering also ...

Abstract	Alternative methods to animal use in toxicology are evolving with new advanced tools and multilevel approaches, to answer from one side to 3Rs requirements, and on the other side offering relevant and valid tests for drugs and chemicals, considering also their combination in test strategies, for a proper risk assessment.While stand-alone methods, have demonstrated to be applicable for some specific toxicological predictions with some limitations, the new strategy for the application of New Approach Methods (NAM), to solve complex toxicological endpoints is addressed by Integrated Approaches for Testing and Assessment (IATA), aka Integrated Testing Strategies (ITS) or Defined Approaches for Testing and Assessment (DA). The central challenge of evidence integration is shared with the needs of risk assessment and systematic reviews of an evidence-based Toxicology. Increasingly, machine learning (aka Artificial Intelligence, AI) lends itself to integrate diverse evidence streams.In this article, we give an overview of the state of the art of alternative methods and IATA in toxicology for regulatory use for various hazards, outlining future orientation and perspectives. We call on leveraging the synergies of integrated approaches and evidence integration from in vivo, in vitro and in silico as true in vivitrosi.
MeSH term(s)	Animal Testing Alternatives ; Animals ; Artificial Intelligence ; Risk Assessment
Language	English
Publishing date	2022-05-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-022-03299-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uf I Zs.90: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: In Vitro Effects of Enniatin A on Steroidogenesis and Proliferation of Bovine Granulosa Cells.

Chiminelli, Ilaria / Spicer, Leon J / Maylem, Excel Rio S / Caloni, Francesca

Toxins

2022 Volume 14, Issue 10

Abstract: The emerging Fusarium mycotoxins enniatins (ENNs) have been the focus of new research because of their well-documented existence in various cereal and grain products. Research findings indicate that reproductive disorders may be caused by exposure to ... ...

Abstract	The emerging Fusarium mycotoxins enniatins (ENNs) have been the focus of new research because of their well-documented existence in various cereal and grain products. Research findings indicate that reproductive disorders may be caused by exposure to Fusarium mycotoxins, but little work has evaluated ENNs on reproductive function. Therefore, to determine the effects of ENNA on the proliferation and steroidogenesis of granulosa cells (GC), experiments were conducted using bovine GC cultures. In vitro, ENNA (1−5 μM) inhibited (p < 0.05) hormone-induced GC progesterone and estradiol production. The inhibitory effect of ENNA on estradiol production was more pronounced in small- than large-follicle GC. In large-follicle GC, 0.3 μM ENNA had no effect (p > 0.10) whereas 1 and 3 μM ENNA inhibited GC proliferation. In small-follicle GC, ENNA (1−5 μM) dramatically decreased (p < 0.05) GC proliferation. Using cell number data, the IC50 of ENNA was estimated at 2 μM for both follicle sizes. We conclude that ENNA can directly inhibit ovarian function in cattle, decreasing the proliferation and steroid production of GC.
MeSH term(s)	Female ; Cattle ; Animals ; Progesterone ; Cells, Cultured ; Granulosa Cells ; Estradiol ; Steroids/pharmacology ; Cell Proliferation ; Fusarium ; Mycotoxins/pharmacology ; Follicle Stimulating Hormone
Chemical Substances	enniatins ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E) ; Steroids ; Mycotoxins ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins14100714
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Emerging mycotoxins and reproductive effects in animals: A short review.

Chiminelli, Ilaria / Spicer, Leon J / Maylem, Excel R S / Caloni, Francesca

Journal of applied toxicology : JAT

2022 Volume 42, Issue 12, Page(s) 1901–1909

Abstract: Emerging Fusarium mycotoxins beauvericin (BEA), enniatins (ENNs), and moniliformin (MON) are gaining increasing interest due to their wide presence especially in cereals and grain-based products. In vitro and in vivo studies indicate that Fusarium ... ...

Abstract	Emerging Fusarium mycotoxins beauvericin (BEA), enniatins (ENNs), and moniliformin (MON) are gaining increasing interest due to their wide presence especially in cereals and grain-based products. In vitro and in vivo studies indicate that Fusarium mycotoxins can be implicated in reproductive disorders in animals. Of these mycotoxins, BEA may affect reproductive functions, impairing the development of oocytes in pigs and sheep. Studies show dramatic inhibitory effects of BEA and ENNA on bovine granulosa cell steroidogenesis. ENNs also inhibit boar sperm motility and cause detrimental effects on embryos in mice and pigs. Although little data are reported on reproductive effects of MON, in vitro studies show inhibitory effects of MON on Chinese hamster ovary cells. The present review aims to summarize the reproductive toxicological effects of emerging Fusarium mycotoxins BEA, ENNs, and MON on embryo development, ovarian function, and testicular function of animals. In vitro and in vivo toxicological data are reported although additional studies are needed for proper risk assessment.
MeSH term(s)	Male ; Animals ; Swine ; Cattle ; Sheep ; Mice ; Cricetinae ; Mycotoxins/toxicity ; CHO Cells ; Sperm Motility ; Cricetulus ; Fusarium ; Edible Grain/chemistry ; Food Contamination/analysis
Chemical Substances	Mycotoxins ; moniliformin (31876-38-7)
Language	English
Publishing date	2022-03-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604625-3
ISSN	1099-1263 ; 0260-437X
ISSN (online)	1099-1263
ISSN	0260-437X
DOI	10.1002/jat.4311
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1661: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Indoor Companion Animal Poisoning by Plants in Europe.

Bertero, Alessia / Fossati, Paola / Caloni, Francesca

Frontiers in veterinary science

2020 Volume 7, Page(s) 487

Abstract: Indoor plant poisoning poses serious threats to companion animals. One of the major reasons of this kind of hazard can be identified in the increased amount of time that the pets spend indoor, sharing the domestic environment with their owners. In this ... ...

Abstract	Indoor plant poisoning poses serious threats to companion animals. One of the major reasons of this kind of hazard can be identified in the increased amount of time that the pets spend indoor, sharing the domestic environment with their owners. In this review, the toxic houseplants most commonly associated with companion animal poisoning in Europe and well-documented in the literature are emphasized. An analysis of the major and emerging plant species accountable for companion animal poisoning is proposed, in order to provide a framework of the factors influencing these incidents. Indeed, knowing the way substances may induce toxic effects in companion animals can be useful in allowing easier diagnosis and treatment processes. In conclusion, the Authors argue that a better characterization of the phenomenon, as well as of its extent, would be allowed by the availability of a centralized system for the data collection. Furthermore, better information and awareness on the issue may help developing a focused corrective approach to prevent indoor pet poisoning in Europe.
Language	English
Publishing date	2020-08-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2020.00487
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Beauvericin: The beauty and the beast.

Caloni, Francesca / Fossati, Paola / Anadón, Arturo / Bertero, Alessia

Environmental toxicology and pharmacology

2020 Volume 75, Page(s) 103349

Abstract: Beauvericin (BEA) is a natural bioactive compound, with a dual nature. On the one hand, the peculiar characteristics of its molecule confer to BEA interesting properties, such as antibacterial, antiviral, antifungal, antiparasitic, insecticidal and ... ...

Abstract	Beauvericin (BEA) is a natural bioactive compound, with a dual nature. On the one hand, the peculiar characteristics of its molecule confer to BEA interesting properties, such as antibacterial, antiviral, antifungal, antiparasitic, insecticidal and anticarcinogenic activities. On the other hand, it is a natural contaminant of food and feed commodities, and an emerging mycotoxin, but lacks a toxicological risk assessment evaluation for long term exposure. This review aims to provide a global and comprehensive overview on BEA from its biological activities, to its in vivo and in vitro toxicological effects covering the multifaceted nature of this substance.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Antifungal Agents/pharmacology ; Antiviral Agents/pharmacology ; Depsipeptides/pharmacology ; Food Contamination ; Insecticides/pharmacology ; Mycotoxins/toxicity
Chemical Substances	Anti-Bacterial Agents ; Antifungal Agents ; Antiviral Agents ; Depsipeptides ; Insecticides ; Mycotoxins ; beauvericin (26S048LS2R)
Language	English
Publishing date	2020-01-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1318302-3
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2020.103349
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4490: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Suspected environmental poisoning by drugs, household products and pesticides in domestic animals.

Bertero, Alessia / Rivolta, Marina / Davanzo, Franca / Caloni, Francesca

Environmental toxicology and pharmacology

2020 Volume 80, Page(s) 103471

Abstract: Animal poisoning by chemicals (pesticides and household products) and drugs is a frequent occurrence and special attention should be paid to this phenomenon to improve prevention and treatment strategies and because of the fundamental role that animals ... ...

Abstract	Animal poisoning by chemicals (pesticides and household products) and drugs is a frequent occurrence and special attention should be paid to this phenomenon to improve prevention and treatment strategies and because of the fundamental role that animals may play as bioindicators. From January 2017 to March 2019 the Poison Control Centre of Milan (CAV) in collaboration with the University of Milan, collected and analyzed epidemiological data on animal poisoning. During this period, the CAV received a total of 442 enquiries on domestic animal poisoning episodes and, among these, 80.3 % were related to chemicals and drugs. Pesticides and drugs were the two major causes of poisoning (34.1 % and 33.5 %, respectively), followed by household products (29.3 %) and other causative agents (3.1 %, n = 11). In conclusion, these findings can provide useful information for the identification and monitoring of known and emerging toxicants, with positive repercussions on human, animal and environmental health.
MeSH term(s)	Animals ; Animals, Domestic ; Household Products/poisoning ; Italy/epidemiology ; Pesticides/poisoning ; Poison Control Centers ; Poisoning/epidemiology ; Poisoning/veterinary
Chemical Substances	Pesticides
Language	English
Publishing date	2020-08-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1318302-3
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2020.103471
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4490: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Indoor poisoning of companion animals by chemicals.

Bertero, Alessia / Fossati, Paola / Caloni, Francesca

The Science of the total environment

2020 Volume 733, Page(s) 139366

Abstract: Episodes of indoor exposure to toxic compounds in companion animals are frequent. Toxico-epidemiological data on this matter are fundamental not only to take proper corrective actions but especially because domestic animals represent crucial sentinels ... ...

Abstract	Episodes of indoor exposure to toxic compounds in companion animals are frequent. Toxico-epidemiological data on this matter are fundamental not only to take proper corrective actions but especially because domestic animals represent crucial sentinels for environmental toxicants. In this review we will present an overview on indoor poisoning of companion animals by chemicals in Europe, providing information on trends and emphasizing emerging indoor contaminants. In general, pesticides are the most frequent class of toxicants involved in indoor animal poisoning episodes in Europe. Among them, insecticides (in particular anticholinesterase compounds) and anticoagulant rodenticides are frequently implicated, but molluscicides (i.e. metaldehyde) together with household products have also shown a growing or at least stable trend in the poisoning episodes. Considering the emerging molecules, neonicotinoids (imidacloprid and acetamiprid) and glyphosate formulations have been pointed out, whereas with regard to households, besides the well-known ethylene glycol, attention should be paid to emerging products such as sodium polyacrylate polymeric hydrogels, xylitol, glowsticks and liquid laundry detergent capsules. The environmental contamination by chemical households is a global challenge and bioindicators like pets may be valuable tools to perform a comprehensive monitoring and risk assessment.
MeSH term(s)	Animals ; Europe ; Insecticides ; Pesticides ; Pets ; Poisoning ; Rodenticides
Chemical Substances	Insecticides ; Pesticides ; Rodenticides
Language	English
Publishing date	2020-05-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.139366
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 949: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Climate Change and Effects on Molds and Mycotoxins.

Zingales, Veronica / Taroncher, Mercedes / Martino, Piera Anna / Ruiz, María-José / Caloni, Francesca

Toxins

2022 Volume 14, Issue 7

Abstract: Earth's climate is undergoing adverse global changes as an unequivocal result of anthropogenic activity. The occurring environmental changes are slowly shaping the balance between plant growth and related fungal diseases. Climate (temperature, available ... ...

Abstract	Earth's climate is undergoing adverse global changes as an unequivocal result of anthropogenic activity. The occurring environmental changes are slowly shaping the balance between plant growth and related fungal diseases. Climate (temperature, available water, and light quality/quantity; as well as extreme drought, desertification, and fluctuations of humid/dry cycles) represents the most important agroecosystem factor influencing the life cycle stages of fungi and their ability to colonize crops, survive, and produce toxins. The ability of mycotoxigenic fungi to respond to Climate Change (CC) may induce a shift in their geographical distribution and in the pattern of mycotoxin occurrence. The present review examines the available evidence on the impact of CC factors on growth and mycotoxin production by the key mycotoxigenic fungi belonging to the genera
MeSH term(s)	Aflatoxins ; Climate Change ; Food Contamination/analysis ; Fumonisins ; Fungi ; Mycotoxins/analysis
Chemical Substances	Aflatoxins ; Fumonisins ; Mycotoxins
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins14070445
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Three-dimensional spheroid cell culture of human MSC-derived neuron-like cells: New in vitro model to assess magnetite nanoparticle-induced neurotoxicity effects.

De Simone, Uliana / Croce, Anna Cleta / Pignatti, Patrizia / Buscaglia, Eleonora / Caloni, Francesca / Coccini, Teresa

Journal of applied toxicology : JAT

2022 Volume 42, Issue 7, Page(s) 1230–1252

Abstract: As nanoparticles (NPs) can access the brain and impact on CNS function, novel in vitro models for the evaluation of NPs-induced neurotoxicity are advocated. Three-dimensional spheroids of primary neuron-like cells (hNLCs) of human origin have been ... ...

Abstract	As nanoparticles (NPs) can access the brain and impact on CNS function, novel in vitro models for the evaluation of NPs-induced neurotoxicity are advocated. Three-dimensional spheroids of primary neuron-like cells (hNLCs) of human origin have been generated, from differentiation of human umbilical cord mesenchymal stem cells (MSCs). The study evaluated Fe
MeSH term(s)	Adenosine Triphosphate/metabolism ; Cell Culture Techniques/methods ; Humans ; Magnetite Nanoparticles/toxicity ; Mesenchymal Stem Cells ; Neurons ; Spheroids, Cellular
Chemical Substances	Magnetite Nanoparticles ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604625-3
ISSN	1099-1263 ; 0260-437X
ISSN (online)	1099-1263
ISSN	0260-437X
DOI	10.1002/jat.4292
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1661: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito