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  1. Article ; Online: Sacubitril/valsartan, left ventricular reverse remodeling and advanced echocardiographic imaging: is it a resolved conundrum?

    Calvieri, Camilla / Cataldi, Claudia / Cavarretta, Elena

    Minerva cardiology and angiology

    2022  Volume 70, Issue 4, Page(s) 428–430

    MeSH term(s) Aminobutyrates/therapeutic use ; Biphenyl Compounds ; Echocardiography ; Valsartan/therapeutic use
    Chemical Substances Aminobutyrates ; Biphenyl Compounds ; sacubitril (17ERJ0MKGI) ; Valsartan (80M03YXJ7I)
    Language English
    Publishing date 2022-01-26
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 3059238-0
    ISSN 2724-5772
    ISSN (online) 2724-5772
    DOI 10.23736/S2724-5683.21.05953-6
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    Zs.A 14: Show issues Location:
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  2. Article ; Online: Intracoronary Imaging of Coronary Atherosclerotic Plaque: From Assessment of Pathophysiological Mechanisms to Therapeutic Implication.

    Gurgoglione, Filippo Luca / Denegri, Andrea / Russo, Michele / Calvieri, Camilla / Benatti, Giorgio / Niccoli, Giampaolo

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality worldwide. Several cardiovascular risk factors are implicated in atherosclerotic plaque promotion and progression and are responsible for the clinical manifestations ... ...

    Abstract Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality worldwide. Several cardiovascular risk factors are implicated in atherosclerotic plaque promotion and progression and are responsible for the clinical manifestations of coronary artery disease (CAD), ranging from chronic to acute coronary syndromes and sudden coronary death. The advent of intravascular imaging (IVI), including intravascular ultrasound, optical coherence tomography and near-infrared diffuse reflectance spectroscopy has significantly improved the comprehension of CAD pathophysiology and has strengthened the prognostic relevance of coronary plaque morphology assessment. Indeed, several atherosclerotic plaque phenotype and mechanisms of plaque destabilization have been recognized with different natural history and prognosis. Finally, IVI demonstrated benefits of secondary prevention therapies, such as lipid-lowering and anti-inflammatory agents. The purpose of this review is to shed light on the principles and properties of available IVI modalities along with their prognostic significance.
    MeSH term(s) Humans ; Plaque, Atherosclerotic/diagnostic imaging ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Spectroscopy, Near-Infrared/methods ; Tomography, Optical Coherence/methods ; Acute Coronary Syndrome ; Coronary Vessels/diagnostic imaging ; Ultrasonography, Interventional/methods
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065155
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  3. Article ; Online: Exposome in ischaemic heart disease: beyond traditional risk factors.

    Montone, Rocco A / Camilli, Massimiliano / Calvieri, Camilla / Magnani, Giulia / Bonanni, Alice / Bhatt, Deepak L / Rajagopalan, Sanjay / Crea, Filippo / Niccoli, Giampaolo

    European heart journal

    2024  Volume 45, Issue 6, Page(s) 419–438

    Abstract: Ischaemic heart disease represents the leading cause of morbidity and mortality, typically induced by the detrimental effects of risk factors on the cardiovascular system. Although preventive interventions tackling conventional risk factors have helped ... ...

    Abstract Ischaemic heart disease represents the leading cause of morbidity and mortality, typically induced by the detrimental effects of risk factors on the cardiovascular system. Although preventive interventions tackling conventional risk factors have helped to reduce the incidence of ischaemic heart disease, it remains a major cause of death worldwide. Thus, attention is now shifting to non-traditional risk factors in the built, natural, and social environments that collectively contribute substantially to the disease burden and perpetuate residual risk. Of importance, these complex factors interact non-linearly and in unpredictable ways to often enhance the detrimental effects attributable to a single or collection of these factors. For this reason, a new paradigm called the 'exposome' has recently been introduced by epidemiologists in order to define the totality of exposure to these new risk factors. The purpose of this review is to outline how these emerging risk factors may interact and contribute to the occurrence of ischaemic heart disease, with a particular attention on the impact of long-term exposure to different environmental pollutants, socioeconomic and psychological factors, along with infectious diseases such as influenza and COVID-19. Moreover, potential mitigation strategies for both individuals and communities will be discussed.
    MeSH term(s) Humans ; Exposome ; Risk Factors ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/etiology ; Coronary Artery Disease ; Morbidity ; Environmental Exposure/adverse effects
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehae001
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  4. Article ; Online: Low-grade endotoxemia is associated with cardiovascular events in community-acquired pneumonia.

    Cangemi, Roberto / Carnevale, Roberto / Nocella, Cristina / Calvieri, Camilla / Bartimoccia, Simona / Frati, Giacomo / Pignatelli, Pasquale / Picchio, Vittorio / Violi, Francesco

    The Journal of infection

    2023  Volume 88, Issue 2, Page(s) 89–94

    Abstract: Objectives: Community-acquired pneumonia (CAP) is associated with low-grade endotoxemia but its relationship with cardiovascular events (CVE) has not been investigated.: Methods: We evaluated the incidence of CVE including myocardial infarction, ... ...

    Abstract Objectives: Community-acquired pneumonia (CAP) is associated with low-grade endotoxemia but its relationship with cardiovascular events (CVE) has not been investigated.
    Methods: We evaluated the incidence of CVE including myocardial infarction, stroke, and cardiovascular death in 523 adult patients hospitalized for CAP. Serum lipopolysaccharide (LPS) and zonulin, a marker of gut permeability, were analyzed in the cohort, that was followed-up during hospitalization and up to 43 months thereafter.
    Results: During the hospital-stay, 55 patients experienced CVE with a progressive increase from the lowest (0.6%) to highest LPS tertile (23.6%, p < 0.001). Logistic regression analyses showed that higher LPS tertile was independently associated with CVE; LPS significantly correlated with age, hs-CRP and zonulin. In a sub-group of 23 CAP patients, blood E. coli DNA was higher in patients compared to 24 controls and correlated with LPS. During the long-term follow-up, 102 new CVE were registered; the highest tertile of LPS levels was associated with incident CVE; Cox regression analysis showed that LPS tertiles, age, history of CHD, and diabetes independently predicted CVE.
    Conclusions: In CAP low-grade endotoxemia is associated to short- and long-term risk of CVE. Further study is necessary to assess if lowering LPS by non-absorbable antibiotics may result in improved outcomes.
    MeSH term(s) Adult ; Humans ; Endotoxemia/epidemiology ; Endotoxemia/complications ; Lipopolysaccharides ; Escherichia coli ; Pneumonia/epidemiology ; Stroke/complications ; Cardiovascular Diseases/epidemiology ; Risk Factors
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.11.010
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    Zs.A 1501: Show issues Location:
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    Zs.MG 48: Show issues

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  5. Article ; Online: Effect of corticosteroids on myocardial injury among patients hospitalized for community-acquired pneumonia: rationale and study design. The colosseum trial.

    Violi, Francesco / Calvieri, Camilla / Cangemi, Roberto

    Internal and emergency medicine

    2019  Volume 15, Issue 1, Page(s) 79–86

    Abstract: Community-acquired pneumonia (CAP) is often complicated by elevation of cardiac troponin, a marker of myocardial injury that can be isolated or associated with myocardial infarction (MI). A retrospective study showed that corticosteroid treatment lowers ... ...

    Abstract Community-acquired pneumonia (CAP) is often complicated by elevation of cardiac troponin, a marker of myocardial injury that can be isolated or associated with myocardial infarction (MI). A retrospective study showed that corticosteroid treatment lowers the incidence of MI during the hospital stay. No data exist so far on the effect of corticosteroids on myocardial injury in CAP patients. The primary objective of the study is to evaluate if methylprednisolone is able to reduce myocardial injury, as assessed by serum high-sensitivity cardiac T Troponin (hs-cTnT), in a cohort of patients hospitalized for CAP. Secondary aims are to evaluate the potential effect of methylprednisolone on cardiovascular events during hospitalization, at 30 days from hospital admission and during 2 years' follow-up. The trial will also examine whether the potential protective effects of methylprednisolone might be due to platelet activation down-regulation. Double-blind randomized placebo-controlled trial. One hundred twenty-two eligible patients will be randomized to a week treatment with iv methylprednisolone (20 mg b.i.d) or placebo from hospital admission. Serum hs-cTnT will be measured at admission and every day until up 3 days from admission. ECG will be monitored every day until discharge. After discharge, all patients will be followed-up 2 years. This is the first clinical trial aimed at examining whether methylprednisolone treatment may reduce myocardial injury. The results of this trial may constitute the basis for conducting a larger multicenter trial aimed to evaluate the effect of corticosteroid on cardiovascular events in this setting.
    MeSH term(s) Adrenal Cortex Hormones/pharmacology ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Analysis of Variance ; Biomarkers/analysis ; Biomarkers/blood ; Cardiomyopathies/etiology ; Cardiomyopathies/prevention & control ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/physiopathology ; Double-Blind Method ; Female ; Humans ; Incidence ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Placebos ; Pneumonia/drug therapy ; Pneumonia/physiopathology ; Proportional Hazards Models ; Retrospective Studies ; Troponin T/analysis ; Troponin T/blood
    Chemical Substances Adrenal Cortex Hormones ; Biomarkers ; Placebos ; Troponin T
    Keywords covid19
    Language English
    Publishing date 2019-05-31
    Publishing country Italy
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-019-02117-0
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    Zs.A 6673: Show issues Location:
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  6. Article: Mapping of low-voltage bridges with a high-density multipolar catheter in a child with atrioventricular nodal reentry tachycardia.

    Drago, Fabrizio / Calvieri, Camilla / Allegretti, Greta / Silvetti, Massimo Stefano

    HeartRhythm case reports

    2019  Volume 6, Issue 1, Page(s) 8–10

    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2019.09.009
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  7. Article ; Online: Corticosteroid use, myocardial injury and in-hospital cardiovascular events in patients with community-acquired pneumonia.

    Cangemi, Roberto / Carnevale, Roberto / Cammisotto, Vittoria / Nocella, Cristina / Bartimoccia, Simona / Taliani, Gloria / Falcone, Marco / Calvieri, Camilla / Pignatelli, Pasquale / Violi, Francesco

    British journal of clinical pharmacology

    2021  Volume 88, Issue 1, Page(s) 155–165

    Abstract: Background and purpose: Corticosteroids are often prescribed to community-acquired pneumonia (CAP) patients, but the relationship with major cardiovascular events (MACEs) is unclear.: Experimental approach: 541 CAP patients were recruited (334 males, ...

    Abstract Background and purpose: Corticosteroids are often prescribed to community-acquired pneumonia (CAP) patients, but the relationship with major cardiovascular events (MACEs) is unclear.
    Experimental approach: 541 CAP patients were recruited (334 males, mean age 71.9 ± 16.2 years). High-sensitivity troponin T (hs-cTnT) was measured at admission, during the hospital stay and at discharge. MACE occurrence was registered during a long-term follow-up.
    Key results: Overall, 318 patients (59%) showed hs-cTnT elevation >99th percentile (>0.014 μg/L). Age, heart failure and the increasing quintiles of hs-cTnT (hazard ratio [HR] 2.16, 95% confidence interval [CI] 1.82-2.58, P < .001) predicted MACEs. Among patients with hs-cTnT >0.014 μg/L at admission, 102 patients (31%) were on corticosteroids and showed lower hs-cTnT increase (P = .021), (NADPH) oxidase-2 (Nox2) activation (P = .005) and incidence of MACEs than untreated ones (HR 0.64, 95% CI 0.41-0.97, P = .038); no effect of corticosteroids on MACEs was observed in CAP patients with normal troponin. In vitro study showed that glucocorticoids have an antioxidant effect via downregulation of Nox2 activity.
    Conclusion and implications: The study provides evidence that corticosteroid use is associated with lower increase of hs-cTnT and incidence of MACEs in CAP patients.
    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Aged ; Aged, 80 and over ; Biomarkers ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/epidemiology ; Heart Failure ; Hospitals ; Humans ; Male ; Middle Aged ; Pneumonia/drug therapy ; Pneumonia/epidemiology ; Prognosis ; Troponin T
    Chemical Substances Adrenal Cortex Hormones ; Biomarkers ; Troponin T
    Language English
    Publishing date 2021-07-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.14936
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    Zs.A 1118: Show issues Location:
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  8. Article ; Online: Microvascular Complications Are Associated With Coronary Collateralization in Type 2 Diabetes and Chronic Occlusion.

    Gurgoglione, Filippo Luca / Pitocco, Dario / Montone, Rocco A / Rinaldi, Riccardo / Bonadonna, Riccardo C / Magnani, Giulia / Calvieri, Camilla / Solinas, Emilia / Rizzi, Alessandro / Tartaglione, Linda / Flex, Andrea / Viti, Luca / Trani, Carlo / Ardissino, Diego / Crea, Filippo / Niccoli, Giampaolo

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 1, Page(s) 237–244

    Abstract: Context: Coronary collateral (CC) vessel development appears to be protective with regard to adverse cardiovascular events and survival in patients with coronary chronic total occlusion (CTO). The influence of type 2 diabetes mellitus (T2DM) on CC ... ...

    Abstract Context: Coronary collateral (CC) vessel development appears to be protective with regard to adverse cardiovascular events and survival in patients with coronary chronic total occlusion (CTO). The influence of type 2 diabetes mellitus (T2DM) on CC growth has been controversial. In particular, the role of diabetic microvascular complications (DMC) in determining coronary collateralization has not been elucidated.
    Objective: To investigate whether patients with DMC presented differences in CC vessel presence and grading as compared with patients without DMC.
    Methods: We conducted a single-center observational study, including consecutive T2DM patients, without previous cardiovascular history, undergoing a clinically indicated coronary angiography for chronic coronary syndrome (CCS) and angiographic evidence of at least one CTO. Patients were subdivided into 2 study groups according to the presence/absence of at least one DMC (neuropathy, nephropathy, or retinopathy). The presence and grading of angiographically visible CC development from the patent vessels to the occluded artery were assessed using the Rentrop classification.
    Results: We enrolled 157 patients (mean age 68.6 ± 9.8 years; 120 [76.4%] men). Patients with DMC (75 [47.8%]) had a higher prevalence of CC (69 [92.0%] vs 62 [75.6%], P = .006) and high-grade CC (55 [73.3%] vs 39 [47.6%], P = .001) compared with those without, and we found a positive association between the number of DMC in each patient and the prevalence of high-grade CC.
    Conclusion: Among T2DM patients with coronary CTO, the presence of DMC was associated with a high CC development.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Female ; Diabetes Mellitus, Type 2/complications ; Coronary Occlusion/complications ; Coronary Occlusion/epidemiology ; Risk Factors ; Collateral Circulation ; Percutaneous Coronary Intervention ; Coronary Angiography/adverse effects ; Chronic Disease
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad396
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    Uh III Zs.134: Show issues Location:
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  9. Article: Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction.

    Calvieri, Camilla / Galea, Nicola / Cilia, Francesco / Pambianchi, Giacomo / Mancuso, Giuseppe / Filomena, Domenico / Cimino, Sara / Carbone, Iacopo / Francone, Marco / Agati, Luciano / Catalano, Carlo

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 786509

    Abstract: Aims: Left ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) is a complex process, defined as changes of LV volumes over time. CMR feature tracking analysis (CMR-FT) offers an accurate quantitative assessment of LV wall ... ...

    Abstract Aims: Left ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) is a complex process, defined as changes of LV volumes over time. CMR feature tracking analysis (CMR-FT) offers an accurate quantitative assessment of LV wall deformation and myocardial contractile function. This study aimed to evaluate the role of myocardial strain parameters in predicting LV remodeling and to investigate the effect of Aspirin (ASA) dose before primary coronary angioplasty (pPCI) on myocardial injury and early LV remodeling.
    Methods and results: Seventy-eight patients undergoing CMR, within 9 days from symptom onset and after 6 months, were enrolled in this cohort retrospective study. We divided the study population into three groups based on a revised Bullock's classification and we evaluated the role of baseline CMR features in predicting early LV remodeling. Regarding CMR strain analysis, worse global circumferential and longitudinal strain (GCS and GLS) values were associated with adverse LV remodeling. Patients were also divided based on pre-pPCI ASA dosage. Significant differences were detected in patients receiving ASA 500 mg dose before pPCI, which showed lower infarct size extent and better strain values compared to those treated with ASA 250 mg. The stepwise multivariate logistic regression analysis, adjusted for covariates, indicated that a 500 mg ASA dose remained an inverse independent predictor of early adverse LV remodeling.
    Conclusion: GCS and GLS have high specificity to detect early LV adverse remodeling. We first reported a protective effect of ASA loading dose of 500 mg before pPCI on LV myocardial damage and in reducing early LV adverse remodeling.
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.786509
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  10. Article ; Online: Hospitalization for pneumonia and risk of cardiovascular disease.

    Violi, Francesco / Cangemi, Roberto / Calvieri, Camilla

    JAMA

    2015  Volume 313, Issue 17, Page(s) 1753

    MeSH term(s) Cardiovascular Diseases/etiology ; Female ; Hospitalization ; Humans ; Male ; Pneumonia/complications
    Language English
    Publishing date 2015-05-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2015.3130
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