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Book ; Conference proceedings: Cartilage and bone development and its disorders

Camacho-Hübner, Cecilia / Nilsson, Ola G. / Sävendahl, Lars

3 tables

(Endocrine development ; 21)

2011

Event/congress	Advanced Seminar in Developmental Endocrinology (4, 2010, Stockholm)
Author's details	4th ESPE Advanced Seminar in Developmental Endocrinology, Stockholm, June 30 - July 1, 2010. vol. ed. Cecilia Camacho-Hübner , Ola Nolsson, Lars Sävendahl
Series title	Endocrine development ; 21
Collection
Keywords	Cartilage / growth & development ; Cartilage Diseases ; Bone Development / genetics ; Bone Diseases, Endocrine ; Kind ; Knochenwachstum ; Knochenkrankheit ; Knorpel ; Endokrinologie
Subject	Knorpelgewebe ; Cartilago ; Osteopathie ; Knochenerkrankung ; Skelettwachstum ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
Language	English
Size	XI, 120 S. : Ill., graph. Darst., 26 cm
Publisher	Karger
Publishing place	Basel u.a.
Publishing country	Switzerland ; Germany
Document type	Book ; Conference proceedings
Note	Literaturangaben
HBZ-ID	HT016958052
ISBN	978-3-8055-9792-0 ; 3-8055-9792-4 ; 9783805597937 ; 3805597932
Database	Catalogue ZB MED Medicine, Health

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2011 A 3392	order for loan	Magazin

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Book ; Conference proceedings: 23rd International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism

Camacho-Hübner, Cecilia

proceedings of a meeting held in Paris, France, 11 - 12 April 1997

(Acta paediatrica : Supplement ; 423)

1997

Event/congress	International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism (23, 1997, Paris) ; Workshop on IUGR, SGA: Basic and Clinical Update (1997, Chantilly)
Series title	Acta paediatrica : Supplement ; 423 Acta paediatrica Acta paediatrica ; Supplement
Collection	Acta paediatrica Acta paediatrica ; Supplement
Keywords	Somatropin / deficiency / congresses ; Growth Disorders / congresses ; Prader-Willi Syndrome / congresses
Language	English
Size	217 S. : Ill., graph. Darst.
Publisher	Scandinavian Univ. Press
Publishing place	Oslo u.a.
Publishing country	Norway
Document type	Book ; Conference proceedings
HBZ-ID	HT008018195
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Um IV Zs 95 -Suppl.423-	verfügbar in Königswinter	Königswinter

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Article ; Online: Assessment of potential transthyretin amyloid cardiomyopathy cases in the Brazilian public health system using a machine learning model.

Zuppo Laper, Isabella / Camacho-Hubner, Cecilia / Vansan Ferreira, Rafaela / Leite Bertoli de Souza, Claudenice / Simões, Marcus Vinicius / Fernandes, Fabio / de Barros Correia, Edileide / de Jesus Lopes de Abreu, Ariane / Silva Julian, Guilherme

PloS one

2024 Volume 19, Issue 2, Page(s) e0278738

Abstract: Objectives: To identify and describe the profile of potential transthyretin cardiac amyloidosis (ATTR-CM) cases in the Brazilian public health system (SUS), using a predictive machine learning (ML) model.: Methods: This was a retrospective ... ...

Abstract	Objectives: To identify and describe the profile of potential transthyretin cardiac amyloidosis (ATTR-CM) cases in the Brazilian public health system (SUS), using a predictive machine learning (ML) model. Methods: This was a retrospective descriptive database study that aimed to estimate the frequency of potential ATTR-CM cases in the Brazilian public health system using a supervised ML model, from January 2015 to December 2021. To build the model, a list of ICD-10 codes and procedures potentially related with ATTR-CM was created based on literature review and validated by experts. Results: From 2015 to 2021, the ML model classified 262 hereditary ATTR-CM (hATTR-CM) and 1,581 wild-type ATTR-CM (wtATTR-CM) potential cases. Overall, the median age of hATTR-CM and wtATTR-CM patients was 66.8 and 59.9 years, respectively. The ICD-10 codes most presented as hATTR-CM and wtATTR-CM were related to heart failure and arrythmias. Regarding the therapeutic itinerary, 13% and 5% of hATTR-CM and wtATTR-CM received treatment with tafamidis meglumine, respectively, while 0% and 29% of hATTR-CM and wtATTR-CM were referred to heart transplant. Conclusion: Our findings may be useful to support the development of health guidelines and policies to improve diagnosis, treatment, and to cover unmet medical needs of patients with ATTR-CM in Brazil.
MeSH term(s)	Humans ; Brazil/epidemiology ; Prealbumin ; Public Health ; Retrospective Studies ; Machine Learning ; Amyloidosis ; Cardiomyopathies/diagnosis ; Cardiomyopathies/epidemiology ; Amyloid Neuropathies, Familial/diagnosis ; Amyloid Neuropathies, Familial/epidemiology
Chemical Substances	Prealbumin
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0278738
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Adult height prediction by bone age determination in children with isolated growth hormone deficiency.

Reinehr, Thomas / Carlsson, Martin / Chrysis, Dionisios / Camacho-Hübner, Cecilia

Endocrine connections

2020 Volume 9, Issue 5, Page(s) 370–378

Abstract: Background: The precision of adult height prediction by bone age determination in children with idiopathic growth hormone deficiency (IGHD) is unknown.: Methods: The near adult height (NAH) of patients with IGHD in the KIGS database was compared ... ...

Abstract	Background: The precision of adult height prediction by bone age determination in children with idiopathic growth hormone deficiency (IGHD) is unknown. Methods: The near adult height (NAH) of patients with IGHD in the KIGS database was compared retrospectively to adult height prediction calculated by the Bayley-Pinneau (BP) prediction based on bone age by Greulich-Pyle (GP) in 315 children and based on the Tanner-Whitehouse 2 (TW2) method in 121 children. Multiple linear regression analyses adjusted for age at GH start, age at puberty, mean dose and years of of GH treatment, and maximum GH peak in stimulation test were calculated. Results: The mean underestimation of adult height based on the BP method was at baseline 4.1 ± 0.7 cm in girls and 6.1 ± 0.6 cm in boys, at 1 year of GH treatment 2.5 ± 0.5 cm in girls and 0.9 ± 0.4 cm in boys, while at last bone age determination adult height was overestimated in mean by 0.4 ± 0.6 cm in girls and 3.8 ± 0.5 cm in boys. The mean underestimation of adult height based on the TW2 method was at baseline 5.3 ± 2.0 cm in girls and 7.9 ± 0.8 cm in boys, at 1 year of GH treatment adult height was overestimated in girls 0.1 ± 0.6 cm in girls and underestimated 4.1 ± 0.4 cm in boys, while at last bone age determination adult height was overestimated in mean by 3.1 ± 1.5 cm in girls and 3.6 ± 0.8 cm in boys. Conclusions: Height prediction by BP and TW2 at onset of GH treatment underestimates adult height in prepubertal IGHD children, while in mean 6 years after onset of GH treatment these prediction methods overestimated adult height.
Language	English
Publishing date	2020-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2668428-7
ISSN	2049-3614
ISSN	2049-3614
DOI	10.1530/EC-20-0090
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Conference proceedings ; Online: Cartilage and bone development and its disorders

Camacho-Hübner, Cecilia

4th ESPE Advanced Seminar in Developmental Endocrinology, Stockholm, June 30 - July 1, 2010 ; 3 tables

(Endocrine development ; 21)

2011

Institution	Advanced Seminar in Developmental Endocrinology European Society for Pediatric Endocrinology
Event/congress	ESPE Advanced Seminar in Developmental Endocrinology (4, 2010.06.30-07.01, StockholmSweden)
Author's details	vol. eds. Cecilia Camacho-Hübner
Series title	Endocrine development ; 21
MeSH term(s)	Bone Development/genetics ; Bone Diseases, Endocrine ; Cartilage/growth & development ; Cartilage Diseases
Keywords	Bone diseases in children ; Bones/Growth ; Cartilage/Diseases ; Cartilage/Growth ; Chondrogenesis ; Pediatric endocrinology ; Kind ; Endokrinologie ; Knochenwachstum ; Knochenkrankheit ; Knorpel
Language	English
Size	Online-Ressource (XII, 120 S.), 26 cm
Publisher	Karger
Publishing place	Basel ;Freiburg, Br. ;Paris ;London ;New York, NY ;New Delhi ;Bangkok ;Beijing ;Tokyo ;Kuala Lumpur ;Singapore ;Sydney
Document type	Book ; Conference proceedings ; Online
Note	Literaturangaben
ISBN	1283439301 ; 1283439492 ; 9781283439497 ; 9783805597920 ; 9783805597920 ; 9783805597937 ; 9781283439305 ; 3805597924 ; 3805597924 ; 3805597932
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Conference proceedings ; Online: Cartilage and bone development and its disorders

Camacho-Hübner, Cecilia

4th ESPE Advanced Seminar in Developmental Endocrinology, Stockholm, June 30 - July 1, 2010 ; 3 tables

(Endocrine development ; 21)

2011

Institution	Advanced Seminar in Developmental Endocrinology European Society for Pediatric Endocrinology
Event/congress	ESPE Advanced Seminar in Developmental Endocrinology (4, 2010.06.30-07.01, StockholmSweden)
Author's details	vol. eds. Cecilia Camacho-Hübner
Series title	Endocrine development ; 21
MeSH term(s)	Bone Development/genetics ; Bone Diseases, Endocrine ; Cartilage/growth & development ; Cartilage Diseases
Keywords	Bone diseases in children ; Bones/Growth ; Cartilage/Diseases ; Cartilage/Growth ; Chondrogenesis ; Pediatric endocrinology ; Kind ; Endokrinologie ; Knochenwachstum ; Knochenkrankheit ; Knorpel
Language	English
Size	Online-Ressource (XII, 120 S.), 26 cm
Publisher	Karger
Publishing place	Basel ; Freiburg, Br ; Paris ; London ; New York, NY ; New Delhi ; Bangkok ; Beijing ; Tokyo ; Kuala Lumpur ; Singapore ; Sydney
Document type	Book ; Conference proceedings ; Online
Note	Literaturangaben
ISBN	1283439301 ; 1283439492 ; 9781283439497 ; 9783805597920 ; 9783805597920 ; 9783805597937 ; 9781283439305 ; 3805597924 ; 3805597924 ; 3805597932
DOI	10.1159/isbn.978-3-8055-9644-2
Database	Special collection on veterinary medicine and general parasitology

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Article ; Online: Targeted literature review of the humanistic and economic burden of adult growth hormone deficiency.

Loftus, Jane / Camacho-Hubner, Cecilia / Hey-Hadavi, Judith / Goodrich, Kelly

Current medical research and opinion

2018 Volume 35, Issue 6, Page(s) 963–973

Abstract: Background: Quality of life (QoL) and health economic data are becoming increasingly important factors in healthcare decision making. While there is a wealth of information establishing the benefit of growth hormone (GH) replacement therapy in adults ... ...

Abstract	Background: Quality of life (QoL) and health economic data are becoming increasingly important factors in healthcare decision making. While there is a wealth of information establishing the benefit of growth hormone (GH) replacement therapy in adults with growth hormone deficiency (aGHD), recent reviews on the QoL and health economic impact of aGHD and the effect of treatment on these factors is limited. Objective: The aim of this article is to summarize the impact of early and sustained treatment on the QoL and economic burden of aGHD by conducting a targeted literature review. Methods: Standard electronic databases, including PubMed and the Cochrane collaboration website, were searched for publications between January 2006 and July 2016 for evidence of the humanistic and economic burden of aGHD. Search terms included growth hormone deficiency, health-related quality of life, HRQoL, patient-reported outcomes, outcome assessment, well-being and adherence. Results: The literature search identified 732 initial hits and a final 14 publications were included. The analysis showed that the economic burden of aGHD is largely driven by the productivity losses associated with the disease. This is because most patients with aGHD are of working age and the QoL domains (memory & concentration and energy & vitality) most commonly affected by aGHD severely impair a person's ability to work and may limit their contribution to society. Conclusion: Untreated aGHD can seriously affect patients' functioning. Early and continued treatment with GH replacement therapy could potentially improve the QoL and reduce the economic burden associated with aGHD. This review has limitations: only English language articles published since January 2006 were included and many of the studies were conducted in the Nordic countries; it is unclear how representative these studies are of the population as a whole. This was a literature review and not a systematic review, as it was thought to be unlikely that, in this rare disease, any additional publications would have been identified. Overall, this review reveals a paucity of data in this underserved population and points to research gaps which could be addressed with new studies.
MeSH term(s)	Adult ; Cost of Illness ; Hormone Replacement Therapy/methods ; Human Growth Hormone/administration & dosage ; Human Growth Hormone/deficiency ; Humans ; Quality of Life
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2018-12-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1080/03007995.2018.1546682
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Treatment with Growth Hormone in Noonan Syndrome Observed during 25 Years of KIGS: Near Adult Height and Outcome Prediction.

Ranke, Michael B / Lindberg, Anders / Carlsson, Martin / Camacho-Hübner, Cecilia / Rooman, Raoul

Hormone research in paediatrics

2019 Volume 91, Issue 1, Page(s) 46–55

Abstract: Background/aims: There is little information how rhGH treatment affects height in NS. This study aims to analyze data from the NS patients assembled in KIGS over 25 years.: Patients/methods: Of 613 (389 m/224 f) NS patients documented, 476 (302 m/174 ...

Abstract	Background/aims: There is little information how rhGH treatment affects height in NS. This study aims to analyze data from the NS patients assembled in KIGS over 25 years. Patients/methods: Of 613 (389 m/224 f) NS patients documented, 476 (302 m/174 f) were treated for 1 year, 237 (160 m/77 f) of which served to develop a 1st year height velocity (HV) prediction algorithm. One-hundred and forty (74 m/66 f) had reached near adult height (NAH). Factors affecting NAH on rhGH were determined. Results: At the start of rhGH, the NAH groups were (median, m, f) 11.0 and 10.3 years, with a height SDS of -3.2 and -3.8 SDS (Prader), respectively. The total gain after 6.3 and 5.6 years on rhGH (0.27 and 0.30 mg/kg/week) was 1.2 and 1.3 SDS. Age at the start of rhGH (negative), height at the start of rhGH, rhGH dose, number of rhGH injections/wk and birth weight (all positive) explained 36% of the variability of 1st year HV. Height at the start of rhGH, 1st year growth on rhGH, birth weight, and gender explained 74% of the variability of NAH. Causes for rhGH treatment discontinuation and adverse events were also analyzed. Conclusion: rhGH treatment increases NAH in NS. Prediction algorithms may optimize treatment in the future.
MeSH term(s)	Adolescent ; Adolescent Development/drug effects ; Adult ; Age Factors ; Body Height/drug effects ; Child ; Child Development/drug effects ; Female ; Follow-Up Studies ; Human Growth Hormone/administration & dosage ; Humans ; Male ; Noonan Syndrome/drug therapy ; Noonan Syndrome/pathology ; Noonan Syndrome/physiopathology
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2019-04-02
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	2537278-6
ISSN	1663-2826 ; 1663-2818
ISSN (online)	1663-2826
ISSN	1663-2818
DOI	10.1159/000498859
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pituitary function and the response to GH therapy in patients with Langerhans cell histiocytosis: analysis of the KIMS database.

Touraine, Philippe / Sagna, Yempabou / Mattsson, Anders F / Burman, Pia / Van Beek, André P / Carlsson, Martin Ove / Aydin, Ferah / Feldt-Rasmussen, Ulla / Camacho-Hübner, Cecilia

European journal of endocrinology

2022 Volume 187, Issue 3, Page(s) 373–381

Abstract: Objective: To analyze the effectiveness and safety of growth hormone (GH) replacement treatment in adult patients with Langerhans cell histiocytosis (LCH) and GH deficiency (GHD) enrolled in KIMS (Pfizer International Metabolic Database).: Patients ... ...

Abstract	Objective: To analyze the effectiveness and safety of growth hormone (GH) replacement treatment in adult patients with Langerhans cell histiocytosis (LCH) and GH deficiency (GHD) enrolled in KIMS (Pfizer International Metabolic Database). Patients and methods: Patients with LCH and GHD were studied at baseline and some of them after 1 year of GH treatment. The effectiveness of GH is presented as change after 1 year of treatment (mean, 95% CI). The LCH population was compared to two other groups of patients enrolled in KIMS, granulomatous and lymphocytic hypophysitis. Results: At baseline, 81 adults with LCH (27 with childhood onset, 56% females), mean age at GHD onset of 29 (15) years were studied. Diabetes insipidus was diagnosed in 86% of patients. Analysis of 1 year of GH treatment was possible in 37 patients. One-year cross-sectional values for the GH dose were 0.39 (s.d.± 0.21) mg and -0.5 (-1.2 to 0.2) for insulin-like growth factor-1 s.d. Total cholesterol decreased 0.9 (-1.5 to -0.3 (mmol/L); P < 0.05); AGHDA-QoL-score (n = 20) was improved by 2.8 points (-5.6 to 0.0; P < 0.05), while mean BMI increased 0.6 ± 3 kg/m2 (95% CI: -0.2 to 1.4). All these effects did not differ from the two other groups after adjusting for age, gender, and baseline values. In 20 of 77 patients included in the safety analysis, 36 serious adverse events were reported during 435 patient-years (82.8/1000); no new safety signals were reported. Conclusion: After 1 year of GH treatment in patients with LCH, metabolic variables and quality of life improved, with no new safety signals.
MeSH term(s)	Adult ; Child ; Cross-Sectional Studies ; Dwarfism, Pituitary ; Female ; Histiocytosis, Langerhans-Cell/drug therapy ; Hormone Replacement Therapy ; Human Growth Hormone/therapeutic use ; Humans ; Hypopituitarism/drug therapy ; Male ; Quality of Life
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2022-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1530/EJE-22-0160
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Near-Adult Height After Growth Hormone Treatment in Children Born Prematurely-Data From KIGS.

Boguszewski, Margaret C S / Carlsson, Martin / Lindberg, Anders / Dahlgren, Jovanna / Aydin, Ferah / Camacho-Hübner, Cecilia / Hokken-Koelega, Anita C S

The Journal of clinical endocrinology and metabolism

2020 Volume 105, Issue 7

Abstract: Context: Children born prematurely have been treated with growth hormone (GH), and a significant improvement in height during the first years of treatment has been described.: Objective: To evaluate the influence of prematurity on near-adult height ( ... ...

Abstract	Context: Children born prematurely have been treated with growth hormone (GH), and a significant improvement in height during the first years of treatment has been described. Objective: To evaluate the influence of prematurity on near-adult height (NAH) after GH treatment. Design: KIGS (Pfizer International Growth Database) was queried for children born preterm treated with GH. Setting: KIGS database. Patients: A total of 586 children short in stature born preterm with various GH status and with available gestational age (GA), birth weight, and NAH, all treated with GH. Intervention: GH treatment. Main outcome measure: NAH. Results: Values were expressed as median. From the 586 children included, 482 born appropriate for GA (AGA; median age 8.26 years) and 104 born small for gestational age (SGA) (median age 8.54 years); 66.6% of preterm AGA had GH peak < 7 µg/L during a provocation test, whereas only 8.6% of preterm SGA. Change in height standard deviation scores (SDS) from GH start to NAH after 8.04 years of GH treatment was 1.82 in preterm AGA. Respective values were 7.08 years and 1.08 SDS for preterm SGA (P < 0.001); 57% of the variability of the growth response to NAH could be explained, and the distance to parental height was the strongest predictor. No significant changes in height SDS were observed from puberty start to NAH. No correlation was found with GA. GH treatment was well tolerated. Conclusion: GH treatment resulted in significant improvement in height in children born preterm, particularly during prepubertal years and for those with GH deficiency. The degree of prematurity did not influence the growth response.
MeSH term(s)	Body Height/drug effects ; Child ; Female ; Growth Disorders/drug therapy ; Human Growth Hormone/administration & dosage ; Human Growth Hormone/therapeutic use ; Humans ; Infant, Premature ; Infant, Small for Gestational Age/growth & development ; Male ; Treatment Outcome
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgaa203
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