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  1. AU="Camelia-Maria Monoranu"
  2. AU="Zanette, Dalila Lucíola"
  3. AU="Beaumont, Vahri"
  4. AU="Sorrentino, Gregorio"
  5. AU="Matulionyte, Raimonda"
  6. AU="Afshar, Sabereh"
  7. AU=Armstrong James PK AU=Armstrong James PK
  8. AU="Leshem, Shahaf"
  9. AU="García-García, Ana"
  10. AU="Terrón, Alberto"
  11. AU=Hanel Martin
  12. AU="Saro-Buendía, Miguel"
  13. AU="John R. Kouvaris"
  14. AU="Tripathy, Ashutosh"
  15. AU="Sharpley, Ann L"
  16. AU="Kragt, Lea"
  17. AU="Cui, Yanyan"
  18. AU="Morton, Jennifer P"

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  1. Artikel ; Online: No Metagenomic Evidence of Causative Viral Pathogens in Postencephalitic Parkinsonism Following Encephalitis Lethargica

    Dániel Cadar / Kurt A. Jellinger / Peter Riederer / Sabrina Strobel / Camelia-Maria Monoranu / Dennis Tappe

    Microorganisms, Vol 9, Iss 1716, p

    2021  Band 1716

    Abstract: Postencephalitic parkinsonism (PEP) is a disease of unknown etiology and pathophysiology following encephalitis lethargica (EL), an acute-onset polioencephalitis of cryptic cause in the 1920s. PEP is a tauopathy with multisystem neuronal loss and gliosis, ...

    Abstract Postencephalitic parkinsonism (PEP) is a disease of unknown etiology and pathophysiology following encephalitis lethargica (EL), an acute-onset polioencephalitis of cryptic cause in the 1920s. PEP is a tauopathy with multisystem neuronal loss and gliosis, clinically characterized by bradykinesia, rigidity, rest tremor, and oculogyric crises. Though a viral cause of EL is likely, past polymerase chain reaction-based investigations in the etiology of both PEP and EL were negative. PEP might be caused directly by an unknown viral pathogen or the consequence of a post-infectious immunopathology. The development of metagenomic next-generation sequencing in conjunction with bioinformatic techniques has generated a broad-range tool for the detection of unknown pathogens in the recent past. Retrospective identification and characterization of pathogens responsible for past infectious diseases can be successfully performed with formalin-fixed paraffin-embedded (FFPE) tissue samples. In this study, we analyzed 24 FFPE brain samples from six patients with PEP by unbiased metagenomic next-generation sequencing. Our results show that no evidence for the presence of a specific or putative (novel) viral pathogen was found, suggesting a likely post-infectious immune-mediated etiology of PEP.
    Schlagwörter postencephalitic parkinsonism ; encephalitis lethargica ; von Economo ; metagenomics ; neuropathology ; tauopathy ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: SOAT1

    Mario Löhr / Wolfgang Härtig / Almut Schulze / Matthias Kroiß / Silviu Sbiera / Constantin Lapa / Bianca Mages / Sabrina Strobel / Jennifer Elisabeth Hundt / Simone Bohnert / Stefan Kircher / Sudha Janaki-Raman / Camelia-Maria Monoranu

    International Journal of Molecular Sciences, Vol 23, Iss 3726, p

    A Suitable Target for Therapy in High-Grade Astrocytic Glioma?

    2022  Band 3726

    Abstract: Targeting molecular alterations as an effective treatment for isocitrate dehydrogenase-wildtype glioblastoma (GBM) patients has not yet been established. Sterol-O-Acyl Transferase 1 (SOAT1), a key enzyme in the conversion of endoplasmic reticulum ... ...

    Abstract Targeting molecular alterations as an effective treatment for isocitrate dehydrogenase-wildtype glioblastoma (GBM) patients has not yet been established. Sterol-O-Acyl Transferase 1 (SOAT1), a key enzyme in the conversion of endoplasmic reticulum cholesterol to esters for storage in lipid droplets (LD), serves as a target for the orphan drug mitotane to treat adrenocortical carcinoma. Inhibition of SOAT1 also suppresses GBM growth. Here, we refined SOAT1-expression in GBM and IDH -mutant astrocytoma, CNS WHO grade 4 (HGA), and assessed the distribution of LD in these tumors. Twenty-seven GBM and three HGA specimens were evaluated by multiple GFAP, Iba1, IDH1 R132H, and SOAT1 immunofluorescence labeling as well as Oil Red O staining. To a small extent SOAT1 was expressed by tumor cells in both tumor entities. In contrast, strong expression was observed in glioma-associated macrophages. Triple immunofluorescence labeling revealed, for the first time, evidence for SOAT1 colocalization with Iba1 and IDH1 R132H, respectively. Furthermore, a notable difference in the amount of LD between GBM and HGA was observed. Therefore, SOAT1 suppression might be a therapeutic option to target GBM and HGA growth and invasiveness. In addition, the high expression in cells related to neuroinflammation could be beneficial for a concomitant suppression of protumoral microglia/macrophages.
    Schlagwörter SOAT1 ; glioblastoma ; astrocytoma ; IDH1 / 2 ; lipid droplets ; mitotane ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Melanin and Neuromelanin Fluorescence Studies Focusing on Parkinson’s Disease and Its Inherent Risk for Melanoma

    Dieter Leupold / Lukasz Szyc / Goran Stankovic / Sabrina Strobel / Hans-Ullrich Völker / Ulrike Fleck / Thomas Müller / Matthias Scholz / Peter Riederer / Camelia-Maria Monoranu

    Cells, Vol 8, Iss 6, p

    2019  Band 592

    Abstract: Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neuromelanin is ... ...

    Abstract Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin. For the first time, the fluorescence of melanin and neuromelanin is selectively accessible using a new method of nonlinear spectroscopy, based on a stepwise two-photon excitation. Cutaneous pigmentation and postmortem neuromelanin of Parkinson patients were characterized by fluorescence spectra and compared with controls. Spectral differences could not be documented, implying that there is neither a Parkinson fingerprint in cutaneous melanin spectra nor a melanin-associated fingerprint indicating an increased melanoma risk. Our measurements suggest that Parkinson’s disease occurs without a configuration change of neuromelanin. However, Parkinson patients displayed the same dermatofluorescence spectroscopic fingerprint of a local malignant transformation as controls. This is the first comparative retrospective fluorescence analysis of cutaneous melanin and postmortem neuromelanin based on nonlinear spectroscopy in patients with Parkinson’s disease and controls, and this method is a very suitable diagnostic tool for melanoma screening and early detection in Parkinson patients. Our results suggest a non-pigmentary pathway as the main link between Parkinson’s disease and melanoma, and they do not rule out the melanocortin-1-receptor gene as an additional bridge between both diseases.
    Schlagwörter Parkinson’s disease ; melanin ; neuromelanin ; dermatofluoroscopy ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Inflammatory Pathways in Parkinson’s Disease; A BNE Microarray Study

    Edna Grünblatt / David T. Dexter / Peter Riederer / Richard Reynolds / Francesca S. Fernando / Camelia Maria Monoranu / Jordan Evans / Pascal. F. Durrenberger

    Parkinson's Disease, Vol

    2012  Band 2012

    Schlagwörter Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Tumor-associated macrophages in glioblastoma multiforme-a suitable target for somatostatin receptor-based imaging and therapy?

    Constantin Lapa / Thomas Linsenmann / Katharina Lückerath / Samuel Samnick / Ken Herrmann / Carolin Stoffer / Ralf-Ingo Ernestus / Andreas K Buck / Mario Löhr / Camelia-Maria Monoranu

    PLoS ONE, Vol 10, Iss 3, p e

    2015  Band 0122269

    Abstract: Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Tumor-associated macrophages (TAM) have been shown to promote malignant growth and to correlate with poor prognosis. [1,4,7,10-tetraazacyclododecane-NN',N″,N'″-tetraacetic ... ...

    Abstract Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Tumor-associated macrophages (TAM) have been shown to promote malignant growth and to correlate with poor prognosis. [1,4,7,10-tetraazacyclododecane-NN',N″,N'″-tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) labeled with Gallium-68 selectively binds to somatostatin receptor 2A (SSTR2A) which is specifically expressed and up-regulated in activated macrophages. On the other hand, the role of SSTR2A expression on the cell surface of glioma cells has not been fully elucidated yet. The aim of this study was to non-invasively assess SSTR2A expression of both glioma cells as well as macrophages in GBM.15 samples of patient-derived GBM were stained immunohistochemically for macrophage infiltration (CD68), proliferative activity (Ki67) as well as expression of SSTR2A. Anti-CD45 staining was performed to distinguish between resident microglia and tumor-infiltrating macrophages. In a subcohort, positron emission tomography (PET) imaging using 68Ga-DOTATATE was performed and the semiquantitatively evaluated tracer uptake was compared to the results of immunohistochemistry.The amount of microglia/macrophages ranged from <10% to >50% in the tumor samples with the vast majority being resident microglial cells. A strong SSTR2A immunostaining was observed in endothelial cells of proliferating vessels, in neurons and neuropile. Only faint immunostaining was identified on isolated microglial and tumor cells. Somatostatin receptor imaging revealed areas of increased tracer accumulation in every patient. However, retention of the tracer did not correlate with immunohistochemical staining patterns.SSTR2A seems not to be overexpressed in GBM samples tested, neither on the cell surface of resident microglia or infiltrating macrophages, nor on the surface of tumor cells. These data suggest that somatostatin receptor directed imaging and treatment strategies are less promising in GBM.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Sturm, Dominik / Brent A. Orr / Umut H. Toprak / Volker Hovestadt / David T.W. Jones / David Capper / Martin Sill / Ivo Buchhalter / Paul A. Northcott / Irina Leis / Marina Ryzhova / Christian Koelsche / Elke Pfaff / Sariah J. Allen / Gnanaprakash Balasubramanian / Barbara C. Worst / Kristian W. Pajtler / Sebastian Brabetz / Pascal D. Johann /
    Felix Sahm / Jüri Reimand / Alan Mackay / Diana M. Carvalho / Marc Remke / Joanna J. Phillips / Arie Perry / Cynthia Cowdrey / Rachid Drissi / Maryam Fouladi / Felice Giangaspero / Maria Łastowska / Wiesława Grajkowska / Wolfram Scheurlen / Torsten Pietsch / Christian Hagel / Johannes Gojo / Daniela Lötsch / Walter Berger / Irene Slavc / Christine Haberler / Anne Jouvet / Stefan Holm / Silvia Hofer / Marco Prinz / Catherine Keohane / Iris Fried / Christian Mawrin / David Scheie / Bret C. Mobley / Matthew J. Schniederjan / Mariarita Santi / Anna M. Buccoliero / Sonika Dahiya / Christof M. Kramm / André O. von Bueren / Katja von Hoff / Stefan Rutkowski / Christel Herold-Mende / Michael C. Frühwald / Till Milde / Martin Hasselblatt / Pieter Wesseling / Jochen Rößler / Ulrich Schüller / Martin Ebinger / Jens Schittenhelm / Stephan Frank / Rainer Grobholz / Istvan Vajtai / Volkmar Hans / Reinhard Schneppenheim / Karel Zitterbart / V. Peter Collins / Eleonora Aronica / Pascale Varlet / Stephanie Puget / Christelle Dufour / Jacques Grill / Dominique Figarella-Branger / Marietta Wolter / Martin U. Schuhmann / Tarek Shalaby / Michael Grotzer / Timothy van Meter / Camelia-Maria Monoranu / Jörg Felsberg / Guido Reifenberger / Matija Snuderl / Lynn Ann Forrester / Jan Koster / Rogier Versteeg / Richard Volckmann / Peter van Sluis / Stephan Wolf / Tom Mikkelsen / Amar Gajjar / Kenneth Aldape / Andrew S. Moore / Michael D. Taylor / Chris Jones / Nada Jabado / Matthias A. Karajannis / Roland Eils / Matthias Schlesner / Peter Lichter / Andreas von Deimling / Stefan M. Pfister / David W. Ellison / Andrey Korshunov / Marcel Kool

    Cell. 2016 Feb. 25, v. 164

    2016  

    Abstract: Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a ... ...

    Abstract Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated “CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2),” “CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC),” “CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1),” and “CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR),” will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.
    Schlagwörter adolescents ; adults ; brain ; children ; clinical trials ; histopathology ; patients ; sarcoma ; therapeutics
    Sprache Englisch
    Erscheinungsverlauf 2016-0225
    Umfang p. 1060-1072.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2016.01.015
    Datenquelle NAL Katalog (AGRICOLA)

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