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  1. AU="Cameron S. Carter"
  2. AU="Cater, J" AU="Cater, J"

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  1. Artikel ; Online: Cognitive Control and Discourse Comprehension in Schizophrenia

    Tamara Y. Swaab / Cameron S. Carter / Megan A. Boudewyn

    Schizophrenia Research and Treatment, Vol

    2012  Band 2012

    Schlagwörter Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Psychiatry ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Functional network changes and cognitive control in schizophrenia

    Kimberly L. Ray / Tyler A. Lesh / Amber M. Howell / Taylor P. Salo / J. Daniel Ragland / Angus W. MacDonald / James M. Gold / Steven M. Silverstein / Deana M. Barch / Cameron S. Carter

    NeuroImage: Clinical, Vol 15, Iss , Pp 161-

    2017  Band 170

    Abstract: Cognitive control is a cognitive and neural mechanism that contributes to managing the complex demands of day-to-day life. Studies have suggested that functional impairments in cognitive control associated brain circuitry contribute to a broad range of ... ...

    Abstract Cognitive control is a cognitive and neural mechanism that contributes to managing the complex demands of day-to-day life. Studies have suggested that functional impairments in cognitive control associated brain circuitry contribute to a broad range of higher cognitive deficits in schizophrenia. To examine this issue, we assessed functional connectivity networks in healthy adults and individuals with schizophrenia performing tasks from two distinct cognitive domains that varied in demands for cognitive control, the RiSE episodic memory task and DPX goal maintenance task. We characterized general and cognitive control-specific effects of schizophrenia on functional connectivity within an expanded frontal parietal network (FPN) and quantified network topology properties using graph analysis. Using the network based statistic (NBS), we observed greater network functional connectivity in cognitive control demanding conditions during both tasks in both groups in the FPN, and demonstrated cognitive control FPN specificity against a task independent auditory network. NBS analyses also revealed widespread connectivity deficits in schizophrenia patients across all tasks. Furthermore, quantitative changes in network topology associated with diagnostic status and task demand were observed. The present findings, in an analysis that was limited to correct trials only, ensuring that subjects are on task, provide critical insights into network connections crucial for cognitive control and the manner in which brain networks reorganize to support such control. Impairments in this mechanism are present in schizophrenia and these results highlight how cognitive control deficits contribute to the pathophysiology of this illness.
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: A multicenter study of ketamine effects on functional connectivity

    Leah M. Fleming / Daniel C. Javitt / Cameron S. Carter / Joshua T. Kantrowitz / Ragy R. Girgis / Lawrence S. Kegeles / John D. Ragland / Richard J. Maddock / Tyler A. Lesh / Costin Tanase / James Robinson / William Z. Potter / Marlene Carlson / Melanie M. Wall / Tse-Hwei Choo / Jack Grinband / Jeffrey Lieberman / John H. Krystal / Philip R. Corlett

    NeuroImage: Clinical, Vol 22, Iss , Pp - (2019)

    Large scale network relationships, hubs and symptom mechanisms

    2019  

    Abstract: Ketamine is an uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist. It induces effects in healthy individuals that mimic symptoms associated with schizophrenia. We sought to root these experiences in altered brain function, ... ...

    Abstract Ketamine is an uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist. It induces effects in healthy individuals that mimic symptoms associated with schizophrenia. We sought to root these experiences in altered brain function, specifically aberrant resting state functional connectivity (rsfMRI). In the present study, we acquired rsfMRI data under ketamine and placebo in a between-subjects design and analyzed seed-based measures of rsfMRI using large-scale networks, dorsolateral prefrontal cortex (DLPFC) and sub-nuclei of the thalamus. We found ketamine-induced alterations in rsfMRI connectivity similar to those seen in patients with schizophrenia, some changes that may be more comparable to early stages of schizophrenia, and other connectivity signatures seen in patients that ketamine did not recreate. We do not find any circuits from our regions of interest that correlates with positive symptoms of schizophrenia in our sample, although we find that DLPFC connectivity with ACC does correlate with a mood measure. These results provide support for ketamine's use as a model of certain biomarkers of schizophrenia, particularly for early or at-risk patients. Keywords: Ketamine, Functional connectivity, Psychosis, Resting state
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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