Article ; Online: IRE1α and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells.
2020 Volume 10, Issue 1, Page(s) 8348
Abstract: To date current therapies of glioblastoma multiforme (GBM) are largely ineffective. The induction of apoptosis by an unresolvable unfolded protein response (UPR) represents a potential new therapeutic strategy. Here we tested 12ADT, a sarcoendoplasmic ... ...
| Abstract | To date current therapies of glioblastoma multiforme (GBM) are largely ineffective. The induction of apoptosis by an unresolvable unfolded protein response (UPR) represents a potential new therapeutic strategy. Here we tested 12ADT, a sarcoendoplasmic reticulum Ca |
|---|---|
| MeSH term(s) | Adult ; Apoptosis/drug effects ; Brain/pathology ; Brain/surgery ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/mortality ; Brain Neoplasms/surgery ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Endoplasmic Reticulum Stress/drug effects ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Gene Expression Regulation, Neoplastic ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/mortality ; Glioblastoma/surgery ; Humans ; Insulin-Like Growth Factor Binding Protein 3/genetics ; Insulin-Like Growth Factor Binding Protein 3/metabolism ; Insulin-Like Growth Factor Binding Protein 5/genetics ; Insulin-Like Growth Factor Binding Protein 5/metabolism ; Primary Cell Culture ; Progression-Free Survival ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; RNA-Seq ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/antagonists & inhibitors ; Signal Transduction/genetics ; Spheroids, Cellular ; Thapsigargin/analogs & derivatives ; Thapsigargin/pharmacology ; Thapsigargin/therapeutic use ; Tumor Cells, Cultured ; Unfolded Protein Response/drug effects |
| Chemical Substances | IGFBP3 protein, human ; IGFBP5 protein, human ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor Binding Protein 5 ; Thapsigargin (67526-95-8) ; ERN1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) |
| Language | English |
| Publishing date | 2020-05-20 |
| Publishing country | England |
| Document type | Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-020-65320-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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