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  1. Article ; Online: Fibroids-related complications in pregnancy: a twelve-year long experience at a maternal-fetal medicine referral center.

    Lazzarin, Sara / Ornaghi, Sara / Roncaglia, Nadia / Mariani, Silvana / Cameroni, Irene / Vergani, Patrizia

    Minerva obstetrics and gynecology

    2022  Volume 75, Issue 6, Page(s) 520–525

    Abstract: Background: Uterine fibroids are the most frequent female benign tumor, which can cause complications during pregnancy, mainly pain. Differential diagnosis may be challenging and a standardized management approach is lacking. We aim to propose an ... ...

    Abstract Background: Uterine fibroids are the most frequent female benign tumor, which can cause complications during pregnancy, mainly pain. Differential diagnosis may be challenging and a standardized management approach is lacking. We aim to propose an algorithm for the differential diagnosis of pain during pregnancy and for management of fibroid-related pain.
    Methods: A retrospective cohort study of all pregnant women admitted to our center for complications related to fibroids between 2008 and 2019. Data regarding clinical examination, laboratory results, imaging parameters, as well as perinatal outcomes, were collected and assessed (Fisher's Exact Test).
    Results: Twenty-four pregnant patients were admitted for fibroid-related complications. Six patients were admitted more than one times, for a total of 34 admissions. The main cause of hospital admission was pain (N.=33, 94.1%), which was successfully managed with acetaminophen and/or ketoprofen in 91.2%. In two cases, conservative management failed and a surgical approach was undertaken. Most women (N.=20, 90.9%) delivered at term, with a cesarean delivery and post-partum hemorrhage rate of 22.7%. All newborns had normal APGAR score, umbilical artery pH and birth weight.
    Conclusions: Pain is the most common complication of fibroids during pregnancy. Accurate differential diagnosis and adequate management are pivotal to ensure good perinatal outcomes.
    MeSH term(s) Female ; Pregnancy ; Humans ; Infant, Newborn ; Uterine Neoplasms/complications ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/therapy ; Retrospective Studies ; Perinatology ; Leiomyoma/complications ; Leiomyoma/diagnosis ; Leiomyoma/therapy ; Parturition ; Pain/complications
    Language English
    Publishing date 2022-10-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062815-5
    ISSN 2724-6450
    ISSN (online) 2724-6450
    DOI 10.23736/S2724-606X.22.05146-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute spontaneous non-hemorrhagic adrenal infarction in pregnancy: case-report and literature review.

    Ornaghi, Sara / Fernicola, Federica / Marelli, Elisabetta / Perotti, Mario / Di Gennaro, Filiberto / Cameroni, Irene / Mariani, Eloisa M / Pincelli, Angela I / Colciago, Elisabetta / Cetin, Irene / Vergani, Patrizia

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2023  Volume 39, Issue 1, Page(s) 2234492

    Abstract: Unilateral non-hemorrhagic adrenal infarction (NHAI) is a very uncommon cause of acute abdomen in pregnancy. Diagnosis is highly challenging due to its rarity, heterogeneity of clinical presentation, and inconclusiveness of the initial workup. Timely ... ...

    Abstract Unilateral non-hemorrhagic adrenal infarction (NHAI) is a very uncommon cause of acute abdomen in pregnancy. Diagnosis is highly challenging due to its rarity, heterogeneity of clinical presentation, and inconclusiveness of the initial workup. Timely recognition is pivotal to ensuring optimal outcomes. Here we describe a case of spontaneous unilateral NHAI diagnosed in a singleton pregnant woman at 32 weeks' gestation at our centre and provide the findings of an extensive literature review on the topic. We identified 22 articles describing 31 NHAI cases in 30 obstetric patients: NHAI occurs more frequently on the right side and in the third trimester, and diagnosis is formulated more than 24 h after clinical presentation in 50% of cases; second-level imaging is always necessary to reach a definitive diagnosis and start appropriate treatment. A high degree of clinical suspicion is needed to promptly recognize NHAI in pregnancy, thus allowing appropriate multidisciplinary management and timely treatment initiation. Promotion of knowledge and awareness of NHAI as a potential cause of acute abdomen in pregnancy is mandatory to improve clinical practice and, ultimately, perinatal outcomes.
    MeSH term(s) Pregnancy ; Female ; Humans ; Abdomen, Acute/diagnosis ; Abdomen, Acute/etiology ; Adrenal Gland Diseases/diagnosis ; Pregnancy Trimester, Third ; Infarction/diagnostic imaging ; Infarction/etiology
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2023.2234492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: O6. Uterine artery Doppler in a risk population: What's its role in the prediction of small for gestational age fetuses?

    Cameroni, Irene / Crippa, Isabella / Roncaglia, Nadia / Locatelli, Anna / Ornaghi, Sara / Vergani, Patrizia

    Pregnancy hypertension

    2011  Volume 1, Issue 3-4, Page(s) 260

    Language English
    Publishing date 2011-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2584464-7
    ISSN 2210-7797 ; 2210-7789
    ISSN (online) 2210-7797
    ISSN 2210-7789
    DOI 10.1016/j.preghy.2011.08.038
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  4. Article: Prevention of developmental delays in a Down syndrome mouse model.

    Toso, Laura / Cameroni, Irene / Roberson, Robin / Abebe, Daniel / Bissell, Stephanie / Spong, Catherine Y

    Obstetrics and gynecology

    2008  Volume 112, Issue 6, Page(s) 1242–1251

    Abstract: Objective: To estimate whether prenatal treatment with neuroprotective peptides prevents the developmental delay and the glial deficit in the Ts65Dn mouse model for Down syndrome and to explore the peptides' effects on achievement of normal development.! ...

    Abstract Objective: To estimate whether prenatal treatment with neuroprotective peptides prevents the developmental delay and the glial deficit in the Ts65Dn mouse model for Down syndrome and to explore the peptides' effects on achievement of normal development.
    Methods: Pregnant Ts65Dn females were randomly assigned to NAPVSIPQ+SALLRSIPA or control and were treated by investigators blinded to treatment and genotype on gestational days 8-12. Offspring were tested from postnatal day 5 to 21 for motor and sensory milestones with standardized tests by operators blinded to the pup's treatment and genotype. The pup's genotype was determined after completion of all tests. Activity-dependent neurotrophic factor, glial fibrillary acidic protein, and vasoactive intestinal peptide expression were determined using real-time polymerase chain reaction.
    Results: Trisomic mice achieved milestones with a significant delay in four of five motor and sensory milestones. Trisomic mice that were prenatally exposed to NAPVSIPQ+SALLRSIPA achieved developmental milestones at the same time as the controls in three of four motor and one of four sensory milestones (P<.01). Euploid pups prenatally treated with NAPVSIPQ+SALLRSIPA achieved developmental milestones significantly earlier than the euploid pups prenatally treated with placebo. Activity-dependent neurotrophic factor expression was significantly downregulated in the Ts65Dn brains compared with the controls, prenatal treatment with NAPVSIPQ+ SALLRSIPA prevented the activity-dependent neurotrophic factor decrease in the Ts65Dn brains, and the expression was not different from the controls. The glial marker glial fibrillary acidic protein demonstrated the known glial deficit in the Ts65Dn mice, and treatment with NAPVSIPQ+ SALLRSIPA prevented its downregulation. Lastly, vasoactive intestinal peptide levels were increased in the trisomic brains, whereas treatment with NAPVSIPQ+SALLRSIPA did not prevent its upregulation.
    Conclusion: Prenatal treatment with NAPVSIPQ and SALLRSIPA prevented developmental delay and the glial deficit in Down syndrome. These findings highlight a possibility for the prevention of developmental sequelae in Down syndrome and suggest a potential intervention during pregnancy that may improve the outcome.
    MeSH term(s) Animals ; Animals, Newborn ; Developmental Disabilities/etiology ; Developmental Disabilities/prevention & control ; Disease Models, Animal ; Down Syndrome/complications ; Down Syndrome/drug therapy ; Down Syndrome/genetics ; Female ; Humans ; Infant ; Infusions, Parenteral ; Mice ; Nerve Tissue Proteins/administration & dosage ; Neuroglia/metabolism ; Neuroprotective Agents/administration & dosage ; Oligopeptides/administration & dosage ; Peptide Fragments/administration & dosage ; Pregnancy ; Prenatal Care
    Chemical Substances Nerve Tissue Proteins ; Neuroprotective Agents ; Oligopeptides ; Peptide Fragments ; SALLRSIPA ; davunetide (GF00K3IIWE)
    Language English
    Publishing date 2008-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0b013e31818c91dc
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Prediction of superimposed preeclampsia using uterine artery Doppler velocimetry in women with chronic hypertension.

    Roncaglia, Nadia / Crippa, Isabella / Locatelli, Anna / Cameroni, Irene / Orsenigo, Francesca / Vergani, Patrizia / Ghidini, Alessandro

    Prenatal diagnosis

    2008  Volume 28, Issue 8, Page(s) 710–714

    Abstract: Objective: To assess the role of uterine artery (UtA) Doppler to predict superimposed preeclampsia in women with chronic hypertension.: Methods: In a cohort of 182 women with chronic hypertension, UtA Doppler studies were performed before 25 weeks ( ... ...

    Abstract Objective: To assess the role of uterine artery (UtA) Doppler to predict superimposed preeclampsia in women with chronic hypertension.
    Methods: In a cohort of 182 women with chronic hypertension, UtA Doppler studies were performed before 25 weeks (mean 19.7 +/- 2.1 weeks) and repeated later in pregnancy (mean 28.5 +/- 3.7 weeks).
    Results: The incidence of preeclampsia was 13% (24/182). Rates of preeclampsia increased with advancing gestation of abnormal UtA Doppler: 7% when UtA Doppler were normal at early exam, 18% when abnormal at early exam, and 28% when abnormal at late exam (Chi-square for trend: P < 0.001). The rate of preeclampsia among 40 women with abnormal early but normal late UtA Doppler was similar to that of women with normal findings at early exam (8 vs 7%; P = 1.00). Logistic regression analysis showed that the ability of UtA Doppler to predict preeclampsia was independent from other variables [Odds Ratio (OR) 7.1, 95% Confidence Interval (CI) 2.6-18.9). Receiver operating characteristic (ROC) curve identified a UtA value of 0.58 as the optimal threshold for the prediction of preeclampsia.
    Conclusion: The later in pregnancy the abnormal UtA Doppler findings are observed, the greater the risk of preeclampsia. Normalization of UtA Doppler after 25 weeks reduces the risk of preeclampsia to 8%.
    MeSH term(s) Adult ; Female ; Humans ; Hypertension/complications ; Laser-Doppler Flowmetry ; Placentation ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/etiology ; Pregnancy ; Uterus/blood supply
    Language English
    Publishing date 2008-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 82031-3
    ISSN 1097-0223 ; 0197-3851
    ISSN (online) 1097-0223
    ISSN 0197-3851
    DOI 10.1002/pd.2027
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    Zs.A 1625: Show issues Location:
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  6. Article ; Online: Alterations in phosphorylated cyclic adenosine monophosphate response element of binding protein activity: a pathway for fetal alcohol syndrome-related neurotoxicity.

    Roberson, Robin / Cameroni, Irene / Toso, Laura / Abebe, Daniel / Bissel, Stephanie / Spong, Catherine Y

    American journal of obstetrics and gynecology

    2008  Volume 200, Issue 2, Page(s) 193.e1–5

    Abstract: Objective: Fetal alcohol syndrome (FAS) is the leading cause of a spectrum of preventable nongenetic learning and behavioral disorders. In adult (FAS) mice, we measured phosphorylated cyclic adenosine monophosphate response element of binding protein ( ... ...

    Abstract Objective: Fetal alcohol syndrome (FAS) is the leading cause of a spectrum of preventable nongenetic learning and behavioral disorders. In adult (FAS) mice, we measured phosphorylated cyclic adenosine monophosphate response element of binding protein (pCREB) staining in hippocampal subregions to evaluate a possible mechanism underlying FAS learning deficits.
    Study design: Pregnant C57BL6/J mice were treated on gestational day 8 with alcohol or control (saline). After learning assessment, the offspring were perfused for immunohistochemistry and brain sections probed using SER 133 pCREB antibody. Relative staining density was assessed using National Institutes of Health Image software. Statistical analysis included analysis of variance with P < .05 considered significant.
    Results: In all hippocampal subregions, pCREB staining was greater in the control animals than in the alcohol-treated group (P < or = .0001).
    Conclusion: In utero alcohol exposure decreased pCREB activity in hippocampal subregions of adult mice. The dentate gyrus had the most robust cumulative decrease in pCREB staining, suggesting FAS adult learning deficits may correlate to enhanced dentate gyrus neurodegeneration.
    MeSH term(s) Animals ; Carrier Proteins/metabolism ; Cyclic AMP/metabolism ; Dentate Gyrus/metabolism ; Disease Models, Animal ; Female ; Fetal Alcohol Spectrum Disorders/metabolism ; Hippocampus/metabolism ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL ; Neurotoxicity Syndromes/metabolism ; Pregnancy
    Chemical Substances Carrier Proteins ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2008-12-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2008.08.054
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  7. Article: A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis.

    Roncaglia, Nadia / Locatelli, Anna / Arreghini, Alessandra / Assi, Francesca / Cameroni, Irene / Pezzullo, John C / Ghidini, Alessandro

    BJOG : an international journal of obstetrics and gynaecology

    2004  Volume 111, Issue 1, Page(s) 17–21

    Abstract: Objective: To compare the efficacy of S-adenosyl-l-methionine and ursodeoxycholic acid in improving serum biochemical abnormalities in gestational cholestasis.: Design: Randomised clinical trial.: Setting: University hospital.: Population: All ... ...

    Abstract Objective: To compare the efficacy of S-adenosyl-l-methionine and ursodeoxycholic acid in improving serum biochemical abnormalities in gestational cholestasis.
    Design: Randomised clinical trial.
    Setting: University hospital.
    Population: All women at <36 weeks of gestation with severe gestational cholestasis during June 1996 to December 2001.
    Methods: Enrolled women were randomly assigned oral S-adenosyl-l-methionine 500 mg twice daily or oral ursodeoxycholic acid 300 mg twice daily until delivery.
    Main outcome measures: Reduction in the concentration of serum bile acids. Other variables considered included obstetric and neonatal outcome, clinical symptoms and other laboratory measurements (serum levels of transaminases and bilirubin). The two groups were compared using Student's t test, Wilcoxon's signed rank sum test and Fisher's exact test, with a two-tailed P < 0.05 being considered significant.
    Results: Of the 46 women enrolled, 24 received ursodeoxycholic acid and 22 S-adenosyl-l-methionine. At enrolment, gestational age, duration of therapy, rate of nulliparity, pruritus score and biochemical characteristics were similar between the groups. Both therapies significantly and equally improved pruritus. Women receiving ursodeoxycholic acid had a significantly greater improvement in the concentration of serum bile acids (P= 0.001), aspartate aminotransferase (P= 0.01), alanine aminotransferase (<0.001) and bilirubin (P= 0.002) compared with those receiving S-adenosyl-l-methionine. Duration of therapy was significantly greater in women receiving ursodeoxycholic acid compared with S-adenosyl-l-methionine (P= 0.04), whereas gestational age at delivery and rate of prematurity were similar in the two groups.
    Conclusions: In women with intrahepatic cholestasis of pregnancy, ursodeoxycholic acid is more effective than S-adenosyl-l-methionine at improving the concentration of serum bile acids and other tests of liver function, whereas both therapies are equally effective at improving pruritus.
    MeSH term(s) Administration, Oral ; Bile Acids and Salts/blood ; Cholagogues and Choleretics/administration & dosage ; Cholestasis, Intrahepatic/blood ; Cholestasis, Intrahepatic/drug therapy ; Female ; Humans ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/drug therapy ; S-Adenosylmethionine/administration & dosage ; Treatment Outcome ; Ursodeoxycholic Acid/administration & dosage
    Chemical Substances Bile Acids and Salts ; Cholagogues and Choleretics ; Ursodeoxycholic Acid (724L30Y2QR) ; S-Adenosylmethionine (7LP2MPO46S)
    Language English
    Publishing date 2004-03-01
    Publishing country England
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 1470-0328 ; 0306-5456
    ISSN (online) 1471-0528
    ISSN 1470-0328 ; 0306-5456
    DOI 10.1046/j.1471-0528.2003.00029.x
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