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  1. AU="Camilla Caimi"
  2. AU="Huynh, Nancy"
  3. AU="Sun, Weilin"
  4. AU="Whalon, Mark E."
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  6. AU="Quaranta, Gianluigi"
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Artikel ; Online: Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation

Gabriele Pagani / Andrea Giacomelli / Federico Conti / Dario Bernacchia / Rossana Rondanin / Andrea Prina / Vittore Scolari / Arianna Rizzo / Martina Beltrami / Camilla Caimi / Cecilia Eugenia Gandolfi / Silvana Castaldi / Bruno Alessandro Rivieccio / Giacomo Buonanno / Giuseppe Marano / Cosimo Ottomano / Patrizia Boracchi / Elia Biganzoli / Massimo Galli

PLoS ONE, Vol 16, Iss 2, p e

Mass seroepidemiological screening in Castiglione d'Adda, Italy.

2021  Band 0246513

Abstract: Castiglione D'Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic in Lombardy. With our study we aimed to understand the diffusion of the infection by mass ...

Abstract Castiglione D'Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic in Lombardy. With our study we aimed to understand the diffusion of the infection by mass serological screening. We searched for SARS-CoV-2 IgGs in the entire population on a voluntary basis using lateral flow immunochromatographic tests (RICT) on capillary blood (rapid tests). We then performed chemioluminescent serological assays (CLIA) and naso-pharyngeal swabs (NPS) in a randomized representative sample and in each subject with a positive rapid test. Factors associated with RICT IgG positivity were assessed by uni- and multivariate logistic regression models. Out of the 4143 participants, 918 (22·2%) showed RICT IgG positivity. In multivariable analysis, IgG positivity increases with age, with a significant non-linear effect (p = 0·0404). We found 22 positive NPSs out of the 1330 performed. Albeit relevant, the IgG prevalence is lower than expected and suggests that a large part of the population remains susceptible to the infection. The observed differences in prevalence might reflect a different infection susceptibility by age group. A limited persistence of active infections could be found after several weeks after the epidemic peak in the area.
Schlagwörter Medicine ; R ; Science ; Q
Sprache Englisch
Erscheinungsdatum 2021-01-01T00:00:00Z
Verlag Public Library of Science (PLoS)
Dokumenttyp Artikel ; Online
Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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