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Article ; Online: Effects of a beaver dam on the benthic copepod assemblage of a Mediterranean river.

Di Lorenzo, T / Tabilio Di Camillo, A / Mori, E / Viviano, A / Mazza, G / Pontalti, A / Rogora, M / Fiasca, B / Di Cicco, M / Galassi, D M P

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8956

Abstract: As known "ecosystem engineers", beavers influence river hydrology, geomorphology, biochemistry, and biological assemblages. However, there is a lack of research regarding the effects of beaver activities on freshwater meiofauna. In this study, we ... ...

Abstract	As known "ecosystem engineers", beavers influence river hydrology, geomorphology, biochemistry, and biological assemblages. However, there is a lack of research regarding the effects of beaver activities on freshwater meiofauna. In this study, we investigated the taxonomic and functional composition of the benthic copepod assemblage of a segment of the Tiber River (Italy) where a beaver dam, created about 7 weeks before our survey, had formed a semi-lentic habitat upstream and a lotic habitat downstream of the dam. We also analyzed the copepod assemblage before and after a flood event that destroyed the beaver dam, providing a unique opportunity to observe changes in a naturally reversing scenario. Our analyses revealed that, while the taxonomic composition and functional traits of the copepod assemblage remained largely unchanged across the recently formed semi-lentic and lotic habitats, substantial differences were evident between the dammed and undammed states. The dammed state showed lower copepod abundances, biomass, and functionality than the undammed one. These results highlight the role of beaver dams in changing the composition and functionality of meiofaunal assemblages offering insights into the dynamic interactions within aquatic ecosystems.
MeSH term(s)	Animals ; Ecosystem ; Copepoda ; Rodentia ; Rivers ; Biomass
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59456-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Modeling Stygofauna Resilience to the Impact of the Climate Change in the Karstic Groundwaters of South Italy

Tabilio Di Camillo, Agostina / Masciopinto, Costantino

Water. 2022 Aug. 31, v. 14, no. 17

2022

Abstract: We predicted the global warming effects on the stygofauna of Murgia–Salento karstic groundwaters in Italy for 2050, which contribute to a biodiversity loss assessment in the climate change context. For quantitative impact estimations, we defined a local ... ...

Abstract	We predicted the global warming effects on the stygofauna of Murgia–Salento karstic groundwaters in Italy for 2050, which contribute to a biodiversity loss assessment in the climate change context. For quantitative impact estimations, we defined a local resilience score (LRS) for sampled species between 2018 and 2021. A resilience model equation of the stygobiont species conservation was obtained from a surface best-fit of the assigned LRS and the corresponding values of independent variables describing the environmental quality of monitored habitats and LRS. The principal components of the correlation between the monitored variables and LRS were obtained via factor analysis. Three-dimensional surface maps of stygofauna species resilience (SSR) were constructed to visualize and quantitatively compare the biodiversity loss of species assemblages owing to environmental and habitat quality modifications. The proposed SSR model was applied to the sampled stygofauna, and the decrease in local species resilience for 2050 was predicted. Independent variable factors were updated for 2050 to consider increases of up to 2 °C and 0.04 mS/cm in groundwater temperature and electric conductance observed for 2021. The SSR model results predicted a high impact on the resilience of Parastenocaris cf. orcina (80%), newly retrieved Crustacea Copepod Cyclopidae gen 1 sp 1, and three other stygobites (~50%). The resilience of Metacyclops stammeri had minor impacts.
Keywords	Cyclopidae ; aquifers ; biodiversity ; climate change ; electrical conductivity ; environmental quality ; equations ; factor analysis ; groundwater ; habitats ; models ; temperature ; Italy
Language	English
Dates of publication	2022-0831
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w14172715
Database	NAL-Catalogue (AGRICOLA)

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Article: Generational cohort theory and wine: analyzing how gen Z differs from other American wine consuming generations

Thach, L. / Riewe, S. / Camillo, A.

International Journal of Wine Business Research

2021 Volume 33, Issue 1, Page(s) 1–27

Abstract: Generation cohort theory; Gen Z; market segmentation; wine consumers behavior; surveys; United states of America; wines; survey research. ...

Institution	Sonoma State University, Rohnert Park, California, USA
Abstract	Generation cohort theory; Gen Z; market segmentation; wine consumers behavior; surveys; United states of America; wines; survey research.
Language	English
Document type	Article
ZDB-ID	2279092-5
ISSN	1751-1070 ; 1751-1062
ISSN (online)	1751-1070
ISSN	1751-1062
Database	Viticulture and Oenology Abstracts

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Article ; Online: Lead Bioaccumulation and Translocation in Herbaceous Plants Grown in Urban and Peri-Urban Soil and the Potential Human Health Risk

Ada Baldi / Stefano Cecchi / Chiara Grassi / Camillo A. Zanchi / Simone Orlandini / Marco Napoli

Agronomy, Vol 11, Iss 2444, p

2021 Volume 2444

Abstract: Lead (Pb) contamination risks to crops grown in urban and peri-urban soils is a great concern that should be better evaluated to define the Pb maximum levels in soils for safe cultivation and to identify suitable strategies to remediate Pb polluted urban ...

Abstract	Lead (Pb) contamination risks to crops grown in urban and peri-urban soils is a great concern that should be better evaluated to define the Pb maximum levels in soils for safe cultivation and to identify suitable strategies to remediate Pb polluted urban soils. The objective of this work was to evaluate the potential risk for human health from the ingestion of the edible portions of barley, castor bean, common bean, Indian mustard, sorghum, spinach, and tomato grown in an unpolluted soil (initial Pb content 32.6 mg kg −1 ) spiked with 0, 300, 650, 1000 mg Pb kg −1 , respectively. The potential possibility of using these plants to phyto-remediate the soil of Pb was also assessed. Pot trials were conducted for two years (2008 and 2009). Results highlighted that all the investigated species were able to attain growth to maturity in high Pb spiked soil, although Pb influenced dry matter accumulation. Even in soils with low Pb concentrations, Pb accumulated the edible parts. Noteworthy, even in untreated control soils, all tested species revealed a Pb concentration in the edible parts that was higher than the safe limit set by FAO/WHO. None of the investigated species were considered Pb hyperaccumulators, but all were shown to be potentially suitable for phyto-stabilization.
Keywords	lead toxicity ; urban agriculture ; soil pollution ; lead bioconcentration ; foodstuff ; Agriculture ; S
Subject code	333
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage.

Ma, Kaige / Pham, Tiep / Wang, Jun / O-Sullivan, InSug / DiCamillo, Amy / Du, Shiyu / Mwale, Fackson / Farooqui, Zeba / Votta-Velis, Gina / Bruce, Benjamin / van Wijnen, Andre J / Liu, Ying / Im, Hee-Jeong

Science advances

2024 Volume 10, Issue 7, Page(s) eadi5501

Abstract: Osteoarthritis (OA) is characterized by cartilage damage, inflammation, and pain. Vascular endothelial growth factor receptors (VEGFRs) have been associated with OA severity, suggesting that inhibitors targeting these receptors alleviate pain (via VEGFR1) ...

Abstract	Osteoarthritis (OA) is characterized by cartilage damage, inflammation, and pain. Vascular endothelial growth factor receptors (VEGFRs) have been associated with OA severity, suggesting that inhibitors targeting these receptors alleviate pain (via VEGFR1) or cartilage degeneration (via VEGFR2). We have developed a nanoparticle-based formulation of pazopanib (Votrient), an FDA-approved anticancer drug that targets both VEGFR1 and VEGFR2 (Nano-PAZII). We demonstrate that a single intraarticular injection of Nano-PAZII can effectively reduce joint pain for a prolonged time without substantial side effects in two different preclinical OA rodent models involving either surgical (upon partial medial meniscectomy) or nonsurgical induction (with monoiodoacetate). The injection of Nano-PAZII blocks VEGFR1 and relieves OA pain by suppressing sensory neuronal ingrowth into the knee synovium and neuronal plasticity in the dorsal root ganglia and spinal cord. Simultaneously, the inhibition of VEGFR2 reduces cartilage degeneration. These findings provide a mechanism-based disease-modifying drug strategy that addresses both pain symptoms and cartilage loss in OA.
MeSH term(s)	Animals ; Vascular Endothelial Growth Factor A/metabolism ; Osteoarthritis/drug therapy ; Osteoarthritis/etiology ; Osteoarthritis/metabolism ; Pain/drug therapy ; Pain/etiology ; Knee Joint/metabolism ; Arthralgia ; Disease Models, Animal
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adi5501
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Article: Lead Bioaccumulation and Translocation in Herbaceous Plants Grown in Urban and Peri-Urban Soil and the Potential Human Health Risk

Baldi, Ada / Cecchi, Stefano / Grassi, Chiara / Zanchi, Camillo A. / Orlandini, Simone / Napoli, Marco

Agronomy. 2021 Nov. 30, v. 11, no. 12

2021

Abstract	Lead (Pb) contamination risks to crops grown in urban and peri-urban soils is a great concern that should be better evaluated to define the Pb maximum levels in soils for safe cultivation and to identify suitable strategies to remediate Pb polluted urban soils. The objective of this work was to evaluate the potential risk for human health from the ingestion of the edible portions of barley, castor bean, common bean, Indian mustard, sorghum, spinach, and tomato grown in an unpolluted soil (initial Pb content 32.6 mg kg⁻¹) spiked with 0, 300, 650, 1000 mg Pb kg⁻¹, respectively. The potential possibility of using these plants to phyto-remediate the soil of Pb was also assessed. Pot trials were conducted for two years (2008 and 2009). Results highlighted that all the investigated species were able to attain growth to maturity in high Pb spiked soil, although Pb influenced dry matter accumulation. Even in soils with low Pb concentrations, Pb accumulated the edible parts. Noteworthy, even in untreated control soils, all tested species revealed a Pb concentration in the edible parts that was higher than the safe limit set by FAO/WHO. None of the investigated species were considered Pb hyperaccumulators, but all were shown to be potentially suitable for phyto-stabilization.
Keywords	Brassica juncea ; agronomy ; barley ; beans ; bioaccumulation ; castor beans ; dry matter accumulation ; human health ; hyperaccumulators ; ingestion ; risk ; spinach ; tomatoes
Language	English
Dates of publication	2021-1130
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2607043-1
ISSN	2073-4395
ISSN	2073-4395
DOI	10.3390/agronomy11122444
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A PDK-1 allosteric agonist improves spatial learning and memory in a βAPP/PS-1 transgenic mouse-high fat diet intervention model of Alzheimer's disease.

Querfurth, Henry / Slitt, Angela / DiCamillo, Amy / Surles, Nathan / DeBoef, Brenton / Lee, Han-Kyu

Behavioural brain research

2022 Volume 438, Page(s) 114183

Abstract: Diabetes mellitus (DM), peripheral insulin resistance (IR) and obesity are clear risk factors for Alzheimer's disease. Several anti-diabetic drugs and insulin have been tested in rodents and humans with MCI or AD, yielding promising but inconclusive ... ...

Abstract	Diabetes mellitus (DM), peripheral insulin resistance (IR) and obesity are clear risk factors for Alzheimer's disease. Several anti-diabetic drugs and insulin have been tested in rodents and humans with MCI or AD, yielding promising but inconclusive results. The PDK-1/Akt axis, essential to the action of insulin, has not however been pharmacologically interrogated to a similar degree. Our previous cell culture and in vitro studies point to such an approach. Double transgenic APPsw/PSENdE9 mice, a model for Alzheimer's disease, were used to test the oral administration of PS48, a PDK-1 agonist, on preventing the expected decline in learning and memory in the Morris Water Maze (MWM). Mice were raised on either standard (SD) or high fat (HFD) diets, dosed beginning 10 months age and tested at an advanced age of 14 months. PS48 had positive effects on learning the spatial location of a hidden platform in the TG animals, on either SD or HFD, compared to vehicle diet and WT animals. On several measures of spatial memory following successful acquisition (probe trials), the drug also proved significantly beneficial to animals on either diet. The PS48 treatment-effect size was more pronounced in the TG animals on HFD compared to on SD in several of the probe measures. HFD produced some of the intended metabolic effects of weight gain and hyperglycemia, as well as accelerating cognitive impairment in the TG animals. PS48 was found to have added value in modestly reducing body weights and improving OGTT responses in TG groups although results were not definitive. PS48 was well tolerated without obvious clinical signs or symptoms and did not itself affect longevity. These results recommend a larger preclinical study before human trial.
MeSH term(s)	Animals ; Mice ; Alzheimer Disease/drug therapy ; Diet, High-Fat/adverse effects ; Insulin ; Mice, Transgenic ; Spatial Learning
Chemical Substances	Insulin
Language	English
Publishing date	2022-10-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2022.114183
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Article: Some like it hot: Thermal preference of the groundwater amphipod Niphargus longicaudatus (Costa, 1851) and climate change implications.

Di Cicco, Mattia / Di Lorenzo, Tiziana / Fiasca, Barbara / Galmarini, Emma / Vaccarelli, Ilaria / Cerasoli, Francesco / Tabilio Di Camillo, Agostina / Galassi, Diana Maria Paola

Journal of thermal biology

2023 Volume 116, Page(s) 103654

Abstract: Groundwater is a crucial resource for humans and the environment, but its global human demand currently exceeds available volumes by 3.5 times. Climate change is expected to exacerbate this situation by increasing the frequency of droughts along with ... ...

Abstract	Groundwater is a crucial resource for humans and the environment, but its global human demand currently exceeds available volumes by 3.5 times. Climate change is expected to exacerbate this situation by increasing the frequency of droughts along with human impacts on groundwater ecosystems. Despite prior research on the quantitative effects of climate change on groundwater, the direct impacts on groundwater biodiversity, especially obligate groundwater species, remain largely unexplored. Therefore, investigating the potential impacts of climate change, including groundwater temperature changes, is crucial for the survival of obligate groundwater species. This study aimed to determine the thermal niche breadth of the crustacean amphipod species Niphargus longicaudatus by using the chronic method. We found that N. longicaudatus has a wide thermal niche with a natural performance range of 7-9 °C, which corresponds to the thermal regime this species experiences within its distribution range in Italy. The observed range of preferred temperature (PT) was different from the mean annual temperature of the sites from which the species has been collected, challenging the idea that groundwater species are only adapted to narrow temperature ranges. Considering the significant threats of climate change to groundwater ecosystems, these findings provide crucial information for the conservation of obligate groundwater species, suggesting that some of them may be more resilient to temperature changes than previously thought. Understanding the fundamental thermal niche of these species can inform conservation efforts and management strategies to protect groundwater ecosystems and their communities.
MeSH term(s)	Animals ; Humans ; Ecosystem ; Climate Change ; Amphipoda ; Biodiversity ; Groundwater ; Temperature
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1498364-3
ISSN	1879-0992 ; 0306-4565
ISSN (online)	1879-0992
ISSN	0306-4565
DOI	10.1016/j.jtherbio.2023.103654
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Article: Phytoextraction of copper from a contaminated soil using arable and vegetable crops

Napoli, Marco / Ada Baldi / Camillo A. Zanchi / Chiara Grassi / Simone Orlandini / Stefano Cecchi

Chemosphere. 2019 Mar., v. 219

2019

Abstract: Copper (Cu) is among the main contaminant of agricultural soil. The reclamation of Cu polluted soils can be achieved with phytoextraction even if, in general, plants are Cu-excluders and uncommon are Cu-accumulators. The research objectives were to ... ...

Abstract	Copper (Cu) is among the main contaminant of agricultural soil. The reclamation of Cu polluted soils can be achieved with phytoextraction even if, in general, plants are Cu-excluders and uncommon are Cu-accumulators. The research objectives were to establish the Cu removal capacity by arable and vegetable crops and to investigate the distribution of Cu in their roots, stems and leaves, and fruits. Pot trials were conducted for two subsequent years in Tuscany (Italy). Cu was added into soil in four levels (0, 200, 400, 600 mg kg−1 of Cu). At harvesting, the crops roots, stems and leaves, and fruits or seeds were separately collected, oven dried, weighted, milled and separately analyzed.The results show that the GDUs value to reach the physiological maturity for barley, common bean, Indian mustard, and ricinus was significantly positively correlated with Cu concentration in soil in contrast with observed in sorghum, spinach, and tomato. Leaves and stems of spinach and ricinus have a good storage capacity in contrast with common bean, tomato, Indian mustard sorghum and barley. Tomato storage Cu mainly in fruits and roots which show a remarkable concentration of Cu that increases progressively with the increase of Cu concentration in the soil. In addition, the roots of common bean and ricinus showed a very high concentration of Cu. All species can be considered Cu-excluders because of their low capacity to uptake high quantity of Cu. Indian mustard can be considered a plant able to translocate the metal from root to epigeal tissue.
Keywords	agricultural soils ; barley ; beans ; Brassica juncea ; copper ; fruits ; harvesting ; leaves ; ovens ; phytoaccumulation ; polluted soils ; roots ; seeds ; spinach ; stems ; tomatoes ; vegetable crops ; Italy
Language	English
Dates of publication	2019-03
Size	p. 122-129.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2018.12.017
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2540: Show issues

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Article ; Online: A Mouse Model of Furosemide-Induced Overactive Bladder.

Saporito, Michael S / Zuvich, Eva / DiCamillo, Amy

Current protocols in pharmacology

2016 Volume 74, Page(s) 5.68.1–5.68.11

Abstract: Detailed in this unit is a mouse model of overactive bladder and urinary incontinence based on diuretic stress-induced urination. The procedure involves the use of a unique, highly sensitive, and automated urine capturing method to measure urinary ... ...

Abstract	Detailed in this unit is a mouse model of overactive bladder and urinary incontinence based on diuretic stress-induced urination. The procedure involves the use of a unique, highly sensitive, and automated urine capturing method to measure urinary latency, frequency, and void volume. Although this method was first described and validated using an anti-muscarinic drug used for treating overactive bladder, subsequent work has shown that effective non-cholinergic agents can be detected. These findings indicate good predictive value for this model regarding the possible clinical utility of test agents as treatments for overactive bladder, regardless of their site of action. © 2016 by John Wiley & Sons, Inc.
MeSH term(s)	Animals ; Disease Models, Animal ; Furosemide ; Male ; Mice ; Muscarinic Antagonists/therapeutic use ; Urinary Bladder ; Urinary Bladder, Overactive/chemically induced ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder, Overactive/physiopathology ; Urinary Incontinence/drug therapy ; Urination
Chemical Substances	Muscarinic Antagonists ; Furosemide (7LXU5N7ZO5)
Language	English
Publishing date	2016-09-16
Publishing country	United States
Document type	Journal Article
ISSN	1934-8290
ISSN (online)	1934-8290
DOI	10.1002/cpph.10
Database	MEDical Literature Analysis and Retrieval System OnLINE

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