LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex

    Cheng Tang / Roger Herikstad / Aishwarya Parthasarathy / Camilo Libedinsky / Shih-Cheng Yen

    eLife, Vol

    2020  Volume 9

    Abstract: The lateral prefrontal cortex is involved in the integration of multiple types of information, including working memory and motor preparation. However, it is not known how downstream regions can extract one type of information without interference from ... ...

    Abstract The lateral prefrontal cortex is involved in the integration of multiple types of information, including working memory and motor preparation. However, it is not known how downstream regions can extract one type of information without interference from the others present in the network. Here, we show that the lateral prefrontal cortex of non-human primates contains two minimally dependent low-dimensional subspaces: one that encodes working memory information, and another that encodes motor preparation information. These subspaces capture all the information about the target in the delay periods, and the information in both subspaces is reduced in error trials. A single population of neurons with mixed selectivity forms both subspaces, but the information is kept largely independent from each other. A bump attractor model with divisive normalization replicates the properties of the neural data. These results provide new insights into neural processing in prefrontal regions.
    Keywords working memory ; motor preparation ; lateral prefrontal cortex ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Time-invariant working memory representations in the presence of code-morphing in the lateral prefrontal cortex

    Aishwarya Parthasarathy / Cheng Tang / Roger Herikstad / Loong Fah Cheong / Shih-Cheng Yen / Camilo Libedinsky

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Working memory is maintained in the recurrent connectivity of prefrontal neurons; however, distractors lead to a morphing of the population code. Here, the authors show that a low dimensional subspace of activity maintains memory information even with a ... ...

    Abstract Working memory is maintained in the recurrent connectivity of prefrontal neurons; however, distractors lead to a morphing of the population code. Here, the authors show that a low dimensional subspace of activity maintains memory information even with a distractor and can be modeled as a bump attractor.
    Keywords Science ; Q
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Time-invariant working memory representations in the presence of code-morphing in the lateral prefrontal cortex

    Aishwarya Parthasarathy / Cheng Tang / Roger Herikstad / Loong Fah Cheong / Shih-Cheng Yen / Camilo Libedinsky

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Working memory is maintained in the recurrent connectivity of prefrontal neurons; however, distractors lead to a morphing of the population code. Here, the authors show that a low dimensional subspace of activity maintains memory information even with a ... ...

    Abstract Working memory is maintained in the recurrent connectivity of prefrontal neurons; however, distractors lead to a morphing of the population code. Here, the authors show that a low dimensional subspace of activity maintains memory information even with a distractor and can be modeled as a bump attractor.
    Keywords Science ; Q
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures.

    Shuang Wu / Kah Junn Tan / Lakshmi Narasimhan Govindarajan / James Charles Stewart / Lin Gu / Joses Wei Hao Ho / Malvika Katarya / Boon Hui Wong / Eng-King Tan / Daiqin Li / Adam Claridge-Chang / Camilo Libedinsky / Li Cheng / Sherry Shiying Aw

    PLoS Biology, Vol 17, Iss 6, p e

    2019  Volume 3000346

    Abstract: Some neurodegenerative diseases, like Parkinsons Disease (PD) and Spinocerebellar ataxia 3 (SCA3), are associated with distinct, altered gait and tremor movements that are reflective of the underlying disease etiology. Drosophila melanogaster models of ... ...

    Abstract Some neurodegenerative diseases, like Parkinsons Disease (PD) and Spinocerebellar ataxia 3 (SCA3), are associated with distinct, altered gait and tremor movements that are reflective of the underlying disease etiology. Drosophila melanogaster models of neurodegeneration have illuminated our understanding of the molecular mechanisms of disease. However, it is unknown whether specific gait and tremor dysfunctions also occur in fly disease mutants. To answer this question, we developed a machine-learning image-analysis program, Feature Learning-based LImb segmentation and Tracking (FLLIT), that automatically tracks leg claw positions of freely moving flies recorded on high-speed video, producing a series of gait measurements. Notably, unlike other machine-learning methods, FLLIT generates its own training sets and does not require user-annotated images for learning. Using FLLIT, we carried out high-throughput and high-resolution analysis of gait and tremor features in Drosophila neurodegeneration mutants for the first time. We found that fly models of PD and SCA3 exhibited markedly different walking gait and tremor signatures, which recapitulated characteristics of the respective human diseases. Selective expression of mutant SCA3 in dopaminergic neurons led to a gait signature that more closely resembled those of PD flies. This suggests that the behavioral phenotype depends on the neurons affected rather than the specific nature of the mutation. Different mutations produced tremors in distinct leg pairs, indicating that different motor circuits were affected. Using this approach, fly models can be used to dissect the neurogenetic mechanisms that underlie movement disorders.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Independent Mobility Achieved through a Wireless Brain-Machine Interface.

    Camilo Libedinsky / Rosa So / Zhiming Xu / Toe K Kyar / Duncun Ho / Clement Lim / Louiza Chan / Yuanwei Chua / Lei Yao / Jia Hao Cheong / Jung Hyup Lee / Kulkarni Vinayak Vishal / Yongxin Guo / Zhi Ning Chen / Lay K Lim / Peng Li / Lei Liu / Xiaodan Zou / Kai K Ang /
    Yuan Gao / Wai Hoe Ng / Boon Siew Han / Keefe Chng / Cuntai Guan / Minkyu Je / Shih-Cheng Yen

    PLoS ONE, Vol 11, Iss 11, p e

    2016  Volume 0165773

    Abstract: Individuals with tetraplegia lack independent mobility, making them highly dependent on others to move from one place to another. Here, we describe how two macaques were able to use a wireless integrated system to control a robotic platform, over which ... ...

    Abstract Individuals with tetraplegia lack independent mobility, making them highly dependent on others to move from one place to another. Here, we describe how two macaques were able to use a wireless integrated system to control a robotic platform, over which they were sitting, to achieve independent mobility using the neuronal activity in their motor cortices. The activity of populations of single neurons was recorded using multiple electrode arrays implanted in the arm region of primary motor cortex, and decoded to achieve brain control of the platform. We found that free-running brain control of the platform (which was not equipped with any machine intelligence) was fast and accurate, resembling the performance achieved using joystick control. The decoding algorithms can be trained in the absence of joystick movements, as would be required for use by tetraplegic individuals, demonstrating that the non-human primate model is a good pre-clinical model for developing such a cortically-controlled movement prosthetic. Interestingly, we found that the response properties of some neurons differed greatly depending on the mode of control (joystick or brain control), suggesting different roles for these neurons in encoding movement intention and movement execution. These results demonstrate that independent mobility can be achieved without first training on prescribed motor movements, opening the door for the implementation of this technology in persons with tetraplegia.
    Keywords Medicine ; R ; Science ; Q
    Subject code 629
    Language English
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Undergraduate teaching of evolution in chile

    PATRICIO AHUMADA / GUADALUPE ASTORGA / KESTER BULL-HEREÑU / RICARDO CABRERA / LUCIANO CAPUTO / CARLOS CARMONA / M. CLAUDIA CECCHI / NELSON CORTÉS / SOLEDAD CORTEZ / CRISTINA DORADOR / FELIPE FREDES / CARLOS GUERRERO-BOSAGNA / PABLO HENNY / CAMILO LIBEDINSKY / WARA MARCELO / I. NATALIA MÁRQUEZ / JAIME MARTÍNEZ / MAURICIO MEDINA / DANIELA PARRA /
    NÉLIDA POHL / HANS POTTSTOCK / TOMÁS OSSANDÓN / PABLO RAZETO / DAVID RUBILAR / CARLOS SALAS / FERNANDA SALINAS / ESTEBAN SEPÚLVEDA / CAROLINA SOTO / RODRIGO SUÁREZ / ALEXANDER VARGAS / TOMÁS VEGA-ZÚNIGA / NELSON VELÁSQUEZ / JUAN VIDAL / CRISTIÁN A. VILLAGRA / CAMILA P. VILLAVICENCIO

    Revista Chilena de Historia Natural, Vol 78, Iss 1, Pp 169-

    more than natural selection Enseñanza de la evolución en Chile: más que selección natural

    2005  Volume 170

    Keywords Zoology ; QL1-991 ; Botany ; QK1-989
    Language English
    Publishing date 2005-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top