Article ; Online: Functionality of retinal vessels in central serous retinopathy: A comparison between eplerenone and photodynamic therapy.
European journal of ophthalmology
2022 Volume 33, Issue 3, Page(s) 1443–1451
Abstract: Purpose: To investigate retinal vessels functionality in patients with acute central serous chorioretinopathy (CSC) undergoing oral eplerenone or photodynamic therapy (PDT) using Retinal Vessel Analyzer (RVA) and Dynamic Vessel Analyzer (DVA), ... ...
| Abstract | Purpose: To investigate retinal vessels functionality in patients with acute central serous chorioretinopathy (CSC) undergoing oral eplerenone or photodynamic therapy (PDT) using Retinal Vessel Analyzer (RVA) and Dynamic Vessel Analyzer (DVA), respectively. Methods: Treatment naïve acute CSC patients presenting between May 2017 and June 2017 were recruited. A complete ophthalmological examination was performed in all participants before and after oral eplerenone (eplerenone group) or half-dose PDT (PDT group). Results: Eighteen eyes of 18 patients affected by acute CSC underwent either oral eplerenone (10 eyes of 10 patients, 47.6 ± 8.9 years old) or half-dose PDT (8 eyes of 8 patients, 57.4 ± 6.2 years old), respectively. After 2 months of treatment, non-significant variations of static retinal vessels analysis, dynamic arterial and venous dilatation were reported in eplerenone group. Similarly, in PDT group non-significant variations of static retinal vessels analysis, dynamic arterial and venous dilatation were found after 2 months of treatment. Conclusions: Static and dynamic retinal functionalities in acute CSC may not be significantly improved by oral eplerenone and half-dose PDT. Although their choroidal effects, these treatments could not exert a significant effect on retinal vessels motility. Thus, both local and systemic therapies might not help avoiding the onset of vascular and other retinal known alterations of CSC. |
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| MeSH term(s) | Humans ; Adult ; Middle Aged ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/drug therapy ; Eplerenone/therapeutic use ; Photochemotherapy ; Fluorescein Angiography ; Tomography, Optical Coherence ; Retinal Vessels ; Photosensitizing Agents/therapeutic use ; Porphyrins/therapeutic use ; Chronic Disease | |||||
| Chemical Substances | Eplerenone (6995V82D0B) ; Photosensitizing Agents ; Porphyrins | |||||
| Language | English | |||||
| Publishing date | 2022-12-12 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1089461-5 | |||||
| ISSN | 1724-6016 ; 1120-6721 | |||||
| ISSN (online) | 1724-6016 | |||||
| ISSN | 1120-6721 | |||||
| DOI | 10.1177/11206721221145049 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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