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  1. Article: Towards an operational irrigation management system for Sweden with a water–food–energy nexus perspective

    Campana, P.E. / Lastanao, P. / Zainali, S. / Zhang, J. / Landelius, T. / Melton, F.

    Agricultural water management. 2022 May 16,

    2022  

    Abstract: The 2018 drought in Sweden prompted questions about climate-adaptation and -mitigation measures – especially in the agricultural sector, which suffered the most. This study applies a water–food–energy nexus modelling framework to evaluate drought impacts ...

    Abstract The 2018 drought in Sweden prompted questions about climate-adaptation and -mitigation measures – especially in the agricultural sector, which suffered the most. This study applies a water–food–energy nexus modelling framework to evaluate drought impacts on irrigation and agriculture in Sweden using 2018 and 2019 as case studies. A previous water–food–energy nexus model was updated to facilitate an investigation of the benefits of data-driven irrigation scheduling as compared to existing irrigation guidelines. Moreover, the benefits of assimilating earth observation data in the crop model have been explored. The assimilation of leaf area index data from the Copernicus Global Land Service improves the crop yield estimation as compared to default crop model parameters. The results show that the irrigation water productivities of the proposed model are measurably improved compared to conventional and static irrigation guidelines for both 2018 and 2019. This is mostly due to the advantage of the proposed model in providing ETc-driven guidelines by using spatially explicit data generated by mesoscale models from the Swedish Meteorological and Hydrological Institute. During the drought year 2018, the developed model showed no irrigation water savings as compared to irrigation scenarios based on conventional irrigation guidelines. Nevertheless, the crop yield increase from the proposed irrigation management system varied between 10% and 60% as compared to conventional irrigation scenarios. During a normal year, the proposed irrigation management system leads to significant water savings as compared to conventional irrigation guidelines. The modelling results show that temperature stress during the 2018 drought also played a key role in reducing crop yields, with yield reductions of up to 30%. From a water–food–energy nexus, this motivates the implementation of new technologies to reduce water and temperature stress to mitigate likely negative effects of climate change and extremes. By using an open-source package for Google Earth®, a prototype of cost-effective visualization platform is developed for helping farmers, and water- and energy-management agencies to better understand the connections between water and energy use, and food production. This can be significant, especially during the occurrence of extreme events, but also to adapt to the negative effects on agricultural production of climate changes.
    Keywords agricultural industry ; climate ; climate change ; cost effectiveness ; crop models ; crop yield ; drought ; energy ; food production ; irrigation water ; leaf area index ; management systems ; prototypes ; temperature ; Sweden
    Language English
    Dates of publication 2022-0516
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 751144-9
    ISSN 1873-2283 ; 0378-3774
    ISSN (online) 1873-2283
    ISSN 0378-3774
    DOI 10.1016/j.agwat.2022.107734
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Can aldosterone increase interleukin-6 levels in Covid-19 pneumonia?

    Campana, Pasquale / Flocco, Veronica / Aruta, Francesco / Cacciatore, Francesco / Abete, Pasquale

    Journal of medical virology

    2020  Volume 93, Issue 2, Page(s) 622–623

    MeSH term(s) Aldosterone/blood ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/immunology ; Cytokine Release Syndrome/immunology ; Female ; Guillain-Barre Syndrome/etiology ; Humans ; Interleukin-6/blood ; Middle Aged ; Receptors, Interleukin-6/blood
    Chemical Substances IL6 protein, human ; IL6R protein, human ; Interleukin-6 ; Receptors, Interleukin-6 ; Aldosterone (4964P6T9RB)
    Keywords covid19
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dendritic Cells and SARS-CoV-2 Infection

    Campana, P. / Parisi, V. / Leosco, D. / Bencivenga, D. / Della Ragione, F. / Borriello, A.

    Still an Unclarified Connection

    2020  

    Abstract: The ongoing pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has so far infected about 2.42 × 107 (as at 27 August 2020) subjects with more than 820,000 deaths. It is the third zoonotic coronavirus-dependent outbreak in the ... ...

    Abstract The ongoing pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has so far infected about 2.42 × 107 (as at 27 August 2020) subjects with more than 820,000 deaths. It is the third zoonotic coronavirus-dependent outbreak in the last twenty years and represents a major infective threat for public health worldwide. A main aspect of the infection, in analogy to other viral infections, is the so-called "cytokine storm", an inappropriate molecular response to virus spread which plays major roles in tissue and organ damage. Immunological therapies, including vaccines and humanized monoclonal antibodies, have been proposed as major strategies for prevention and treatment of the disease. Accordingly, a detailed mechanistic knowledge of the molecular events with which the virus infects cells and induces an immunological response appears necessary. In this review, we will report details of the initial process of SARS-CoV-2 cellular entry with major emphasis on the maturation of the spike protein. Then, a particular focus will be devoted to describe the possible mechanisms by which dendritic cells, a major cellular component of innate and adaptive immune responses, may play a role in the spread of the virus in the human body and in the clinical evolution of the disease.
    Keywords Covid-19 ; DC-SIGN ; dendritic cells ; SARS-CoV-2 ; spike protein ; covid19
    Subject code 610
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Aortic rupture in patient on oral therapy with levofloxacin.

    Campana, Pasquale / Leosco, Dario / Petraglia, Laura / Radice, Leonardo / Parisi, Valentina

    Aging clinical and experimental research

    2019  Volume 32, Issue 4, Page(s) 755–757

    Language English
    Publishing date 2019-07-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-019-01267-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dendritic Cells and SARS-CoV-2 Infection: Still an Unclarified Connection.

    Campana, Pasquale / Parisi, Valentina / Leosco, Dario / Bencivenga, Debora / Della Ragione, Fulvio / Borriello, Adriana

    Cells

    2020  Volume 9, Issue 9

    Abstract: The ongoing pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has so far infected about 2.42 × ... ...

    Abstract The ongoing pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has so far infected about 2.42 × 10
    MeSH term(s) Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Dendritic Cells/virology ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Pyroptosis ; Renin-Angiotensin System ; SARS-CoV-2 ; Virus Internalization
    Keywords covid19
    Language English
    Publishing date 2020-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9092046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The elderly at risk: aldosterone as modulator of the immune response to SARS-CoV-2 infection.

    Campana, Pasquale / Palaia, Maria Emiliana / Conte, Maddalena / Cante, Teresa / Petraglia, Laura / Femminella, Grazia Daniela / Parisi, Valentina / Leosco, Dario

    GeroScience

    2021  Volume 44, Issue 2, Page(s) 567–572

    Abstract: The elderly population is the most susceptible to SARS-CoV-2 infection and develops the worst clinical phenotype with severe pneumonia and cardiac complications. Older COVID-19 patients are also at higher risk of sudden death, mainly attributable to ... ...

    Abstract The elderly population is the most susceptible to SARS-CoV-2 infection and develops the worst clinical phenotype with severe pneumonia and cardiac complications. Older COVID-19 patients are also at higher risk of sudden death, mainly attributable to electrolyte disorders and to an uncontrolled inflammatory response. After the identification of ACE 2 as the receptor of SARS-CoV-2 in human cells, several research studies have focused on the role of the activation of Renin Angiotensin System in COVID-19 clinical course. In the present opinion paper, we discuss the role of hyperaldosteronism in the increasing risk of cardiac complications in COVID-19 older patients. In particular, we focus on the immunoregulatory activity of aldosterone, as the last mediator of the Renin Angiotensin System cascade, in activating the innate and adaptive immune response related to SARS-CoV-2 infection in the elderly. Aldosterone may stimulate dendritic cells and the recruitment of monocytes/macrophages in the endothelium of coronary vessels, favoring the production of pro-inflammatory mediators and T-cells response. Higher basal levels of aldosterone together with SARS-CoV-2-induced production may explain the unfavorable course of COVID-19 in the elderly.
    MeSH term(s) Adaptive Immunity ; Aged ; Aldosterone ; COVID-19 ; Humans ; Renin-Angiotensin System/physiology ; SARS-CoV-2
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2021-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-021-00481-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Can aldosterone increase interleukin‐6 levels in Covid‐19 pneumonia?

    Campana, Pasquale / Flocco, Veronica / Aruta, Francesco / Cacciatore, Francesco / Abete, Pasquale

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26382
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Epicardial Adipose Tissue and Postoperative Atrial Fibrillation.

    Petraglia, Laura / Conte, Maddalena / Comentale, Giuseppe / Cabaro, Serena / Campana, Pasquale / Russo, Carmela / Amaranto, Ilaria / Bruzzese, Dario / Formisano, Pietro / Pilato, Emanuele / Ferrara, Nicola / Leosco, Dario / Parisi, Valentina

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 810334

    Abstract: Background: Atrial fibrillation (AF) often occurs after cardiac surgery and is associated with increased risk of stroke and mortality. Prior studies support the important role of inflammation in the pathogenesis of postoperative atrial fibrillation ( ... ...

    Abstract Background: Atrial fibrillation (AF) often occurs after cardiac surgery and is associated with increased risk of stroke and mortality. Prior studies support the important role of inflammation in the pathogenesis of postoperative atrial fibrillation (POAF). It is known that an increased volume and a pro-inflammatory phenotype of epicardial adipose tissue (EAT) are both associated with AF onset in non surgical context. In the present study, we aim to evaluate whether also POAF occurrence may be triggered by an increased production of inflammatory mediators from EAT.
    Methods: The study population was composed of 105 patients, with no history of paroxysmal or permanent AF, undergoing elective cardiac surgery. After clinical evaluation, all patients performed an echocardiographic study including the measurement of EAT thickness. Serum samples and EAT biopsies were collected before surgery. Levels of 10 inflammatory cytokines were measured in serum and EAT conditioned media. After surgery, cardiac rhythm was monitored for 7 days.
    Results: Forty-four patients (41.3%) developed POAF. As regard to cardiovascular therapy, only statin use was significantly lower in POAF patients (65.1% vs. 84.7%;
    Conclusion: Higher EAT levels of IL-6 and MCP-1 are significantly associated with the occurrence of POAF. Statin therapy seems to play a role in preventing POAF. These results might pave the way for a targeted use of these drugs in the perioperative period.
    Language English
    Publishing date 2022-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.810334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Inflammation and Cardiovascular Diseases in the Elderly: The Role of Epicardial Adipose Tissue.

    Conte, Maddalena / Petraglia, Laura / Poggio, Paolo / Valerio, Vincenza / Cabaro, Serena / Campana, Pasquale / Comentale, Giuseppe / Attena, Emilio / Russo, Vincenzo / Pilato, Emanuele / Formisano, Pietro / Leosco, Dario / Parisi, Valentina

    Frontiers in medicine

    2022  Volume 9, Page(s) 844266

    Abstract: Human aging is a complex phenomenon characterized by a wide spectrum of biological changes which impact on behavioral and social aspects. Age-related changes are accompanied by a decline in biological function and increased vulnerability leading to ... ...

    Abstract Human aging is a complex phenomenon characterized by a wide spectrum of biological changes which impact on behavioral and social aspects. Age-related changes are accompanied by a decline in biological function and increased vulnerability leading to frailty, thereby advanced age is identified among the major risk factors of the main chronic human diseases. Aging is characterized by a state of chronic low-grade inflammation, also referred as inflammaging. It recognizes a multifactorial pathogenesis with a prominent role of the innate immune system activation, resulting in tissue degeneration and contributing to adverse outcomes. It is widely recognized that inflammation plays a central role in the development and progression of numerous chronic and cardiovascular diseases. In particular, low-grade inflammation, through an increased risk of atherosclerosis and insulin resistance, promote cardiovascular diseases in the elderly. Low-grade inflammation is also promoted by visceral adiposity, whose accumulation is paralleled by an increased inflammatory status. Aging is associated to increase in epicardial adipose tissue (EAT), the visceral fat depot of the heart. Structural and functional changes in EAT have been shown to be associated with several heart diseases, including coronary artery disease, aortic stenosis, atrial fibrillation, and heart failure. EAT increase is associated with a greater production and secretion of pro-inflammatory mediators and neuro-hormones, so that thickened EAT can pathologically influence, in a paracrine and vasocrine manner, the structure and function of the heart and is associated to a worse cardiovascular outcome. In this review, we will discuss the evidence underlying the interplay between inflammaging, EAT accumulation and cardiovascular diseases. We will examine and discuss the importance of EAT quantification, its characteristics and changes with age and its clinical implication.
    Language English
    Publishing date 2022-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.844266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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