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Book ; Online: The Figurativeness of the Language of Mystical Experience

Bakešová, Václava / Brezováková, Monika / Brodňanová, Silvia / Campana, Silvia / Civáňová, Zuzana / Fermín, Javier / Gallik, Ján / Gritti, Fabiano / Horka, Róbert / Hornáčková Klapicová, Edita / Juhásová, Jana / Kaizerová, Petra / Knapík, Ján / Mancebi, Juan / Pariláková, Eva / Príhodová, Edita / Rathouzská, Lucie / Rybárová, Silvia / Šavelová, Monika /

Štěpánek, Pavel / Tierraseca, Mónica / Raušerová, Andrea / Sancho Fermín, Francisco / Barnés, Antonio / Kučerková, Magda

Particularities and Interpretations

2021

Keywords	Literary studies: general ; mystical experience, individual and spontaneous experience, tradition, imagery, literary form, mystery, art
Language	0\|e
Size	1 electronic resource (278 pages)
Publisher	Masaryk University Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021610904
ISBN	9788021099975 ; 8021099976
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Microbiology of cystic fibrosis persons not chronically infected with

Dolce, Daniela / Ravenni, Novella / Fevola, Cristina / Francalanci, Michela / Bonomi, Paolo / Cavicchi, Maria Chiara / Galici, Valeria / Neri, Anna Silvia / Taccetti, Giovanni / Terlizzi, Vito / Innocenti, Diletta / Ferrari, Beatrice / Bianchimani, Chiara / Camera, Erica / Orioli, Tommaso / Campana, Silvia

Heliyon

2024 Volume 10, Issue 5, Page(s) e26978

Abstract: Background: The upper airways of cystic fibrosis (CF) persons are an evolutionary niche where genetically adapted bacterial strains are selected for lung infection. The microbiological studies conducted up to now on the upper airways are not easily ... ...

Abstract	Background: The upper airways of cystic fibrosis (CF) persons are an evolutionary niche where genetically adapted bacterial strains are selected for lung infection. The microbiological studies conducted up to now on the upper airways are not easily comparable. Methods: Using classical culture methods, we simultaneously studied the microbiological status of upper and lower airways in persons not chronically infected with Results: A total of 194 persons were enrolled in this study. Pathogenic flora was found in 128 (6.6%) of 194 upper airways samples and in 164 (84.6%) lower airways samples. A statistically significant difference between the upper airways and the lower airways was found in the isolation of Conclusions: In our study population, cultures of the upper airway and lower airway differ in CF persons. In people sampled with nasal lavage according to Mainz more non-fermenter gram negatives were detected than with rhino-set. The two sampling methods were comparable with regard to the caused pain, nasal lavage according to Mainz method being quicker to perform.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26978
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Book: Violencia familiar y acceso a la justicia en el mundo rural

Bellatin, Paloma / Benavides, Martín / Campana, Silvia / Sarmiento, Paola

estudios de caso de cuatro comunidades

(Documento de investigación / Grupo de Análisis para el Desarrollo : Etnicidad, género, ciudadanía y derechos ; 77)

2015

Author's details	Martín Benavides; Paloma Bellatin; Paola Sarmiento; Silvia Campana
Series title	Documento de investigación / Grupo de Análisis para el Desarrollo : Etnicidad, género, ciudadanía y derechos ; 77
Keywords	Gewalt ; Familie ; Strafjustiz ; Ländlicher Raum ; Peru
Language	Spanish
Size	102 S., graph. Darst.
Publisher	GRADE
Publishing place	Lima
Document type	Book
ISBN	9789972615863 ; 9972615863
Database	ECONomics Information System

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Article: Nutritional Status and Circulating Levels of Fat-Soluble Vitamins in Cystic Fibrosis Patients: A Cohort Study and Evaluation of the Effect of CFTR Modulators.

Francalanci, Michela / Terlizzi, Vito / Fevola, Cristina / Di Rosa, Giulia / Pierattini, Valentina / Roselli, Elena / Bonomi, Paolo / Cavicchi, Maria Chiara / Galici, Valeria / Neri, Anna Silvia / Bianchimani, Chiara / Campana, Silvia / Dolce, Daniela / Ravenni, Novella / Camera, Erica / Orioli, Tommaso / Taccetti, Giovanni

Children (Basel, Switzerland)

2023 Volume 10, Issue 2

Abstract: Background: Improved therapy in CF has led to an overall improvement in nutritional status. The objectives of our study are: to cross-sectionally assess nutritional status and serum levels of fat-soluble vitamins; to retrospectively evaluate the ... ...

Abstract	Background: Improved therapy in CF has led to an overall improvement in nutritional status. The objectives of our study are: to cross-sectionally assess nutritional status and serum levels of fat-soluble vitamins; to retrospectively evaluate the efficacy of modulators on nutritional status and fat-soluble vitamin levels. Methods: In patients younger than 2 years of age, we evaluated growth, in patients aged 2-18 years, we assessed BMI z-scores, and in adults, we assessed absolute BMI values. Levels of 25(OH)D, vitamins A, and E were measured. Results: A cross-sectional analysis was conducted on 318 patients, 109 (34.3%) with pancreatic sufficiency. Only three patients were under 2 years old. In 135 patients aged 2-18 years, the median BMI z-score was 0.11, and 5 (3.7%) patients had malnutrition (z-score ≤ 2SD). In 180 adults, the median BMI was 21.8 kg/m Conclusions: Malnutrition is present in a limited number of subjects. The prevalence of subjects with suboptimal 25(OH)D levels is high. ETI showed a beneficial effect on nutritional status and circulating levels of fat-soluble vitamins.
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10020252
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Article ; Online: Impact of Pancreatitis-Associated Protein on Newborn Screening Outcomes and Detection of CFTR-Related Metabolic Syndrome (CRMS)/Cystic Fibrosis Screen Positive, Inconclusive Diagnosis (CFSPID): A Monocentric Prospective Pilot Experience.

Bianchimani, Chiara / Dolce, Daniela / Centrone, Claudia / Campana, Silvia / Ravenni, Novella / Orioli, Tommaso / Camera, Erica / Mergni, Gianfranco / Fevola, Cristina / Bonomi, Paolo / Taccetti, Giovanni / Terlizzi, Vito

International journal of neonatal screening

2022 Volume 8, Issue 3

Abstract: Pancreatitis-Associated Protein (PAP)-based Cystic Fibrosis (CF) newborn bloodspot screening (NBS) protocols detect less CFTR-Related Metabolic Syndrome (CRMS)/CF Screen Positive, Inconclusive Diagnosis (CFSPID). We prospectively evaluated the impact of ... ...

Abstract	Pancreatitis-Associated Protein (PAP)-based Cystic Fibrosis (CF) newborn bloodspot screening (NBS) protocols detect less CFTR-Related Metabolic Syndrome (CRMS)/CF Screen Positive, Inconclusive Diagnosis (CFSPID). We prospectively evaluated the impact of PAP as the second step of the CF NBS protocol, before the CFTR genetic analysis, on NBS outcomes and CRMS/CFSPID detection in the Tuscany region, Italy. In parallel to the usual protocol (IRT/DNA, protocol 1), PAP was analyzed in IRT-positive infants (IRT/PAP/DNA, protocol 2) from 1 June 2020 until 31 May 2022. We defined an infant as NBS positive if PAP was >1.8 μg/L for IRT value 99th percentile-100 μg/L or >0.6 μg/L for IRT value >100 μg/L. To increase the positive predictive value (PPV) of protocol 2, we retrospectively lowered the upper IRT range value from 100 to 90 μg/L (modified protocol 2). We identified 8 CF and 13 CRMS/CFSPID with protocol 1, 5 CF and 5 CRMS/CFSPID with protocol 2 and 8 CF and 5 CRMS/CFSPID with modified protocol 2. With the PAP-based protocols, we observed a reduction of sweat tests, healthy carrier detection and a significant increase in PPV to 15.38%. Further data are needed in order to evaluate the outcomes of CRMS/CFSPID after a long follow-up.
Language	English
Publishing date	2022-08-03
Publishing country	Switzerland
Document type	Journal Article
ISSN	2409-515X
ISSN (online)	2409-515X
DOI	10.3390/ijns8030046
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Article ; Online: Chronic infection sustained by a Pseudomonas aeruginosa High-Risk clone producing the VIM-1 metallo-β-lactamase in a cystic fibrosis patient after lung transplantation.

Pollini, Simona / Mugnaioli, Claudia / Dolce, Daniela / Campana, Silvia / Neri, Anna Silvia / Taccetti, Giovanni / Rossolini, Gian Maria

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

2018 Volume 17, Issue 4, Page(s) 470–474

Abstract: Background: The significance of chronic lung infection by multidrug-resistant (MDR) pathogens in Cystic Fibrosis (CF) transplanted patients remains controversial, and the available information is overall limited. Here we describe the case of a chronic ... ...

Abstract	Background: The significance of chronic lung infection by multidrug-resistant (MDR) pathogens in Cystic Fibrosis (CF) transplanted patients remains controversial, and the available information is overall limited. Here we describe the case of a chronic infection, sustained by a metallo-β-lactamase (MBL)-producing P. aeruginosa strain, in a CF patient following lung transplantation. Methods: Twelve P. aeruginosa isolates collected from a CF patient over a 15-years follow-up period after lung transplantation were analysed for their antibiotic susceptibility profile, MBL production and clonal relatedness. Available clinical and microbiological records were reviewed. Results: The transplanted CF patient was chronically infected by an MBL-producing P. aeruginosa strain which harboured a bla Conclusions: This report provides one of the few descriptions of MBL-producing P. aeruginosa infections in CF patients, and the first description of such an infection after lung transplantation in these patients. Infection with the MBL-producing strain apparently did not significantly affect the patient pulmonary function.
MeSH term(s)	Adult ; Aftercare ; Cystic Fibrosis/complications ; Cystic Fibrosis/microbiology ; Cystic Fibrosis/physiopathology ; Cystic Fibrosis/surgery ; DNA, Bacterial/analysis ; Humans ; Lung Transplantation/methods ; Male ; Microbial Sensitivity Tests ; Postoperative Period ; Pseudomonas Infections/complications ; Pseudomonas Infections/diagnosis ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/isolation & purification ; Pseudomonas aeruginosa/metabolism ; Respiratory Function Tests/methods ; Treatment Outcome ; beta-Lactamases/metabolism
Chemical Substances	DNA, Bacterial ; VIM-1 metallo-beta-lactamase (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2018-02-12
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091075-7
ISSN	1873-5010 ; 1569-1993
ISSN (online)	1873-5010
ISSN	1569-1993
DOI	10.1016/j.jcf.2018.01.007
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Article ; Online: Community-associated meticillin-resistant Staphylococcus aureus.

Taccetti, Giovanni / Cocchi, Priscilla / Festini, Filippo / Braggion, Cesare / Campana, Silvia

Lancet (London, England)

2010 Volume 376, Issue 9743, Page(s) 767–768

MeSH term(s)	Community-Acquired Infections/diagnosis ; Community-Acquired Infections/epidemiology ; Cystic Fibrosis/complications ; Humans ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Severity of Illness Index ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/epidemiology
Language	English
Publishing date	2010-09-04
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(10)61371-2
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Ua VI Zs.5: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital.

Manara, Serena / Pasolli, Edoardo / Dolce, Daniela / Ravenni, Novella / Campana, Silvia / Armanini, Federica / Asnicar, Francesco / Mengoni, Alessio / Galli, Luisa / Montagnani, Carlotta / Venturini, Elisabetta / Rota-Stabelli, Omar / Grandi, Guido / Taccetti, Giovanni / Segata, Nicola

Genome medicine

2018 Volume 10, Issue 1, Page(s) 82

Abstract: Background: Staphylococcus aureus is an opportunistic pathogen and a leading cause of nosocomial infections. It can acquire resistance to all the antibiotics that entered the clinics to date, and the World Health Organization defined it as a high- ... ...

Abstract	Background: Staphylococcus aureus is an opportunistic pathogen and a leading cause of nosocomial infections. It can acquire resistance to all the antibiotics that entered the clinics to date, and the World Health Organization defined it as a high-priority pathogen for research and development of new antibiotics. A deeper understanding of the genetic variability of S. aureus in clinical settings would lead to a better comprehension of its pathogenic potential and improved strategies to contrast its virulence and resistance. However, the number of comprehensive studies addressing clinical cohorts of S. aureus infections by simultaneously looking at the epidemiology, phylogenetic reconstruction, genomic characterisation, and transmission pathways of infective clones is currently low, thus limiting global surveillance and epidemiological monitoring. Methods: We applied whole-genome shotgun sequencing (WGS) to 184 S. aureus isolates from 135 patients treated in different operative units of an Italian paediatric hospital over a timespan of 3 years, including both methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) from different infection types. We typed known and unknown clones from their genomes by multilocus sequence typing (MLST), Staphylococcal Cassette Chromosome mec (SCCmec), Staphylococcal protein A gene (spa), and Panton-Valentine Leukocidin (PVL), and we inferred their whole-genome phylogeny. We explored the prevalence of virulence and antibiotic resistance genes in our cohort, and the conservation of genes encoding vaccine candidates. We also performed a timed phylogenetic investigation for a potential outbreak of a newly emerging nosocomial clone. Results: The phylogeny of the 135 single-patient S. aureus isolates showed a high level of diversity, including 80 different lineages, and co-presence of local, global, livestock-associated, and hypervirulent clones. Five of these clones do not have representative genomes in public databases. Variability in the epidemiology is mirrored by variability in the SCCmec cassettes, with some novel variants of the type IV cassette carrying extra antibiotic resistances. Virulence and resistance genes were unevenly distributed across different clones and infection types, with highly resistant and lowly virulent clones showing strong association with chronic diseases, and highly virulent strains only reported in acute infections. Antigens included in vaccine formulations undergoing clinical trials were conserved at different levels in our cohort, with only a few highly prevalent genes fully conserved, potentially explaining the difficulty of developing a vaccine against S. aureus. We also found a recently diverged ST1-SCCmecIV-t127 PVL- clone suspected to be hospital-specific, but time-resolved integrative phylogenetic analysis refuted this hypothesis and suggested that this quickly emerging lineage was acquired independently by patients. Conclusions: Whole genome sequencing allowed us to study the epidemiology and genomic repertoire of S. aureus in a clinical setting and provided evidence of its often underestimated complexity. Some virulence factors and clones are specific of disease types, but the variability and dispensability of many antigens considered for vaccine development together with the quickly changing epidemiology of S. aureus makes it very challenging to develop full-coverage therapies and vaccines. Expanding WGS-based surveillance of S. aureus to many more hospitals would allow the identification of specific strains representing the main burden of infection and therefore reassessing the efforts for the discovery of new treatments and clinical practices.
MeSH term(s)	Acute Disease ; Base Sequence ; Bayes Theorem ; Child ; Chronic Disease ; Conserved Sequence ; Drug Resistance, Bacterial/genetics ; Genes, Bacterial ; Genome, Bacterial ; Hospitals, Pediatric ; Humans ; Italy/epidemiology ; Likelihood Functions ; Phylogeny ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/genetics ; Staphylococcal Vaccines/immunology ; Staphylococcus aureus/classification ; Staphylococcus aureus/genetics ; Staphylococcus aureus/pathogenicity ; Virulence Factors/metabolism
Chemical Substances	Staphylococcal Vaccines ; Virulence Factors
Language	English
Publishing date	2018-11-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2484394-5
ISSN	1756-994X ; 1756-994X
ISSN (online)	1756-994X
ISSN	1756-994X
DOI	10.1186/s13073-018-0593-7
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Article ; Online: Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients.

Marvig, Rasmus Lykke / Dolce, Daniela / Sommer, Lea M / Petersen, Bent / Ciofu, Oana / Campana, Silvia / Molin, Søren / Taccetti, Giovanni / Johansen, Helle Krogh

BMC microbiology

2015 Volume 15, Page(s) 218

Abstract: Background: Chronic infection with Pseudomonas aeruginosa is a major cause of morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of P. aeruginosa within-host genomic evolution, transmission, and population ... ...

Abstract	Background: Chronic infection with Pseudomonas aeruginosa is a major cause of morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of P. aeruginosa within-host genomic evolution, transmission, and population genomics may provide a basis for improving intervention strategies. Here, we report the first genomic analysis of P. aeruginosa isolates sampled from Italian CF patients. Results: By genome sequencing of 26 isolates sampled over 19 years from four patients, we elucidated the within-host evolution of clonal lineages in each individual patient. Many of the identified mutations were located in pathoadaptive genes previously associated with host adaptation, and we correlated mutations with changes in CF-relevant phenotypes such as antibiotic resistance. In addition, the genomic analysis revealed that three patients shared the same clone. Furthermore, we compared the genomes of the Italian CF isolates to a panel of genome sequenced strains of P. aeruginosa from other countries. Isolates from two of the Italian lineages belonged to clonal complexes of P. aeruginosa that have previously been identified in Danish CF patients, and our genomic comparison showed that clonal isolates from the same country may be more distantly related than clonal isolates from different countries. Conclusions: This is the first whole-genome analysis of P. aeruginosa isolated from Italian CF patients, and together with both phenotypic and clinical information this dataset facilitates a more detailed understanding of P. aeruginosa within-host genomic evolution, transmission, and population genomics. We conclude that the evolution of the Italian lineages resembles what has been found in other countries.
MeSH term(s)	Child, Preschool ; Cystic Fibrosis/complications ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Evolution, Molecular ; Female ; Genome, Bacterial ; Humans ; Infant ; Italy ; Male ; Molecular Sequence Data ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/classification ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/isolation & purification ; Respiratory System/microbiology ; Sequence Analysis, DNA ; Young Adult
Chemical Substances	DNA, Bacterial
Language	English
Publishing date	2015-10-19
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2180
ISSN (online)	1471-2180
DOI	10.1186/s12866-015-0563-9
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Article ; Online: Methicillin-resistant Staphylococcus aureus eradication in cystic fibrosis patients: A randomized multicenter study.

Dolce, Daniela / Neri, Stella / Grisotto, Laura / Campana, Silvia / Ravenni, Novella / Miselli, Francesca / Camera, Erica / Zavataro, Lucia / Braggion, Cesare / Fiscarelli, Ersilia V / Lucidi, Vincenzina / Cariani, Lisa / Girelli, Daniela / Faelli, Nadia / Colombo, Carla / Lucanto, Cristina / Lombardo, Mariangela / Magazzù, Giuseppe / Tosco, Antonella /

Raia, Valeria / Manara, Serena / Pasolli, Edoardo / Armanini, Federica / Segata, Nicola / Biggeri, Annibale / Taccetti, Giovanni

PloS one

2019 Volume 14, Issue 3, Page(s) e0213497

Abstract: Background: Few studies, based on a limited number of patients using non-uniform therapeutic protocols, have analyzed Methicillin-resistant Staphylococcus aureus (MRSA) eradication.: Methods: In a randomized multicenter trial conducted on patients ... ...

Abstract	Background: Few studies, based on a limited number of patients using non-uniform therapeutic protocols, have analyzed Methicillin-resistant Staphylococcus aureus (MRSA) eradication. Methods: In a randomized multicenter trial conducted on patients with new-onset MRSA infection we evaluated the efficacy of an early eradication treatment (arm A) compared with an observational group (B). Arm A received oral rifampicin and trimethoprim/sulfamethoxazole (21 days). Patients' microbiological status, FEV1, BMI, pulmonary exacerbations and use of antibiotics were assessed. Results: Sixty-one patients were randomized. Twenty-nine (47.5%) patients were assigned to active arm A and 32 (52.5%) patients to observational arm B. Twenty-nine (47.5%) patients, 10 patients in arm A and 19 in arm B, dropped out of the study. At 6 months MRSA was eradicated in 12 (63.2%) out of 19 patients in arm A while spontaneous clearance was observed in 5 (38.5%) out of 13 patients in arm B. A per-protocol analysis showed a 24.7% difference in the proportion of MRSA clearance between the two groups (z = 1.37, P(Z>z) = 0.08). Twenty-seven patients, 15 (78.9%) out of 19 in arm A and 12 (92.3%) out of 13 in arm B, were able to perform spirometry. The mean (±SD) FEV1 change from baseline was 7.13% (±14.92) in arm A and -1.16% (±5.25) in arm B (p = 0.08). In the same period the BMI change (mean ±SD) from baseline was 0.54 (±1.33) kg/m2 in arm A and -0.38 (±1.56) kg/m2 in arm B (p = 0.08). At 6 months no statistically significant differences regarding the number of pulmonary exacerbations, days spent in hospital and use of antibiotics were observed between the two arms. Conclusions: Although the statistical power of the study is limited, we found a 24.7% higher clearance of MRSA in the active arm than in the observational arm at 6 months. Patients in the active arm A also had favorable FEV1 and BMI tendencies.
MeSH term(s)	Adolescent ; Adult ; Anti-Bacterial Agents/administration & dosage ; Child ; Child, Preschool ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Female ; Humans ; Male ; Methicillin-Resistant Staphylococcus aureus ; Middle Aged ; Rifampin/administration & dosage ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/physiopathology ; Time Factors ; Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage
Chemical Substances	Anti-Bacterial Agents ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2019-03-22
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Observational Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0213497
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