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  1. Article ; Online: Haemoglobin mass responses and performance outcomes among high-performance swimmers following a 3-week live-high, train-high camp at 2320 m.

    Astridge, Daniel J / McKenna, Michael / Campbell, Adrian / Turner, Anthony P

    European journal of applied physiology

    2024  

    Abstract: Aim: Greater quantification and characterisation of training load (TL) throughout Live-high, train-high (LHTH) altitude (ALT) training is required to identify periodisation strategies that may lead to physiological and performance improvements in ... ...

    Abstract Aim: Greater quantification and characterisation of training load (TL) throughout Live-high, train-high (LHTH) altitude (ALT) training is required to identify periodisation strategies that may lead to physiological and performance improvements in swimmers.
    Purpose: This study aimed to examine the physiological responses and performance outcomes of 14 high-performance swimmers (FINA points: 836.0 ± 35.1) following 3 weeks of LHTH at 2320 m, while characterising the training load periodisation strategy adopted during the intervention.
    Methods: Haemoglobin (Hb) mass was measured pre-, 7 and 14 days post-ALT via CO rebreathing. Performance in each athlete's primary event at national standard meets were converted to FINA points and compared from pre-to-post-ALT. TL was quantified at sea level (SL) and ALT through session rating of perceived exertion (RPE), where duration of each session was multiplied by its RPE for each athlete, with all sessions totalled to give a weekly TL. Pre-to-post-ALT changes were evaluated using repeated-measures ANOVA.
    Results: Hb mass increased significantly from 798 ± 182 g pre-ALT to 828 ± 187 g at 7 days post (p = 0.013) and 833 ± 205 g 14 days post-ALT (p = 0.026). Weekly TL increased from SL (3179 ± 638 au) during week one (4797 ± 1349 au, p < 0.001) and week two (4373 ± 967 au, p < 0.001), but not week three (3511 ± 730 au, p = 0.149). No evidence of improved SL swimming performance was identified.
    Conclusion: A periodisation strategy characterised by a sharp spike in TL followed by a slight de-load towards the end of a LHTH intervention led to improved physiological characteristics but no change in the competitive performance of high-performance swimmers.
    Language English
    Publishing date 2024-03-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-024-05454-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeting G protein-coupled receptor signalling by blocking G proteins.

    Campbell, Adrian P / Smrcka, Alan V

    Nature reviews. Drug discovery

    2018  Volume 17, Issue 11, Page(s) 789–803

    Abstract: G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to their druggability, diversity and physiological efficacy. Many drugs selectively target specific subtypes of GPCRs, but high specificity for individual GPCRs may ... ...

    Abstract G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to their druggability, diversity and physiological efficacy. Many drugs selectively target specific subtypes of GPCRs, but high specificity for individual GPCRs may not be desirable in complex multifactorial disease states in which multiple receptors may be involved. One approach is to target G protein subunits rather than the GPCRs directly. This approach has the potential to achieve broad efficacy by blocking pathways shared by multiple GPCRs. Additionally, because many GPCRs couple to multiple G protein signalling pathways, blocking specific G protein subunits can 'bias' GPCR signals by inhibiting only a subset of these signals. Molecules that target G protein α or βγ-subunits have been developed and show strong efficacy in multiple preclinical disease models and biased inhibition of G protein signalling. In this Review, we discuss the development and characterization of G protein α and βγ-subunit ligands and the preclinical evidence that this exciting new approach has potential for therapeutic efficacy in a number of indications, such as pain, thrombosis, asthma and heart failure.
    MeSH term(s) Animals ; Humans ; Ligands ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Signal Transduction/drug effects
    Chemical Substances Ligands ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2018-09-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/nrd.2018.135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characterisation of bis(4-aminoquinoline)s as α

    Chen, Junli / Campbell, Adrian P / Wakelin, Laurence P G / Finch, Angela M

    European journal of pharmacology

    2021  Volume 916, Page(s) 174659

    Abstract: The development of sub-type selective ... ...

    Abstract The development of sub-type selective α
    MeSH term(s) Adrenergic alpha-1 Receptor Antagonists/chemistry ; Adrenergic alpha-1 Receptor Antagonists/pharmacology ; Allosteric Regulation/drug effects ; Aminoquinolines/chemistry ; Aminoquinolines/pharmacokinetics ; Aminoquinolines/pharmacology ; Animals ; Binding Sites ; COS Cells ; Chlorocebus aethiops ; Kinetics ; Norepinephrine/pharmacology ; Prazosin/pharmacology ; Receptors, Adrenergic, alpha-1/drug effects
    Chemical Substances Adrenergic alpha-1 Receptor Antagonists ; Aminoquinolines ; Receptors, Adrenergic, alpha-1 ; 4-aminoquinoline (GTE5P5L97N) ; Norepinephrine (X4W3ENH1CV) ; Prazosin (XM03YJ541D)
    Language English
    Publishing date 2021-12-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2021.174659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Key aspects of modern GPCR drug discovery.

    Addis, Phil / Bali, Utsav / Baron, Frank / Campbell, Adrian / Harborne, Steven / Jagger, Liz / Milne, Gavin / Pearce, Martin / Rosethorne, Elizabeth M / Satchell, Rupert / Swift, Denise / Young, Barbara / Unitt, John F

    SLAS discovery : advancing life sciences R & D

    2023  Volume 29, Issue 1, Page(s) 1–22

    Abstract: G-protein-coupled receptors (GPCRs) are the largest and most versatile cell surface receptor family with a broad repertoire of ligands and functions. We've learned an enormous amount about discovering drugs of this receptor class since the first GPCR was ...

    Abstract G-protein-coupled receptors (GPCRs) are the largest and most versatile cell surface receptor family with a broad repertoire of ligands and functions. We've learned an enormous amount about discovering drugs of this receptor class since the first GPCR was cloned and expressed in 1986, such that it's now well-recognized that GPCRs are the most successful target class for approved drugs. Here we take the reader through a GPCR drug discovery journey from target to the clinic, highlighting the key learnings, best practices, challenges, trends and insights on discovering drugs that ultimately modulate GPCR function therapeutically in patients. The future of GPCR drug discovery is inspiring, with more desirable drug mechanisms and new technologies enabling the delivery of better and more successful drugs.
    MeSH term(s) Humans ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Drug Discovery
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2885123-7
    ISSN 2472-5560 ; 2472-5552
    ISSN (online) 2472-5560
    ISSN 2472-5552
    DOI 10.1016/j.slasd.2023.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Federalism and local politics in Russia

    Campbell, Adrian / Ross, Cameron

    (BASEES / Routledge series on Russian and East European Studies ; 51)

    2009  

    Abstract: With articles by a high quality set of contributors, including Richard Sakwa, Darrell Slider and Vladimir Gel'man, this book explores the increasingly authoritarian character of Putin's rule, especially in his second term since ... ...

    Institution ebrary, Inc
    Author's details edited by Cameron Ross and Adrian Campbell
    Series title BASEES / Routledge series on Russian and East European Studies ; 51
    Abstract With articles by a high quality set of contributors, including Richard Sakwa, Darrell Slider and Vladimir Gel'man, this book explores the increasingly authoritarian character of Putin's rule, especially in his second term since 2004
    Keywords Authoritarianism ; Central-local government relations ; Local government
    Language English
    Size Online-Ressource (xv, 306 p)
    Publisher Rputledge
    Publishing place London ;New York
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 0203891511 ; 0415437024 ; 9780203891513 ; 9780415437028
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book ; Online: The Political Executive

    Batley, Richard / Campbell, Adrian

    Politicians and Management in European Local Government

    2014  

    Abstract: First Published in 1992. Routledge is an imprint of Taylor & Francis, an informa ... ...

    Abstract First Published in 1992. Routledge is an imprint of Taylor & Francis, an informa company
    Language English
    Size Online-Ressource (96 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780714634807 ; 0714634808
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Book ; Online: Local Government in Central and Eastern Europe

    Coulson, Andrew / Campbell, Adrian

    The Rebirth of Local Democracy

    2013  

    Abstract: Advocates of democratization in Central and Eastern Europe before 1989 placed great emphasis on community self-government as the basis of civil society and democracy. After the 'Velvet Revolutions' of 1989 and the break up of the Soviet Union in 1991, ... ...

    Abstract Advocates of democratization in Central and Eastern Europe before 1989 placed great emphasis on community self-government as the basis of civil society and democracy. After the 'Velvet Revolutions' of 1989 and the break up of the Soviet Union in 1991, the new states created an elected local government, whereby cities, towns and villages elected their own representatives and started running local services. This unleashed the development potential of urban communities across the region, but also led to the emergence of a different logic based on resource efficiency and service effectiveness. Loc
    Language English
    Size Online-Ressource (172 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780415411523 ; 0415411521
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Online: Homobivalent Conjugation Increases the Allosteric Effect of 9-aminoacridine at the α1-Adrenergic Receptors.

    Campbell, Adrian P / Wakelin, Laurence P G / Denny, William A / Finch, Angela M

    Molecular pharmacology

    2017  Volume 91, Issue 2, Page(s) 135–144

    Abstract: ... The ... ...

    Abstract The α
    MeSH term(s) Adrenergic alpha-1 Receptor Antagonists/pharmacology ; Allosteric Regulation/drug effects ; Allosteric Site/drug effects ; Aminacrine/chemistry ; Aminacrine/pharmacology ; Animals ; Biological Assay ; COS Cells ; Cercopithecus aethiops ; Humans ; Kinetics ; Norepinephrine/pharmacology ; Prazosin/pharmacology ; Receptors, Adrenergic, alpha-1/metabolism ; Tritium/metabolism
    Chemical Substances Adrenergic alpha-1 Receptor Antagonists ; Receptors, Adrenergic, alpha-1 ; Tritium (10028-17-8) ; Aminacrine (78OY3Z0P7Z) ; Norepinephrine (X4W3ENH1CV) ; Prazosin (XM03YJ541D)
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 124034-1
    ISSN 1521-0111 ; 0026-895X
    ISSN (online) 1521-0111
    ISSN 0026-895X
    DOI 10.1124/mol.116.105874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: High speed non-mechanical two-dimensional KTN beam deflector enabled by space charge and temperature gradient deflection.

    Chao, Ju-Hung / Zhu, Wenbin / Chen, Chang-Jiang / Campbell, Adrian L / Henry, Michael G / Yin, Shizhuo / Hoffman, Robert C

    Optics express

    2017  Volume 25, Issue 13, Page(s) 15481–15492

    Abstract: In this paper, a high-speed non-mechanical two-dimensional KTN beam deflector is reported. The scanning mechanism is based on the combination of space charge controlled beam deflection and temperature gradient enabled beam deflection in a nanodisordered ... ...

    Abstract In this paper, a high-speed non-mechanical two-dimensional KTN beam deflector is reported. The scanning mechanism is based on the combination of space charge controlled beam deflection and temperature gradient enabled beam deflection in a nanodisordered KTN crystal. Both theoretical analyses and experimental investigations are provided, which agree relatively well with each other. This work provides an effective way for realizing multi-dimensional high-speed non-mechanical beam deflection, which can be very useful for a variety of applications, including high-speed 3D laser printing, high resolution high speed scanning imaging, and free space reconfigurable laser communications.
    Language English
    Publishing date 2017-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.25.015481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An aspartate in the second extracellular loop of the α(1B) adrenoceptor regulates agonist binding.

    Campbell, Adrian P / MacDougall, Iain J A / Griffith, Renate / Finch, Angela M

    European journal of pharmacology

    2014  Volume 733, Page(s) 90–96

    Abstract: The extracellular loops of the adrenoceptors present a potential therapeutic target in the design of highly selective adrenergic drugs. These regions are less conserved than the orthosteric binding site but have to date not been implicated in activation ... ...

    Abstract The extracellular loops of the adrenoceptors present a potential therapeutic target in the design of highly selective adrenergic drugs. These regions are less conserved than the orthosteric binding site but have to date not been implicated in activation of adrenoceptors. A previously generated homology model identified an extracellular residue, D191, as a potential regulator of agonist binding. We have generated mutants of the α1B adrenoceptor replacing the charged aspartate, D191, as well as a potential interaction partner, K331, with uncharged alanines to observe effects on ligand binding and receptor activation. Significant 4-6 fold reductions in affinity for the endogenous agonists, epinephrine and norepinephrine were observed for receptors with the D191A mutation in the second extracellular loop. While changes in EC50 were observed, operational analysis yielded no apparent change in receptor activation. Based on these findings, we suggest that D191, in the second extracellular loop of the α1B adrenoceptor, acts as a 'point of first contact' for the receptor's endogenous agonists. Implication of the non-conserved extracellular regions of the receptor in agonist binding makes it a potential target for the design of highly selective drugs.
    MeSH term(s) Adrenergic alpha-1 Receptor Agonists/pharmacology ; Alanine/genetics ; Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Aspartic Acid/genetics ; Binding, Competitive ; COS Cells ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cercopithecus aethiops ; Conserved Sequence ; Ligands ; Models, Molecular ; Protein Binding ; Protein Structure, Secondary ; Radioligand Assay ; Receptors, Adrenergic, alpha-1/chemistry ; Receptors, Adrenergic, alpha-1/genetics ; Receptors, Adrenergic, alpha-1/metabolism
    Chemical Substances Adrenergic alpha-1 Receptor Agonists ; Ligands ; Receptors, Adrenergic, alpha-1 ; Aspartic Acid (30KYC7MIAI) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2014-06-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2014.03.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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