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Article: Use of Acellular Biologic Matrix Envelope for Cardiac Implantable Electronic Device Placement to Correct Migration into Submuscular Breast Implant Pocket.

Terry, Peyton / Bilchick, Kenneth / Campbell, Chris A

2023 Volume 50, Issue 2, Page(s) 156–159

Abstract: Breast implants whether used for cosmetic or reconstructive purposes can be placed in pockets either above or below the pectoralis major muscle, depending on clinical circumstances such as subcutaneous tissue volume, history of radiation, and patient ... ...

Abstract	Breast implants whether used for cosmetic or reconstructive purposes can be placed in pockets either above or below the pectoralis major muscle, depending on clinical circumstances such as subcutaneous tissue volume, history of radiation, and patient preference. Likewise, cardiac implantable electronic devices (CIEDs) can be placed above or below the pectoralis major muscle. When a patient has both devices, knowledge of the pocket location is important for procedural planning and for durability of device placement and performance. Here, we report a patient who previously failed subcutaneous CIED placement due to incision manipulation with prior threatened device exposure requiring plane change to subpectoral pocket. Her course was complicated by submuscular migration of the CIED into her breast implant periprosthetic pocket. With subcutaneous plane change being inadvisable due to patient noncompliance, soft tissue support of subpectoral CIED placement with an acellular biologic matrix (ABM) was performed. Similar to soft tissue support used for breast implants, submuscular CIED neo-pocket creation with ABM was performed with durable CIED device positioning confirmed at 9 months postprocedure.
Language	English
Publishing date	2023-03-28
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2694943-X
ISSN	2234-6171 ; 2234-6163
ISSN (online)	2234-6171
ISSN	2234-6163
DOI	10.1055/a-2015-8803
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Role of Triple-Antibiotic Saline Irrigation in Breast Implant Surgery.

Campbell, Chris A

Annals of plastic surgery

2018 Volume 80, Issue 6S Suppl 6, Page(s) S398–S402

Abstract: Implant-based breast reconstruction accounts for more than 70% of all breast reconstructions, and breast augmentation is the most commonly performed cosmetic operation annually. The clinically significant impact of infection and capsular contracture ... ...

Abstract	Implant-based breast reconstruction accounts for more than 70% of all breast reconstructions, and breast augmentation is the most commonly performed cosmetic operation annually. The clinically significant impact of infection and capsular contracture after breast implant surgery has brought clinicians to create infection reduction protocols for both oncologic and cosmetic operations alike. The use of triple-antibiotic saline irrigation has become a recommended intraoperative maneuver within these protocols to minimize surgical site infections, but the constituents of the irrigation, its individual efficacy, and the acceptability of including povidone-iodine within irrigation recipes have been debated. This review will investigate the microbiological data behind the selection of the constituents of triple-antibiotic saline. In vitro testing of the effectiveness of topical antibiotics used in saline irrigation against microorganisms responsible for breast implant infection is reviewed. Clinical data are presented describing the impact of triple-antibiotic saline on implant infection and capsular contracture after cosmetic and reconstructive surgery.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis/methods ; Breast Implantation ; Drug Therapy, Combination ; Female ; Humans ; Implant Capsular Contracture/prevention & control ; Intraoperative Care/methods ; Saline Solution/administration & dosage ; Saline Solution/therapeutic use ; Surgical Wound Infection/prevention & control ; Therapeutic Irrigation/methods ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Saline Solution
Language	English
Publishing date	2018-02-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000001345
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Zs.A 1419: Show issues

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Article ; Online: Safety Profile and Predictors of Aesthetic Outcomes After Prepectoral Breast Reconstruction With Meshed Acellular Dermal Matrix.

Belmonte, Briana M / Campbell, Chris A

Annals of plastic surgery

2021 Volume 86, Issue 6S Suppl 5, Page(s) S585–S592

Abstract: Introduction: Prepectoral acellular dermal matrix (ADM)-assisted breast reconstruction has demonstrated improved pain scores, faster return to full range of motion, and an appropriate postoperative safety profile when compared with cohorts with ... ...

Abstract	Introduction: Prepectoral acellular dermal matrix (ADM)-assisted breast reconstruction has demonstrated improved pain scores, faster return to full range of motion, and an appropriate postoperative safety profile when compared with cohorts with submuscular implant placement; however, there are limited data on aesthetic outcomes. Basic science biointegration research has previously demonstrated faster ADM incorporation with fenestrated compared with confluent ADM. We report the safety profile of anterior support meshed ADM prepectoral breast reconstruction and analyze predictive factors for aesthetic outcomes after gel implant placement. Methods: All consecutive immediate staged prepectoral expander-to-implant breast reconstructions with more than 6 months of follow-up were compared with a partially submuscular cohort for demographics, comorbidities, and postoperative complications. All patients 1 to 3.5 years after gel implant placement were evaluated for the impact of clinical characteristics on aesthetic outcomes. Results: Two hundred twenty-four prepectoral tissue expander placements were compared with 535 partially submuscular tissue expanders with no significant differences in demographics. There was increased wound dehiscence repaired in clinic and insignificantly decreased seromas with prepectoral expander placement. One hundred sixty breasts were reconstructed with gel implants, and 12 underwent autologous reconstruction during the conduct of the study. The remaining 21 patients were continuing expansion, and 3 succumbed to disease progression. Regression analysis of 86 breast reconstructions showed that a body mass index of greater than 30, fat grafting, and highly cohesive anatomic implants decreased rippling, whereas radiation increased capsular contracture (P < 0.05). Conclusions: Prepectoral meshed ADM breast reconstruction has an equivalent safety profile to partially submuscular ADM-assisted reconstruction and early aesthetic ratings comparable with other published accounts of implant-based reconstruction. Radiated skin envelopes carry higher capsular contracture rates. Thin patients have a higher risk of visible rippling, whereas fat grafting and higher cohesivity implants are associated with less rippling.
MeSH term(s)	Acellular Dermis ; Breast Implantation ; Breast Implants ; Breast Neoplasms ; Esthetics ; Female ; Humans ; Mammaplasty ; Tissue Expansion
Language	English
Publishing date	2021-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000002764
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Zs.A 1419: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Sustainability via PebblePad digitization of pharmacy practice resources.

Hope, Denise L / Campbell, Chris

Currents in pharmacy teaching & learning

2021 Volume 14, Issue 2, Page(s) 173–181

Abstract: Introduction: Digitization of learning and teaching resources allows for paper-free, digitally-enabled approaches to learning. While PebblePad is well recognized as an electronic portfolio platform, this study aimed to evaluate PebblePad for delivery of ...

Abstract	Introduction: Digitization of learning and teaching resources allows for paper-free, digitally-enabled approaches to learning. While PebblePad is well recognized as an electronic portfolio platform, this study aimed to evaluate PebblePad for delivery of foundational workshop materials to provide sustainable and ongoing student access. Methods: From 2017, all workshops in a foundational pharmacy practice course were transferred from a paper-based manual to a modular digitized format hosted in PebblePad. An electronic survey tool assessed students' experiences with the platform. The voluntary and anonymous survey sought participant opinions on use, usability, ways of using, and reflection on using PebblePad on a five-point Likert-type scale (strongly disagree to strongly agree). Participants were asked to identify techniques they used to become familiar with PebblePad and the ways in which they used the platform. Results: From 2017 to 2019, 81 (45.3%) of 179 second-year pharmacy students participated in the research. Students most strongly agreed with statements related to comfort with online technologies for learning (n = 46/80, 57.5%), ease of use of PebblePad (n = 41/80, 51.3%), and having sufficient support from teaching staff (n = 39/78, 50%). The primary technique for becoming familiar with PebblePad was individual guidance from the teacher. The main use was to complete required workbook templates. Free-text comments demonstrated overwhelming support for PebblePad used in this teaching context. Conclusions: PebblePad provided a valuable and sustainable platform for hosting digitized foundational pharmacy practice workshop resources.
MeSH term(s)	Education, Pharmacy/methods ; Humans ; Learning ; Pharmacy ; Students, Pharmacy ; Surveys and Questionnaires
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2515217-8
ISSN	1877-1300 ; 1877-1297
ISSN (online)	1877-1300
ISSN	1877-1297
DOI	10.1016/j.cptl.2021.11.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Understanding the Evidence and Improving Outcomes with Implant-Based Prepectoral Breast Reconstruction.

Campbell, Chris A / Losken, Albert

Plastic and reconstructive surgery

2021 Volume 148, Issue 3, Page(s) 437e–450e

Abstract: Learning objectives: After studying this article, the participant should be able to: 1. Describe the risks, benefits, and safety profile of prepectoral breast reconstruction. 2. Have knowledge of primary immediate and delayed prepectoral breast ... ...

Abstract	Learning objectives: After studying this article, the participant should be able to: 1. Describe the risks, benefits, and safety profile of prepectoral breast reconstruction. 2. Have knowledge of primary immediate and delayed prepectoral breast reconstruction techniques and secondary procedures required. 3. Describe data on outcomes of prepectoral breast reconstruction. Summary: Once considered to have an unacceptable complication profile, prepectoral breast reconstruction is increasing in popularity because of decreased surgical invasiveness and postoperative pain and the absence of animation deformity. Short-term outcomes studies comparing prepectoral breast reconstruction to partially submuscular techniques demonstrate similarly acceptable rates of postoperative complications. Aesthetic outcomes demonstrate similar rates of capsular contracture but increased rippling and implant palpability of the upper pole. Postoperative functional data are limited but overall show decreased pain and more rapid return of function but equivalent satisfaction on the BREAST-Q. Long-term aesthetic data and rates of revision are lacking.
MeSH term(s)	Acellular Dermis/adverse effects ; Breast/anatomy & histology ; Breast/surgery ; Breast Implantation/adverse effects ; Breast Implantation/instrumentation ; Breast Implantation/methods ; Breast Implants/adverse effects ; Breast Neoplasms/surgery ; Esthetics ; Evidence-Based Medicine/methods ; Female ; Humans ; Mastectomy/adverse effects ; Pectoralis Muscles/transplantation ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Tissue Expansion/adverse effects ; Tissue Expansion/methods
Language	English
Publishing date	2021-08-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000008229
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Uk I Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: 'Kindness and empathy beyond all else': Challenges to professional identities of Higher Education teachers during COVID-19 times.

Cain, Melissa / Campbell, Chris / Coleman, Kathryn

Australian educational researcher

2022 , Page(s) 1–19

Abstract: COVID-19 has continued to effect higher education globally in significant ways. During 2020, many institutions shifted learning online overnight as the sector closed its doors and opened new sites for remote teaching. This article reports on an ... ...

Abstract	COVID-19 has continued to effect higher education globally in significant ways. During 2020, many institutions shifted learning online overnight as the sector closed its doors and opened new sites for remote teaching. This article reports on an international study [Phillips et al., 2021] that sought to capture how cross-sectoral teachers experienced these emergency changes during the first months of restrictions. The data, analysed using narrative identity theory, revealed concerns that fall into two broad categories: technologies and relationships. Significantly, it was not a loss of content delivery or changes to assessment that prompted the greatest anxiety for our colleagues, but that they held significant concerns about their students' mental health; inequities of access to a range of services including technological; and challenges connecting emotionally with their students at a distance. The results provide actionable strategies for higher education institutions to apply in future emergencies where remote teaching is necessary.
Language	English
Publishing date	2022-08-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2130100-1
ISSN	2210-5328 ; 0311-6999
ISSN (online)	2210-5328
ISSN	0311-6999
DOI	10.1007/s13384-022-00552-1
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Article: Use of Acellular Biologic Matrix Envelope for Cardiac Implantable Electronic Device Placement to Correct Migration into Submuscular Breast Implant Pocket

Terry, Peyton / Bilchick, Kenneth / Campbell, Chris A

Archives of Plastic Surgery

2023

Abstract	Breast implants whether used for cosmetic or reconstructive purposes can be placed in pockets either above or below the pectoralis major muscle, depending on clinical circumstances such as subcutaneous tissue volume, history of radiation and patient preference. Likewise, cardiac implantable electronic devices (CIEDs) can be placed above or below the pectoralis major muscle. When a patient has both devices, knowledge of the pocket location is important for procedural planning and for durability of device placement and performance. Here we report a patient who previously failed subcutaneous CIED placement due to incision manipulation with prior threatened device exposure requiring plane change to sub-pectoral pocket. Her course was complicated by submuscular migration of the CIED into her breast implant peri-prosthetic pocket for a patient who also had submuscular implants. With subcutaneous plane Plane change being inadvisable due to was not appropriate patient non-compliance, for this patient and therefore, soft tissue support of subpectoral CIED placement with an acellular biologic matrix (ABM)(Cangaroo) was performed. Similar to soft tissue support used for breast implants, submuscular CIED neo-pocket creation with ABM, was performedused with durable CIED device positioning confirmed at 9 months post-procedure.
Language	English
Publishing date	2023-01-19
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2694943-X
ISSN	2234-6171 ; 2234-6163 ; 2234-6171
ISSN (online)	2234-6171
ISSN	2234-6163 ; 2234-6171
DOI	10.1055/a-2015-8803
Database	Thieme publisher's database

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Article ; Online: Systemic Fibrocyte Levels and Keloid Expression of the Chemoattractant CXCL12 Are Upregulated Compared With Patients With Normal Scar.

Campbell, Chris A / Burdick, Marie D / Strieter, Robert M

Annals of plastic surgery

2021 Volume 87, Issue 2, Page(s) 150–155

Abstract: Background: Fibrocytes are bone marrow mesenchymal precursors with a surface phenotype compatible with leukocytes, fibroblasts, and hematopoietic progenitors that have been shown to traffic to wound healing sites in response to described chemokine ... ...

Abstract	Background: Fibrocytes are bone marrow mesenchymal precursors with a surface phenotype compatible with leukocytes, fibroblasts, and hematopoietic progenitors that have been shown to traffic to wound healing sites in response to described chemokine pathways. Keloids are focal fibrotic responses to cutaneous trauma characterized by disordered collagen, which may be associated with elevated systemic fibrocyte levels and/or wound bed chemokine expression. Methods: Blood specimens from patients with longstanding keloids and those who form grossly normal scars were assayed by fluorescence activated cell sorting analysis for fibrocytes (CD45+, Col I+). The expression of the fibrocyte chemotactic cell surface marker CXCR4, intracellular markers of fibroblast differentiation (pSMAD2/3), and plasma levels of the CXCR4 cognate CXCL12 were compared. Keloid specimens and grossly normal scars were excised, and local expression of CXCL12 was assayed. Results: Keloid-forming patients demonstrated a significantly greater number of circulating fibrocytes (17.4 × 105 cells/mL) than control patients (1.01 × 105 cells/mL, P = 0.004). The absolute number of fibrocytes expressing CXCR4 was significantly greater (P = 0.012) in keloid-forming patients. Systemic CXCL12 levels were insignificantly greater in keloid-forming patients than controls. Keloid specimens had significantly greater CXCL12 expression (529.3 pg/mL) than normal scar (undetectable). Conclusions: Systemic fibrocyte levels and the CXCR4/CXCL12 biologic axis responsible for fibrocyte trafficking to areas of regional fibrosis were both upregulated in patients who form keloids compared with controls. Keloids persistently expressed CXLC12, which serves both as the main chemoattractant for fibrocytes and a downstream mediator for local inflammation, suggesting a role for this biologic axis in keloid formation and possibly recurrence.
MeSH term(s)	Cell Differentiation ; Chemokine CXCL12 ; Chemotactic Factors ; Cicatrix ; Fibroblasts/pathology ; Fibrosis ; Humans ; Keloid/pathology
Chemical Substances	CXCL12 protein, human ; Chemokine CXCL12 ; Chemotactic Factors
Language	English
Publishing date	2021-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000002929
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Zs.A 1419: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Acellular Dermal Matrix Favorably Modulates the Healing Response after Surgery.

du Plessis, Miriam I / Cottler, Patrick S / Campbell, Chris A

Plastic and reconstructive surgery

2022 Volume 150, Issue 2, Page(s) 290e–299e

Abstract: Summary: When first described for breast reconstruction, the presence of acellular dermal matrices was associated with increased seroma formation and infection. However, clinical safety data have gradually improved with surgeon experience to an ... ...

Abstract	Summary: When first described for breast reconstruction, the presence of acellular dermal matrices was associated with increased seroma formation and infection. However, clinical safety data have gradually improved with surgeon experience to an acceptable outcomes profile of acellular dermal matrix-assisted reconstruction when compared to submuscular implant coverage. In fact, acellular dermal matrix use potentially decreases capsular contracture rates and facilitates expansion for staged prepectoral breast reconstruction. Because of new regulatory requirements, the collection of unbiased, well-powered premarket approval data summarizing long-term clinical outcomes will be essential over the coming years to understand the clinical performance of acellular dermal matrix use in breast reconstruction. Currently, the authors can highlight the physiologic benefits of acellular dermal matrix use in breast reconstruction by evaluating the components of surgical wound healing that are favorably augmented by the implanted collagen substrate. Acellular dermal matrix takes advantage of the wound healing cascade to incorporate into the patient's tissues-a process that requires a coordinated inflammatory infiltrate and angiogenesis. The presence of acellular dermal matrix augments and modulates the wound healing process to its advantage by simultaneously increasing the invasion of appropriate cellular constituents to facilitate expeditious healing and accelerate angiogenesis. In this article, the authors summarize the wound healing literature to demonstrate the mechanisms acellular dermal matrices use to biointegrate and the literature in which cellular constituents and soluble growth factors are up-regulated in the presence of acellular dermal matrix. Lastly, the authors use their experimental observations of acellular dermal matrix incorporation to corroborate the literature.
MeSH term(s)	Acellular Dermis ; Breast Implantation/adverse effects ; Breast Implants/adverse effects ; Breast Neoplasms/complications ; Collagen/therapeutic use ; Female ; Humans ; Mammaplasty/adverse effects ; Retrospective Studies ; Seroma/etiology ; Wound Healing
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000009338
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Uk I Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effectiveness of Liposomal Bupivacaine Transversus Abdominis Plane Block in DIEP Flap Breast Reconstruction: Randomized Controlled Trial.

Park, Rachel H / Chou, Jesse / DeVito, Robert G / Elmer, Aric / Hollenbeck, Scott T / Campbell, Chris A / Stranix, John T

Plastic and reconstructive surgery

2024

Abstract: Background: Transversus Abdominis Plane (TAP) blocks improve pain control and reduce narcotic medication requirements in various surgical procedures. Liposomal bupivacaine may provide more sustained analgesia. This study compares pain related outcomes ... ...

Abstract	Background: Transversus Abdominis Plane (TAP) blocks improve pain control and reduce narcotic medication requirements in various surgical procedures. Liposomal bupivacaine may provide more sustained analgesia. This study compares pain related outcomes between standard bupivacaine and liposomal bupivacaine TAP blocks after autologous breast reconstruction. Methods: Prospective single-center, single-blinded, randomized controlled trial between March 2021 and December 2022. DIEP flap breast reconstruction patients in a standardized Enhanced Recovery After Surgery (ERAS) pathway were randomized to receive intraoperative TAPs with either bupivacaine / epinephrine (control) or liposomal bupivacaine / bupivacaine / epinephrine (experimental). Primary outcome was postoperative narcotic medication requirements, with secondary outcomes of pain scores, length of stay (LOS), and narcotic medication refills. Results: 117 patients met inclusion criteria (59 control, 58 experimental). Patient demographics, comorbidities, breast pathologic variables, surgery laterality and immediate versus delayed reconstruction status were equivalent between groups. Control group had significantly higher average pain scores postoperatively (4.3 vs. 3.6, p=0.004). However, there were no significant differences in mean narcotic use (66.9 MME vs 60.2 MME, p=0.47). Both LOS and postoperative narcotic prescription refills were equivalent between groups (2.1 vs 2.2 days, p = 0.55, 22% vs 17.2%, p=0.52). Conclusion: Addition of liposomal bupivacaine to standard bupivacaine TAP block mixture in a standardized ERAS protocol did not demonstrate a significant reduction in postoperative narcotic requirements after DIEP flap breast reconstruction compared to standard bupivacaine alone. Patient-reported pain scores, however, were lower among liposomal bupivacaine patients after the initial 24 hours postoperatively and consistent with a longer duration of analgesia.
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000011326
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