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Artikel ; Online: Murine Cytomegalovirus Encodes a Specific Cell Surface Marker That Can Trigger Attack by NK Cells.

Campbell, Kerry S

Journal of immunology (Baltimore, Md. : 1950)

2023 Band 210, Heft 5, Seite(n) 519–520

Mesh-Begriff(e)	Mice ; Animals ; Muromegalovirus ; Killer Cells, Natural
Sprache	Englisch
Erscheinungsdatum	2023-03-07
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2200843
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Natural killer cell protocols

Campbell, Kerry S.

cellular and molecular methods

(Methods in molecular biology ; 612 ; Springer protocols)

2010

Verfasserangabe	ed. by Kerry S. Campbell
Serientitel	Methods in molecular biology ; 612 Springer protocols
Überordnung
Schlagwörter	Killer Cells, Natural / immunology ; Cytotoxicity Tests, Immunologic / methods
Sprache	Englisch
Umfang	XIV, 550 S. : Ill., graph. Darst., 26 cm
Ausgabenhinweis	2. ed.
Verlag	Humana Press
Erscheinungsort	New York
Erscheinungsland	Vereinigte Staaten
Dokumenttyp	Buch
HBZ-ID	HT016177056
ISBN	978-1-60761-361-9 ; 1-60761-361-1 ; 9781607613626 ; 160761362X
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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Artikel ; Online: Mystery Checkpoint Revealed: KIR3DL3 Finally Found a Ligand in HHLA2.

Campbell, Kerry S

Cancer immunology research

2021 Band 9, Heft 2, Seite(n) 128

Abstract: Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand ... ...

Abstract	Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2
Mesh-Begriff(e)	Immunoglobulins ; Killer Cells, Natural ; Ligands ; Receptors, KIR
Chemische Substanzen	Immunoglobulins ; Ligands ; Receptors, KIR
Sprache	Englisch
Erscheinungsdatum	2021-02-03
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Comment
ZDB-ID	2732489-8
ISSN	2326-6074 ; 2326-6066
ISSN (online)	2326-6074
ISSN	2326-6066
DOI	10.1158/2326-6066.CIR-20-0996
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Natural killer cell protocols

Campbell, Kerry S.

cellular and molecular methods

(Methods in molecular biology ; 121)

2000

Verfasserangabe	ed. by Kerry S. Campbell
Serientitel	Methods in molecular biology ; 121
Überordnung
Schlagwörter	Killerzelle ; Methode ; Natürliche Killerzelle
Schlagwörter	NK-Zelle ; Methodik ; Verfahren ; Technik ; Methoden ; K-Zelle ; Cytotoxische Zelle ; Zytotoxische Zelle ; Zytotoxischer T-Lymphozyt ; Cytotoxischer T-Lymphozyt
Sprache	Englisch
Umfang	XVII, 398 S. : Ill., graph. Darst.
Verlag	Humana Press
Erscheinungsort	Totowa, NJ
Erscheinungsland	Vereinigte Staaten
Dokumenttyp	Buch
HBZ-ID	HT012762551
ISBN	0-89603-683-9 ; 978-0-89603-683-3
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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Artikel ; Online: Dogs can discriminate between human baseline and psychological stress condition odours.

Wilson, Clara / Campbell, Kerry / Petzel, Zachary / Reeve, Catherine

PloS one

2022 Band 17, Heft 9, Seite(n) e0274143

Abstract: Previous research suggests that dogs can detect when humans are experiencing stress. This study tested whether baseline and stress odours were distinguishable to dogs, using a double-blind, two-phase, three-alternative forced-choice procedure. Combined ... ...

Abstract	Previous research suggests that dogs can detect when humans are experiencing stress. This study tested whether baseline and stress odours were distinguishable to dogs, using a double-blind, two-phase, three-alternative forced-choice procedure. Combined breath and sweat samples were obtained from participants at baseline, and after a stress-inducing (mental arithmetic) task. Participants' stress was validated with self-report and physiological measures recorded via a Biopac MP150 system. Thirty-six participants' samples were presented to four dogs across 36 sessions (16, 11, 7 and 2 sessions, respectively). Each session consisted of 10 Phase One training trials and 20 Phase Two discrimination trials. In Phase One, the dog was presented with a participant's stress sample (taken immediately post-task) alongside two blanks (the sample materials without breath or sweat), and was required to identify the stress sample with an alert behaviour. In Phase Two, the dog was presented with the stress sample, the same participant's baseline sample (taken pre-task), and a blank. Which sample (blank, baseline, or stress) the dog performed their alert behaviour on was measured. If dogs can correctly alert on the stress sample in Phase Two (when the baseline sample was present), it suggests that baseline and stress odours are distinguishable. Performance ranged from 90.00% to 96.88% accuracy with a combined accuracy of 93.75% (N trials = 720). A binomial test (where probability of success on a single trial was 0.33, and alpha was 0.05) showed that the proportion of correct trials was greater than that expected by chance (p < 0.001). Results indicate that the physiological processes associated with an acute psychological stress response produce changes in the volatile organic compounds emanating from breath and/or sweat that are detectable to dogs. These results add to our understanding of human-dog relationships and could have applications to Emotional Support and Post Traumatic Stress Disorder (PTSD) service dogs.
Mesh-Begriff(e)	Animals ; Dogs ; Double-Blind Method ; Humans ; Odorants ; Stress Disorders, Post-Traumatic ; Stress, Psychological ; Volatile Organic Compounds
Chemische Substanzen	Volatile Organic Compounds
Sprache	Englisch
Erscheinungsdatum	2022-09-28
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0274143
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders.

Maskalenko, Nicholas A / Zhigarev, Dmitry / Campbell, Kerry S

Nature reviews. Drug discovery

2022 Band 21, Heft 8, Seite(n) 559–577

Abstract: Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and viral infections. They are 'first responders' that can spontaneously recognize abnormal cells in the body, rapidly eliminate them through focused cytotoxicity ... ...

Abstract	Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and viral infections. They are 'first responders' that can spontaneously recognize abnormal cells in the body, rapidly eliminate them through focused cytotoxicity mechanisms and potently produce pro-inflammatory cytokines and chemokines that recruit and activate other immune cells to initiate an adaptive response. From the initial discovery of the diverse cell surface receptors on NK cells to the characterization of regulatory events that control their function, our understanding of the basic biology of NK cells has improved dramatically in the past three decades. This advanced knowledge has revealed increased mechanistic complexity, which has opened the doors to the development of a plethora of exciting new therapeutics that can effectively manipulate and target NK cell functional responses, particularly in cancer patients. Here, we summarize the basic mechanisms that regulate NK cell biology, review a wide variety of drugs, cytokines and antibodies currently being developed and used to stimulate NK cell responses, and outline evolving NK cell adoptive transfer approaches to treat cancer.
Mesh-Begriff(e)	Cytokines/metabolism ; Humans ; Immunotherapy ; Killer Cells, Natural ; Neoplasms/therapy
Chemische Substanzen	Cytokines
Sprache	Englisch
Erscheinungsdatum	2022-03-21
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2062954-0
ISSN	1474-1784 ; 1474-1776
ISSN (online)	1474-1784
ISSN	1474-1776
DOI	10.1038/s41573-022-00413-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Suppressing the killer instinct.

Campbell, Kerry S

Science signaling

2016 Band 9, Heft 429, Seite(n) fs8

Abstract: Natural killer (NK) cells are innate lymphoid cells that have adopted activating and inhibitory signaling mechanisms enabling them to be tolerant of normal cells but to distinguish and eliminate tumor cells and virus-infected cells. In this issue of ... ...

Abstract	Natural killer (NK) cells are innate lymphoid cells that have adopted activating and inhibitory signaling mechanisms enabling them to be tolerant of normal cells but to distinguish and eliminate tumor cells and virus-infected cells. In this issue of Science Signaling, Matalon et al show how inhibitory receptors disrupt NK cell activation by stimulating dephosphorylation of the adaptor protein LAT (linker of activated T cells) and phospholipase C-γ by the phosphatase SHP-1 [Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1], as well as ubiquitylation of LAT by Cbl family E3 ubiquitin ligases.
Mesh-Begriff(e)	Adaptor Proteins, Signal Transducing ; Instinct ; Killer Cells, Natural/cytology ; Phospholipase C gamma ; Phosphorylation ; Protein Tyrosine Phosphatase, Non-Receptor Type 11 ; Protein Tyrosine Phosphatase, Non-Receptor Type 6
Chemische Substanzen	Adaptor Proteins, Signal Transducing ; Protein Tyrosine Phosphatase, Non-Receptor Type 11 (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 6 (EC 3.1.3.48) ; Phospholipase C gamma (EC 3.1.4.3)
Sprache	Englisch
Erscheinungsdatum	2016-05-24
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review ; Comment
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.aaf6348
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The effect of repeated testing on judgement bias in domestic dogs (Canis familiaris).

Wilson, Clara / Hall, Nathan / Aviles-Rosa, Edgar O / Campbell, Kerry / Arnott, Gareth / Reeve, Catherine

Animal cognition

2022 Band 26, Heft 2, Seite(n) 477–489

Abstract: Judgement bias paradigms are increasingly being used as a measure of affective state in dogs. Approach to an ambiguous stimulus is commonly used as a measure of affect, however, this may also be influenced by learning. This study directly measured the ... ...

Abstract	Judgement bias paradigms are increasingly being used as a measure of affective state in dogs. Approach to an ambiguous stimulus is commonly used as a measure of affect, however, this may also be influenced by learning. This study directly measured the impact of learning on a commonly used judgement bias paradigm in the absence of an affective state manipulation. Dogs (N = 15) were tested on a judgement bias task across five sessions. The dogs' latency to approach a bowl placed in one of three ambiguous locations between non-baited (negative) and baited (positive) locations was measured. Results show that session number had a significant effect on the dogs' latencies to reach the ambiguous bowl locations, with post-hoc tests revealing that dogs were significantly slower to approach the locations as the number of sessions increased. Session number also had a significant effect on the number of times the dogs did not approach the bowl within 30 s of being released, with the number of no approaches generally increasing across sessions. When dog identity was included as a fixed effect, a significant effect on latency to approach was found, suggesting that some dogs were consistently faster than others across sessions. To assess whether the paradigm produced repeatable results, Intraclass Correlation Coefficients were used. A low degree of reliability was found between latencies to approach each bowl position across sessions. This study demonstrates that dogs learned that the ambiguous locations were not rewarded with repeated exposures, and that this impacted their responses. We conclude that this judgement bias paradigm may require further consideration if applied across multiple exposures and that repeated results should be interpreted with caution as they are likely impacted by learning.
Mesh-Begriff(e)	Dogs ; Animals ; Judgment/physiology ; Reproducibility of Results ; Emotions ; Learning ; Reward
Sprache	Englisch
Erscheinungsdatum	2022-09-12
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1466332-6
ISSN	1435-9456 ; 1435-9448
ISSN (online)	1435-9456
ISSN	1435-9448
DOI	10.1007/s10071-022-01689-3
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT.

Wasserman, Jason S / Fowle, Holly / Hashmi, Rumesa / Atar, Diba / Patel, Kishan / Yarmahmoodi, Amir / Macfarlane, Alexander W / Tan, Yinfei / Cukierman, Edna / Gligorijevic, Bojana / Karami, Adam / Whelan, Kelly A / Campbell, Kerry S / Graña, Xavier

Research square

2024

Abstract: Prostate cancer (PCa) is the most common cancer diagnosed in men worldwide and the second leading cause of cancer-related deaths in US males in 2022. Prostate cancer also represents the second highest cancer mortality disparity between non-Hispanic ... ...

Abstract	Prostate cancer (PCa) is the most common cancer diagnosed in men worldwide and the second leading cause of cancer-related deaths in US males in 2022. Prostate cancer also represents the second highest cancer mortality disparity between non-Hispanic blacks and whites. However, there is a relatively small number of prostate normal and cancer cell lines compared to other cancers. To identify the molecular basis of PCa progression, it is important to have prostate epithelial cell (PrEC) lines as karyotypically normal as possible. Our lab recently developed a novel methodology for the rapid and efficient immortalization of normal human PrEC that combines simultaneous CRISPR-directed inactivation of CDKN2A exon 2 (which directs expression of p16INK4A and p14ARF) and ectopic expression of an hTERT transgene. To optimize this methodology to generate immortalized lines with minimal genetic alterations, we sought to target exon 1α of the CDKN2A locus so that p16INK4A expression is ablated while p14ARF expression remains unaltered. Here we describe the establishment of two cell lines: one with the above-mentioned p16INK4A only loss, and a second line targeting both products in the CDKN2A locus. We characterize the potential lineage origin of these new cell lines along with our previously obtained clones, revealing distinct gene expression signatures. Based on the analyses of protein markers and RNA expression signatures, these cell lines are most closely related to a subpopulation of basal prostatic cells. Given the simplicity of this one-step methodology and the fact that it uses only the minimal genetic alterations necessary for immortalization, it should also be suitable for the establishment of cell lines from primary prostate tumor samples, an urgent need given the limited number of available prostate cancer cell lines.
Sprache	Englisch
Erscheinungsdatum	2024-05-06
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.21203/rs.3.rs-4294058/v1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma.

Campbell, Kerry S / Cohen, Adam D / Pazina, Tatiana

Frontiers in immunology

2018 Band 9, Seite(n) 2551

Abstract: Multiple myeloma (MM) is a bone marrow plasma cell neoplasm and is the second most-common hematologic malignancy. Despite advances in therapy, MM remains largely incurable. Elotuzumab is a humanized IgG1 monoclonal antibody targeting SLAMF7, which is ... ...

Abstract	Multiple myeloma (MM) is a bone marrow plasma cell neoplasm and is the second most-common hematologic malignancy. Despite advances in therapy, MM remains largely incurable. Elotuzumab is a humanized IgG1 monoclonal antibody targeting SLAMF7, which is highly expressed on myeloma cells, and the antibody is approved for the treatment of relapsed and/or refractory (RR) MM in combination with lenalidomide and dexamethasone. Elotuzumab can stimulate robust antibody-dependent cellular cytotoxicity (ADCC) through engaging with FcγRIIIA (CD16) on NK cells and antibody-dependent cellular phagocytosis (ADCP) by macrophages. Interestingly, SLAMF7 is also expressed on cytolytic NK cells, which also express the requisite adaptor protein, EAT-2, to mediate activation signaling. Accumulating evidence indicates that antibody crosslinking of SLAMF7 on human and mouse NK cells can stimulate EAT-2-dependent activation of PLCγ, ERK, and intracellular calcium mobilization. The binding of SLAMF7 by elotuzumab can directly induce signal transduction in human NK cells, including co-stimulation of the calcium signaling triggered through other surface receptors, such as NKp46 and NKG2D. In RRMM patients, elotuzumab monotherapy did not produce objective responses, but did enhance the activity of approved standard of care therapies, including lenalidomide or bortezomib, which are known to enhance anti-tumor responses by NK cells. Taken together, these preclinical results and accumulating experience in the clinic provide compelling evidence that the mechanism of action of elotuzumab in MM patients involves the activation of NK cells through both CD16-mediated ADCC and direct co-stimulation via engagement with SLAMF7, as well as promoting ADCP by macrophages. We review the current understanding of how elotuzumab utilizes multiple mechanisms to facilitate immune-mediated attack of myeloma cells, as well as outline goals for future research.
Mesh-Begriff(e)	Animals ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/immunology ; Dexamethasone/therapeutic use ; GPI-Linked Proteins/immunology ; Humans ; Killer Cells, Natural/immunology ; Lenalidomide/therapeutic use ; Lymphocyte Activation/immunology ; Macrophages/immunology ; Mice ; Multiple Myeloma/drug therapy ; Multiple Myeloma/immunology ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Natural Cytotoxicity Triggering Receptor 1/metabolism ; Phagocytosis/immunology ; Plasma Cells/pathology ; Receptors, IgG/immunology ; Signaling Lymphocytic Activation Molecule Family/immunology ; Transcription Factors/metabolism
Chemische Substanzen	Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; Biomarkers, Tumor ; FCGR3B protein, human ; GPI-Linked Proteins ; KLRK1 protein, human ; NCR1 protein, human ; NK Cell Lectin-Like Receptor Subfamily K ; Natural Cytotoxicity Triggering Receptor 1 ; Receptors, IgG ; SH2D1B protein, human ; SLAMF7 protein, human ; Signaling Lymphocytic Activation Molecule Family ; Transcription Factors ; elotuzumab (1351PE5UGS) ; Dexamethasone (7S5I7G3JQL) ; Lenalidomide (F0P408N6V4)
Sprache	Englisch
Erscheinungsdatum	2018-11-05
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02551
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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