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  1. Article: Real-World Safety Data of the Orphan Drug Onasemnogene Abeparvovec (Zolgensma

    Ruggiero, Rosanna / Balzano, Nunzia / Nicoletti, Maria Maddalena / di Mauro, Gabriella / Fraenza, Federica / Campitiello, Maria Rosaria / Rossi, Francesco / Capuano, Annalisa

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: The recent introduction of the innovative therapy, onasemnogene abeparvovec ( ... ...

    Abstract The recent introduction of the innovative therapy, onasemnogene abeparvovec (Zolgensma
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Immune Checkpoint Inhibitors and Scleroderma: Data from the European Pharmacovigilance Database.

    Nicoletti, Maria Maddalena / Crisci, Erminia / Cosenza, Vincenzo / Riccardi, Consiglia / Campitiello, Maria Rosaria / Ruggiero, Donatella / Berrino, Pasquale Maria / Docimo, Giovanni / Scavone, Cristina

    Drugs - real world outcomes

    2023  Volume 11, Issue 1, Page(s) 33–41

    Abstract: Background: Immune checkpoint inhibitors (ICIs) can be commonly associated with the occurrence of immune-related adverse drug reactions (irADRs), which can involve any tissue and organ. ICI-induced skin toxicities are common irADRs and they can be a ... ...

    Abstract Background: Immune checkpoint inhibitors (ICIs) can be commonly associated with the occurrence of immune-related adverse drug reactions (irADRs), which can involve any tissue and organ. ICI-induced skin toxicities are common irADRs and they can be a consequence of a rheumatologic ADR, such as in the case of scleroderma. A recent literature review reported that scleroderma and scleroderma mimics represent a group of disorders with significant morbidity that have been described during ICIs' use.
    Objective and methods: Considering the clinical significance of scleroderma cases, the present study aimed to analyze the occurrence of these events in patients receiving ICIs by describing data from individual case safety reports (ICSRs) retrieved from the European spontaneous reporting system, EudraVigilance (EV).
    Results: Until February 2023, 70 ICSRs with at least one ICI as the suspected drug and at least one preferred term (PT) related to scleroderma cases were retrieved from the EV. Pembrolizumab was reported as suspected in 41 ICSRs, nivolumab in 25 ICSRs, ipilimumab in 8 ICSRs and atezolizumab in 3 ICSRs. Patients who experienced scleroderma cases were adults, and no differences were found in terms of sex distribution. Scleroderma cases were mainly classified as serious, while the outcome was mainly reported as favorable. The most reported PTs were scleroderma and morphea.
    Conclusions: Considering the seriousness of ICI-induced scleroderma cases and the recent marketing authorization of some ICIs, we believe that further high-quality clinical studies should be conducted on this topic to better estimate the impact of these events in patients with cancer.
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806600-5
    ISSN 2198-9788 ; 2199-1154
    ISSN (online) 2198-9788
    ISSN 2199-1154
    DOI 10.1007/s40801-023-00399-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Role of β1 Integrin/CD29 as a Potential Prognostic Factor for the Risk of Progression to Cervical Carcinoma in HPV-Associated Lesions.

    Schettino, Maria Teresa / Preti, Eleonora Petra / Vietri, Valeria / Agrillo, Nadia / Iavazzo, Nicola / Fasulo, Diego Domenico / De Franciscis, Pasquale / Campitiello, Maria Rosaria / Vastarella, Maria Giovanna / Riemma, Gaetano / Gardella, Barbara / Murina, Filippo

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 3

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Female ; Humans ; Integrin beta1 ; Papillomavirus Infections/complications ; Prognosis ; Neoplasm Recurrence, Local ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Dysplasia ; Carcinoma
    Chemical Substances Integrin beta1
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60030364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Sodium-glucose cotransporter-2 (SGLT2) inhibitors and the reporting of falls and fractures: an european pharmacovigilance analysis.

    Mascolo, Annamaria / Rafaniello, Concetta / di Mauro, Gabriella / Ruggiero, Donatella / Campitiello, Maria Rosaria / Donniacuo, Maria / Berrino, Pasquale Maria / Rossi, Francesco / Paolisso, Giuseppe / Capuano, Annalisa

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1245642

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1245642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genetic Variants of Gonadotropins and Their Receptors Could Influence Controlled Ovarian Stimulation: IVF Data from a Prospective Multicenter Study.

    Alviggi, Carlo / Longobardi, Salvatore / Papaleo, Enrico / Santi, Daniele / Alfano, Simona / Vanni, Valeria Stella / Campitiello, Maria Rosaria / De Rosa, Pasquale / Strina, Ida / Huhtaniemi, Ilpo / Pursiheimo, Juha-Pekka / D'Hooghe, Thomas / Humaidan, Peter / Conforti, Alessandro

    Genes

    2023  Volume 14, Issue 6

    Abstract: Background: Specific polymorphisms might influence controlled ovarian stimulation in women undergoing assisted reproductive technologies (ARTs). Data regarding possible interactions of these polymorphisms are still scanty. The aim of this analysis was ... ...

    Abstract Background: Specific polymorphisms might influence controlled ovarian stimulation in women undergoing assisted reproductive technologies (ARTs). Data regarding possible interactions of these polymorphisms are still scanty. The aim of this analysis was to evaluate the effect of polymorphisms of gonadotropins and their receptors in women undergoing ART.
    Methods: A total of 94 normogonadotropic patients from three public ART units were enrolled. Patients underwent a gonadotropin releasing hormone (GnRH) long down-regulation protocol with a starting dose of 150 IU of recombinant follicular stimulating hormone (FSH) daily. Eight polymorphisms were genotyped.
    Results: A total of 94 women (mean age 30.71 ± 2.61) were recruited. Fewer fertilized and mature oocytes were retrieved in homozygous carriers of luteinizing hormone/choriogonadotropin receptor (LHCGR) 291 (T/T) than in heterozygous C/T carriers (
    Conclusions: Our study demonstrated that specific polymorphisms affect the response to ovarian stimulation. Despite this finding, more robust studies are required to establish the clinical utility of genotype analysis before ovarian stimulation.
    MeSH term(s) Female ; Animals ; Prospective Studies ; Gonadotropins/therapeutic use ; Follicle Stimulating Hormone ; Ovulation Induction ; Fertilization in Vitro
    Chemical Substances Gonadotropins ; Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14061269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures.

    Sgueglia, Giulia / Longobardi, Salvatore / Valerio, Domenico / Campitiello, Maria Rosaria / Colacurci, Nicola / Di Pietro, Cinzia / Battaglia, Rosalia / D'Hooghe, Thomas / Altucci, Lucia / Dell'Aversana, Carmela

    Clinical epigenetics

    2023  Volume 15, Issue 1, Page(s) 76

    Abstract: The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) ... ...

    Abstract The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success.
    MeSH term(s) Pregnancy ; Female ; Humans ; Aged ; DNA Methylation ; Pregnancy Rate ; Fertilization in Vitro/adverse effects ; Infertility, Female/genetics ; Infertility, Female/therapy ; Fertility
    Language English
    Publishing date 2023-05-04
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-023-01490-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Skin Toxicities Associated with Botulin Toxin Injection for Aesthetic Procedures: Data from the European Spontaneous Reporting System.

    Nicoletti, Maria Maddalena / Anatriello, Antonietta / Liguori, Valerio / Cantone, Andrea / di Mauro, Gabriella / Izzo, Imma / Lettera, Nicoletta / Della Ragione, Joao Marcos / Campitiello, Maria Rosaria / Cosenza, Vincenzo / Scavone, Cristina

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 11

    Abstract: Botulinum toxin is a protein deriving from the ... ...

    Abstract Botulinum toxin is a protein deriving from the bacteria
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16111611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Genetic Variants of Gonadotropins and Their Receptors Could Influence Controlled Ovarian Stimulation: IVF Data from a Prospective Multicenter Study

    Alviggi, Carlo / Longobardi, Salvatore / Papaleo, Enrico / Santi, Daniele / Alfano, Simona / Vanni, Valeria Stella / Campitiello, Maria Rosaria / De Rosa, Pasquale / Strina, Ida / Huhtaniemi, I. T. / Pursiheimo, Juha-Pekka / D’Hooghe, Thomas / Humaidan, Peter / Conforti, Alessandro

    Genes (Basel). 2023 June 15, v. 14, no. 6

    2023  

    Abstract: Background: Specific polymorphisms might influence controlled ovarian stimulation in women undergoing assisted reproductive technologies (ARTs). Data regarding possible interactions of these polymorphisms are still scanty. The aim of this analysis was to ...

    Abstract Background: Specific polymorphisms might influence controlled ovarian stimulation in women undergoing assisted reproductive technologies (ARTs). Data regarding possible interactions of these polymorphisms are still scanty. The aim of this analysis was to evaluate the effect of polymorphisms of gonadotropins and their receptors in women undergoing ART. Methods: A total of 94 normogonadotropic patients from three public ART units were enrolled. Patients underwent a gonadotropin releasing hormone (GnRH) long down-regulation protocol with a starting dose of 150 IU of recombinant follicular stimulating hormone (FSH) daily. Eight polymorphisms were genotyped. Results: A total of 94 women (mean age 30.71 ± 2.61) were recruited. Fewer fertilized and mature oocytes were retrieved in homozygous carriers of luteinizing hormone/choriogonadotropin receptor (LHCGR) 291 (T/T) than in heterozygous C/T carriers (p = 0.035 and p = 0.05, respectively). In FSH receptor (FSHR) rs6165 and FSHR rs6166 carriers, the ratio between total gonadotropin consumption and number of oocytes retrieved differed significantly among three genotypes (p = 0.050), and the ratio was lower in homozygous A/A carriers than in homozygous G/G and heterozygous carriers. Women who co-expressed allele G in FSHR-29 rs1394205 and FSHR rs6166 and allele C LHCGR 291 rs12470652 are characterized by an increased ratio between total FSH dosage and number of oocytes collected after ovarian stimulation (risk ratio: 5.44, CI 95%: 3.18–7.71, p < 0.001). Conclusions: Our study demonstrated that specific polymorphisms affect the response to ovarian stimulation. Despite this finding, more robust studies are required to establish the clinical utility of genotype analysis before ovarian stimulation.
    Keywords alleles ; chorionic gonadotropins ; follicle-stimulating hormone receptors ; genotyping ; heterozygosity ; homozygosity ; luteinizing hormone ; oocytes ; relative risk
    Language English
    Dates of publication 2023-0615
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14061269
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Inhibition of Galectins and the P2X7 Purinergic Receptor as a Therapeutic Approach in the Neurovascular Inflammation of Diabetic Retinopathy.

    Lepre, Caterina Claudia / Russo, Marina / Trotta, Maria Consiglia / Petrillo, Francesco / D'Agostino, Fabiana Anna / Gaudino, Gennaro / D'Amico, Giovanbattista / Campitiello, Maria Rosaria / Crisci, Erminia / Nicoletti, Maddalena / Gesualdo, Carlo / Simonelli, Francesca / D'Amico, Michele / Hermenean, Anca / Rossi, Settimio

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Diabetic retinopathy (DR) is the most frequent microvascular retinal complication of diabetic patients, contributing to loss of vision. Recently, retinal neuroinflammation and neurodegeneration have emerged as key players in DR progression, and therefore, ...

    Abstract Diabetic retinopathy (DR) is the most frequent microvascular retinal complication of diabetic patients, contributing to loss of vision. Recently, retinal neuroinflammation and neurodegeneration have emerged as key players in DR progression, and therefore, this review examines the neuroinflammatory molecular basis of DR. We focus on four important aspects of retinal neuroinflammation: (i) the exacerbation of endoplasmic reticulum (ER) stress; (ii) the activation of the NLRP3 inflammasome; (iii) the role of galectins; and (iv) the activation of purinergic 2X7 receptor (P2X7R). Moreover, this review proposes the selective inhibition of galectins and the P2X7R as a potential pharmacological approach to prevent the progression of DR.
    MeSH term(s) Humans ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/etiology ; Neuroinflammatory Diseases ; Galectins/therapeutic use ; Inflammation/drug therapy ; Inflammasomes/metabolism ; Receptors, Purinergic P2X7 ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Diabetes Mellitus
    Chemical Substances Galectins ; Inflammasomes ; Receptors, Purinergic P2X7 ; NLR Family, Pyrin Domain-Containing 3 Protein
    Language English
    Publishing date 2023-06-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Does Intrauterine Injection of hCG Improve IVF Outcome? A Systematic Review and a Meta-Analysis.

    Conforti, Alessandro / Longobardi, Salvatore / Carbone, Luigi / Iorio, Giuseppe Gabriele / Cariati, Federica / Campitiello, Maria Rosaria / Strina, Ida / Palese, Michela / D'Hooghe, Thomas / Alviggi, Carlo

    International journal of molecular sciences

    2022  Volume 23, Issue 20

    Abstract: Various interventions have been proposed to improve embryo implantation in IVF. Among these, intrauterine injections of human chorionic gonadotropin seem to have promising results. Consequently, we conducted a review and meta-analysis to assess IVF ... ...

    Abstract Various interventions have been proposed to improve embryo implantation in IVF. Among these, intrauterine injections of human chorionic gonadotropin seem to have promising results. Consequently, we conducted a review and meta-analysis to assess IVF outcomes by comparing couples who underwent intrauterine hCG injection transfer versus those who underwent embryo transfer with intrauterine injection of placebo, or without any additional intervention. The primary outcome was the clinical pregnancy rate. Secondary outcomes were the implantation rate, miscarriage rate, and live birth rate. A meta-analysis was conducted using the random effects model, while bias within studies was detected using the Cochrane risk of bias tool. Ectopic pregnancies and stillbirths were also assessed. The clinical pregnancy (RR 1.38, 95% CI 1.17−1.62, p < 0.0001) and implantation rate (RR 1.40, 95% CI 1.12−1.75, p = 0.003) were significantly higher in women who underwent hCG injection than in the control group. These significant effects persisted only in women who underwent cleavage-stage embryo transfer. No significant differences between groups were observed in the other secondary outcomes. In conclusion, our systematic review and meta-analysis demonstrate that intrauterine injection of hCG could be a valuable approach in women who undergo cleavage-stage embryo transfer. Given the lack of data about the live birth rate, caution should be exercised in interpreting these data.
    MeSH term(s) Pregnancy ; Female ; Humans ; Embryo Transfer/methods ; Pregnancy Rate ; Chorionic Gonadotropin/pharmacology ; Embryo Implantation ; Fertilization in Vitro/methods
    Chemical Substances Chorionic Gonadotropin
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232012193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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