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Article ; Online: One-size-fits-all peak VO

Campodonico, Jeness / Agostoni, Piergiuseppe

2018 Volume 263, Page(s) 94–95

MeSH term(s)	Dreams ; Mental Recall ; Surveys and Questionnaires
Language	English
Publishing date	2018-05-13
Publishing country	Netherlands
Document type	Editorial ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2018.04.046
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Article ; Online: Acute heart failure: Diagnosis first and then treatment.

Cosentino, Nicola / Campodonico, Jeness

International journal of cardiology

2018 Volume 269, Page(s) 224–225

MeSH term(s)	Acute Disease ; Heart Failure ; Humans ; Natriuretic Peptide, Brain
Chemical Substances	Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2018-07-06
Publishing country	Netherlands
Document type	Editorial ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2018.07.032
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Article ; Online: Role of comorbidities in heart failure prognosis Part I: Anaemia, iron deficiency, diabetes, atrial fibrillation.

Paolillo, Stefania / Scardovi, Angela B / Campodonico, Jeness

European journal of preventive cardiology

2020 Volume 27, Issue 2_suppl, Page(s) 27–34

Abstract: Cardiovascular and non-cardiovascular comorbidities are frequently observed in heart failure patients, complicating the therapeutic management and leading to poor prognosis. The prompt recognition of associated comorbid conditions is of great importance ... ...

Abstract	Cardiovascular and non-cardiovascular comorbidities are frequently observed in heart failure patients, complicating the therapeutic management and leading to poor prognosis. The prompt recognition of associated comorbid conditions is of great importance to optimize the clinical management, the follow-up, and the treatment of patients affected by chronic heart failure. Anaemia and iron deficiency are commonly reported in all heart failure forms, have a multifactorial aetiology and are responsible for reduced exercise tolerance, impaired quality of life, and poor long-term prognosis. Diabetes mellitus is highly prevalent in heart failure and a poor glycaemic control is associated with worst outcome. Two specific heart failure forms are usually observed in diabetic patients: an ischaemic cardiomyopathy or a typical diabetic cardiomyopathy. The implementation of use of sodium-glucose cotransporter-2 inhibitors will much improve in the near future the long-term prognosis of patients affected by heart failure and diabetes. Among cardiovascular comorbidities, atrial fibrillation is the most common arrhythmic disease of heart failure patients and it is still not clear whether its presence should be considered as a prognostic indicator or as a marker of advanced disease. The aim of the present review was to explore the clinical and prognostic impact of anaemia and iron deficiency, diabetes mellitus, and atrial fibrillation in patients affected by chronic heart failure.
MeSH term(s)	Anemia, Iron-Deficiency/blood ; Anemia, Iron-Deficiency/diagnosis ; Anemia, Iron-Deficiency/epidemiology ; Anemia, Iron-Deficiency/therapy ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/therapy ; Biomarkers/blood ; Blood Glucose/metabolism ; Comorbidity ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Heart Disease Risk Factors ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/therapy ; Hemoglobins/metabolism ; Humans ; Iron/blood ; Prognosis ; Risk Assessment
Chemical Substances	Biomarkers ; Blood Glucose ; Hemoglobins ; Iron (E1UOL152H7)
Language	English
Publishing date	2020-12-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487320960288
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Article ; Online: Physiology of exercise and heart failure treatments: cardiopulmonary exercise testing as a tool for choosing the optimal therapeutic strategy.

Campodonico, Jeness / Contini, Mauro / Alimento, Marina / Mapelli, Massimo / Salvioni, Elisabetta / Mattavelli, Irene / Bonomi, Alice / Agostoni, Piergiuseppe

European journal of preventive cardiology

2023 Volume 30, Issue Suppl 2, Page(s) ii54–ii62

Abstract: In the last decades, the pharmacological treatment of heart failure (HF) become more complex due to the availability of new highly effective drugs. Although the cardiovascular effects of HF therapies have been extensively described, less known are their ... ...

Abstract	In the last decades, the pharmacological treatment of heart failure (HF) become more complex due to the availability of new highly effective drugs. Although the cardiovascular effects of HF therapies have been extensively described, less known are their effects on cardiopulmonary function considered as a whole, both at rest and in response to exercise. This is a 'holistic' approach to disease treatment that can be accurately evaluated by a cardiopulmonary exercise test. The aim of this paper is to assess the main differences in the effects of different drugs [angiotensin-converting enzyme (ACE)-inhibitors, Angiotensin II receptor blockers, β-blockers, Angiotensin receptor-neprilysin inhibitors, renal sodium-glucose co-transporter 2 inhibitors, iron supplementation] on cardiopulmonary function in patients with HF, both at rest and during exercise, and to understand how these differences can be taken into account when choosing the most appropriate treatment protocol for each individual patient leading to a precision medicine approach.
MeSH term(s)	Humans ; Exercise Test ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Adrenergic beta-Antagonists/therapeutic use ; Stroke Volume
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists ; Adrenergic beta-Antagonists
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwad189
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Article: Cardiopulmonary exercise testing and heart failure: a tale born from oxygen uptake.

Mapelli, Massimo / Salvioni, Elisabetta / Mattavelli, Irene / Vignati, Carlo / Galotta, Arianna / Magrì, Damiano / Apostolo, Anna / Sciomer, Susanna / Campodonico, Jeness / Agostoni, Piergiuseppe

European heart journal supplements : journal of the European Society of Cardiology

2023 Volume 25, Issue Suppl C, Page(s) C319–C325

Abstract: Since 50 years, cardiopulmonary exercise testing (CPET) plays a central role in heart failure (HF) assessment. Oxygen uptake ( ... ...

Abstract	Since 50 years, cardiopulmonary exercise testing (CPET) plays a central role in heart failure (HF) assessment. Oxygen uptake (VO
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1463769-8
ISSN	1554-2815 ; 1520-765X
ISSN (online)	1554-2815
ISSN	1520-765X
DOI	10.1093/eurheartjsupp/suad057
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Zs.A 1563 -Suppl.-: Show issues

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Article: Acute Myocardial Infarction During the COVID-19 Pandemic: An Update on Clinical Characteristics and Outcomes.

Toscano, Olga / Cosentino, Nicola / Campodonico, Jeness / Bartorelli, Antonio L / Marenzi, Giancarlo

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 648290

Abstract: The outbreak of coronavirus disease 2019 (COVID-19) has rapidly become a worldwide pandemic. On top of respiratory complications, COVID-19 is associated with major direct and indirect cardiovascular consequences, with the latter probably being even more ... ...

Abstract	The outbreak of coronavirus disease 2019 (COVID-19) has rapidly become a worldwide pandemic. On top of respiratory complications, COVID-19 is associated with major direct and indirect cardiovascular consequences, with the latter probably being even more relevant, especially in the setting of time-dependent cardiovascular emergencies. A growing amount of data suggests a dramatic decline in hospital admissions for acute myocardial infarction (AMI) worldwide during the COVID-19 pandemic, mostly since patients did not activate emergency medical systems because hospitals were perceived as dangerous places regarding the infection risk. Moreover, during the COVID-19 pandemic, patients with AMI had a significantly higher in-hospital mortality compared to those admitted before COVID-19, potentially due to late arrival to the hospital. Finally, no consensus has been reached regarding the most adequate healthcare management pathway for AMI and shared guidance on how to handle patients with AMI during the pandemic is still needed. In this review, we will provide an update on epidemiology, clinical characteristics, and outcomes of patients with AMI during the COVID-19 pandemic, with a special focus on its collateral cardiac impact.
Language	English
Publishing date	2021-12-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.648290
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Article ; Online: Inside OUES: fact or fiction?

Agostoni, Piergiuseppe / Gugliandolo, Paola / Campodonico, Jeness

European journal of preventive cardiology

2018 Volume 26, Issue 2, Page(s) 174–176

MeSH term(s)	Exercise Test ; Humans ; Oxygen Consumption
Language	English
Publishing date	2018-11-22
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487318814977
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Article: Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Cosentino, Nicola / Campodonico, Jeness / Milazzo, Valentina / De Metrio, Monica / Brambilla, Marta / Camera, Marina / Marenzi, Giancarlo

Nutrients. 2021 Oct. 14, v. 13, no. 10

2021

Abstract: Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population, observed across all ethnicities and among all age groups. Besides the established role of vitamin D in calcium homeostasis, its deficiency is emerging as a new ... ...

Abstract	Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population, observed across all ethnicities and among all age groups. Besides the established role of vitamin D in calcium homeostasis, its deficiency is emerging as a new risk factor for cardiovascular disease (CVD). In particular, several epidemiological and clinical studies have reported a close association between low vitamin D levels and major CVDs, such as coronary artery disease, heart failure, and atrial fibrillation. Moreover, in all these clinical settings, vitamin deficiency seems to predispose to increased morbidity, mortality, and recurrent cardiovascular events. Despite this growing evidence, interventional trials with supplementation of vitamin D in patients at risk of or with established CVD are still controversial. In this review, we aimed to summarize the currently available evidence supporting the link between vitamin D deficiency and major CVDs in terms of its prevalence, clinical relevance, prognostic impact, and potential therapeutic implications.
Keywords	atrial fibrillation ; calcium ; coronary artery disease ; heart failure ; homeostasis ; morbidity ; mortality ; risk factors ; therapeutics
Language	English
Dates of publication	2021-1014
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13103603
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Role of impaired iron transport on exercise performance in heart failure patients.

Campodonico, Jeness / Junod, Daniele / Carulli, Ermes / Lo Russo, Gerardo / Gaudenzi Asinelli, Margherita / Doni, Francesco / Bonomi, Alice / Agostoni, Piergiuseppe

European journal of preventive cardiology

2022 Volume 29, Issue 7, Page(s) 1104–1111

Abstract: Aims: Impaired iron transport (IIT) occurs frequently in heart failure (HF) patients, even in the absence of anaemia and it is associated with a poor quality of life and prognosis. The impact of IIT on exercise capacity, as assessed by the ... ...

Abstract	Aims: Impaired iron transport (IIT) occurs frequently in heart failure (HF) patients, even in the absence of anaemia and it is associated with a poor quality of life and prognosis. The impact of IIT on exercise capacity, as assessed by the cardiopulmonary exercise test (CPET), in HF is at present unknown. The aim of this article is to evaluate in HF patients the impact on exercise performance of IIT, defined as transferrin saturation (TSAT) <20%. Methods and results: We collected data of 676 patients hospitalized for HF. All underwent laboratory analysis, cardiac ultrasound, and CPET. Patients were grouped by the presence/absence of IIT and anaemia (haemoglobin <13 and <12 g/dL in male and female, respectively): Group 1 (G1) no anaemia, no IIT; Group 2 (G2) anaemia, no IIT; Group 3 (G3) no anaemia, IIT; Group 4 (G4) anaemia and IIT. Peak oxygen uptake (peakVO2) reduced from G1 to G3 and from G2 to G4 (G1: 1266 ± 497 mL/min, G2: 1011 ± 385 mL/min, G3: 1041 ± 395 mL/min, G4: 833 ± 241 mL/min), whereas the ventilation to carbon dioxide relationship slope (VE/VCO2 slope) increased (G1: 31.8 ± 7.5, G2: 34.5 ± 7.4, G3: 36.1 ± 10.2, G4: 37.5 ± 8.4). At multivariate regression analysis, peakVO2 independent predictors were anaemia, brain natriuretic peptide (BNP), and left ventricular ejection fraction, whereas VE/VCO2 slope independent predictors were IIT and BNP. Conclusion: In HF IIT is associated with exercise performance impairment independently from anaemia, and it is a predictor of elevated VE/VCO2 slope, a pivotal index of HF prognosis.
MeSH term(s)	Exercise Test/methods ; Female ; Heart Failure/diagnosis ; Humans ; Iron ; Male ; Oxygen Consumption ; Prognosis ; Quality of Life ; Stroke Volume ; Ventricular Function, Left
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwab216
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Article ; Online: Treatment of refractory vasospastic angina complicated by acute pulmonary oedema with levosimendan: a case report.

Moltrasio, Marco / Cosentino, Nicola / Conte, Edoardo / Campodonico, Jeness / Marenzi, Giancarlo

European heart journal. Case reports

2019 Volume 3, Issue 1, Page(s) ytz002

Abstract: Background: Vasospastic angina (VA) is an important cause of chest pain and patients often have 3- to 6-month clusters of recurrent attacks, separated by relatively asymptomatic periods. During these episodes the resulting myocardial ischaemia can lead ... ...

Abstract	Background: Vasospastic angina (VA) is an important cause of chest pain and patients often have 3- to 6-month clusters of recurrent attacks, separated by relatively asymptomatic periods. During these episodes the resulting myocardial ischaemia can lead to clinical complications of different severity, including acute myocardial infarction, acute heart failure, and cardiogenic shock. The management of severe and recurrent VA attacks is challenging, and no specific recommendations exist in recent cardiologic guidelines on the pharmacological strategy (inotropic/vasopressor agents) to adopt for this acute clinical setting. Case summary: We present a case of recurrent episodes of VA complicated by acute pulmonary oedema and cardiogenic shock despite maximal tolerated therapy (intravenous calcium antagonist and nitrates) that was successfully treated with levosimendan. Discussion: Levosimendan rapidly reverted cardiogenic shock, acute pulmonary oedema, and mitral regurgitation caused by a refractory coronary spasm, contributing to persistent clinical stabilization. Further evidence and a longer follow-up are needed to support our observation on the efficacy of levosimendan in this specific clinical setting.
Language	English
Publishing date	2019-02-05
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytz002
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