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Article: PSEN1 c.1292C

Orozco-Barajas, Maribel / Oropeza-Ruvalcaba, Yulisa / Canales-Aguirre, Alejandro A / Sánchez-González, Victor J

2022 Volume 14, Page(s) 860529

Abstract: Alzheimer's disease (AD) is the most common cause of dementia, characterized by progressive loss of cognitive function, with β-amyloid plaques and neurofibrillary tangles being its major pathological findings. Although the disease mainly affects the ... ...

Abstract	Alzheimer's disease (AD) is the most common cause of dementia, characterized by progressive loss of cognitive function, with β-amyloid plaques and neurofibrillary tangles being its major pathological findings. Although the disease mainly affects the elderly, c. 5-10% of the cases are due to
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.860529
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long chain capsaicin analogues synthetized by CALB-CLEAs show cytotoxicity on glioblastoma cell lines.

Diaz-Vidal, Tania / Armenta-Pérez, Vicente Paúl / Rosales-Rivera, Luis Carlos / Basulto-Padilla, Georgina Cristina / Martínez-Pérez, Raúl Balam / Mateos-Díaz, Juan Carlos / Gutiérrez-Mercado, Yanet K / Canales-Aguirre, Alejandro A / Rodríguez, Jorge A

Applied microbiology and biotechnology

2024 Volume 108, Issue 1, Page(s) 106

Abstract: Glioblastoma is one of the most lethal tumors, displaying striking cellular heterogeneity and drug resistance. The prognosis of patients suffering from glioblastoma after 5 years is only 5%. In the present work, capsaicin analogues bearing modifications ... ...

Abstract	Glioblastoma is one of the most lethal tumors, displaying striking cellular heterogeneity and drug resistance. The prognosis of patients suffering from glioblastoma after 5 years is only 5%. In the present work, capsaicin analogues bearing modifications on the acyl chain with long-chain fatty acids showed promising anti-tumoral activity by its cytotoxicity on U-87 and U-138 glioblastoma multiforme cells. The capsaicin analogues were enzymatically synthetized with cross-linked enzyme aggregates of lipase B from Candida antarctica (CALB). The catalytic performance of recombinant CALB-CLEAs was compared to their immobilized form on a hydrophobic support. After 72 h of reaction, the synthesis of capsaicin analogues from linoleic acid, docosahexaenoic acid, and punicic acid achieved a maximum conversion of 69.7, 8.3 and 30.3% with CALB-CLEAs, respectively. Similar values were obtained with commercial CALB, with conversion yields of 58.3, 24.2 and 22% for capsaicin analogues from linoleic acid, DHA and punicic acid, respectively. Olvanil and dohevanil had a significant cytotoxic effect on both U-87 and U-138 glioblastoma cells. Irrespective of the immobilization form, CALB is an efficient biocatalyst for the synthesis of anti-tumoral capsaicin derivatives. KEY POINTS: • This is the first report concerning the enzymatic synthesis of capsaicin analogues from docosahexaenoic acid and punicic acid with CALB-CLEAs. • The viability U-87 and U-138 glioblastoma cells was significantly affected after incubation with olvanil and dohevanil. • Capsaicin analogues from fatty acids obtained by CALB-CLEAs are promising candidates for therapeutic use as cytotoxic agents in glioblastoma cancer cells.
MeSH term(s)	Humans ; Capsaicin/pharmacology ; Enzymes, Immobilized/metabolism ; Glioblastoma/drug therapy ; Fungal Proteins/metabolism
Chemical Substances	olvanil (4P7KIU7003) ; dohevanil ; Capsaicin (S07O44R1ZM) ; Enzymes, Immobilized ; Fungal Proteins
Language	English
Publishing date	2024-01-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-023-12856-y
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Article ; Online: Chitosan-Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine.

Ojeda-Hernández, Doddy Denise / Canales-Aguirre, Alejandro A / Matias-Guiu, Jordi A / Matias-Guiu, Jorge / Gómez-Pinedo, Ulises / Mateos-Díaz, Juan Carlos

International journal of molecular sciences

2022 Volume 23, Issue 20

Abstract: Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages ... ...

Abstract	Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages of this interesting polysaccharide is its modifiability, which facilitates its use in tailor-made applications. In this way, the molecular structure of chitosan has been conjugated with multiple molecules to modify its mechanical, biological, or chemical properties. Here, we review the conjugation of chitosan with some bioactive molecules: hydroxycinnamic acids (HCAs); since these derivatives have been probed to enhance some of the biological effects of chitosan and to fine-tune its characteristics for its application in the biomedical field. First, the main characteristics of chitosan and HCAs are presented; then, the currently employed conjugation strategies between chitosan and HCAs are described; and, finally, the studied biomedical applications of these derivatives are discussed to present their limitations and advantages, which could lead to proximal therapeutic uses.
MeSH term(s)	Chitosan/chemistry ; Biocompatible Materials/chemistry ; Coumaric Acids/therapeutic use ; Tissue Engineering ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Anti-Infective Agents/chemistry
Chemical Substances	Chitosan (9012-76-4) ; Biocompatible Materials ; Coumaric Acids ; Anti-Infective Agents
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232012473
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Article ; Online: In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2.

Villalobos-Sánchez, Erendira / García-Ruiz, Daniel / Camacho-Villegas, Tanya A / Canales-Aguirre, Alejandro A / Gutiérrez-Ortega, Abel / Muñoz-Medina, José E / Elizondo-Quiroga, Darwin E

Viruses

2023 Volume 15, Issue 5

Abstract: The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral ... ...

Abstract	The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush (
MeSH term(s)	Animals ; Chlorocebus aethiops ; SARS-CoV-2 ; Masoprocol/pharmacology ; Masoprocol/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19 ; Vero Cells
Chemical Substances	Masoprocol (7BO8G1BYQU) ; Antiviral Agents
Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15051155
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Article: Potential benefits of structured lipids in bulk compound chocolate: Insights on bioavailability and effect on serum lipids

Ledesma, Rosa / Martínez-Pérez, Raúl B. / Curiel, David A. / Fernández, Laura M. / Silva, María L. / Canales-Aguirre, Alejandro A. / Rodríguez, Jorge A. / Mateos-Díaz, Juan C. / Lerma, Ana M. Preza y / Madrigal, Miguel

Food chemistry. 2022 May 01, v. 375

2022

Abstract: The bioavailability impact of serum lipids in compound chocolate products based on structured lipids was studied. Compound chocolate products containing fat with and without structured lipids were digested in vitro under simulated gastrointestinal ... ...

Abstract	The bioavailability impact of serum lipids in compound chocolate products based on structured lipids was studied. Compound chocolate products containing fat with and without structured lipids were digested in vitro under simulated gastrointestinal lipolysis conditions and were studied in vivo in healthy C57BL/6J mice. The in vitro digestion results show that products containing structured lipids, milk compound chocolate filling and white compound coating, significantly reduced the release rate of Free Fatty Acids (FFA) and improved the caloric reduction between 12.49% and 13.71% compared to products without structured lipids, suggesting that FFA were not absorbed. Animal feeding studies revealed no adverse effects on the compound products intake; in fact, these products reduced total cholesterol, LDL-c, VLDL-c and triacylglycerols. The present work shows the relevance of developing functional compound chocolate as providing a potential healthy initiative through the biological effect of the bioactive ingredients incorporated.
Keywords	active ingredients ; bioavailability ; blood serum ; chocolate ; cholesterol ; digestion ; food chemistry ; gastrointestinal system ; lipolysis ; milk ; triacylglycerols
Language	English
Dates of publication	2022-0501
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131824
Database	NAL-Catalogue (AGRICOLA)

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Article: A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1.

Hernández-Sapiéns, Mercedes A / Reza-Zaldívar, Edwin E / Cevallos, Ricardo R / Márquez-Aguirre, Ana L / Gazarian, Karlen / Canales-Aguirre, Alejandro A

Frontiers in cellular neuroscience

2020 Volume 14, Page(s) 151

Abstract: Alzheimer's disease (AD) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-β (Aβ) and intracellular accumulation of hyperphosphorylated tau ... ...

Abstract	Alzheimer's disease (AD) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-β (Aβ) and intracellular accumulation of hyperphosphorylated tau protein, primarily in areas implicated in memory and learning as prefrontal cortex and hippocampus. There are two forms of AD, a late-onset form that affects people over 65 years old, and the early-onset form, which is hereditable and affect people at early ages ~45 years. To date, there is no cure for the disease; consequently, it is essential to develop new tools for the study of processes implicated in the disease. Currently,
Language	English
Publishing date	2020-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2020.00151
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Article: Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System.

Ojeda-Hernández, Doddy Denise / Canales-Aguirre, Alejandro A / Matias-Guiu, Jorge / Gomez-Pinedo, Ulises / Mateos-Díaz, Juan C

Frontiers in bioengineering and biotechnology

2020 Volume 8, Page(s) 389

Abstract: It is well known that the central nervous system (CNS) has a limited regenerative capacity and that many therapeutic molecules cannot cross the blood brain barrier (BBB). The use of biomaterials has emerged as an alternative to overcome these limitations. ...

Abstract	It is well known that the central nervous system (CNS) has a limited regenerative capacity and that many therapeutic molecules cannot cross the blood brain barrier (BBB). The use of biomaterials has emerged as an alternative to overcome these limitations. For many years, biomedical applications of chitosan have been studied due to its remarkable biological properties, biocompatibility, and high versatility. Moreover, the interest in this biomaterial for CNS biomedical implementation has increased because of its ability to cross the BBB, mucoadhesiveness, and hydrogel formation capacity. Several chitosan-based biomaterials have been applied with promising results as drug, cell and gene delivery vehicles. Moreover, their capacity to form porous scaffolds and to bear cells and biomolecules has offered a way to achieve neural regeneration. Therefore, this review aims to bring together recent works that highlight the potential of chitosan and its derivatives as adequate biomaterials for applications directed toward the CNS. First, an overview of chitosan and its derivatives is provided with an emphasis on the properties that favor different applications. Second, a compilation of works that employ chitosan-based biomaterials for drug delivery, gene therapy, tissue engineering, and regenerative medicine in the CNS is presented. Finally, the most interesting trends and future perspectives of chitosan and its derivatives applications in the CNS are shown.
Language	English
Publishing date	2020-05-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2020.00389
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Article: Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.

Hernandez-Sapiens, Mercedes A / Reza-Zaldívar, Edwin E / Márquez-Aguirre, Ana L / Gómez-Pinedo, Ulises / Matias-Guiu, Jorge / Cevallos, Ricardo R / Mateos-Díaz, Juan C / Sánchez-González, Víctor J / Canales-Aguirre, Alejandro A

Neural regeneration research

2021 Volume 17, Issue 1, Page(s) 31–37

Abstract: The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is ...

Abstract	The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core of the γ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein, Notch-1, N- and E-cadherin, LRP, Syndecan, Delta, Jagged, CD44, ErbB4, and Nectin1a. Presenilin 1 plays an essential role in neural progenitor maintenance, neurogenesis, neurite outgrowth, synaptic function, neuronal function, myelination, and plasticity. Therefore, an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling, synaptic dysfunction, memory impairment, and increased Aβ
Language	English
Publishing date	2021-06-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.313016
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Article ; Online: Potential benefits of structured lipids in bulk compound chocolate: Insights on bioavailability and effect on serum lipids.

Ledesma, Rosa / Martínez-Pérez, Raúl B / Curiel, David A / Fernández, Laura M / Silva, María L / Canales-Aguirre, Alejandro A / Rodríguez, Jorge A / Mateos-Díaz, Juan C / Lerma, Ana M Preza Y / Madrigal, Miguel

Food chemistry

2021 Volume 375, Page(s) 131824

Abstract	The bioavailability impact of serum lipids in compound chocolate products based on structured lipids was studied. Compound chocolate products containing fat with and without structured lipids were digested in vitro under simulated gastrointestinal lipolysis conditions and were studied in vivo in healthy C57BL/6J mice. The in vitro digestion results show that products containing structured lipids, milk compound chocolate filling and white compound coating, significantly reduced the release rate of Free Fatty Acids (FFA) and improved the caloric reduction between 12.49% and 13.71% compared to products without structured lipids, suggesting that FFA were not absorbed. Animal feeding studies revealed no adverse effects on the compound products intake; in fact, these products reduced total cholesterol, LDL-c, VLDL-c and triacylglycerols. The present work shows the relevance of developing functional compound chocolate as providing a potential healthy initiative through the biological effect of the bioactive ingredients incorporated.
MeSH term(s)	Animals ; Biological Availability ; Cacao ; Chocolate ; Lipids ; Mice ; Mice, Inbred C57BL
Chemical Substances	Lipids
Language	English
Publishing date	2021-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131824
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer's Disease.

Reza-Zaldivar, Edwin E / Hernández-Sapiéns, Mercedes A / Minjarez, Benito / Gutiérrez-Mercado, Yanet K / Márquez-Aguirre, Ana L / Canales-Aguirre, Alejandro A

Frontiers in cellular neuroscience

2018 Volume 12, Page(s) 317

Abstract: Alzheimer's disease (AD) is the most common type of dementia affecting regions of the central nervous system that exhibit synaptic plasticity and are involved in higher brain functions such as learning and memory. AD is characterized by progressive ... ...

Abstract	Alzheimer's disease (AD) is the most common type of dementia affecting regions of the central nervous system that exhibit synaptic plasticity and are involved in higher brain functions such as learning and memory. AD is characterized by progressive cognitive dysfunction, memory loss and behavioral disturbances of synaptic plasticity and energy metabolism. Cell therapy has emerged as an alternative treatment of AD. The use of adult stem cells, such as neural stem cells and Mesenchymal Stem Cells (MSCs) from bone marrow and adipose tissue, have the potential to decrease cognitive deficits, possibly by reducing neuronal loss through blocking apoptosis, increasing neurogenesis, synaptogenesis and angiogenesis. These processes are mediated primarily by the secretion of many growth factors, anti-inflammatory proteins, membrane receptors, microRNAs (miRNA) and exosomes. Exosomes encapsulate and transfer several functional molecules like proteins, lipids and regulatory RNA which can modify cell metabolism. In the proteomic characterization of the content of MSC-derived exosomes, more than 730 proteins have been identified, some of which are specific cell type markers and others are involved in the regulation of binding and fusion of exosomes with adjacent cells. Furthermore, some factors were found that promote the recruitment, proliferation and differentiation of other cells like neural stem cells. Moreover, within exosomal cargo, a wide range of miRNAs were found, which can control functions related to neural remodeling as well as angiogenic and neurogenic processes. Taking this into consideration, the use of exosomes could be part of a strategy to promote neuroplasticity, improve cognitive impairment and neural replacement in AD. In this review, we describe how exosomes are involved in AD pathology and discuss the therapeutic potential of MSC-derived exosomes mediated by miRNA and protein cargo.
Language	English
Publishing date	2018-09-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2018.00317
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