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  1. Article ; Online: An expanded toxicological profile of tetramethyl bisphenol F (TMBPF), a precursor for a new food-contact metal packaging coating.

    Maffini, Maricel V / Canatsey, Ryan D

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2019  Volume 135, Page(s) 110889

    Abstract: Tetramethyl bisphenol F (TMBPF) has been shown to impart unique physical properties critical for high performance of epoxy can coatings without the estrogenic activity concerns associated with other bisphenols. To further characterize the toxicological ... ...

    Abstract Tetramethyl bisphenol F (TMBPF) has been shown to impart unique physical properties critical for high performance of epoxy can coatings without the estrogenic activity concerns associated with other bisphenols. To further characterize the toxicological profile of TMBPF, additional endocrine-related endpoints including in vitro aromatase inhibition and steroidogenesis assays, and in vivo androgen agonism/antagonism were performed. Systemic toxicity was also assessed by a repeat dose 90-day dietary toxicity study followed by 28-day recovery period. TMBPF did not inhibit aromatase activity, and induced estradiol and testosterone at highest non-cytotoxic concentrations (10 μM) in the steroidogenesis assay. In the Hershberger assay, TMBPF showed no androgenic activity at any dose and equivocal anti-androgenic activity at the highest dose (1000 mg/kg-bw/d). In a 90-day dietary toxicity study with 28-day recovery period, observations including changes in clinical pathology, absolute and relative organ weights, and microscopic findings are discussed. In this current study, the no observed adverse effect level was considered to be 750 mg/kg-bw/d for female rats and 1000 mg/kg-bw/d for male rats with no biologically significant changes to endocrine endpoints at any dose level. Our findings provide further evidence that TMBPF is a low-toxicity substance with a toxicology profile distinct from some other bisphenols.
    MeSH term(s) Animals ; Benzhydryl Compounds/administration & dosage ; Benzhydryl Compounds/chemistry ; Benzhydryl Compounds/toxicity ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Female ; Food Packaging ; Gonadal Steroid Hormones/antagonists & inhibitors ; Humans ; Male ; Metals/chemistry ; No-Observed-Adverse-Effect Level ; Phenols/administration & dosage ; Phenols/chemistry ; Phenols/toxicity ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Benzhydryl Compounds ; Gonadal Steroid Hormones ; Metals ; Phenols ; bisphenol F
    Language English
    Publishing date 2019-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2019.110889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: An expanded toxicological profile of tetramethyl bisphenol F (TMBPF), a precursor for a new food-contact metal packaging coating

    Maffini, Maricel V / Canatsey, Ryan D

    Food and chemical toxicology. 2020 Jan., v. 135

    2020  

    Abstract: Tetramethyl bisphenol F (TMBPF) has been shown to impart unique physical properties critical for high performance of epoxy can coatings without the estrogenic activity concerns associated with other bisphenols. To further characterize the toxicological ... ...

    Abstract Tetramethyl bisphenol F (TMBPF) has been shown to impart unique physical properties critical for high performance of epoxy can coatings without the estrogenic activity concerns associated with other bisphenols. To further characterize the toxicological profile of TMBPF, additional endocrine-related endpoints including in vitro aromatase inhibition and steroidogenesis assays, and in vivo androgen agonism/antagonism were performed. Systemic toxicity was also assessed by a repeat dose 90-day dietary toxicity study followed by 28-day recovery period. TMBPF did not inhibit aromatase activity, and induced estradiol and testosterone at highest non-cytotoxic concentrations (10 μM) in the steroidogenesis assay. In the Hershberger assay, TMBPF showed no androgenic activity at any dose and equivocal anti-androgenic activity at the highest dose (1000 mg/kg-bw/d). In a 90-day dietary toxicity study with 28-day recovery period, observations including changes in clinical pathology, absolute and relative organ weights, and microscopic findings are discussed. In this current study, the no observed adverse effect level was considered to be 750 mg/kg-bw/d for female rats and 1000 mg/kg-bw/d for male rats with no biologically significant changes to endocrine endpoints at any dose level. Our findings provide further evidence that TMBPF is a low-toxicity substance with a toxicology profile distinct from some other bisphenols.
    Keywords antagonism ; aromatase ; bisphenol F ; coatings ; dietary exposure ; enzyme activity ; enzyme inhibition ; epoxides ; estradiol ; estrogenic properties ; females ; hormone antagonists ; males ; no observed adverse effect level ; packaging ; physical properties ; rats ; steroidogenesis ; testosterone
    Language English
    Dates of publication 2020-01
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2019.110889
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Characterization of a new polymeric food contact coating with emphasis on the chemical analysis and safety assessment of non-intentionally added substances (NIAS)

    Mallen, Thomas R. / Abston, Kadijah D. / Parizek, Nathanial J. / Negley, Judith / Shores, Kevin S. / Canatsey, Ryan D. / Dubail, Sarah / Maier, Mark S. / Maffini, Maricel V.

    Food and Chemical Toxicology. 2023 Mar., v. 173 p.113635-

    2023  

    Abstract: Regulators have established safety requirements for food packaging raw materials and finished products, including by-products of polymer synthesis known as non-intentionally added substances (NIAS). However, there are no official guidance or regulations ... ...

    Abstract Regulators have established safety requirements for food packaging raw materials and finished products, including by-products of polymer synthesis known as non-intentionally added substances (NIAS). However, there are no official guidance or regulations for best practices to evaluate the safety of NIAS. Here we described the process we followed to identify, characterize, and prioritize for safety assessment low molecular weight NIAS from an epoxy coating (V70) made with tetramethyl bisphenol F-based diglycidyl ether resin (TMBPF-DGE). We assembled a database of 15000 potential oligomers with masses up to 1000 Da and conducted extraction and migration testing of V70 coating. Acetonitrile extract contained higher number and concentration of substances compared to ethanolic-based food simulants. The extract contained 16 substances with matches in the database with estimated concentration of 18.27 μg/6 dm²; seven of these substances have potentially genotoxic oxirane functionality. TMBPF-DGE + hydroquinone (TMBPF-DGE + HQ) was most abundant (55% of total concentration) and was synthesized and prioritized for safety assessment. TMBPF-DGE + HQ exposure from can beverage was estimated at 5.2 μg/person/day, and it was not mutagenic or genotoxic in in vitro assays. The overall mixture of substances that migrated into ethanolic simulant was also negative in the mutagenicity bioassay. Our findings suggest that exposure to TMBPF-DGE + HQ from the V70 coating is exceedingly small and that the coating migrates are not genotoxic.
    Keywords acetonitrile ; beverages ; bioassays ; chemical analysis ; databases ; epoxides ; ethylene oxide ; hydroquinone ; molecular weight ; mutagenicity ; mutagens ; polymers ; safety assessment ; toxicology ; Food ; can coating ; NIAS ; Polymer synthesis ; Bioassay
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2023.113635
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4035: Show issues

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  4. Article ; Online: Characterization of a new polymeric food contact coating with emphasis on the chemical analysis and safety assessment of non-intentionally added substances (NIAS).

    Mallen, Thomas R / Abston, Kadijah D / Parizek, Nathanial J / Negley, Judith / Shores, Kevin S / Canatsey, Ryan D / Dubail, Sarah / Maier, Mark S / Maffini, Maricel V

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2023  Volume 173, Page(s) 113635

    Abstract: Regulators have established safety requirements for food packaging raw materials and finished products, including by-products of polymer synthesis known as non-intentionally added substances (NIAS). However, there are no official guidance or regulations ... ...

    Abstract Regulators have established safety requirements for food packaging raw materials and finished products, including by-products of polymer synthesis known as non-intentionally added substances (NIAS). However, there are no official guidance or regulations for best practices to evaluate the safety of NIAS. Here we described the process we followed to identify, characterize, and prioritize for safety assessment low molecular weight NIAS from an epoxy coating (V70) made with tetramethyl bisphenol F-based diglycidyl ether resin (TMBPF-DGE). We assembled a database of 15000 potential oligomers with masses up to 1000 Da and conducted extraction and migration testing of V70 coating. Acetonitrile extract contained higher number and concentration of substances compared to ethanolic-based food simulants. The extract contained 16 substances with matches in the database with estimated concentration of 18.27 μg/6 dm
    MeSH term(s) Humans ; Food Packaging ; Polymers/toxicity ; Food ; Chromatography, Gas ; Mutagens/analysis ; Allergens/analysis ; Food Contamination/analysis
    Chemical Substances V 70 (15545-97-8) ; Polymers ; Mutagens ; bisphenol F diglycidyl ether (V3625OQU1K) ; Allergens
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2023.113635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma.

    Cohen, Jennifer D / Labenski, Matthew / Mastrandrea, Nicholas J / Canatsey, Ryan D / Monks, Terrence J / Lau, Serrine S

    Molecular carcinogenesis

    2016  Volume 55, Issue 8, Page(s) 1243–1250

    Abstract: Increased activity of B-Raf has been identified in approximately 7% of human cancers. Treatment of Eker rats (Tsc-2(EK/+) ), bearing a mutation in one allele of the tuberous sclerosis-2 (Tsc-2) gene, with the nephrocarcinogen 2,3,5-tris-(glutathion-S-yl) ...

    Abstract Increased activity of B-Raf has been identified in approximately 7% of human cancers. Treatment of Eker rats (Tsc-2(EK/+) ), bearing a mutation in one allele of the tuberous sclerosis-2 (Tsc-2) gene, with the nephrocarcinogen 2,3,5-tris-(glutathion-S-yl) hydroquinone (TGHQ) results in loss of the wild-type allele of Tsc-2 in renal preneoplastic lesions and tumors. These tumors have increased protein expression of B-Raf, C-Raf (Raf-1), and increased expression and activity of ERK kinase. Similar changes are observed in Raf kinases following TGHQ-mediated transformation of primary renal epithelial cells derived from Tsc-2(EK/+) rats (QTRRE cells), cells that are also null for tuberin. Herein, we utilized LC-MS/MS to identify constitutive phosphorylation of S345 and S483 in both 100- and 95-kDa forms of B-Raf in QTRRE cells. Using microRotofor liquid-phase isoelectric focusing, we identified four fractions of B-Raf that contain different post-translational modification profiles in QTRRE cells. Amplification of the kinase domain of B-Raf from QTRRE cells, outer-stripe of the outer medulla of 8-month TGHQ- or vehicle-treated Tsc-2(+/+) and Tsc-2(EK/+) rats, as well as tumors excised from 8-month TGHQ-treated Tsc-2(EK/+) rats revealed three splice variants of B-Raf within the kinase domain. These splice variants differed by approximately 340, 544, and 600 bp; confirmed by sequencing. No point mutations within the kinase domain of B-Raf were identified. In addition, B-Raf/Raf-1/14-3-3 complex formation in the QTRRE cells was decreased by sorafenib, with concomitant selective decreases in p-ERK levels. Transcriptional and post-translational characterization of critical kinases, such as B-Raf, may contribute to the progression of tuberous sclerosis RCC. (246/250) © 2015 Wiley Periodicals, Inc.
    MeSH term(s) Animals ; Carcinoma, Renal Cell/chemically induced ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Cell Line ; Cell Transformation, Neoplastic/chemically induced ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Glutathione/analogs & derivatives ; Glutathione/toxicity ; Humans ; Hydroquinones/toxicity ; Kidney Neoplasms/chemically induced ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Male ; Neoplasms, Experimental ; Phosphorylation ; Protein Domains ; Protein Processing, Post-Translational ; Proto-Oncogene Proteins B-raf/chemistry ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Proto-Oncogene Proteins c-raf ; RNA Splicing/drug effects ; Rats ; Tuberous Sclerosis/chemically induced ; Tuberous Sclerosis/genetics ; Tuberous Sclerosis/metabolism ; Tumor Suppressor Proteins/deficiency
    Chemical Substances Hydroquinones ; Tumor Suppressor Proteins ; 2,3,5-(triglutathion-S-yl)hydroquinone (119212-33-8) ; tuberous sclerosis complex 2 protein (4JG2LF96VF) ; Braf protein, rat (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1) ; Raf1 protein, rat (EC 2.7.11.1) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1004029-8
    ISSN 1098-2744 ; 0899-1987
    ISSN (online) 1098-2744
    ISSN 0899-1987
    DOI 10.1002/mc.22366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2664: Show issues Location:
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