Article ; Online: COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.
2021 Volume 21, Issue 8, Page(s) 2774–2784
Abstract: Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been ... ...
| Abstract | Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p = .02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p = .032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0-2.6, p = .04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0-11.3, p = .05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality. |
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| MeSH term(s) | Adult ; Aged ; COVID-19 ; Cohort Studies ; Humans ; Lung ; Organ Transplantation/adverse effects ; SARS-CoV-2 ; Transplant Recipients | |||||
| Language | English | |||||
| Publishing date | 2021-07-24 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural | |||||
| ZDB-ID | 2060594-8 | |||||
| ISSN | 1600-6143 ; 1600-6135 | |||||
| ISSN (online) | 1600-6143 | |||||
| ISSN | 1600-6135 | |||||
| DOI | 10.1111/ajt.16692 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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