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  1. Article ; Online: Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade.

    Liu, Lin / Xie, Bowen / Fan, Ming / Candas-Green, Demet / Jiang, Joy X / Wei, Ryan / Wang, Yinsheng / Chen, Hong-Wu / Hu, Yiyang / Li, Jian Jian

    Developmental cell

    2019  Volume 52, Issue 2, Page(s) 196–209.e9

    Abstract: Saturated fatty acids (SFAs) (the "bad" fat), especially palmitate (PA), in the human diet are blamed for potential health risks such as obesity and cancer because of SFA-induced lipotoxicity. However, epidemiological results demonstrate a latent benefit ...

    Abstract Saturated fatty acids (SFAs) (the "bad" fat), especially palmitate (PA), in the human diet are blamed for potential health risks such as obesity and cancer because of SFA-induced lipotoxicity. However, epidemiological results demonstrate a latent benefit of SFAs, and it remains elusive whether a certain low level of SFAs is physiologically essential for maintaining cell metabolic hemostasis. Here, we demonstrate that although high-level PA (HPA) indeed induces lipotoxic effects in liver cells, low-level PA (LPA) increases mitochondrial functions and alleviates the injuries induced by HPA or hepatoxic agent carbon tetrachloride (CCl
    MeSH term(s) Animals ; CDC2 Protein Kinase/genetics ; CDC2 Protein Kinase/metabolism ; Carbon Tetrachloride/toxicity ; Carnitine O-Palmitoyltransferase/genetics ; Carnitine O-Palmitoyltransferase/metabolism ; Cells, Cultured ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Palmitates/pharmacology ; Sirtuin 3/genetics ; Sirtuin 3/metabolism
    Chemical Substances Palmitates ; Sirt3 protein, mouse ; Carbon Tetrachloride (CL2T97X0V0) ; Carnitine O-Palmitoyltransferase (EC 2.3.1.21) ; CDC2 Protein Kinase (EC 2.7.11.22) ; Cdk1 protein, mouse (EC 2.7.11.22) ; Sirtuin 3 (EC 3.5.1.-)
    Language English
    Publishing date 2019-12-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2019.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells.

    Candas-Green, Demet / Xie, Bowen / Huang, Jie / Fan, Ming / Wang, Aijun / Menaa, Cheikh / Zhang, Yanhong / Zhang, Lu / Jing, Di / Azghadi, Soheila / Zhou, Weibing / Liu, Lin / Jiang, Nian / Li, Tao / Gao, Tianyi / Sweeney, Colleen / Shen, Rulong / Lin, Tzu-Yin / Pan, Chong-Xian /
    Ozpiskin, Omer M / Woloschak, Gayle / Grdina, David J / Vaughan, Andrew T / Wang, Ji Ming / Xia, Shuli / Monjazeb, Arta M / Murphy, William J / Sun, Lun-Quan / Chen, Hong-Wu / Lam, Kit S / Weichselbaum, Ralph R / Li, Jian Jian

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 4591

    Abstract: Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, the immunosuppressive factors induced by radiation on tumor cells remain to be identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently ... ...

    Abstract Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, the immunosuppressive factors induced by radiation on tumor cells remain to be identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast cancer (BC) cells and RT-treated mouse syngeneic BC. Co-expression of both receptors is more frequently detected in recurrent BC patients with poor prognosis. CD47 is upregulated preferentially in HER2-expressing cells, and blocking CD47 or HER2 reduces both receptors with diminished clonogenicity and augmented phagocytosis. CRISPR-mediated CD47 and HER2 dual knockouts not only inhibit clonogenicity but also enhance macrophage-mediated attack. Dual antibody of both receptors synergizes with RT in control of syngeneic mouse breast tumor. These results provide the evidence that aggressive behavior of radioresistant BC is caused by CD47-mediated anti-phagocytosis conjugated with HER2-prompted proliferation. Dual blockade of CD47 and HER2 is suggested to eliminate resistant cancer cells in BC radiotherapy.
    MeSH term(s) Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; CD47 Antigen/genetics ; CD47 Antigen/metabolism ; Cell Proliferation ; Clone Cells ; Female ; Humans ; MCF-7 Cells ; Macrophages/metabolism ; Mice ; Models, Biological ; NF-kappa B/metabolism ; Phagocytosis ; Radiation Tolerance ; Receptor, ErbB-2/metabolism ; Signal Transduction ; Transcription, Genetic ; Tumor Burden
    Chemical Substances CD47 Antigen ; NF-kappa B ; ERBB2 protein, human (EC 2.7.10.1) ; Erbb2 protein, mouse (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2020-09-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-18245-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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