Article ; Online: Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB).
International journal of molecular sciences
2021 Volume 22, Issue 22
Abstract: Five novel analogs of 6-(ethyl)(4-isobutoxy-3-isopropylphenyl)amino)nicotinic acid-or NEt-4IB-in addition to seven novel analogs of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) were prepared and evaluated ... ...
| Abstract | Five novel analogs of 6-(ethyl)(4-isobutoxy-3-isopropylphenyl)amino)nicotinic acid-or NEt-4IB-in addition to seven novel analogs of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) were prepared and evaluated for selective retinoid-X-receptor (RXR) agonism alongside bexarotene ( |
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| MeSH term(s) | Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Bexarotene/analogs & derivatives ; Bexarotene/chemical synthesis ; Bexarotene/pharmacology ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Gene Expression ; Humans ; Leukocytes/drug effects ; Leukocytes/metabolism ; Leukocytes/pathology ; Nicotinic Acids/chemical synthesis ; Nicotinic Acids/pharmacology ; Retinoid X Receptor alpha/agonists ; Retinoid X Receptor alpha/genetics ; Retinoid X Receptor alpha/metabolism ; Structure-Activity Relationship |
| Chemical Substances | Antineoplastic Agents ; ApoE protein, human ; Apolipoproteins E ; Nicotinic Acids ; RXRA protein, human ; Retinoid X Receptor alpha ; Bexarotene (A61RXM4375) |
| Language | English |
| Publishing date | 2021-11-16 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms222212371 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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