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  1. Article ; Online: Spontaneous Preterm Birth Phenotyping Based on Cervical Length and Immune-Mediated Factors.

    Cavoretto, Paolo Ivo / Candiani, Massimo / Farina, Antonio

    JAMA network open

    2024  Volume 7, Issue 4, Page(s) e244559

    MeSH term(s) Infant, Newborn ; Humans ; Female ; Premature Birth/epidemiology
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.4559
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  2. Article: Editorial: Update in pediatric gynecology.

    Perelli, Federica / Grimaldi, Chiara / Candiani, Massimo / Masieri, Lorenzo / Mantovani, Alberto

    Frontiers in surgery

    2024  Volume 11, Page(s) 1391435

    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2024.1391435
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  3. Article ; Online: Cesarean Delivery Uptake Trends Associated With Patient Features and Threshold for Labor Anomalies.

    Cavoretto, Paolo Ivo / Candiani, Massimo / Farina, Antonio

    JAMA network open

    2023  Volume 6, Issue 3, Page(s) e235436

    MeSH term(s) Pregnancy ; Female ; Humans ; Cesarean Section ; Labor, Obstetric
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.5436
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  4. Article ; Online: Commentary: Predicting adverse outcomes in pregnant patients positive for SARS-CoV-2 by a machine learning approach.

    Salmeri, Noemi / Candiani, Massimo / Cavoretto, Paolo Ivo

    BMC pregnancy and childbirth

    2023  Volume 23, Issue 1, Page(s) 554

    Abstract: SARS-CoV-2 infection poses a significant risk increase for adverse pregnancy outcomes both from maternal and fetal sides. A recent publication in BMC Pregnancy and Childbirth presented a machine learning algorithm to predict this risk. This commentary ... ...

    Abstract SARS-CoV-2 infection poses a significant risk increase for adverse pregnancy outcomes both from maternal and fetal sides. A recent publication in BMC Pregnancy and Childbirth presented a machine learning algorithm to predict this risk. This commentary will discuss potential implications and applications of this study for future global health policies.
    MeSH term(s) Pregnancy ; Female ; Humans ; SARS-CoV-2 ; COVID-19 ; Retrospective Studies ; Pregnancy Outcome/epidemiology ; Machine Learning
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-023-05864-3
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  5. Article ; Online: Histological Features of Neovaginal Epithelium after Vaginoplasty in Mayer-Rokitansky-Küster-Hauser Syndrome.

    Candiani, Massimo / Fedele, Francesco / Ruffolo, Alessandro Ferdinando / Di Fatta, Simona / Salvatore, Stefano / Parazzini, Fabio

    Journal of pediatric and adolescent gynecology

    2024  

    Abstract: Objective: To analyze the features of the epithelia coating neovaginas after vaginoplasty in women affected by Mayer-Rokitansky-Küster-Hauser syndrome STUDY DESIGN: We conducted a retrospective analysis of prospectively collected data. Women affected by ...

    Abstract Objective: To analyze the features of the epithelia coating neovaginas after vaginoplasty in women affected by Mayer-Rokitansky-Küster-Hauser syndrome STUDY DESIGN: We conducted a retrospective analysis of prospectively collected data. Women affected by Rokitansky syndrome who underwent neovaginal biopsy after vaginoplasty (McIndoe surgery, intestinal vaginoplasty, Vecchietti surgery, and Davydov surgery) were included. Macroscopic mucosal features were assessed through clinical examination and the Schilling test. Each biopsy specimen was prepared for examination by light microscopy and in some cases by scanning electron microscopy (SEM).
    Results: Thirty-six patients (4 McIndoe, 2 intestinal vaginoplasty, 14 Vecchietti, and 16 Davydov) were included. All biopsies were performed without complications. In McIndoe's neovaginas, the mucosal microscopic features were similar to normal skin, with large areas of preserved epithelium, heterogeneous presence of dermal papillae, and superficial keratinization. The characteristics of the intestinal neovagina's surface were similar to those of a sigmoid colon, with well-shaped glands, cylindrical cells, and a secreting mucosa. In Vecchietti neovaginas, the surface the epithelium was flat and multilayered, highly similar to that of a normal vagina, with the presence of glycogen and superficial desquamation. On medium SEM magnification evaluation, the epithelium presented flattened polygonal cells. Finally, in Davydov neovaginas, none of the specimens had persistent mesothelial elements. The squamous neo-epithelium had regular aspects of differentiation with the presence of glycogen. At greater SEM magnification, microridges were evident, with a regular distribution.
    Conclusion: Each different technique of vaginoplasty leads to unique histological and structural features of the neovagina's mucosa. Knowledge of these elements must be the basis for the choice of the most appropriate intervention.
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1325079-6
    ISSN 1873-4332 ; 1083-3188
    ISSN (online) 1873-4332
    ISSN 1083-3188
    DOI 10.1016/j.jpag.2024.01.002
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    Zs.A 2337: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Maternal plasma markers in intrauterine growth restriction and small for gestational age complicated pregnancy: the role of sFlt-1/PlGF.

    Libretti, Alessandro / Valsecchi, Luca / Zerbini, Gianpaolo / Remorgida, Valentino / Candiani, Massimo

    Minerva obstetrics and gynecology

    2023  Volume 75, Issue 6, Page(s) 588–589

    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Fetal Growth Retardation/diagnosis ; Gestational Age ; Placenta Growth Factor ; Infant, Small for Gestational Age ; Vascular Endothelial Growth Factor Receptor-1
    Chemical Substances Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2023-08-04
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 3062815-5
    ISSN 2724-6450
    ISSN (online) 2724-6450
    DOI 10.23736/S2724-606X.23.05384-8
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    Um I Zs.245: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Rokitansky Syndrome or Cervicovaginal Atresia?

    Fedele, Francesco / Parazzini, Fabio / Vercellini, Paolo / Bergamini, Valentino / Candiani, Massimo

    Journal of minimally invasive gynecology

    2023  Volume 30, Issue 9, Page(s) 742–747

    Abstract: Study objective: To investigate the possibility of conservative management of rudimentary uterine horns associated with vaginal agenesis.: Design: Observational study on cohort of consecutive cases treated with the same criteria from 2008 to 2021.: ...

    Abstract Study objective: To investigate the possibility of conservative management of rudimentary uterine horns associated with vaginal agenesis.
    Design: Observational study on cohort of consecutive cases treated with the same criteria from 2008 to 2021.
    Setting: Two academic institutions and teaching hospitals in Milan, Italy.
    Patients: Eight patients with vaginal agenesis associated with rudimentary cavitated uterine horns treated by the same team and postoperatively followed.
    Interventions: All the subjects underwent the same standardized surgical procedure: laparoscopy, intraoperative ultrasound, and horn-vestibular direct anastomosis. Postoperatively vaginoscopy was performed every 6 months.
    Measurements and main results: The postoperative course was generally uneventful and the mean hospital stay was 4.3 ± 2.5 (SD) days. All the patients began to menstruate a few months after the operation. Menstrual flows were light but regular. All patients had a neovaginal length > 4 cm at 1 year postoperatively, reaching approximately 6 cm at 2 years. During the follow-up period, 5 patients were sexually active without dyspareunia. In all cases, surgery restored the continuity of the neovagina and uterine horn through the creation of a "vaginal-horn fistula tract."
    Conclusion: In patients with vaginal agenesis associated with the presence of a uterine cavitary horn, it is possible to recover not only sexual activity but also menstrual function. The horn-vestibular anastomosis may be considered a valid, safe, and effective therapeutic option but requires accurate preoperative and intraoperative evaluation of rudimentary uterine structures.
    MeSH term(s) Female ; Humans ; Abnormalities, Multiple/surgery ; Congenital Abnormalities/surgery ; Laparoscopy ; Mullerian Ducts/surgery ; Mullerian Ducts/abnormalities ; Plastic Surgery Procedures ; Uterus/surgery ; Uterus/abnormalities ; Vagina/surgery ; Vagina/abnormalities ; Vaginal Fistula/surgery
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2023.05.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome.

    Salmeri, Noemi / Viganò, Paola / Cavoretto, Paolo / Marci, Roberto / Candiani, Massimo

    Reviews in endocrine & metabolic disorders

    2023  Volume 25, Issue 2, Page(s) 239–257

    Abstract: Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with a significant impact on the health and quality of life of women affected. A novel hypothesis by evolutionary biologists suggested that these two diseases ...

    Abstract Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with a significant impact on the health and quality of life of women affected. A novel hypothesis by evolutionary biologists suggested that these two diseases are inversely related to one another, representing a pair of diametrical diseases in terms of opposite alterations in reproductive physiological processes but also contrasting phenotypic traits. However, to fully explain the phenotypic features observed in women with these conditions, we need to establish a potential nexus system between the reproductive system and general biological functions. The recent discovery of kisspeptin as pivotal mediator of internal and external inputs on the hypothalamic-pituitary-gonadal axis has led to a new understanding of the neuroendocrine upstream regulation of the human reproductive system. In this review, we summarize the current knowledge on the physiological roles of kisspeptin in human reproduction, as well as its involvement in complex biological functions such as metabolism, inflammation and pain sensitivity. Importantly, these functions are known to be dysregulated in both PCOS and endometriosis. Within the evolving scientific field of "kisspeptinology", we critically discuss the clinical relevance of these discoveries and their potential translational applications in endometriosis and PCOS. By exploring the possibilities of manipulating this complex signaling system, we aim to pave the way for novel targeted therapies in these reproductive diseases.
    MeSH term(s) Female ; Humans ; Polycystic Ovary Syndrome/metabolism ; Kisspeptins/metabolism ; Kisspeptins/therapeutic use ; Endometriosis ; Quality of Life ; Reproduction/physiology
    Chemical Substances Kisspeptins
    Language English
    Publishing date 2023-07-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-023-09826-0
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    Zs.A 6069: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Toward Risk Assessment for Amniotic Fluid Embolisms.

    Cavoretto, Paolo Ivo / Rovere-Querini, Patrizia / Candiani, Massimo

    JAMA network open

    2022  Volume 5, Issue 11, Page(s) e2242850

    MeSH term(s) Humans ; Pregnancy ; Female ; Embolism, Amniotic Fluid/diagnosis ; Risk Assessment ; Ultrasonography, Prenatal
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.42850
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  10. Article ; Online: Prognostic Significance of Neutrophil/Lymphocytes Ratio (NLR) in Predicting Recurrence of Cervical Dysplasia.

    Origoni, Massimo / Cantatore, Francesco / Candotti, Giorgio / Candiani, Massimo

    BioMed research international

    2022  Volume 2022, Page(s) 1149789

    Abstract: Objective: The objective of the present study was to investigate the potential prognostic role of neutrophil-lymphocyte ratio (NLR) in comparison with known parameters of prediction for the detection of recurrences of cervical intraepithelial neoplasia ( ...

    Abstract Objective: The objective of the present study was to investigate the potential prognostic role of neutrophil-lymphocyte ratio (NLR) in comparison with known parameters of prediction for the detection of recurrences of cervical intraepithelial neoplasia (CIN) after treatment.
    Methods: We retrospectively evaluated patients who underwent surgical treatment for CIN2, CIN3, and carcinoma in situ (CIN2+) between 2010 and 2019. NLR was recorded before surgery, and the follow-up records of patients were analyzed. Cases were splitted into two subgroups according to baseline NLR-low-NLR for <2 and high-NLR for ≥2 values of the index-and correlated with recurrences.
    Results: 428 cases fulfilled the criteria and were included in the study. Recurrence rate in patients with NLR <2.0 and NLR ≥2.0 was 15.2% and 27.3%, respectively, being the odd ratio for recurrence significantly higher in patients with NLR ≥2 (OR = 2.09; 95% CI 1.28-3.41;
    Conclusion: Preoperative NLR categorization is a strong independent prognostic factor for recurrences after surgical excision of CIN. NLR evaluation is a simple, reproducible, and cost-effective clinical instrument that could optimally be introduced in clinical practice in every setting.
    MeSH term(s) Cervical Intraepithelial Neoplasia/diagnosis ; Cervical Intraepithelial Neoplasia/pathology ; Cervical Intraepithelial Neoplasia/surgery ; Female ; Humans ; Lymphocytes/pathology ; Neoplasm Recurrence, Local/pathology ; Neutrophils/pathology ; Prognosis ; Recurrence ; Retrospective Studies ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/1149789
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