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Article ; Online: Prognostic Significance of Neutrophil/Lymphocytes Ratio (NLR) in Predicting Recurrence of Cervical Dysplasia.

Origoni, Massimo / Cantatore, Francesco / Candotti, Giorgio / Candiani, Massimo

2022 Volume 2022, Page(s) 1149789

Abstract: Objective: The objective of the present study was to investigate the potential prognostic role of neutrophil-lymphocyte ratio (NLR) in comparison with known parameters of prediction for the detection of recurrences of cervical intraepithelial neoplasia ( ...

Abstract	Objective: The objective of the present study was to investigate the potential prognostic role of neutrophil-lymphocyte ratio (NLR) in comparison with known parameters of prediction for the detection of recurrences of cervical intraepithelial neoplasia (CIN) after treatment. Methods: We retrospectively evaluated patients who underwent surgical treatment for CIN2, CIN3, and carcinoma in situ (CIN2+) between 2010 and 2019. NLR was recorded before surgery, and the follow-up records of patients were analyzed. Cases were splitted into two subgroups according to baseline NLR-low-NLR for <2 and high-NLR for ≥2 values of the index-and correlated with recurrences. Results: 428 cases fulfilled the criteria and were included in the study. Recurrence rate in patients with NLR <2.0 and NLR ≥2.0 was 15.2% and 27.3%, respectively, being the odd ratio for recurrence significantly higher in patients with NLR ≥2 (OR = 2.09; 95% CI 1.28-3.41; Conclusion: Preoperative NLR categorization is a strong independent prognostic factor for recurrences after surgical excision of CIN. NLR evaluation is a simple, reproducible, and cost-effective clinical instrument that could optimally be introduced in clinical practice in every setting.
MeSH term(s)	Cervical Intraepithelial Neoplasia/diagnosis ; Cervical Intraepithelial Neoplasia/pathology ; Cervical Intraepithelial Neoplasia/surgery ; Female ; Humans ; Lymphocytes/pathology ; Neoplasm Recurrence, Local/pathology ; Neutrophils/pathology ; Prognosis ; Recurrence ; Retrospective Studies ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery
Language	English
Publishing date	2022-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/1149789
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sentinel lymph node biopsy in open surgery for gynecological malignancies.

Bocciolone, Luca / Candotti, Giorgio / Cioffi, Raffaella / Rabaiotti, Emanuela / Bergamini, Alice / Candiani, Massimo

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023 Volume 33, Issue 4, Page(s) 636–637

MeSH term(s)	Female ; Humans ; Sentinel Lymph Node Biopsy ; Genital Neoplasms, Female/surgery ; Genital Neoplasms, Female/pathology ; Lymph Nodes/pathology ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node/pathology ; Uterine Cervical Neoplasms/pathology ; Lymph Node Excision ; Neoplasm Staging
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2022-003898
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Article: Current Evidence on Immunotherapy for Gestational Trophoblastic Neoplasia (GTN).

Mangili, Giorgia / Sabetta, Giulia / Cioffi, Raffaella / Rabaiotti, Emanuela / Candotti, Giorgio / Pella, Francesca / Candiani, Massimo / Bergamini, Alice

Cancers

2022 Volume 14, Issue 11

Abstract: Background: Gestational trophoblastic disease includes a rare group of benign and malignant tumors derived from abnormal trophoblastic proliferation. Malignant forms are called gestational trophoblastic neoplasia (GTN) and include invasive mole, ... ...

Abstract	Background: Gestational trophoblastic disease includes a rare group of benign and malignant tumors derived from abnormal trophoblastic proliferation. Malignant forms are called gestational trophoblastic neoplasia (GTN) and include invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Standard treatment of GTN is chemotherapy. The regimen of choice mainly depends on the FIGO prognostic score. Low-risk and high-risk GTN is treated with single-agent or multiagent chemotherapy, respectively. In the case of chemoresistance, immunotherapy may represent a new therapeutic strategy. Methods: Literature obtained from searches on PubMed concerning GTN and immunotherapy was reviewed. Results: Programmed cell death 1 (PD-1) and its ligands (PD-L1/2) are expressed in GTN. Published data on PD-1/PD-L1 inhibitors alone in GTN were available for 51 patients. Pembrolizumab is an anti-PD-1 inhibitor used in chemoresistant forms of GTN. In the TROPHIMMUN trial, Avelumab, a monoclonal antibody inhibiting PD-L1, showed promising results only in patients with GTN resistant to monochemotherapy. Conversely, in patients with resistance to multiagent chemotherapy, treatment with Avelumab was discontinued due to severe toxicity and disease progression. The association of Camrelizumab and Apatinib could represent a different treatment for forms of GTN refractory to polychemotherapy or for relapses. Conclusions: Anti-PD-1 or anti-PD-L1 might represent an important new treatment strategy for the management of chemoresistant/refractory GTN.
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14112782
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Article: Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes.

Bergamini, Alice / Mangili, Giorgia / Ambrosi, Alessandro / Taccagni, Gianluca / Rabaiotti, Emanuela / Bocciolone, Luca / Candotti, Giorgio / Cioffi, Raffaella / Pella, Francesca / Sabetta, Giulia / Saponaro, Costanza / Candiani, Massimo

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 8

Abstract: Evidence indicates that different pathways of malignant degeneration underlie the development of endometriosis-associated ovarian tumors of endometrioid and clear cell histotypes. The aim of this study was to compare data from patients affected by these ... ...

Abstract	Evidence indicates that different pathways of malignant degeneration underlie the development of endometriosis-associated ovarian tumors of endometrioid and clear cell histotypes. The aim of this study was to compare data from patients affected by these two histotypes to investigate the hypothesis of a dichotomy in the histogenesis of these tumors. Clinical data and tumor characteristics of 48 patients who were diagnosed with either pure clear cell ovarian cancer and mixed endometrioid-clear cell ovarian cancer arising from endometriosis (ECC,
Language	English
Publishing date	2023-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13081425
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Article ; Online: Endometriosis and spontaneous hemoperitoneum in pregnancy: evaluation of the magnitude of the risk in women becoming pregnant via in vitro fertilization.

Benaglia, Laura / Reschini, Marco / La Vecchia, Irene / Candotti, Giorgio / Somigliana, Edgardo / Vercellini, Paolo

Fertility and sterility

2020 Volume 115, Issue 4, Page(s) 1023–1028

Abstract: Objective: To estimate the frequency of spontaneous hemoperitoneum in pregnancy (SHiP) in women with endometriosis achieving pregnancy with in vitro fertilization (IVF).: Design: Retrospective case series.: Setting: Referral academic assisted ... ...

Abstract	Objective: To estimate the frequency of spontaneous hemoperitoneum in pregnancy (SHiP) in women with endometriosis achieving pregnancy with in vitro fertilization (IVF). Design: Retrospective case series. Setting: Referral academic assisted reproductive technology (ART) center. Patient(s): Three hundred and forty-eight women with a history of surgery for endometriosis and women with ovarian endometriomas or deep endometriotic nodules detected at basal transvaginal ultrasound performed before IVF cycle. Intervention(s): Information obtained from patients' charts on basal characteristics, IVF cycle, and pregnancy outcomes, and binomial distribution model created to determine the 95% confidence interval (CI) of the proportion of SHiP. Main outcome measure(s): Rate of SHiP. Result(s): Overall, 362 pregnancies were included, among which 238 (66%) had a history of previous surgery for endometriosis and 231 (64%) had endometriosis detected at ultrasound (107 women, 30%, had both). Pregnancies were achieved after fresh and frozen cycles in 244 (67%) and 118 (33%) women, respectively. One case of SHiP was recorded, corresponding to a rate of 0.3%. Conclusion(s): In the general population of women with endometriosis undergoing IVF, SHiP is uncommon. Future studies should better identify the risk factors for SHiP to disentangle the subgroups of women at higher risk.
MeSH term(s)	Adult ; Cohort Studies ; Endometriosis/diagnostic imaging ; Endometriosis/epidemiology ; Female ; Fertilization in Vitro/adverse effects ; Fertilization in Vitro/trends ; Follow-Up Studies ; Hemoperitoneum/diagnostic imaging ; Hemoperitoneum/epidemiology ; Humans ; Infertility, Female/diagnostic imaging ; Infertility, Female/epidemiology ; Infertility, Female/therapy ; Pregnancy ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2020-12-04
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2020.10.030
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Impact of COVID-19 on medical treatment patterns in gynecologic oncology: a MITO group survey.

Cioffi, Raffaella / Sabetta, Giulia / Rabaiotti, Emanuela / Bergamini, Alice / Bocciolone, Luca / Candotti, Giorgio / Candiani, Massimo / Valabrega, Giorgio / Mangili, Giorgia / Pignata, Sandro

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2021 Volume 31, Issue 10, Page(s) 1363–1368

Abstract: Objective: COVID-19 is a global public health emergency. The increasing spread of COVID-19 presents challenges for the clinical care of patients with gynecological tumors. The Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies ( ... ...

Abstract	Objective: COVID-19 is a global public health emergency. The increasing spread of COVID-19 presents challenges for the clinical care of patients with gynecological tumors. The Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) performed a survey to evaluate the impact of the COVID-19 pandemic on medical treatment of gynecological cancer, with a focus on chemotherapy and oral treatment with poly(ADP)-ribose polymerase inhibitors (PARP-i). Methods: The survey consisted of a self-administered online questionnaire, sent via email between November 2020 and January 2021 to all members of MITO group. Results: Forty-nine centers completed the questionnaire. The majority of respondents (83%) use screening tests to determine COVID-19 status in patients who were to undergo chemotherapy or oral medications. All respondents to our survey continued cancer therapy in patients who tested negative for COVID-19 during the pandemic. Seventy-three percent of respondents declared they stopped treatment with chemotherapy or PARP-i only after a positive swab and resumed therapy when negative tests were confirmed. Conclusions: COVID-19 positivity impacted patterns of treatment in patients diagnosed with ovarian cancer within the MITO group. Further investigations are needed to evaluate whether these modifications influence oncological clinical outcomes.
MeSH term(s)	Administration, Oral ; Adult ; Aged ; Antineoplastic Agents/therapeutic use ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/prevention & control ; COVID-19 Testing/statistics & numerical data ; Female ; Genital Neoplasms, Female/complications ; Genital Neoplasms, Female/drug therapy ; Health Care Surveys ; Health Services Accessibility/statistics & numerical data ; Humans ; Italy ; Male ; Middle Aged ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Practice Patterns, Physicians'/statistics & numerical data ; Withholding Treatment/statistics & numerical data
Chemical Substances	Antineoplastic Agents ; Poly(ADP-ribose) Polymerase Inhibitors
Language	English
Publishing date	2021-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2021-002784
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Zs.A 3198: Show issues

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Article: New Keystone flap application in vulvo-perineal reconstructive surgery: A case series.

Peiretti, Michele / Corvetto, Elisabetta / Candotti, Giorgio / Angioni, Stefano / Figus, Andrea / Mais, Valerio

Gynecologic oncology reports

2019 Volume 30, Page(s) 100505

Abstract: Objective: This study aimed to evaluate the application of the Keystone flap technique and the long-term results of vulvovaginal reconstruction after vulvar surgery: Methods: This is the first case series describing the application of the Keystone ... ...

Abstract	Objective: This study aimed to evaluate the application of the Keystone flap technique and the long-term results of vulvovaginal reconstruction after vulvar surgery Methods: This is the first case series describing the application of the Keystone perforator island flaps (KPIF) technique to close a wide defect after radical vulvectomy. We prospectively collected patient demographics, operative times, complications, pathologic results, and length of stay on all patients. The benefits, cosmetic results and satisfaction of patients were analyzed in the follow up. Results: Five patients were selected for the study: four underwent radical vulvectomy for squamous cell vulvar cancer, and one underwent vulvar wide excision for Paget disease followed by reconstruction with the Keystone flap technique. The defects were successfully covered by the Keystone flap technique in all patients. Conclusions: Keystone flaps seem to be easy to design and elevate, and it offers rapid fasciocutaneous closure in wide vulvo-perineal defects with excellent long-term results.
Language	English
Publishing date	2019-10-18
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2818505-5
ISSN	2352-5789
ISSN	2352-5789
DOI	10.1016/j.gore.2019.100505
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Article: Ovarian Cancer Radiosensitivity: What Have We Understood So Far?

Barcellini, Amelia / Charalampopoulou, Alexandra / De Cecco, Loris / Fodor, Andrei / Rabaiotti, Emanuela / Candotti, Giorgio / Secondino, Simona / Facoetti, Angelica / Locati, Laura Deborah / Pignata, Sandro / Orlandi, Ester / Mangili, Giorgia

Life (Basel, Switzerland)

2022 Volume 13, Issue 1

Abstract: Radiotherapy has been increasingly considered as an active treatment to combine with other approaches (i.e., surgery, chemotherapy, and novel target-based drugs) in ovarian cancers to palliate symptoms and/or to prolong chemotherapy-free intervals. This ... ...

Abstract	Radiotherapy has been increasingly considered as an active treatment to combine with other approaches (i.e., surgery, chemotherapy, and novel target-based drugs) in ovarian cancers to palliate symptoms and/or to prolong chemotherapy-free intervals. This narrative review aimed to summarize the current knowledge of the radiosensitivity/radioresistance of ovarian cancer which remains the most lethal gynecological cancer worldwide. Indeed, considering the high rate of recurrence in and out of the radiotherapy fields, in the era of patient-tailored oncology, elucidating the mechanisms of radiosensitivity and identifying potential radioresistance biomarkers could be crucial in guiding clinical decision-making.
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13010006
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Article ; Online: Experimental drugs for fallopian cancer: promising agents in the clinical trials and key stumbling blocks for researchers.

Cioffi, Raffaella / Galli, Federica / Rabaiotti, Emanuela / Candiani, Massimo / Pella, Francesca / Candotti, Giorgio / Bocciolone, Luca / De Marzi, Patrizia / Mangili, Giorgia / Bergamini, Alice

Expert opinion on investigational drugs

2022 Volume 31, Issue 12, Page(s) 1339–1357

Abstract: Introduction: Fallopian tube carcinoma (FC) as a single entity is a rare disease. Although its diagnosis is increasing thanks to the widespread use of prophylactic salpingectomy, there are no clinical trials exclusively designed for FC.: Areas covered! ...

Abstract	Introduction: Fallopian tube carcinoma (FC) as a single entity is a rare disease. Although its diagnosis is increasing thanks to the widespread use of prophylactic salpingectomy, there are no clinical trials exclusively designed for FC. Areas covered: This review aims at identifying the most promising trials and future therapeutic pathways in the setting of FC. Expert opinion: Hot topics in FC treatment include the consequences of using PARP inhibitors (PARPi) as first-line therapy, ways to overcome platinum resistance, and the role of immunotherapy. Patient selection is a key point for future development of target therapies. Next-generation sequencing (NGS) is one of the most investigated technologies both for drug discovery and identification of reverse mutations, involved in resistance to PARPi and platinum. New, promising molecular targets are emerging. Notwithstanding the disappointing outcomes when used by itself, immunotherapy in FC treatment could still have a role in combination with other agents, exploiting synergistic effects at the molecular level. The development of cancer vaccines is currently hampered by the high variability of tumor neoantigens in FC. Genomic profiling could be a solution, allowing the synthesis of individualized vaccines.
MeSH term(s)	Female ; Humans ; Platinum/therapeutic use ; Neoplasms/drug therapy ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Mutation ; Immunotherapy
Chemical Substances	Platinum (49DFR088MY) ; Poly(ADP-ribose) Polymerase Inhibitors
Language	English
Publishing date	2022-12-28
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1182884-5
ISSN	1744-7658 ; 0967-8298 ; 1354-3784
ISSN (online)	1744-7658
ISSN	0967-8298 ; 1354-3784
DOI	10.1080/13543784.2022.2160313
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Article ; Online: Erratum to 'What women want: Fertility sparing surgery in Borderline ovarian tumours patients and pregnancy outcome' [European Journal of Surgical Oncology 46/5 (2020) 888-892].

Candotti, Giorgio / Peiretti, Michele / Mangili, Giorgia / Bergamini, Alice / Candiani, Massimo / Cioffi, Raffaella / Mais, Valerio / Rabaiotti, Emanuela / Bocciolone, Luca

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2020 Volume 46, Issue 10 Pt A, Page(s) 1972

Language	English
Publishing date	2020-07-30
Publishing country	England
Document type	Published Erratum
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2020.07.021
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