Article: Validating the Reliability and Clinical Relevance of a Nasolabial Fold Photonumeric Scale.
Journal of drugs in dermatology : JDD
2024 Volume 23, Issue 1, Page(s) 1319–1324
Abstract: Background: The use of tissue fillers to treat age-related deepening of the nasolabial fold (NLF) has increased and become the standard clinical approach, creating a need for evidence-based, objective evaluation for pre- and post-procedure assessment of ...
| Abstract | Background: The use of tissue fillers to treat age-related deepening of the nasolabial fold (NLF) has increased and become the standard clinical approach, creating a need for evidence-based, objective evaluation for pre- and post-procedure assessment of the NLF. Methods: A 5-point rating scale was developed to assess the NLF, specifically the presence of depression and shadowing. Live validation of the scale was performed with a total of 73 participants representing the full range of NLF severities. Physicians board-certified in a core aesthetic specialty (3 trained raters) performed the scale validation over 2 rounds, 2 weeks apart. Training was carried out, and test-retest reliability was quantitated through the determination of intra- and inter-rater reliability by percentage of agreement, weighted kappa statistic with 95% confidence interval (CI), and intraclass correlation coefficient with 95% CI. To evaluate the clinical relevance of a 1-grade difference, rater assessments of 90 photo pairs were compared with previous designations of clinically different or not clinically different. Results: The NLF scale achieved near-perfect intra- and inter-rater reliability when utilized by trained raters to assess a diverse group of live participants. Furthermore, clinically relevant differences between grades were established, and a 1-point difference was detectable by trained evaluators using the NLF scale. Conclusion: The clinically relevant and highly reliable validated NLF scale provides a standardized grading system with a user-friendly design for objectively assessing NLF in clinical practice and as a research tool for clinical approval studies of new aesthetic products and technologies. J Drugs Dermatol. 2024;23(1):1284-1291. doi:10.36849/JDD.7316. |
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| MeSH term(s) | Humans ; Clinical Relevance ; Nasolabial Fold ; Reproducibility of Results ; Esthetics ; Physicians |
| Language | English |
| Publishing date | 2024-01-11 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2145090-0 |
| ISSN | 1545-9616 |
| ISSN | 1545-9616 |
| DOI | 10.36849/JDD.7316 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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