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  1. Article ; Online: Malignant renal angiomyolipoma: A giant abdominal disease entity.

    Gao, Zehai / Tang, Wenting / Jiang, Long / Cang, Yu

    Asian journal of surgery

    2023  Volume 46, Issue 11, Page(s) 5258–5259

    MeSH term(s) Humans ; Kidney Neoplasms/pathology ; Angiomyolipoma/pathology ; Tuberous Sclerosis ; Nephrectomy ; Hamartoma
    Language English
    Publishing date 2023-08-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.07.057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Architecture Controls Phonon Propagation in All-Solid Brush Colloid Metamaterials.

    Cang, Yu / Sainidou, Rebecca / Rembert, Pascal / Matyjaszewski, Krzysztof / Bockstaller, Michael / Graczykowski, Bartlomiej / Fytas, George

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 20, Issue 13, Page(s) e2304157

    Abstract: Brillouin light scattering and elastodynamic theory are concurrently used to determine and interpret the hypersonic phonon dispersion relations in brush particle solids as a function of the grafting density with perspectives in optomechanics, heat ... ...

    Abstract Brillouin light scattering and elastodynamic theory are concurrently used to determine and interpret the hypersonic phonon dispersion relations in brush particle solids as a function of the grafting density with perspectives in optomechanics, heat management, and materials metrology. In the limit of sparse grafting density, the phonon dispersion relations bear similarity to polymer-embedded colloidal assembly structures in which phonon dispersion can be rationalized on the basis of perfect boundary conditions, i.e., isotropic stiffness transitions across the particle interface. In contrast, for dense brush assemblies, more complex dispersion characteristics are observed that imply anisotropic stiffness transition across the particle/polymer interface. This provides direct experimental validation of phonon propagation changes associated with chain conformational transitions in dense particle brush materials. A scaling relation between interface tangential stiffness and crowding of polymer tethers is derived that provides a guideline for chemists to design brush particle materials with tailored phononic dispersion characteristics. The results emphasize the role of interfaces in composite materials systems. Given the fundamental relevance of phonon dispersion to material properties such as thermal transport or mechanical properties, it is also envisioned that the results will spur the development of novel functional hybrid materials.
    Language English
    Publishing date 2023-11-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202304157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unusual High-Frequency Mechanical Properties of Polymer-Grafted Nanoparticle Melts.

    Jhalaria, Mayank / Cang, Yu / Huang, Yucheng / Benicewicz, Brian / Kumar, Sanat K / Fytas, George

    Physical review letters

    2022  Volume 128, Issue 18, Page(s) 187801

    Abstract: Brillouin light spectroscopy is used to measure the elastic moduli of spherical polymer-grafted nanoparticle (GNP) melts as a function of chain length at fixed grafting density (0.47  chains/nm^{2}) and nanoparticle radius (8 nm). While the moduli follow ...

    Abstract Brillouin light spectroscopy is used to measure the elastic moduli of spherical polymer-grafted nanoparticle (GNP) melts as a function of chain length at fixed grafting density (0.47  chains/nm^{2}) and nanoparticle radius (8 nm). While the moduli follow a rule of mixtures (Wood's law) for long chains, they display enhanced elasticity and anomalous dissipation for graft chains <100  kDa. GNP melts with long polymers at high σ have a dry zone near the GNP core, surrounded by a region where the grafts can interpenetrate with chain fragments from adjacent GNPs. We propose that the departures from Wood's law for short chains are due to the effectively larger silica volume fraction in the region where sound propagates-this is caused by the short, interpenetrated chain fragments being pushed out of the way. We thus conclude that transport mechanisms (of gas, ions, sound, thermal phonons) in GNP melts are radically different if interpenetrated chain segments can be "pushed out of the way" or not. This provides a facile new means for manipulating the properties of these materials.
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.187801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: On the origin of elasticity and heat conduction anisotropy of liquid crystal elastomers at gigahertz frequencies.

    Cang, Yu / Liu, Jiaqi / Ryu, Meguya / Graczykowski, Bartlomiej / Morikawa, Junko / Yang, Shu / Fytas, George

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 5248

    Abstract: Liquid crystal elastomers that offer exceptional load-deformation response at low frequencies often require consideration of the mechanical anisotropy only along the two symmetry directions. However, emerging applications operating at high frequencies ... ...

    Abstract Liquid crystal elastomers that offer exceptional load-deformation response at low frequencies often require consideration of the mechanical anisotropy only along the two symmetry directions. However, emerging applications operating at high frequencies require all five true elastic constants. Here, we utilize Brillouin light spectroscopy to obtain the engineering moduli and probe the strain dependence of the elasticity anisotropy at gigahertz frequencies. The Young's modulus anisotropy, E
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-32865-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Identification and experimental validation of key extracellular proteins as potential targets in intervertebral disc degeneration.

    Zhang, Guang-Zhi / Li, Lei / Luo, Zhang-Bin / Zhang, Cang-Yu / Wang, Yong-Gang / Kang, Xue-Wen

    Bone & joint research

    2023  Volume 12, Issue 9, Page(s) 522–535

    Abstract: Aims: This study aimed, through bioinformatics analysis and in vitro experiment validation, to identify the key extracellular proteins of intervertebral disc degeneration (IDD).: Methods: The gene expression profile of GSE23130 was downloaded from ... ...

    Abstract Aims: This study aimed, through bioinformatics analysis and in vitro experiment validation, to identify the key extracellular proteins of intervertebral disc degeneration (IDD).
    Methods: The gene expression profile of GSE23130 was downloaded from the Gene Expression Omnibus (GEO) database. Extracellular protein-differentially expressed genes (EP-DEGs) were screened by protein annotation databases, and we used Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) to analyze the functions and pathways of EP-DEGs. STRING and Cytoscape were used to construct protein-protein interaction (PPI) networks and identify hub EP-DEGs. NetworkAnalyst was used to analyze transcription factors (TFs) and microRNAs (miRNAs) that regulate hub EP-DEGs. A search of the Drug Signatures Database (DSigDB) for hub EP-DEGs revealed multiple drug molecules and drug-target interactions.
    Results: A total of 56 EP-DEGs were identified in the differential expression analysis. EP-DEGs were enriched in the extracellular structure organization, ageing, collagen-activated signalling pathway, PI3K-Akt signalling pathway, and AGE-RAGE signalling pathway. PPI network analysis showed that the top ten hub EP-DEGs are closely related to IDD. Correlation analysis also demonstrated a significant correlation between the ten hub EP-DEGs (p<0.05), which were selected to construct TF-gene interaction and TF-miRNA coregulatory networks. In addition, ten candidate drugs were screened for the treatment of IDD.
    Conclusion: The findings clarify the roles of extracellular proteins in IDD and highlight their potential as promising novel therapeutic targets.
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669244-2
    ISSN 2046-3758
    ISSN 2046-3758
    DOI 10.1302/2046-3758.129.BJR-2022-0369.R2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.

    Li, Yuwei / Wang, Huishan / Sun, Bin / Su, Guifeng / Cang, Yu / Zhao, Ling / Zhao, Shuhua / Li, Yan / Mao, Bingyu / Ma, Pengcheng

    Cell death & disease

    2023  Volume 14, Issue 8, Page(s) 494

    Abstract: Sonic hedgehog (Shh)-group medulloblastoma (MB) (Shh-MB) encompasses a clinically and molecularly distinct group of cancers originating from the developing nervous system with aberrant high Shh signaling as a causative driver. We recently reported that ... ...

    Abstract Sonic hedgehog (Shh)-group medulloblastoma (MB) (Shh-MB) encompasses a clinically and molecularly distinct group of cancers originating from the developing nervous system with aberrant high Shh signaling as a causative driver. We recently reported that RNF220 is required for sustained high Shh signaling during Shh-MB progression; however, how high RNF220 expression is achieved in Shh-MB is still unclear. In this study, we found that the ubiquitin E3 ligases Smurf1 and Smurf2 interact with RNF220, and target it for polyubiquitination and degradation. In MB cells, knockdown or overexpression of Smurf1 or Smurf2 promotes or inhibits cell proliferation, colony formation and xenograft growth, respectively, by controlling RNF220 protein levels, and thus modulating Shh signaling. Furthermore, in clinical human MB samples, the protein levels of Smurf1 or Smurf2 were negatively correlated with those of RNF220 or GAB1, a Shh-MB marker. Overall, this study highlights the importance of the Smurf1- and Smurf2-RNF220 axes during the pathogenesis of Shh-MB and provides new therapeutic targets for Shh-MB treatment.
    MeSH term(s) Humans ; Cerebellar Neoplasms/metabolism ; Cerebellar Neoplasms/pathology ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Medulloblastoma/metabolism ; Medulloblastoma/pathology ; Signal Transduction ; Ubiquitination ; Animals ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Hedgehog Proteins ; SMURF1 protein, human (EC 2.3.2.26) ; SMURF2 protein, human (EC 2.3.2.26) ; RNF220 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-06025-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Free Standing Dry and Stable Nanoporous Polymer Films Made through Mechanical Deformation.

    Hsu, Hsiao-Ping / Singh, Manjesh K / Cang, Yu / Thérien-Aubin, Héloïse / Mezger, Markus / Berger, Rüdiger / Lieberwirth, Ingo / Fytas, George / Kremer, Kurt

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 18, Page(s) e2207472

    Abstract: A new straight forward approach to create nanoporous polymer membranes with well defined average pore diameters is presented. The method is based on fast mechanical deformation of highly entangled polymer films at high temperatures and a subsequent ... ...

    Abstract A new straight forward approach to create nanoporous polymer membranes with well defined average pore diameters is presented. The method is based on fast mechanical deformation of highly entangled polymer films at high temperatures and a subsequent quench far below the glass transition temperature T
    MeSH term(s) Polymers/chemistry ; Nanopores ; Polystyrenes/chemistry ; Temperature ; Hot Temperature
    Chemical Substances Polymers ; Polystyrenes
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202207472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Food safety inspection and the adoption of traceability in aquatic wholesale markets

    Cang-yu JIN / Retsef LEVI / Qiao LIANG / Nicholas RENEGAR / Jie-hong ZHOU

    Journal of Integrative Agriculture, Vol 20, Iss 10, Pp 2807-

    A game-theoretic model and empirical evidence

    2021  Volume 2819

    Abstract: Supply chain traceability is key to reduce food safety risks, since it allows problems to be traced to their sources. Moreover, it allows regulatory agencies to understand where risk is introduced into the supply chain, and offers a major disincentive ... ...

    Abstract Supply chain traceability is key to reduce food safety risks, since it allows problems to be traced to their sources. Moreover, it allows regulatory agencies to understand where risk is introduced into the supply chain, and offers a major disincentive for upstream agricultural businesses engaging in economically motivated adulteration. This paper focuses on the aquatic supply chain in China, and seeks to understand the adoption of traceability both through an analytical model, and empirical analysis based on data collected through an extensive (largest ever) field survey of Chinese aquatic wholesale markets. The field survey includes 76 managers and 753 vendors, covering all aquatic wholesale markets in Zhejiang and Hunan provinces. The analytical and empirical results suggest that the adoption of traceability among wholesale market vendors is significantly associated with inspection intensity, their individual history of food safety problems, and their risk awareness. The effect of inspection intensity on traceability adoption is stronger in markets which are privately owned than in markets with state/collective ownership. The analysis offers insights into the current state of traceability in China. More importantly, it suggests several hypothesized factors that might affect the adoption of traceability and could be leveraged by regulatory organizations to improve it.
    Keywords food safety ; traceability ; supply chain ; wholesale markets ; China ; Agriculture (General) ; S1-972
    Subject code 650
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Food safety inspection and the adoption of traceability in aquatic wholesale markets: A game-theoretic model and empirical evidence

    JIN, Cang-yu / LEVI, Retsef / LIANG, Qiao / RENEGAR, Nicholas / ZHOU, Jie-hong

    CAAS. Publishing services by Elsevier B.V Journal of integrative agriculture. 2021 Oct., v. 20, no. 10

    2021  

    Abstract: Supply chain traceability is key to reduce food safety risks, since it allows problems to be traced to their sources. Moreover, it allows regulatory agencies to understand where risk is introduced into the supply chain, and offers a major disincentive ... ...

    Abstract Supply chain traceability is key to reduce food safety risks, since it allows problems to be traced to their sources. Moreover, it allows regulatory agencies to understand where risk is introduced into the supply chain, and offers a major disincentive for upstream agricultural businesses engaging in economically motivated adulteration. This paper focuses on the aquatic supply chain in China, and seeks to understand the adoption of traceability both through an analytical model, and empirical analysis based on data collected through an extensive (largest ever) field survey of Chinese aquatic wholesale markets. The field survey includes 76 managers and 753 vendors, covering all aquatic wholesale markets in Zhejiang and Hunan provinces. The analytical and empirical results suggest that the adoption of traceability among wholesale market vendors is significantly associated with inspection intensity, their individual history of food safety problems, and their risk awareness. The effect of inspection intensity on traceability adoption is stronger in markets which are privately owned than in markets with state/collective ownership. The analysis offers insights into the current state of traceability in China. More importantly, it suggests several hypothesized factors that might affect the adoption of traceability and could be leveraged by regulatory organizations to improve it.
    Keywords adulterated products ; agriculture ; empirical research ; food safety ; models ; ownership ; risk ; supply chain ; surveys ; traceability ; wholesale marketing ; China
    Language English
    Dates of publication 2021-10
    Size p. 2807-2819.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2660426-7
    ISSN 2095-3119
    ISSN 2095-3119
    DOI 10.1016/S2095-3119(21)63624-9
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Origin of the Acoustic Bandgaps in Hypersonic Colloidal Phononics: The Role of the Elastic Impedance

    Cang, Yu / Sainidou, Rebecca / Rembert, Pascal / Magnabosco, Giulia / Still, Tim / Vogel, Nicolas / Graczykowski, Bartlomiej / Fytas, George

    Journal of physical chemistry. 2022 Aug. 23, v. 126, no. 34

    2022  

    Abstract: How phonons propagate in nanostructures determines the flow of elastic and thermal energy in dielectric materials. However, a reliable theoretical prediction of the phonon dispersion relation requires experimental verification both near to and far from ... ...

    Abstract How phonons propagate in nanostructures determines the flow of elastic and thermal energy in dielectric materials. However, a reliable theoretical prediction of the phonon dispersion relation requires experimental verification both near to and far from the Brillouin zone of the nanostructure. We report on the experimental hypersonic phonon dispersion of hard (SiO₂) and soft (polymer) fcc colloidal crystals infiltrated in liquid polydimethylsiloxane with different elastic impedance contrast using Brillouin light spectroscopy. We discuss the distinct differences with first-principles full elastodynamic calculations involving a multiple-scattering theory. Interparticle contacts strongly impact the long-wavelength speed of sound and the nature of the particle vibration resonance-induced hybridization hypersonic bandgap. The absence of the order-induced Bragg bandgap in SiO₂ and its presence in soft opals cannot be fully accounted for by the theory, limiting its predictive power. Bridging the elasticity of the two colloidal crystals with suitable SiO₂ core–shell (polymer) particles reveals an unprecedented crossover behavior in the dispersion relation. In view of many conversational parameters, the control tuning of phonon propagation in soft matter-based hypersonic phononics remains challenging.
    Keywords acoustics ; hybridization ; liquids ; nanomaterials ; physical chemistry ; polydimethylsiloxane ; prediction ; spectroscopy ; thermal energy ; vibration
    Language English
    Dates of publication 2022-0823
    Size p. 6575-6584.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1520-5207
    DOI 10.1021/acs.jpcb.2c03923
    Database NAL-Catalogue (AGRICOLA)

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