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  1. Article ; Online: Predicting Peritoneal Carcinomatosis in Locally Advanced Gastric Cancer: The Significance of Tumor Markers in the Peritoneal Washing.

    Pinheiro, João Luís / Duarte, Liliana / Santos, Andreia J / Tojal, André / Canhoto, Carolina / Ferreira, Marta / Marques, Conceição / Pereira, Jorge

    Journal of gastrointestinal cancer

    2023  Volume 55, Issue 1, Page(s) 427–434

    Abstract: Purpose: Gastric cancer is the fifth most common malignant tumor worldwide. Many attempts have been made over the years to investigate the relationship between tumor markers and the risk of recurrence. This study aims to explore the predictive value of ... ...

    Abstract Purpose: Gastric cancer is the fifth most common malignant tumor worldwide. Many attempts have been made over the years to investigate the relationship between tumor markers and the risk of recurrence. This study aims to explore the predictive value of tumor markers measured in peritoneal washing during staging laparoscopy, regarding peritoneal carcinomatosis and mortality within 1 year.
    Methods: Patients with locally advanced gastric cancer, staged as at least usT2anyNM0 were submitted to staging laparoscopy in a Portuguese single center. CA 19.9, CEA, CA 125, and CA 72.4 were measured in the peritoneal washing after being harvested during staging laparoscopy.
    Results: Thirty-eight patients were enrolled. After 1 year, 20 patients did not recur (52.5%), 11 (28.9%) developed carcinomatosis, and 7 (18.4%) had distant metastasis. Mortality reached 23.7% (n = 9). A statistically significant prediction of carcinomatosis was obtained for CA 125 (cutoff: 107.6 U/mL (p = 0.019)) and CEA (cutoff: 2.0 ng/mL (p = 0.020)) with 87.5% and 75% sensitivity, respectively. Prediction of mortality was significant for CA 125 (cutoff: 103.8 U/mL (p = 0.044)) and CA 125 + CEA (p = 0.030). CEA and CA 125 had NPVs of 87.9% and 93.1% regarding PC, respectively. NPVs of 88.9% and 89.2% were met concerning mortality, for the same tumor markers.
    Conclusion: Performing the peritoneal liquid harvest during staging laparoscopy makes this analysis cost effective, reproducible, and does not add further morbidity. CA 125 and CEA, individually and in association, are good predictors of progression of disease and mortality within a year of staging laparoscopy in GC patients.
    MeSH term(s) Humans ; Stomach Neoplasms/pathology ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/mortality ; Male ; Female ; Middle Aged ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Aged ; Neoplasm Staging ; Peritoneal Lavage/methods ; CA-125 Antigen/analysis ; CA-125 Antigen/metabolism ; CA-125 Antigen/blood ; Laparoscopy/methods ; Carcinoembryonic Antigen/analysis ; Carcinoembryonic Antigen/metabolism ; Adult ; CA-19-9 Antigen/analysis ; CA-19-9 Antigen/metabolism ; Predictive Value of Tests ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Aged, 80 and over
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-023-00984-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Pneumoperitoneum from acute gastric dilation and perforation.

    Azevedo, Fernando / Canhoto, Carolina / Costa, Beatriz / Carvalho, Hélder

    BMJ case reports

    2019  Volume 12, Issue 11

    MeSH term(s) Acute Disease ; Female ; Gastrectomy ; Gastric Dilatation/complications ; Humans ; Middle Aged ; Pneumoperitoneum/etiology ; Pneumoperitoneum/surgery
    Language English
    Publishing date 2019-11-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-232392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management of afferent loop syndrome after Roux-en-Y subtotal gastrectomy and choledocolithiasis with recurrent cholangitis.

    Azevedo, Fernando / Canhoto, Carolina / Tralhão, José Guilherme / Carvalho, Hélder

    BMJ case reports

    2020  Volume 13, Issue 1

    Abstract: Afferent loop syndrome is a rare complication after gastrectomy with Billroth II or Roux-en-Y reconstruction, caused by an obstruction in the proximal loop. The biliary stasis and bacterial overgrowth secondary to this obstruction can lead to repeated ... ...

    Abstract Afferent loop syndrome is a rare complication after gastrectomy with Billroth II or Roux-en-Y reconstruction, caused by an obstruction in the proximal loop. The biliary stasis and bacterial overgrowth secondary to this obstruction can lead to repeated episodes of acute cholangitis. We present the case of a male patient who had previously undergone gastrectomy with Roux-en-Y reconstruction and later experienced multiple episodes of acute cholangitis secondary to choledocolithiasis. He underwent an open exploration of the bile ducts with choledocolitotomy, but the events of cholangitis persisted. Further investigation permitted to identify a dilation of the biliary loop of the Roux-en-Y anastomosis, suggesting enterobiliary reflux as the cause of recurrent acute cholangitis. Therefore, a bowel enterectomy and new jejunojejunostomy were undertaken, and normal biliary flow was re-established. The surgical treatment is mandatory in benign causes, leading to the resolution of the obstruction and subsequent normalisation of bile flow.
    MeSH term(s) Afferent Loop Syndrome/diagnostic imaging ; Afferent Loop Syndrome/etiology ; Afferent Loop Syndrome/surgery ; Anastomosis, Roux-en-Y/adverse effects ; Cholangitis/diagnostic imaging ; Cholangitis/surgery ; Gastrectomy/adverse effects ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Postoperative Complications/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-01-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-232498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Surgical treatment of giant gist with acute gastrointestinal bleeding: Case report.

    Melo, Catarina / Canhoto, Carolina / Manata, Fernando / Bernardes, António

    International journal of surgery case reports

    2018  Volume 53, Page(s) 354–357

    Abstract: Introduction: Gastrointestinal stromal tumors represent about 1% of the tumors of digestive tract. Their presentation consists often of indolent symptoms. However, they can present as surgical emergencies in rare cases. This work presents a case of a ... ...

    Abstract Introduction: Gastrointestinal stromal tumors represent about 1% of the tumors of digestive tract. Their presentation consists often of indolent symptoms. However, they can present as surgical emergencies in rare cases. This work presents a case of a giant jejunal GIST that required emergent surgical treatment.
    Case presentation: A 60-year-old male presented with abdominal pain and acute low gastrointestinal bleeding. During observation a palpable mass was detected in the periumbilical region, left hypochondrium and left flank. A non-total colonoscopy was inconclusive. An Angio-CT showed a large exophytic tumor arising from the 4
    Conclusions: This case pretends to review an unusual presentation of a giant jejunal intestinal GISTs as well as its management in an emergent context.
    Language English
    Publishing date 2018-11-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2018.11.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inguinal hernia containing bladder and ureteroneocystostomy: a rare cause for acute renal graft dysfunction.

    Coelho, Hugo / Nunes, Pedro / Canhoto, Carolina / Temido, Paulo

    BMJ case reports

    2016  Volume 2016

    Abstract: A 77-year-old man presented with acute graft dysfunction 25 years after a renal transplant in the left iliac fossa. He also had an asymptomatic left inguinal hernia. Renal ultrasound showed a significant pyelocalicial dilation of the kidney graft and the ...

    Abstract A 77-year-old man presented with acute graft dysfunction 25 years after a renal transplant in the left iliac fossa. He also had an asymptomatic left inguinal hernia. Renal ultrasound showed a significant pyelocalicial dilation of the kidney graft and the patient was submitted to a percutaneous nephrostomy. An antegrade nephrostogram was performed, which showed a dilated ureter and the bladder included in the left inguinal hernia that caused the obstructive uropathy. Concomitant retrograde cystography also showed a significant portion of the bladder in the hernia sac. The patient was submitted to inguinal hernia repair, which resolved the obstruction. We present a rare and potentially curable cause of obstructive uropathy in a transplant recipient; it is possible to revert graft dysfunction and prevent graft loss if the condition is recognised early.
    MeSH term(s) Aged ; Hernia, Inguinal/diagnosis ; Hernia, Inguinal/physiopathology ; Hernia, Inguinal/surgery ; Humans ; Kidney/physiopathology ; Kidney Transplantation ; Male ; Treatment Outcome
    Language English
    Publishing date 2016-02-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-214466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Morphophenotypic Classification of Hepatocellular Carcinoma: the Biliary/Stem Cell Subgroup and Worst Outcome-Implications on Patient Selection.

    Caetano Oliveira, Rui / Martins, Ricardo / Abrantes, Ana Margarida / Jesus, Ângela / Teixeira, Paulo / Canhoto, Carolina / Guerreiro, Pedro / Costa, Beatriz / Silva, Mário Rui / Tralhão, José Guilherme / Cipriano, Maria Augusta

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2020  Volume 25, Issue 3, Page(s) 698–707

    Abstract: Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the third cause of cancer-related death. Current clinical/pathological criteria contribute to risk stratification, but are far from the desired on individualized ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the third cause of cancer-related death. Current clinical/pathological criteria contribute to risk stratification, but are far from the desired on individualized medicine. Recently, HCC classifications have been published based on immunohistochemical and morphological features.
    Methods: A retrospective review of patients submitted to surgical treatment-partial hepatectomy (PH) or liver transplantation (LT), with pathological diagnosis of HCC, in a 9-year period (2007-2015) was performed.
    Results: Applying the classification of Srivastava et al. (#1), based on the expression of CD31, p53, AFP and CD44, tumour size and presence of vascular invasion, HCC were categorized as low- and high-risk HCC. With the classification of Tsujikawa et al. (#2), HCC were classified into biliary/stem cell marker positive, Wnt signalling positive and the "all negative" HCC, according to the expression of CK19, SALL4, β-catenin glutamine synthetase, EpCAM and p53. There were sixty-six patients (53 males; 13 females), with median age of 64.5 ± 9.46 years (range 38-86), with solitary HCC, comprehending 37 PH (56.1%) and 29 LT (43.9%). The mean overall survival (OS) was 75.4 ± 6.9 months. Biliary/stem cell type of HCC was a predictive factor of worse OS on the overall population (24.4 versus 78.3 months, p = 0.032) and in PH cohort (11.5 versus 64.01 months, p = 0.016), on uni- and multivariate analyses.
    Conclusion: These results support the relevance of a risk stratification classification of HCC. Classification #2 seems adequate to our reality demonstrating OS impact, allowing its application in future biopsies, prompting individualized medicine.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular ; Female ; Humans ; Liver Neoplasms ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Patient Selection ; Retrospective Studies ; Stem Cells
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-020-04611-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 354: Show issues

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