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  1. Article ; Online: Author Response: Teaching NeuroImage: Partially Reversible Widespread Leukoencephalopathy Associated With Atypical Hemolytic Uremic Syndrome.

    Foschi, Matteo / Cani, Ilaria / Cenni, Patrizia / Righini, Matteo

    Neurology

    2023  Volume 101, Issue 17, Page(s) 770

    MeSH term(s) Humans ; Atypical Hemolytic Uremic Syndrome ; Leukoencephalopathies/complications ; Leukoencephalopathies/diagnostic imaging
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207893
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  2. Article ; Online: Teaching NeuroImage: Partially Reversible Widespread Leukoencephalopathy Associated With Atypical Hemolytic Uremic Syndrome.

    Cani, Ilaria / Righini, Matteo / Cenni, Patrizia / Foschi, Matteo

    Neurology

    2022  Volume 99, Issue 24, Page(s) 1128–1129

    MeSH term(s) Humans ; Atypical Hemolytic Uremic Syndrome/complications ; Leukoencephalopathies/complications ; Leukoencephalopathies/diagnostic imaging
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201378
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  3. Article ; Online: Exploring Cardiovascular Autonomic Function before and after Chronic Deep Brain Stimulation in Parkinson's Disease.

    Cani, Ilaria / Giannini, Giulia / Guaraldi, Pietro / Barletta, Giorgio / Sambati, Luisa / Baldelli, Luca / Cortelli, Pietro / Calandra-Buonaura, Giovanna

    Movement disorders clinical practice

    2024  

    Abstract: Background: Blood pressure control in Parkinson's disease (PD) under subthalamic deep brain stimulation (STN-DBS) is influenced by several intertwined aspects, including autonomic failure and levodopa treatment.: Objective: To evaluate the effect of ... ...

    Abstract Background: Blood pressure control in Parkinson's disease (PD) under subthalamic deep brain stimulation (STN-DBS) is influenced by several intertwined aspects, including autonomic failure and levodopa treatment.
    Objective: To evaluate the effect of chronic STN-DBS, levodopa, and their combination on cardiovascular autonomic functions in PD.
    Methods: We performed cardiovascular reflex tests (CRTs) before and 6-months after STN-DBS surgery in 20 PD patients (pre-DBS vs. post-DBS). CRTs were executed without and with medication (med-OFF vs. med-ON).
    Results: CRT results and occurrence of neurogenic orthostatic hypotension (OH) did not differ between pre- and post-DBS studies in med-OFF condition. After levodopa intake, the BP decrease during HUTT was significantly greater compared to med-OFF, both at pre-DBS and post-DBS evaluation. Levodopa-induced OH was documented in 25% and 5% of patients in pre-DBS/med-ON and post-DBS/med-ON study.
    Conclusion: Chronic stimulation did not influence cardiovascular responses, while levodopa exerts a relevant hypotensive effect. The proportion of patients presenting levodopa-induced OH decreases after STN-DBS surgery.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.14060
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  4. Article ; Online: MECP2

    Cani, Ilaria / Muccioli, Lorenzo / Mignani, Francesco / Licchetta, Laura / Tinuper, Paolo / Provini, Federica / Bisulli, Francesca

    Epilepsy & behavior reports

    2022  Volume 19, Page(s) 100541

    Abstract: MECP2 duplication syndrome (MDS) is a rare and severe neurodevelopmental disorder frequently associated with epilepsy. Different seizure types and electroencephalographic (EEG) patterns were described in patients with MDS, although it lacks a specific ... ...

    Abstract MECP2 duplication syndrome (MDS) is a rare and severe neurodevelopmental disorder frequently associated with epilepsy. Different seizure types and electroencephalographic (EEG) patterns were described in patients with MDS, although it lacks a specific phenotype. We report on an adult patient with long-term epilepsy showing an evolution of the EEG pattern that progressively changed into burst suppression (BS) during sleep. As BS has not been previously reported in MDS, this report expands the neurophysiological phenotype of MDS and further suggest the possible occurrence of a longitudinal spectrum of seizure types and EEG patterns in MDS.
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Case Reports
    ISSN 2589-9864
    ISSN (online) 2589-9864
    DOI 10.1016/j.ebr.2022.100541
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  5. Article: Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson's disease patient on chronic deep brain stimulation.

    Giannini, Giulia / Baldelli, Luca / Leogrande, Gaetano / Cani, Ilaria / Mantovani, Paolo / Lopane, Giovanna / Cortelli, Pietro / Calandra-Buonaura, Giovanna / Conti, Alfredo

    Frontiers in neurology

    2023  Volume 14, Page(s) 1163811

    Abstract: Introduction: Subthalamic (STN) local field potentials (LFPs) in the beta band are considered potential biomarkers for closed-loop deep brain stimulation (DBS) in Parkinson's disease (PD). The beta band is further dissected into low-and high-frequency ... ...

    Abstract Introduction: Subthalamic (STN) local field potentials (LFPs) in the beta band are considered potential biomarkers for closed-loop deep brain stimulation (DBS) in Parkinson's disease (PD). The beta band is further dissected into low-and high-frequency components with somewhat different functions, although their concomitance and association in the single patient is far to be defined. We present a 56-year-old male PD patient undergoing DBS showing a double-beta peak activity on both sides. The aim of the study was to investigate how low-and high-beta peaks were influenced by plasma levodopa (L-dopa) levels, stimulation, and motor performances.
    Methods: A systematic evaluation of raw LFPs, plasma L-dopa levels, and motor tasks was performed in the following four conditions: OFF medications/ON stimulation, OFF medications/OFF stimulation, ON medications/OFF stimulation, and ON medications/ON stimulation.
    Results: The analysis of the LFP spectra suggests the following results: (1) the high-beta peak was suppressed by stimulation, while the low-beta peak showed a partial and not consistent response to stimulation; (2) the high-beta peak is also influenced by plasma L-dopa concentration, showing a progressive amplitude increment concordant with plasma L-dopa levels, while the low-beta peak shows a different behavir; and (3) motor performances seem to impact beta peaks behavior.
    Conclusion: This single exploratory case study illustrates a complex behavior of low-and high-beta peaks in a PD patient, in response to stimulation, L-dopa plasma levels, and motor performances. Our results suggest the importance to investigate patient-specific individual LFP patterns in view of upcoming closed-loop stimulation.
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1163811
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  6. Article ; Online: Levodopa-induced orthostatic hypotension in parkinsonism: A red flag of autonomic failure.

    Cani, Ilaria / Guaraldi, Pietro / Giannini, Giulia / Sambati, Luisa / Barletta, Giorgio / Cortelli, Pietro / Calandra-Buonaura, Giovanna

    European journal of neurology

    2023  Volume 31, Issue 1, Page(s) e16061

    Abstract: Background and purpose: Levodopa (LD) is the main treatment for parkinsonism, but its use may be limited by a potential hypotensive effect.: Methods: We evaluated the cardiovascular effect of LD performing head-up tilt test (HUTT) before and 60 min ... ...

    Abstract Background and purpose: Levodopa (LD) is the main treatment for parkinsonism, but its use may be limited by a potential hypotensive effect.
    Methods: We evaluated the cardiovascular effect of LD performing head-up tilt test (HUTT) before and 60 min after 100/25 mg LD/dopa-decarboxylase inhibitor (pre-LD vs. post-LD HUTT) in 164 patients with parkinsonism on chronic LD treatment. Features predictive of LD-induced orthostatic hypotension (OH) were assessed by logistic regression analysis.
    Results: Basal supine blood pressure (BP) and heart rate (HR) decreased after LD. During post-LD HUTT, BP drop and HR increase were significantly greater than at pre-LD HUTT. Thirty-eight percent of patients had OH at post-LD HUTT compared to 22% of patients presenting OH at pre-LD HUTT (p < 0.001). Risk factors for LD-induced/worsened OH were pre-LD OH (odds ratio [OR] = 36, 95% confidence interval [CI] = 10-131), absence of overshoot at Valsalva maneuver (OR = 9, 95% CI = 4-20), and pathological Valsalva ratio (OR = 6, 95% CI = 2-15).
    Conclusions: LD administration caused/worsened hypotension in both supine and orthostatic conditions. Patients with cardiovascular autonomic failure had a higher risk of developing LD-induced OH. In clinical practice, LD-induced OH could represent a red flag for cardiovascular autonomic failure.
    MeSH term(s) Humans ; Hypotension, Orthostatic/drug therapy ; Levodopa/adverse effects ; Blood Pressure/physiology ; Heart ; Parkinsonian Disorders ; Tilt-Table Test/adverse effects ; Heart Rate
    Chemical Substances Levodopa (46627O600J)
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16061
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  7. Article ; Online: The Degree of Cardiovascular Autonomic Dysfunction is not Different in GBA-Related and Idiopathic Parkinson's Disease Patients: A Case-Control Instrumental Evaluation.

    Giannini, Giulia / Minardi, Raffaella / Barletta, Giorgio / Cani, Ilaria / Cecere, Annagrazia / Baldelli, Luca / Fiorentino, Alessia / Guaraldi, Pietro / Sambati, Luisa / Capellari, Sabina / Cortelli, Pietro / Carelli, Valerio / Calandra-Buonaura, Giovanna

    Journal of Parkinson's disease

    2024  Volume 14, Issue 2, Page(s) 335–346

    Abstract: Background: Increased prevalence of cardiovascular autonomic failure might play a key role on Parkinson's disease (PD) progression of glucocerebrosidase gene (GBA)-mutated patients, determining a malignant phenotype of disease in these patients.: ... ...

    Abstract Background: Increased prevalence of cardiovascular autonomic failure might play a key role on Parkinson's disease (PD) progression of glucocerebrosidase gene (GBA)-mutated patients, determining a malignant phenotype of disease in these patients.
    Objective: To objectively characterize, for the first time, the cardiovascular autonomic profile of GBA-mutated patients compared to idiopathic PD patients by means of cardiovascular reflex tests (CRTs).
    Methods: This is a case-control (1 : 2) study on PD patients belonging to well-characterized prospective cohorts. For each PD patient carrying GBA variants, two idiopathic PD patients, matched for sex and disease duration at CRTs, were selected. Patients recruited in these cohorts underwent a complete clinical and instrumental evaluation including specific autonomic questionnaires, CRTs and extensive genetic analysis.
    Results: A total of 23 GBA-PD patients (19 males, disease duration 7.7 years) were included and matched with 46 non-mutated PD controls. GBA-mutated patients were younger than controls (59.9±8.1 vs. 64.3±7.2 years, p = 0.0257) and showed a more severe phenotype. Despite GBA-mutated patients reported more frequently symptoms suggestive of orthostatic hypotension (OH) than non-mutated patients (39.1% vs 6.5%, p = 0.001), the degree of cardiovascular autonomic dysfunction, when instrumentally assessed, did not differ between the two groups, showing the same prevalence of neurogenic OH, delayed OH and cardiovascular reflex impairment (pathological Valsalva maneuver).
    Conclusion: GBA-PD patients did not show different instrumental cardiovascular autonomic pattern than non-mutated PD. Our findings suggested that symptoms suggestive of OH should be promptly investigated by clinicians to confirm their nature and improve patient care and management.
    MeSH term(s) Humans ; Male ; Autonomic Nervous System Diseases/diagnosis ; Autonomic Nervous System Diseases/etiology ; Case-Control Studies ; Glucosylceramidase/genetics ; Hypotension, Orthostatic ; Mutation ; Parkinson Disease/complications ; Parkinson Disease/genetics ; Prospective Studies
    Chemical Substances Glucosylceramidase (EC 3.2.1.45) ; GBA protein, human (EC 3.2.1.45)
    Language English
    Publishing date 2024-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-230334
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  8. Article: Serum Tumor Markers in Paraneoplastic Neurologic Syndromes: A Systematic Review of Guidelines.

    Trevisiol, Chiara / Cani, Ilaria / Fabricio, Aline S C / Gion, Massimo / Giometto, Bruno / De Massis, Patrizia

    Frontiers in neurology

    2021  Volume 11, Page(s) 607553

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2021-01-18
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.607553
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  9. Article ; Online: Neurological Manifestations as a Harbinger of Myocarditis in Patients Treated With Immune Checkpoint Inhibitors.

    Rossi, Simone / Cani, Ilaria / Raschi, Emanuel / Comito, Francesca / Rinaldi, Rita / Ardizzoni, Andrea / Guarino, Maria / Gelsomino, Francesco

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 41, Issue 5, Page(s) 1151–1153

    MeSH term(s) Humans ; Myocarditis ; Immune Checkpoint Inhibitors ; Immunotherapy ; Patients
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.01602
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  10. Article ; Online: COVID-19-Associated Encephalopathy and Cytokine-Mediated Neuroinflammation.

    Muccioli, Lorenzo / Pensato, Umberto / Cani, Ilaria / Guarino, Maria / Cortelli, Pietro / Bisulli, Francesca

    Annals of neurology

    2020  Volume 88, Issue 4, Page(s) 860–861

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Cytokines ; Encephalitis ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.25855
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