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  1. Article ; Online: DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia (DECONNECT): research protocol for a cross-sectional pilot study.

    Brandt, Yentl / Alers, Robert-Jan / Canjels, Lisanne P W / Jorissen, Laura M / Jansen, Gwyneth / Janssen, Emma B N J / van Kuijk, Sander / Went, Tamara Michelle / Koehn, Dennis / Gerretsen, Suzanne C / Jansen, Jacobus / Backes, Walter / Hurks, Petra P M / van de Ven, Vincent / Kooi, M Eline / Spaanderman, Marc E A / Ghossein-Doha, Chahinda

    BMJ open

    2024  Volume 14, Issue 3, Page(s) e077534

    Abstract: Introduction: Pre-eclampsia is a hypertensive disorder affecting up to 8% of pregnancies. After pre-eclampsia, women are at increased risk of cognitive problems, and cerebrovascular and cardiovascular disorders. These sequelae could result from ... ...

    Abstract Introduction: Pre-eclampsia is a hypertensive disorder affecting up to 8% of pregnancies. After pre-eclampsia, women are at increased risk of cognitive problems, and cerebrovascular and cardiovascular disorders. These sequelae could result from microvascular dysfunction persisting after pre-eclampsia. This study will explore differences in cerebral and myocardial microvascular function between women after pre-eclampsia and women after normotensive gestation. We hypothesise that pre-eclampsia alters cerebral and myocardial microvascular functions, which in turn are related to diminished cognitive and cardiac performance.
    Methods and analysis: The cross-sectional 'DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia' (DECONNECT) pilot study includes women after pre-eclampsia and controls after normotensive pregnancy between 6 months and 20 years after gestation. We recruit women from the Queen of Hearts study, a study investigating subclinical heart failure after pre-eclampsia. Neuropsychological tests are employed to assess different cognitive domains, including attention, processing speed, and cognitive control. Cerebral images are recorded using a 7 Tesla MRI to assess blood-brain barrier integrity, perfusion, blood flow, functional and structural networks, and anatomical dimensions. Cardiac images are recorded using a 3 Tesla MRI to assess cardiac perfusion, strain, dimensions, mass, and degree of fibrosis. We assess the effect of a history of pre-eclampsia using multivariable regression analyses.
    Ethics and dissemination: This study is approved by the Ethics Committee of Maastricht University Medical Centre (METC azM/UM, NL47252.068.14). Knowledge dissemination will include scientific publications, presentations at conferences and public forums, and social media.
    Trial registration number: NCT02347540.
    MeSH term(s) Female ; Humans ; Pregnancy ; Cognition ; Cross-Sectional Studies ; Myocardium ; Pilot Projects ; Pre-Eclampsia
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-077534
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  2. Article ; Online: Attenuated cognitive functioning decades after preeclampsia.

    Alers, Robert-Jan / Ghossein-Doha, Chahinda / Canjels, Lisanne P W / Muijtjens, Eva S H / Brandt, Yentl / Kooi, M Eline / Gerretsen, Suzanne C / Jansen, Jacobus F A / Backes, Walter H / Hurks, Petra P M / van de Ven, Vincent / Spaanderman, Marc E A

    American journal of obstetrics and gynecology

    2023  Volume 229, Issue 3, Page(s) 294.e1–294.e14

    Abstract: Background: Preeclampsia, a hypertensive pregnancy disorder, is a leading cause of maternal and fetal morbidity and mortality, with remote cardio- and cerebrovascular implications. After preeclampsia, women may report serious disabling cognitive ... ...

    Abstract Background: Preeclampsia, a hypertensive pregnancy disorder, is a leading cause of maternal and fetal morbidity and mortality, with remote cardio- and cerebrovascular implications. After preeclampsia, women may report serious disabling cognitive complaints, especially involving executive function, but the extent and time course of these complaints are unknown.
    Objective: This study aimed to determine the impact of preeclampsia on perceived maternal cognitive functioning decades after pregnancy.
    Study design: This study is part of a cross-sectional case-control study named Queen of Hearts (ClinicalTrials.gov Identifier: NCT02347540), a collaboration study of 5 tertiary referral centers within the Netherlands investigating long-term effects of preeclampsia. Eligible participants were female patients aged ≥18 years after preeclampsia and after normotensive pregnancy between 6 months and 30 years after their first (complicated) pregnancy. Preeclampsia was defined as new-onset hypertension after 20 weeks of gestation along with proteinuria, fetal growth restriction, or other maternal organ dysfunction. Women with a history of hypertension, autoimmune disease, or kidney disease before their first pregnancy were excluded. Attenuation of higher-order cognitive functions, that is, executive function, was measured with the Behavior Rating Inventory of Executive Function for Adults. Crude and covariate-adjusted absolute and relative risks of clinical attenuation over time after (complicated) pregnancy were determined with moderated logistic and log-binomial regression.
    Results: This study included 1036 women with a history of preeclampsia and 527 women with normotensive pregnancies. Regarding overall executive function, 23.2% (95% confidence interval, 19.0-28.1) of women experienced clinically relevant attenuation after preeclampsia, as opposed to 2.2% (95% confidence interval, 0.8-6.0) of controls immediately after childbirth (adjusted relative risk, 9.20 [95% confidence interval, 3.33-25.38]). Group differences diminished yet remained statistically significant (P < .05) at least 19 years postpartum. Regardless of history of preeclampsia, women with lower educational attainment, mood or anxiety disorders, or obesity were especially at risk. Neither severity of preeclampsia, multiple gestation, method of delivery, preterm birth, nor perinatal death was related to overall executive function.
    Conclusion: After preeclampsia, women were 9 times more likely to experience clinical attenuation of higher-order cognitive functions as opposed to after normotensive pregnancy. Despite overall steady improvement, elevated risks persisted over decades after childbirth.
    MeSH term(s) Adult ; Female ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Case-Control Studies ; Cognition ; Cross-Sectional Studies ; Hypertension ; Pre-Eclampsia/epidemiology ; Premature Birth ; Adolescent
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2023.02.020
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  3. Article ; Online: Concurrent Respiratory Motion Correction of Abdominal PET and Dynamic Contrast-Enhanced-MRI Using a Compressed Sensing Approach.

    Fuin, Niccolo / Catalano, Onofrio A / Scipioni, Michele / Canjels, Lisanne P W / Izquierdo-Garcia, David / Pedemonte, Stefano / Catana, Ciprian

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2018  Volume 59, Issue 9, Page(s) 1474–1479

    Abstract: We present an approach for concurrent reconstruction of respiratory motion-compensated abdominal dynamic contrast-enhanced (DCE)-MRI and PET data in an integrated PET/MR scanner. The MR and PET reconstructions share the same motion vector fields derived ... ...

    Abstract We present an approach for concurrent reconstruction of respiratory motion-compensated abdominal dynamic contrast-enhanced (DCE)-MRI and PET data in an integrated PET/MR scanner. The MR and PET reconstructions share the same motion vector fields derived from radial MR data; the approach is robust to changes in respiratory pattern and does not increase the total acquisition time.
    MeSH term(s) Abdomen/diagnostic imaging ; Contrast Media ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging ; Movement ; Positron-Emission Tomography ; Respiration ; Signal-To-Noise Ratio ; Time Factors
    Chemical Substances Contrast Media
    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.117.203943
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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  4. Article ; Online: Time-efficient measurement of subtle blood-brain barrier leakage using a T

    van den Kerkhof, Marieke / Voorter, Paulien H M / Canjels, Lisanne P W / de Jong, Joost J A / van Oostenbrugge, Robert J / Kroon, Abraham A / Jansen, Jacobus F A / Backes, Walter H

    Magnetic resonance in medicine

    2020  Volume 85, Issue 5, Page(s) 2761–2770

    Abstract: Purpose: Blood-brain barrier (BBB) disruption is commonly measured with DCE-MRI using continuous dynamic scanning. For precise measurement of subtle BBB leakage, a long acquisition time (>20 minutes) is required. As extravasation of the contrast agent ... ...

    Abstract Purpose: Blood-brain barrier (BBB) disruption is commonly measured with DCE-MRI using continuous dynamic scanning. For precise measurement of subtle BBB leakage, a long acquisition time (>20 minutes) is required. As extravasation of the contrast agent is slow, discrete sampling at strategic time points might be beneficial, and gains scan time for additional sequences. Here, we aimed to explore the feasibility of a sparsely sampled MRI protocol at 7 T.
    Methods: The scan protocol consisted of a precontrast quantitative T
    Results: The simulations showed that two postcontrast T
    Conclusion: The sparsely sampled protocol was demonstrated to be sensitive to quantify subtle BBB leakage, despite using only three T
    MeSH term(s) Blood-Brain Barrier/diagnostic imaging ; Contrast Media ; Gray Matter ; Magnetic Resonance Imaging ; White Matter
    Chemical Substances Contrast Media
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.28629
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    Zs.A 1959: Show issues Location:
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  5. Article ; Online: Volumetric and Functional Activity Lateralization in Healthy Subjects and Patients with Focal Epilepsy: Initial Findings in a 7T MRI Study.

    Canjels, Lisanne P W / Backes, Walter H / van Veenendaal, Tamar M / Vlooswijk, Marielle C G / Hofman, Paul A M / Aldenkamp, Albert P / Rouhl, Rob P W / Jansen, Jacobus F A

    Journal of neuroimaging : official journal of the American Society of Neuroimaging

    2020  Volume 30, Issue 5, Page(s) 666–673

    Abstract: Background and purpose: In 30% of the patients with focal epilepsy, an epileptogenic lesion cannot be visually detected with structural MRI. Ultra-high field MRI may be able to identify subtle pathology related to the epileptic focus. We set out to ... ...

    Abstract Background and purpose: In 30% of the patients with focal epilepsy, an epileptogenic lesion cannot be visually detected with structural MRI. Ultra-high field MRI may be able to identify subtle pathology related to the epileptic focus. We set out to assess 7T MRI-derived volumetric and functional activity lateralization of the hippocampus, hippocampal subfields, temporal and frontal lobe in healthy subjects and MRI-negative patients with focal epilepsy.
    Methods: Twenty controls and 10 patients with MRI-negative temporal or frontal lobe epilepsy (TLE and FLE, respectively) underwent a 7T MRI exam. T
    Results: In controls, volumetric lateralization was symmetric, with a slight asymmetry of the hippocampus and subiculum, while functional lateralization consistently showed symmetry. Contrarily, in epilepsy patients, regions were less symmetric. In TLE patients with known focus, volumetric lateralization in the hippocampus and hippocampal subfields was indicative of smaller ipsilateral volumes. These patients also showed clear functional lateralization, though not consistently ipsilateral or contralateral to the epileptic focus. TLE patients with unknown focus showed an obvious volumetric lateralization, facilitating the localization of the epileptic focus. Lateralization results in the FLE patients were less consistent with the epileptic focus.
    Conclusion: MRI-derived volume and fluctuation amplitude are highly symmetric in controls, whereas in TLE, volumetric and functional lateralization effects were observed. This highlights the potential of the technique.
    MeSH term(s) Adult ; Brain/diagnostic imaging ; Brain/physiopathology ; Epilepsies, Partial/diagnostic imaging ; Epilepsies, Partial/physiopathology ; Female ; Functional Laterality/physiology ; Healthy Volunteers ; Hippocampus/diagnostic imaging ; Hippocampus/physiopathology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Young Adult
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071724-9
    ISSN 1552-6569 ; 1051-2284
    ISSN (online) 1552-6569
    ISSN 1051-2284
    DOI 10.1111/jon.12739
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    Zs.A 3211: Show issues Location:
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  6. Article ; Online: 7T dynamic contrast-enhanced MRI for the detection of subtle blood-brain barrier leakage.

    Canjels, Lisanne P W / Jansen, Jacobus F A / van den Kerkhof, Marieke / Alers, Robert-Jan / Poser, Benedikt A / Wiggins, Christopher J / Schiffer, Veronique M M M / van de Ven, Vincent / Rouhl, Rob P W / Palm, W M / van Oostenbrugge, Robert J / Aldenkamp, Albert P / Ghossein-Doha, Chahinda / Spaanderman, Marc E A / Backes, Walter H

    Journal of neuroimaging : official journal of the American Society of Neuroimaging

    2021  Volume 31, Issue 5, Page(s) 902–911

    Abstract: Background and purpose: Dynamic contrast-enhanced MRI (DCE-MRI) can be employed to assess the blood-brain barrier (BBB) integrity. Detection of BBB leakage at lower field strengths (≤3T) is cumbersome as the signal is noisy, while leakage can be subtle. ...

    Abstract Background and purpose: Dynamic contrast-enhanced MRI (DCE-MRI) can be employed to assess the blood-brain barrier (BBB) integrity. Detection of BBB leakage at lower field strengths (≤3T) is cumbersome as the signal is noisy, while leakage can be subtle. Utilizing the increased signal-to-noise ratio at higher field strengths, we explored the application of 7T DCE-MRI for assessing BBB leakage.
    Methods: A dual-time resolution DCE-MRI method was implemented at 7T and a slow injection rate (0.3 ml/s) and low dose (3 mmol) served to obtain signal changes linearly related to the gadolinium concentration, that is, minimized for T
    Results: K
    Conclusion: We demonstrate how a dual-time resolution DCE-MRI protocol at 7T, with administration of half the clinically used contrast agent dose, can be used for assessing subtle BBB leakage. Although the feasibility of DCE-MRI for assessing the BBB integrity at 3T is well known, we showed that a continuous sampling DCE-MRI method tailored for 7T is also capable of assessing leakage with a high sensitivity over a range of K
    MeSH term(s) Blood-Brain Barrier/diagnostic imaging ; Contrast Media ; Gray Matter ; Humans ; Magnetic Resonance Imaging ; White Matter
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071724-9
    ISSN 1552-6569 ; 1051-2284
    ISSN (online) 1552-6569
    ISSN 1051-2284
    DOI 10.1111/jon.12894
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