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  1. Book ; Conference proceedings: Advances in Renal Osteodystrophy - IV International Symposium

    Cannata Andía, Jorge B.

    [Oviedo, Spain, on June 6 and 7, 2002]

    (Kidney international : Supplement ; 85)

    2003  

    Event/congress Symposium on Advances in Renal Osteodystrophy (4, 2002, Oviedo)
    Author's details guest ed.: Jorge Cannata-Andía
    Series title Kidney international : Supplement ; 85
    Kidney international
    Kidney international ; Supplement
    Collection Kidney international
    Kidney international ; Supplement
    Keywords Niere ; Ossärer Hyperparathyreoidismus
    Subject Osteodystrophia fibrosa cystica generalisata ; Engel-von-Recklinghausen-Syndrom ; Nephros ; Ren
    Language English
    Size S-132 S. : Ill., graph. Darst.
    Publisher Blackwell Publ
    Publishing place Malden, MA
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013715726
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 797 -Suppl.85- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Conference proceedings: Renal osteodystrophy

    Cannata Andía, Jorge B.

    [circa 2000]

    2000  

    Institution Symposium Renal Osteodystrophy
    Author's details [Symposium: Renal Osteodystrophy II]. Jorge B. Cannata Andia, guest ed
    Language English
    Publishing country United States
    Document type Article ; Conference proceedings
    Note In: The American journal of the medical sciences: N.F. - ISSN 0002-9629. - 320 (2000),2, S. 75 - 111
    HBZ-ID HT012845207
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 2/10 -320- verfügbar in Königswinter Königswinter

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  3. Book: Management of the renal patient

    Cannata Andía, Jorge B.

    experts' recommendations and clinical algorithms on renal osteodystrophy and cardiovascular risk factors

    (Nephrology, dialysis, transplantation ; 15, Suppl. 5)

    2000  

    Author's details ed. Jorge Cannata-Andía
    Series title Nephrology, dialysis, transplantation ; 15, Suppl. 5
    Collection
    Language English
    Size 154 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT012839899
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2198 -15,Suppl.5- not available for loan Zeitschriften-Lesesaal

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  4. Book ; Conference proceedings: Advances in renal osteodystrophy

    Cannata Andía, Jorge B.

    second international symposium, March 20 - 21, 1997, Oviedo, Spain

    (Nephrology, dialysis, transplantation ; 13, Suppl. 3)

    1998  

    Event/congress International Symposium on Advances in Renal Osteodystrophy (2, 1997, Oviedo)
    Author's details [Second International Symposium on Advances in Renal Osteodystrophy.] Ed. Jorge B. Cannata Andía
    Series title Nephrology, dialysis, transplantation ; 13, Suppl. 3
    Collection
    Language English
    Size 107 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT008403130
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2198 -13,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  5. Book: Avances en osteodistrofia renal

    Cannata Andía, Jorge B.

    [aportaciones al Simposio Internacional sobre Avances en Osteodistrofia Renal celebrado en Oviedo del 1 al 12 octubre de 1992]

    (Nefrología ; 13, Supl. 3)

    1993  

    Institution Simposio Internacional sobre Avances en Osteodistrofia Renal
    Author's details ed. espec.: JB Cannata
    Series title Nefrología ; 13, Supl. 3
    Collection
    Keywords Hyperparathyroidism, Secondary / congresses ; Aluminum / poisoning / congresses ; Aluminum / metabolism / congresses ; Bone and Bones / metabolism / congresses ; Renal Osteodystrophy / metabolism
    Language English ; Spanish
    Size 180 S. : graph. Darst.
    Publisher Soc. Española de Nefrología
    Publishing place Madrid
    Publishing country Spain
    Document type Book
    Note Beitr. teilw. span., teilw. engl.
    HBZ-ID HT007471009
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 2773 -13,Supl.3- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease

    Donate-Correa, Javier / Martín-Carro, Beatriz / Cannata-Andía, Jorge B. / Mora-Fernández, Carmen / Navarro-González, Juan F.

    Antioxidants. 2023 Jan. 20, v. 12, no. 2

    2023  

    Abstract: Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is characterized by a premature aging syndrome, and to find a modulator targeting against oxidative stress, ... ...

    Abstract Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is characterized by a premature aging syndrome, and to find a modulator targeting against oxidative stress, mitochondrial dysfunction, and cellular senescence in kidney cells could be of great significance to prevent and control the progression of this disease. This review focuses on the pathogenic mechanisms related to the appearance of oxidative stress damage and mitochondrial dysfunction in kidney disease. In this scenario, the anti-aging Klotho protein plays a crucial role by modulating signaling pathways involving the manganese-containing superoxide dismutase (Mn-SOD) and the transcription factors FoxO and Nrf2, known antioxidant systems, and other known mitochondrial function regulators, such as mitochondrial uncoupling protein 1 (UCP1), B-cell lymphoma-2 (BCL-2), Wnt/β-catenin, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha), transcription factor EB, (TFEB), and peroxisome proliferator-activated receptor gamma (PPAR-gamma). Therefore, Klotho is postulated as a very promising new target for future therapeutic strategies against oxidative stress, mitochondria abnormalities, and cellular senescence in kidney disease patients.
    Keywords B-lymphocytes ; antioxidants ; cell senescence ; kidney diseases ; kidneys ; mitochondria ; oxidative stress ; peroxisome proliferator-activated receptor gamma ; superoxide dismutase ; therapeutics
    Language English
    Dates of publication 2023-0120
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020239
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease.

    Donate-Correa, Javier / Martín-Carro, Beatriz / Cannata-Andía, Jorge B / Mora-Fernández, Carmen / Navarro-González, Juan F

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is characterized by a premature aging syndrome, and to find a modulator targeting against oxidative stress, ... ...

    Abstract Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is characterized by a premature aging syndrome, and to find a modulator targeting against oxidative stress, mitochondrial dysfunction, and cellular senescence in kidney cells could be of great significance to prevent and control the progression of this disease. This review focuses on the pathogenic mechanisms related to the appearance of oxidative stress damage and mitochondrial dysfunction in kidney disease. In this scenario, the anti-aging Klotho protein plays a crucial role by modulating signaling pathways involving the manganese-containing superoxide dismutase (Mn-SOD) and the transcription factors FoxO and Nrf2, known antioxidant systems, and other known mitochondrial function regulators, such as mitochondrial uncoupling protein 1 (UCP1), B-cell lymphoma-2 (BCL-2), Wnt/β-catenin, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha), transcription factor EB, (TFEB), and peroxisome proliferator-activated receptor gamma (PPAR-gamma). Therefore, Klotho is postulated as a very promising new target for future therapeutic strategies against oxidative stress, mitochondria abnormalities, and cellular senescence in kidney disease patients.
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows.

    Martín-Vírgala, Julia / Martín-Carro, Beatriz / Fernández-Villabrille, Sara / Ruiz-Torres, María Piedad / Gómez-Alonso, Carlos / Rodríguez-García, Minerva / Fernández-Martín, José Luis / Alonso-Montes, Cristina / Panizo, Sara / Cannata-Andía, Jorge B / Naves-Díaz, Manuel / Carrillo-López, Natalia

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Shortly after the discovery of Klotho, interest grew in its potential role in chronic kidney disease (CKD). There are three isoforms of the Klotho protein: αKlotho, βKlotho and γKlotho. This review will focus on αKlotho due to its relevance as a ... ...

    Abstract Shortly after the discovery of Klotho, interest grew in its potential role in chronic kidney disease (CKD). There are three isoforms of the Klotho protein: αKlotho, βKlotho and γKlotho. This review will focus on αKlotho due to its relevance as a biomarker in CKD. αKlotho is synthesized mainly in the kidneys, but it can be released into the bloodstream and urine as soluble Klotho (sKlotho), which undertakes systemic actions, independently or in combination with FGF23. It is usually accepted that sKlotho levels are reduced early in CKD and that lower levels of sKlotho might be associated with the main chronic kidney disease-mineral bone disorders (CKD-MBDs): cardiovascular and bone disease. However, as results are inconsistent, the applicability of sKlotho as a CKD-MBD biomarker is still a matter of controversy. Much of the inconsistency can be explained due to low sample numbers, the low quality of clinical studies, the lack of standardized assays to assess sKlotho and a lack of consensus on sample processing, especially in urine. In recent decades, because of our longer life expectancies, the prevalence of accelerated-ageing diseases, such as CKD, has increased. Exercise, social interaction and caloric restriction are considered key factors for healthy ageing. While exercise and social interaction seem to be related to higher serum sKlotho levels, it is not clear whether serum sKlotho might be influenced by caloric restriction. This review focuses on the possible role of sKlotho as a biomarker in CKD-MBD, highlighting the difference between solid knowledge and areas requiring further research, including the role of sKlotho in healthy ageing.
    MeSH term(s) Humans ; Biomarkers ; Chronic Kidney Disease-Mineral and Bone Disorder/diagnosis ; Fibroblast Growth Factors ; Glucuronidase ; Healthy Aging/metabolism ; Minerals ; Renal Insufficiency, Chronic/complications ; Klotho Proteins/blood ; Klotho Proteins/metabolism
    Chemical Substances Biomarkers ; Fibroblast Growth Factors (62031-54-3) ; Glucuronidase (EC 3.2.1.31) ; Minerals ; Klotho Proteins (EC 3.2.1.31)
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Alteraciones de metabolismo óseo y mineral en la enfermedad renal crónica

    Cannata-Andía, Jorge B

    avances en patogenia, diagnóstio y tratamiento

    2010  

    Author's details editor, Jorge B. Cannata Andía
    MeSH term(s) Bone Diseases, Metabolic/etiology ; Renal Insufficiency, Chronic/complications
    Language Spanish
    Size xii, 317 p. :, ill.
    Publisher Wolters Kluwer Health España/Lippincott Williams & Wilkins
    Publishing place Barcelona
    Document type Book
    ISBN 9788496921818 ; 8496921816
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: COSMOS Project: Hemodialysis scenario in Europe.

    Cannata-Andía, Jorge B / Fernández Martín, José Luis

    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

    2016  Volume 36, Issue 4, Page(s) 381–388

    Title translation Proyecto COSMOS: escenario de la hemodiálisis en Europa.
    Language Spanish
    Publishing date 2016-07
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 632512-9
    ISSN 1989-2284 ; 0211-6995
    ISSN (online) 1989-2284
    ISSN 0211-6995
    DOI 10.1016/j.nefro.2016.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2773: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 56: Show issues

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