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Article ; Online: One-way endobronchial valves in the management of complex persistent air leaks in a soft tissue sarcoma patient.

Fiorelli, Alfonso / Cannella, Lucia / Capasso, Francesca / Pizzolorusso, Antonio / Picozzi, Feranda / Messina, Gaetana / Natale, Giovanni / Mercadante, Edoardo / Tafuto, Salvatore

Thoracic cancer

2023 Volume 14, Issue 26, Page(s) 2712–2714

Abstract: Complex persistent air leak (PAL) is a clinical condition which is difficult to treat. Herein, we report the clinical case of an 18-year-old woman with lung and bone metastases due an ultrarare sarcoma: "round cell sarcoma non-Ewing". She developed ... ...

Abstract	Complex persistent air leak (PAL) is a clinical condition which is difficult to treat. Herein, we report the clinical case of an 18-year-old woman with lung and bone metastases due an ultrarare sarcoma: "round cell sarcoma non-Ewing". She developed persistent air leaks due to an alveolopleural fistula which developed following two cycles of chemotherapy with doxorubicin. Chest drainage with suction failed to resolve the air leaks, while surgical treatment was unfeasible due to the poor clinical condition of the patient. Thus, she was reviewed for endoscopic treatment with one-way endobronchial valves. A small valve was sequentially inserted within each segment of the right upper bronchus to occlude the entire upper lobe. Two days after the procedure, resolution of the air leaks were obtained. Chest drainage was removed 5 days later and the patient was discharged. Chemotherapy was resumed. The patient died 7 months later because of disease progression.
MeSH term(s)	Female ; Humans ; Adolescent ; Pneumothorax/etiology ; Bronchoscopy/methods ; Lung ; Bronchi ; Sarcoma/surgery ; Soft Tissue Neoplasms
Language	English
Publishing date	2023-08-09
Publishing country	Singapore
Document type	Case Reports
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.15064
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Article: The Management of Phaeochromocytomas and Paragangliomas in the Era of Precision Medicine: Where Are We Now? Evidence-Based Systemic Treatment Options and Future Cluster Oriented Perspectives.

Bracigliano, Alessandra / Marretta, Antonella Lucia / Guerrera, Luigi Pio / Simioli, Roberto / Clemente, Ottavia / Granata, Vincenza / Minopoli, Anita / Della Vittoria Scarpati, Giuseppina / Picozzi, Fernanda / Cannella, Lucia / Pizzolorusso, Antonio / Di Gennaro, Francesca / Tafuto, Roberto / Sarno, Maria Rosaria / Cavalcanti, Ernesta / Ribera, Dario / Tafuto, Salvatore

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 3

Abstract: Pheochromocytomas (PCCs) and Paragangliomas (PGLs), commonly known as PPGLs to include both entities, are rare neuroendocrine tumors that may arise in the context of hereditary syndromes or be sporadic. However, even among sporadic PPGLs, identifiable ... ...

Abstract	Pheochromocytomas (PCCs) and Paragangliomas (PGLs), commonly known as PPGLs to include both entities, are rare neuroendocrine tumors that may arise in the context of hereditary syndromes or be sporadic. However, even among sporadic PPGLs, identifiable somatic alterations in at least one of the known susceptibility genes can be detected. Therefore, about 3/4 of all PPGL patients can be assigned to one of the three molecular clusters that have been identified in the last years with difference in the underlying pathogenetic mechanisms, biochemical phenotype, metastatic potential, and prognosis. While surgery represents the mainstay of treatment for localized PPGLs, several therapeutic options are available in advanced and/or metastatic setting. However, only few of them hinge upon prospective data and a cluster-oriented approach has not yet been established. In order to render management even more personalized and improve the prognosis of this molecularly complex disease, it is undoubtable that genetic testing for germline mutations as well as genome profiling for somatic mutations, where available, must be improved and become standard practice. This review summarizes the current evidence regarding diagnosis and treatment of PPGLs, supporting the need of a more cluster-specific approach in clinical practice.
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17030354
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Article: Multidisciplinary Management of Retroperitoneal Sarcoma: Diagnosis, Prognostic Factors and Treatment.

Carbone, Fabio / Pizzolorusso, Antonio / Di Lorenzo, Giuseppe / Di Marzo, Massimiliano / Cannella, Lucia / Barretta, Maria Luisa / Delrio, Paolo / Tafuto, Salvatore

Cancers

2021 Volume 13, Issue 16

Abstract: Retroperitoneal sarcomas (RPS) are rare cancers whose management can be challenging due to various presentation patterns, multiple organ involvement, and a high local and distant recurrence rate. Histopathology and prognostic factors analysis are ... ...

Abstract	Retroperitoneal sarcomas (RPS) are rare cancers whose management can be challenging due to various presentation patterns, multiple organ involvement, and a high local and distant recurrence rate. Histopathology and prognostic factors analysis are essential to predict the behaviour of the disease and plan the best therapeutic strategy. To date, surgery is still the main therapeutic option that guarantees a chance of cure from the primary disease. While chemotherapy and radiotherapy seem to be good options for controlling metastatic and recurrent irresectable disease, their role in the treatment of primary RPS remains unclear. This literature review aims to provide a comprehensive overview of the multidisciplinary aspects of RPS management in high-volume centres, summarising the diagnostic path, the prognostic factors, and the most suitable therapeutic options.
Language	English
Publishing date	2021-08-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13164016
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Article ; Online: The Impact of O6-Methylguanine-DNA Methyltransferase (

Cannella, Lucia / Della Monica, Rosa / Marretta, Antonella Lucia / Iervolino, Domenico / Vincenzi, Bruno / De Chiara, Anna Rosaria / Clemente, Ottavia / Buonaiuto, Michela / Barretta, Maria Luisa / Di Mauro, Annabella / Di Marzo, Massimiliano / Guida, Michele / Badalamenti, Giuseppe / Chiariotti, Lorenzo / Tafuto, Salvatore

Cells

2023 Volume 12, Issue 12

Abstract: Dacarbazine is an important drug in the therapeutic landscape of leiomyosarcoma (LMS). Alkylating agents are subjected to resistance mechanisms based on anti-apoptotic pathways and repair mechanisms, including the DNA repair enzyme O6-methylguanine-DNA ... ...

Abstract	Dacarbazine is an important drug in the therapeutic landscape of leiomyosarcoma (LMS). Alkylating agents are subjected to resistance mechanisms based on anti-apoptotic pathways and repair mechanisms, including the DNA repair enzyme O6-methylguanine-DNA methyltransferase (
MeSH term(s)	Humans ; Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; Brain Neoplasms/pathology ; Dacarbazine/therapeutic use ; DNA ; DNA Methylation/genetics ; DNA Modification Methylases/genetics ; DNA Modification Methylases/therapeutic use ; DNA Repair Enzymes/genetics ; Leiomyosarcoma/drug therapy ; Leiomyosarcoma/genetics ; Methyltransferases/genetics ; Retrospective Studies ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Tumor Suppressor Proteins/genetics ; Middle Aged
Chemical Substances	Antineoplastic Agents, Alkylating ; Dacarbazine (7GR28W0FJI) ; DNA (9007-49-2) ; DNA Modification Methylases (EC 2.1.1.-) ; DNA Repair Enzymes (EC 6.5.1.-) ; Methyltransferases (EC 2.1.1.-) ; MGMT protein, human (EC 2.1.1.63) ; O-(6)-methylguanine (9B710FV2AE) ; Temozolomide (YF1K15M17Y) ; Tumor Suppressor Proteins
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12121635
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Article ; Online: The Complex Management of the Breast Angiosarcoma: A Retrospective Study.

Cannella, Lucia / Perri, Francesco / Clemente, Ottavia / von Arx, Claudia / Pizzolorusso, Antonio / Di Bonito, Maurizio / Bracigliano, Alessandra / Di Marzo, Massimiliano / Della Vittoria Scarpati, Giuseppina / De Chiara, Annarosaria / Tafuto, Salvatore

Oncology

2022 Volume 101, Issue 4, Page(s) 234–239

Abstract: Background/aim: Breast angiosarcoma is a rare and aggressive disease with a poor prognosis. Two subtypes have been identified: primary angiosarcoma (PBA) and secondary breast angiosarcoma (SBA). In this retrospective analysis, we describe and compare ... ...

Abstract	Background/aim: Breast angiosarcoma is a rare and aggressive disease with a poor prognosis. Two subtypes have been identified: primary angiosarcoma (PBA) and secondary breast angiosarcoma (SBA). In this retrospective analysis, we describe and compare our institute experience with the data existing in the literature. Materials and methods: We included in our analysis 29 patients who received a diagnosis of PBA or SBA between 2006 and 2019. Results: All patients received surgery as frontline treatment, but only 6 patients underwent to adjuvant treatment. Neoadjuvant chemotherapy was administered 2 patients. The preferred chemotherapeutic regimen was taxanes with or without gemcitabine and associated with anthracyclines. A lower median RFS and OS were reported in patients with PBA compared to those with SBA, but the difference observed was not statistically significant. Patients with PBA had a lower median age at the diagnosis (38 vs. 75). Conclusion: In our analysis, we have shown a lower median RFS and OS in patients with PBA compared with those with SBA, and a significantly younger age at diagnosis in patients affected by PBA.
MeSH term(s)	Humans ; Female ; Hemangiosarcoma/drug therapy ; Retrospective Studies ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Antibiotics, Antineoplastic
Chemical Substances	Antibiotics, Antineoplastic
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	250101-6
ISSN	1423-0232 ; 0030-2414
ISSN (online)	1423-0232
ISSN	0030-2414
DOI	10.1159/000525146
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Article: Long-term survival in a patient with metastatic squamous cell lung carcinoma: A case report.

Barletta, Emiddio / Federico, Piera / Tinessa, Vincenza / Germano, Domenico / Cannella, Lucia / Pironti, Teresa / Daniele, Bruno

Molecular and clinical oncology

2017 Volume 7, Issue 5, Page(s) 928–930

Abstract: Non-small-cell lung cancer (NSCLC) is the most common malignancy in industrialized countries, with a 5-year survival rate of only ~15%, as the majority of the patients have advanced-stage disease at diagnosis and the treatment options are limited. ... ...

Abstract	Non-small-cell lung cancer (NSCLC) is the most common malignancy in industrialized countries, with a 5-year survival rate of only ~15%, as the majority of the patients have advanced-stage disease at diagnosis and the treatment options are limited. Squamous cell carcinoma the second most frequent type of NSCLC and is closely associated with cigarette smoking. We herein present the case of a 72-year-old male smoker, diagnosed with stage IV squamous cell lung carcinoma, with a solitary brain metastasis. After the diagnosis, stereotactic radiotherapy was performed on the brain metastasis. Following radiotherapy, chemotherapy with carboplatin + paclitaxel was initiated. However, after 2 cycles of chemotherapy, disease progression in the lung was observed. Therefore, second-line treatment with pemetrexed was started, which was discontinued after 2 cycles due to further disease progression. Third-line treatment with erlotinib was then administered, with notable benefit, as the patient remains alive after 6 years of treatment with a good performance status. The mutation status of EGFR was unknown.
Language	English
Publishing date	2017-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2796865-0
ISSN	2049-9469 ; 2049-9450
ISSN (online)	2049-9469
ISSN	2049-9450
DOI	10.3892/mco.2017.1408
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Article: Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors.

Marretta, Antonella Lucia / Di Lorenzo, Giuseppe / Ribera, Dario / Cannella, Lucia / von Arx, Claudia / Bracigliano, Alessandra / Clemente, Ottavia / Tafuto, Roberto / Pizzolorusso, Antonio / Tafuto, Salvatore

Pharmaceutics

2021 Volume 13, Issue 9

Abstract: Nucleocytoplasmic transport has been found dysregulated in many types of cancer and is often described as a poor prognostic factor. Specifically, Exportin-1 (XPO1) has been found overexpressed in many tumors and has become an attractive target in ... ...

Abstract	Nucleocytoplasmic transport has been found dysregulated in many types of cancer and is often described as a poor prognostic factor. Specifically, Exportin-1 (XPO1) has been found overexpressed in many tumors and has become an attractive target in molecular oncology and therapeutics development. The selective inhibitor of nuclear export, Selinexor, is one of the most scientifically interesting drugs that targets XPO1 in clinical development. In this review, we summarized the most relevant preclinical and clinical results achieved for non-solid tumors, sarcomas, and other kind of solid tumors.
Language	English
Publishing date	2021-09-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13091522
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Article ; Online: Is immunotherapy in the future of therapeutic management of sarcomas?

Clemente, Ottavia / Ottaiano, Alessandro / Di Lorenzo, Giuseppe / Bracigliano, Alessandra / Lamia, Sabrina / Cannella, Lucia / Pizzolorusso, Antonio / Di Marzo, Massimiliano / Santorsola, Mariachiara / De Chiara, Annarosaria / Fazioli, Flavio / Tafuto, Salvatore

Journal of translational medicine

2021 Volume 19, Issue 1, Page(s) 173

Abstract: Sarcomas are rare, ubiquitous and heterogeneous tumors usually treated with surgery, chemotherapy, target therapy, and radiotherapy. However, 25-50% of patients experience local relapses and/or distant metastases after chemotherapy with an overall ... ...

Abstract	Sarcomas are rare, ubiquitous and heterogeneous tumors usually treated with surgery, chemotherapy, target therapy, and radiotherapy. However, 25-50% of patients experience local relapses and/or distant metastases after chemotherapy with an overall survival about 12-18 months. Recently, immuno-therapy has revolutionized the cancer treatments with initial indications for non-small cell lung cancer (NSCLC) and melanoma (immune-checkpoint inhibitors).Here, we provide a narrative review on the topic as well as a critical description of the currently available trials on immunotherapy treatments in patients with sarcoma. Given the promising results obtained with anti-PD-1 monoclonal antibodies (pembrolizumab and nivolumab) and CAR-T cells, we strongly believe that these new immunotherapeutic approaches, along with an innovative characterization of tumor genetics, will provide an exciting opportunity to ameliorate the therapeutic management of sarcomas.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung ; Humans ; Immunotherapy ; Lung Neoplasms ; Neoplasm Recurrence, Local ; Sarcoma/therapy
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Journal Article ; Review
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-021-02829-y
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Article ; Online: Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma.

Minopoli, Michele / Sarno, Sabrina / Di Carluccio, Gioconda / Azzaro, Rosa / Costantini, Susan / Fazioli, Flavio / Gallo, Michele / Apice, Gaetano / Cannella, Lucia / Rea, Domenica / Stoppelli, Maria Patrizia / Boraschi, Diana / Budillon, Alfredo / Scotlandi, Katia / De Chiara, Annarosaria / Carriero, Maria Vincenza

Cells

2020 Volume 9, Issue 4

Abstract: Chondrosarcomas (CHS) are malignant cartilaginous neoplasms with diverse morphological features, characterized by resistance to chemo- and radiation therapies. In this study, we investigated the role of tumor-associated macrophages (TAM)s in tumor ... ...

Abstract	Chondrosarcomas (CHS) are malignant cartilaginous neoplasms with diverse morphological features, characterized by resistance to chemo- and radiation therapies. In this study, we investigated the role of tumor-associated macrophages (TAM)s in tumor tissues from CHS patients by immunohistochemistry. Three-dimensional organotypic co-cultures were set up in order to evaluate the contribution of primary human CHS cells in driving an M2-like phenotype in monocyte-derived primary macrophages, and the capability of macrophages to promote growth and/or invasiveness of CHS cells. Finally, with an in vivo model of primary CHS cells engrafted in nude mice, we tested the ability of a potent peptide inhibitor of cell migration (Ac-d-Tyr-d-Arg-Aib-d-Arg-NH
MeSH term(s)	Adult ; Aged ; Animals ; Antigens, CD/metabolism ; Chondrosarcoma/pathology ; Collagen/pharmacology ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Immunophenotyping ; Male ; Mice, Nude ; Microvessels/pathology ; Middle Aged ; Monocytes/drug effects ; Monocytes/pathology ; Phenotype ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/pathology ; THP-1 Cells ; Time Factors ; Tumor-Associated Macrophages/drug effects ; Tumor-Associated Macrophages/pathology
Chemical Substances	Antigens, CD ; Collagen (9007-34-5)
Language	English
Publishing date	2020-04-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9041062
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Article: Crosstalk between Macrophages and Myxoid Liposarcoma Cells Increases Spreading and Invasiveness of Tumor Cells.

Cancers

2021 Volume 13, Issue 13

Abstract: Myxoid liposarcoma (MLPS) is the second most common subtype of liposarcoma and has tendency to metastasize to soft tissues. To date, the mechanisms of invasion and metastasis of MLPS remain unclear, and new therapeutic strategies that improve patients' ... ...

Abstract	Myxoid liposarcoma (MLPS) is the second most common subtype of liposarcoma and has tendency to metastasize to soft tissues. To date, the mechanisms of invasion and metastasis of MLPS remain unclear, and new therapeutic strategies that improve patients' outcomes are expected. In this study, we analyzed by immunohistochemistry the immune cellular components and microvessel density in tumor tissues from patients affected by MLPS. In order to evaluate the effects of primary human MLPS cells on macrophage polarization and, in turn, the ability of macrophages to influence invasiveness of MLPS cells, non-contact and 3D organotypic co-cultures were set up. High grade MLPS tissues were found heavily vascularized, exhibited a CD3, CD4, and CD8 positive T lymphocyte-poor phenotype and were massively infiltrated by CD163 positive M2-like macrophages. Conversely, low grade MLPS tissues were infiltrated by a discrete amount of CD3, CD4, and CD8 positive T lymphocytes and a scarce amount of CD163 positive macrophages. Kaplan-Meier analysis revealed a shorter Progression Free Survival in MLPS patients whose tumor tissues were highly vascularized and heavily infiltrated by CD163 positive macrophages, indicating a clear-cut link between M2-like macrophage abundance and poor prognosis in patients. Moreover, we documented that, in co-culture, soluble factors produced by primary human MLPS cells induce macrophage polarization toward an M2-like phenotype which, in turn, increases MLPS cell capability to spread into extracellular matrix and to cross endothelial monolayers. The identification of M2-like polarization factors secreted by MLPS cells may allow to develop novel targeted therapies counteracting MLPS progression.
Language	English
Publishing date	2021-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13133298
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