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  1. Article ; Online: Learning curve of optical trocar access during laparoscopic pelvic surgery: A prospective study.

    Gaia, G / Sighinolfi, M C / Rocco, B / Cannoletta, M / Sampogna, V / Lamarca, A / Alboni, C

    Actas urologicas espanolas

    2023  Volume 47, Issue 10, Page(s) 675–680

    Abstract: Introduction: The optical trocar access (OTA) is a modified closed technique that aims to minimize the risk of vascular or bowel injuries while reducing the likelihood of gas leakage. A learning curve (LC) effect for OTA has been invoked with n = 30 ... ...

    Abstract Introduction: The optical trocar access (OTA) is a modified closed technique that aims to minimize the risk of vascular or bowel injuries while reducing the likelihood of gas leakage. A learning curve (LC) effect for OTA has been invoked with n = 30 procedures being considered as a threshold to define expertise. We aim to evaluate the impact of the LC within the first thirty cases of OTA performed by a trainee.
    Methods: This is a prospective randomized study on 60 patients elected to laparoscopic gynecological surgery. Patients were randomized to have OTA insertion by a junior surgeon or by an expert. LC was evaluated by: 1) insertion time; number of: 2) corrections by the senior; 3) times the tip of the trocar stopped in the preperitoneal layer; 4) mistakes of skin incision; 5) times the tip of the trocar ends under the omentum; 6) complications. To analyze the LC within the first 30 cases, procedures were stratified in 3 groups (cases 1-10; 11-20; 21-30) for both trainee and expert and LC variables were compared.
    Results: Overall, mean OTA insertion time was 56 s. No major intra- and post-operative complications were recorded. Mean insertion time was statistically significantly longer for the trainee compared to the expert within the first 10 cases (91 vs 33 s respectively, P = .01). For cases 11-20 and 21-30, time advantage of the senior surgeon is less evident (P = .05). The number of times the tip of the trocar stopped in the preperitoneal layer was similar between groups, as well as times the tip of the trocar ends under the omentum.
    Conclusions: OTA is a fast and simple way to achieve the pneumoperitoneum and first trocar insertion as a single step. The current series confirms the effectiveness of the technique since the beginning of the LC.
    MeSH term(s) Female ; Humans ; Prospective Studies ; Learning Curve ; Laparoscopy/methods ; Abdomen ; Surgical Instruments
    Language Spanish
    Publishing date 2023-07-11
    Publishing country Spain
    Document type Randomized Controlled Trial ; Journal Article
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuroe.2023.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The impact of COVID-19 pandemic on women with endometriosis: a retrospective cohort study on referral center population.

    Spanò Bascio, Ludovica / Gambigliani Zoccoli, Sofia / Pellegrini, Rosamaria / Farulla, Antonino / Cannoletta, Marianna / Paterlini, Laura / La Marca, Antonio / Alboni, Carlo

    Minerva obstetrics and gynecology

    2024  

    Abstract: Background: Patients with endometriosis are thought to have been impacted by the COVID-19 pandemic and estimates suggest that 6.2% of them were infected with SARS-CoV-2.: Methods: This is a retrospective cohort study enrolling 284 women at the ... ...

    Abstract Background: Patients with endometriosis are thought to have been impacted by the COVID-19 pandemic and estimates suggest that 6.2% of them were infected with SARS-CoV-2.
    Methods: This is a retrospective cohort study enrolling 284 women at the Polyclinic of Modena between January 2020 and April 2021. Patients were given specific questionnaires to investigate COVID-19 infection and any changes in gynecological symptoms. All patients were also administered the Hospital Anxiety and Depression Syndrome (HADS) Questionnaire to assess the psychological impact of the COVID-19 pandemic. The primary outcome was to assess the clinical impact and any worsening of gynecological symptoms after COVID-19 infection; the secondary outcome was to evaluate the clinical and psychological impact of the COVID-19 pandemic in patients with endometriosis or chronic pelvic pain.
    Results: A total of 170 women experienced COVID-19 infection, while 114 were consistently negative and asymptomatic for COVID-19. The two groups showed similar baseline. A total of 122 women with COVID-19 infection and 106 COVID-19 negative patients had already the vaccine administration with two doses of vaccine (72.20% vs. 93%, P=0.001). Among the 170 patients affected by COVID-19, 41 (24%) reported worsening gynecologic endometriosis symptoms, during the infection. According to our results, 196 of 284 reported changes in their gynecological health status during pandemic, and 84 reported symptomatic worsening (42.9%); 24% of patients with infection reported feeling slowed down vs. 15.8% of unaffected patients (P=0.065) and 44% of positive patients reported loss of interest in self-care vs. 31% of negative patients (P=0.055).
    Conclusions: Patients with endometriosis seemed to have worsening gynecological and psychological clinical status during the pandemic.
    Language English
    Publishing date 2024-04-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062815-5
    ISSN 2724-6450
    ISSN (online) 2724-6450
    DOI 10.23736/S2724-606X.24.05518-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Modification of blood pressure in postmenopausal women

    Cannoletta M / Cagnacci A

    International Journal of Women's Health, Vol 2014, Iss default, Pp 745-

    role of hormone replacement therapy

    2014  Volume 757

    Abstract: Marianna Cannoletta, Angelo Cagnacci Institute of Obstetrics and Gynecology, Department of Medical and Surgical Sciences of the Mother, Child and Adult, University of Modena and Reggio Emilia, Modena and Reggio Emilia, Emilia-Romagna, Italy Abstract: The ...

    Abstract Marianna Cannoletta, Angelo Cagnacci Institute of Obstetrics and Gynecology, Department of Medical and Surgical Sciences of the Mother, Child and Adult, University of Modena and Reggio Emilia, Modena and Reggio Emilia, Emilia-Romagna, Italy Abstract: The rate of hypertension increases after menopause. Whether estrogen and progesterone deficiency associated with menopause play a role in determining a worst blood pressure (BP) control is still controversial. Also, studies dealing with the administration of estrogens or hormone therapy (HT) have reported conflicting evidence. In general it seems that, despite some negative data on subgroups of later postmenopausal women obtained with oral estrogens, in particular conjugated equine estrogens (CEE), most of the data indicate neutral or beneficial effects of estrogen or HT administration on BP control of both normotensive and hypertensive women. Data obtained with ambulatory BP monitoring and with transdermal estrogens are more convincing and concordant in defining positive effect on BP control of both normotensive and hypertensive postmenopausal women. Overall progestin adjunct does not hamper the effect of estrogens. Among progestins, drospirenone, a spironolactone-derived molecule, appears to be the molecule with the best antihypertensive properties. Keywords: hormone replacement therapy, estrogen, progestin, blood pressure, menopause, hypertension
    Keywords Gynecology and obstetrics ; RG1-991 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2014-08-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Modification of blood pressure in postmenopausal women: role of hormone replacement therapy.

    Cannoletta, Marianna / Cagnacci, Angelo

    International journal of women's health

    2014  Volume 6, Page(s) 745–757

    Abstract: The rate of hypertension increases after menopause. Whether estrogen and progesterone deficiency associated with menopause play a role in determining a worst blood pressure (BP) control is still controversial. Also, studies dealing with the ... ...

    Abstract The rate of hypertension increases after menopause. Whether estrogen and progesterone deficiency associated with menopause play a role in determining a worst blood pressure (BP) control is still controversial. Also, studies dealing with the administration of estrogens or hormone therapy (HT) have reported conflicting evidence. In general it seems that, despite some negative data on subgroups of later postmenopausal women obtained with oral estrogens, in particular conjugated equine estrogens (CEE), most of the data indicate neutral or beneficial effects of estrogen or HT administration on BP control of both normotensive and hypertensive women. Data obtained with ambulatory BP monitoring and with transdermal estrogens are more convincing and concordant in defining positive effect on BP control of both normotensive and hypertensive postmenopausal women. Overall progestin adjunct does not hamper the effect of estrogens. Among progestins, drospirenone, a spironolactone-derived molecule, appears to be the molecule with the best antihypertensive properties.
    Language English
    Publishing date 2014-08-11
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508161-5
    ISSN 1179-1411
    ISSN 1179-1411
    DOI 10.2147/IJWH.S61685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Relation between oxidative stress and climacteric symptoms in early postmenopausal women.

    Cagnacci, A / Cannoletta, M / Palma, F / Bellafronte, M / Romani, C / Palmieri, B

    Climacteric : the journal of the International Menopause Society

    2015  Volume 18, Issue 4, Page(s) 631–636

    Abstract: Objectives: To evaluate the relation between climacteric symptoms or other risk factors for cardiovascular disease and oxidative status of postmenopausal women.: Methods: Cross-sectional investigation performed at the outpatient service for the ... ...

    Abstract Objectives: To evaluate the relation between climacteric symptoms or other risk factors for cardiovascular disease and oxidative status of postmenopausal women.
    Methods: Cross-sectional investigation performed at the outpatient service for the menopause at the University Hospital, on 50 apparently healthy women in physiological postmenopause. The whole-blood free oxygen radical test (FORT), free oxygen radical defence (FORD), age, months since menopause, weight, body mass index, waist circumference, waist-to-hip ratio, estradiol, lipids, glucose, insulin, insulin resistance (glucose/insulin and HOMA-IR), and fibrinogen were evaluated. The Greene Climacteric Scale with its subscales was used to evaluate climacteric symptoms. The pulsatility index, an index of downstream blood flow resistance, was determined for both the internal carotid artery and the brachial artery.
    Results: The waist-to-hip ratio (r = 0.540; p = 0.0001), estradiol (r = 0.548; p = 0.0004) and waist circumference (r = 0.345; p = 0.02) were independently related to blood FORT. The score in the Greene vasomotor subscale was the only parameter independently related to blood FORD (r = 0.554; p = 0.0001). FORT was not related to the artery pulsatility index, while FORD was negatively related to the pulsatility index of both the internal carotid (r = 0.549; p = 0.0001) and the brachial (r = 0.484; p = 0.0001) arteries.
    Discussion: In postmenopausal women, abdominal adiposity and hypoestrogenism increase oxidative stress. Climacteric symptoms, particularly vasomotor symptoms, markedly reduce antioxidant defences. Lower antioxidant defences are associated with higher resistance to blood flow in the great arteries. In women early after the menopause, visceral fat, hypoestrogenism and climacteric symptoms may increase the risk for cardiovascular disease.
    MeSH term(s) Adult ; Aged ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/physiopathology ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Oxidative Stress ; Postmenopause/blood ; Postmenopause/physiology ; Postmenopause/psychology ; Pulsatile Flow ; Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1469153-x
    ISSN 1473-0804 ; 1369-7137
    ISSN (online) 1473-0804
    ISSN 1369-7137
    DOI 10.3109/13697137.2014.999659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: High-dose short-term folate administration modifies ambulatory blood pressure in postmenopausal women. A placebo-controlled study.

    Cagnacci, A / Cannoletta, M / Volpe, A

    European journal of clinical nutrition

    2009  Volume 63, Issue 10, Page(s) 1266–1268

    Abstract: In humans low intake or low levels of folate are related to elevated homocysteine (Hcy) or blood pressure (BP). This study was performed to test whether in healthy postmenopausal women a 3-week administration of folate (5-methyltetrahydrofolate: 5-MTHF) ... ...

    Abstract In humans low intake or low levels of folate are related to elevated homocysteine (Hcy) or blood pressure (BP). This study was performed to test whether in healthy postmenopausal women a 3-week administration of folate (5-methyltetrahydrofolate: 5-MTHF) at the dose of 15 mg/day (n=15), was, in comparison to placebo (n=15), capable of modifying 24-h ambulatory BP, along with Hcy and insulin metabolism. Placebo did not modify any parameter. 5-MTHF significantly decreased nocturnal systolic (-4.48+/-1.8 mm Hg; P=0.029), diastolic (-5.33+/-1.3 mm Hg; P=0.001) and mean (-5.10+/-1.1 mm Hg; P=0.005) BP, in a way that was significantly different from that observed during placebo. 5-MTHF also reduced Hcy (11.77+/-1.15 vs 8.71+/-0.50 micromol/l; P=0.03), and insulin resistance, evaluated by HOMA-IR (2.58+/-0.04 vs 2.03+/-0.04; P=0.01). Whether maintained in the long term, 5-MTHF's cardiovascular and metabolic effect may contribute to primary cardiovascular prevention of postmenopausal women.
    MeSH term(s) Aging/blood ; Aging/physiology ; Blood Pressure/drug effects ; Cardiovascular Diseases/prevention & control ; Circadian Rhythm/physiology ; Dose-Response Relationship, Drug ; Female ; Folic Acid/pharmacology ; Homocysteine/blood ; Humans ; Hyperhomocysteinemia/prevention & control ; Hypertension/prevention & control ; Insulin/metabolism ; Middle Aged ; Postmenopause ; Vitamin B Complex/pharmacology
    Chemical Substances Insulin ; Homocysteine (0LVT1QZ0BA) ; Vitamin B Complex (12001-76-2) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2009-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/ejcn.2009.58
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Seasonal trend of acute pelvic inflammatory disease.

    Xholli, Anjeza / Cannoletta, Marianna / Cagnacci, Angelo

    Archives of gynecology and obstetrics

    2014  Volume 289, Issue 5, Page(s) 1017–1022

    Abstract: Purpose: Many infections follow a seasonal trend. Aim of our study was to check whether acute pelvic inflammatory disease (PID) follows a seasonal progress.: Methods: In a retrospective study on 12,152 hospital records, 158 cases of acute pelvic ... ...

    Abstract Purpose: Many infections follow a seasonal trend. Aim of our study was to check whether acute pelvic inflammatory disease (PID) follows a seasonal progress.
    Methods: In a retrospective study on 12,152 hospital records, 158 cases of acute pelvic inflammatory disease were identified. Periodogram analysis was applied to the date of pelvic inflammatory disease admission and to related environmental factors, such as temperature and photoperiod.
    Results: Pelvic inflammatory disease follows a seasonal rhythm with mean to peak variation of 23 % and maximal values in September (±37.2 days). The rhythm, more evident in married women, is related to the rhythm of temperature advanced by 2 months and of photoperiod advanced by 3 months. Cases of pelvic inflammatory disease are more frequent than expected in unmarried (36 vs. 17.3/34,626, p = 0.015), particularly divorced women 30-40 years of age.
    Conclusions: Our study evidences a seasonal trend and confirms unmarried, particularly divorced status, as important risk factor for acute pelvic inflammatory disease.
    MeSH term(s) Acute Disease ; Adolescent ; Adult ; Circadian Rhythm ; Female ; Hospitalization/statistics & numerical data ; Hospitalization/trends ; Humans ; Italy/epidemiology ; Pelvic Inflammatory Disease/epidemiology ; Pelvic Inflammatory Disease/etiology ; Photoperiod ; Prevalence ; Regression Analysis ; Retrospective Studies ; Risk Factors ; Seasons ; Sexual Behavior ; Socioeconomic Factors ; Young Adult
    Language English
    Publishing date 2014-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-013-3094-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The impact of COVID-19 pandemic on aortic valve surgical service: a single centre experience.

    Vlastos, Dimitrios / Chauhan, Ishaansinh / Mensah, Kwabena / Cannoletta, Maria / Asonitis, Athanasios / Elfadil, Ahmed / Petrou, Mario / De Souza, Anthony / Quarto, Cesare / Bhudia, Sunil K / Rosendahl, Ulrich / Pepper, John / Asimakopoulos, George

    BMC cardiovascular disorders

    2021  Volume 21, Issue 1, Page(s) 434

    Abstract: Background: The coronavirus-disease 2019 (COVID-19) pandemic imposed an unprecedented burden on the provision of cardiac surgical services. The reallocation of workforce and resources necessitated the postponement of elective operations in this cohort ... ...

    Abstract Background: The coronavirus-disease 2019 (COVID-19) pandemic imposed an unprecedented burden on the provision of cardiac surgical services. The reallocation of workforce and resources necessitated the postponement of elective operations in this cohort of high-risk patients. We investigated the impact of this outbreak on the aortic valve surgery activity at a single two-site centre in the United Kingdom.
    Methods: Data were extracted from the local surgical database, including the demographics, clinical characteristics, and outcomes of patients operated on from March 2020 to May 2020 with only one of the two sites resuming operative activity and compared with the respective 2019 period. A similar comparison was conducted with the period between June 2020 and August 2020, when operative activity was restored at both institutional sites. The experience of centres world-wide was invoked to assess the efficiency of our services.
    Results: There was an initial 38.2% reduction in the total number of operations with a 70% reduction in elective cases, compared with a 159% increase in urgent and emergency operations. The attendant surgical risk was significantly higher [median Euroscore II was 2.7 [1.9-5.2] in 2020 versus 2.1 [0.9-3.7] in 2019 (p = 0.005)] but neither 30-day survival nor freedom from major post-operative complications (re-sternotomy for bleeding/tamponade, transient ischemic attack/stroke, renal replacement therapy) was compromised (p > 0.05 for all comparisons). Recommencement of activity at both institutional sites conferred a surgical volume within 17% of the pre-COVID-19 era.
    Conclusions: Our institution managed to offer a considerable volume of aortic valve surgical activity over the first COVID-19 outbreak to a cohort of higher-risk patients, without compromising post-operative outcomes. A backlog of elective cases is expected to develop, the accommodation of which after surgical activity normalisation will be crucial to monitor.
    MeSH term(s) Aged ; Aged, 80 and over ; Aortic Valve/surgery ; COVID-19 ; Cardiac Surgical Procedures/adverse effects ; Cardiac Surgical Procedures/mortality ; Cardiac Surgical Procedures/trends ; Databases, Factual ; Elective Surgical Procedures/trends ; Female ; Heart Valve Diseases/mortality ; Heart Valve Diseases/surgery ; Humans ; London ; Male ; Middle Aged ; Outcome and Process Assessment, Health Care/trends ; Patient Safety ; Postoperative Complications/etiology ; Practice Patterns, Physicians'/trends ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Surgeons/trends ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-021-02253-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Menopausal symptoms and risk factors for cardiovascular disease in postmenopause.

    Cagnacci, A / Cannoletta, M / Palma, F / Zanin, R / Xholli, A / Volpe, A

    Climacteric : the journal of the International Menopause Society

    2012  Volume 15, Issue 2, Page(s) 157–162

    Abstract: Objectives: Conflicting evidence indicates an increased risk for cardiovascular disease in postmenopausal women suffering from hot flushes. In this study, we tested whether, beyond hot flushes, menopausal symptoms are associated with biochemical and ... ...

    Abstract Objectives: Conflicting evidence indicates an increased risk for cardiovascular disease in postmenopausal women suffering from hot flushes. In this study, we tested whether, beyond hot flushes, menopausal symptoms are associated with biochemical and biophysical risk factors for cardiovascular disease.
    Methods: Retrospective cross-sectional analysis on 951 women in surgical or physiological postmenopause, recruited at the menopause outpatient service of our university hospital between April 2002 and December 2009. The Greene Climacteric Scale and its subscales for anxiety, depression, somatic symptoms, vasomotor symptoms and sexuality were used to evaluate menopausal complaints. Blood pressure, fasting glucose and lipids levels were evaluated as risk factors for cardiovascular disease. Anthropometric parameters and those derived by remote and reproductive medical history were used as possible confounders. All data were anonymously retrieved from an electronic database.
    Results: By multiple regression analysis, high density lipoprotein (HDL) cholesterol was inversely related to body mass index, the Greene Climacteric Scale score and years since menopause (R = 0.390; p = 0.0001). The total cholesterol/HDL cholesterol ratio was positively related to waist circumference and the Greene Climacteric Scale score (R = 0.356; p = 0.0001). Triglycerides (R = 0.353; p = 0.0001) and triglyceride/HDL cholesterol (R = 0.425; p = 0.0001) were positively related to waist circumference, the Greene Climacteric Scale score and the Greene vasomotor subscore. Glucose was positively related to waist circumference, years since menopause and the Greene Climacteric Scale score (R = 0.390; p = 0.0001). Blood pressure was not related to menopausal symptoms. The 10-year risk for cardiovascular disease calculated by the Framingham formula was related independently and directly to body mass index and the Greene Climacteric Scale score (R = 0.183; p = 0.0001).
    Conclusions: Menopausal symptoms evaluated by a validated climacteric scale are associated with a worsening of biochemical risk factors for atherosclerosis and cardiovascular disease.
    MeSH term(s) Aged ; Blood Glucose ; Blood Pressure ; Body Mass Index ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Hot Flashes/blood ; Hot Flashes/physiopathology ; Humans ; Middle Aged ; Postmenopause/blood ; Postmenopause/physiology ; Regression Analysis ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Time Factors ; Triglycerides/blood ; Waist Circumference
    Chemical Substances Blood Glucose ; Cholesterol, HDL ; Triglycerides ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1469153-x
    ISSN 1473-0804 ; 1369-7137
    ISSN (online) 1473-0804
    ISSN 1369-7137
    DOI 10.3109/13697137.2011.617852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Relation between body mass index and endothelium-dependent vasodilatation in healthy postmenopausal women.

    Cagnacci, A / Cannoletta, M / Arangino, S / Generali, M / Ferrari, S / Volpe, A

    Climacteric : the journal of the International Menopause Society

    2008  Volume 11, Issue 5, Page(s) 383–389

    Abstract: Objective: To evaluate whether endothelium-dependent vasodilatation is related to anthropometric parameters in 105 healthy postmenopausal women 47-68 years of age.: Methods: Flow-dependent, endothelium-dependent vasodilatation was considered as the ... ...

    Abstract Objective: To evaluate whether endothelium-dependent vasodilatation is related to anthropometric parameters in 105 healthy postmenopausal women 47-68 years of age.
    Methods: Flow-dependent, endothelium-dependent vasodilatation was considered as the maximal dilatation following deflation of a cuff placed on the forearm and inflated to supra-systolic blood pressure values for 4 min. Endothelium-independent vasodilatation was considered as the maximal dilatation induced by sublingual nitroglycerine (400 microg).
    Results: Among parameters such as height, weight, body mass index (BMI), waist, hip, waist/hip ratio, lipids, glucose or insulin, only BMI, an indirect index of adiposity, was independently and directly related to baseline brachial artery diameter (b = 0.042, r = 0.269, p = 0.0055) and flow-mediated endothelium-dependent vasodilatation either expressed as net (b = 0.034, r = 0.315, p = 0.001) or percentage (b = 0.376, r = 0.202, p = 0.039) change. Stratification for BMI categories showed that women with BMI < 22 kg/m(2) had an endothelium-dependent vasodilatation, significantly lower than that of women with BMI >or= 30 kg/m(2) (0.711 +/- 0.076 mm vs. 1.107 +/- 0.141 mm; p = 0.0114). BMI was not related to endothelium-independent vasodilatation.
    Conclusions: Present results show that, in healthy postmenopausal women, endothelium-dependent vasodilatation is related to BMI, arteries of slender women dilating less than those of their heavier counterparts. A low BMI does not appear to be beneficial for artery vasodilatation in healthy postmenopausal women.
    MeSH term(s) Aged ; Blood Pressure/physiology ; Body Mass Index ; Brachial Artery/diagnostic imaging ; Endothelium, Vascular/diagnostic imaging ; Female ; Humans ; Linear Models ; Middle Aged ; Nitroglycerin/pharmacology ; Postmenopause/physiology ; Regional Blood Flow/physiology ; Ultrasonography ; Vasodilation/physiology ; Vasodilator Agents/pharmacology
    Chemical Substances Vasodilator Agents ; Nitroglycerin (G59M7S0WS3)
    Language English
    Publishing date 2008-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1469153-x
    ISSN 1473-0804 ; 1369-7137
    ISSN (online) 1473-0804
    ISSN 1369-7137
    DOI 10.1080/13697130802356630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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